A comprehensive evaluation of the reproductive toxicity of Quassia amara in male rats

Reproductive Toxicology

Volumn 17, Issue 1, 2003, Pages 45-50

  Parveen, Seema ^a   Das, Suwagmani ^a   Prakash Kundra, Chandra ^a   Pereira, B M J ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

Author keywords

Glucosidase; Accessory sex organs; Antifertility; Blood profiles; Epididymis; Quassia amara; Sperm characteristics; Toxicity

Indexed keywords

ACID PHOSPHATASE PROSTATE ISOENZYME; ALANINE AMINOTRANSFERASE; ALPHA GLUCOSIDASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHLOROFORM; CITRIC ACID; FRUCTOSE; HEMOGLOBIN; PLANT EXTRACT; PROTEIN; QUASSIA AMARA EXTRACT; UNCLASSIFIED DRUG; UREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BARK; BLOOD EXAMINATION; CELL COUNT; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DILUTION; ENZYME ACTIVITY; EPIDIDYMIS; MALE; MALE GENITAL SYSTEM; NONHUMAN; PLANT; PROSTATE; QUASSIA AMARA; RAT; REPRODUCTIVE TOXICITY; SEMINAL VESICLE; SPERMATOZOON; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; SPERMATOZOON TAIL; TESTIS WEIGHT;

ANIMALS; ANTISPERMATOGENIC AGENTS; CLINICAL CHEMISTRY TESTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIDIDYMIS; FERTILITY; HEMATOLOGIC TESTS; INJECTIONS, INTRAMUSCULAR; MALE; ORGAN SIZE; PLANT BARK; PLANT EXTRACTS; QUASSIA; RATS; RATS, WISTAR; SPERM MOTILITY; SPERMATOZOA; TESTIS;

AMARA; ANIMALIA; QUASSIA AMARA;

EID: 0037222489     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(02)00080-1     Document Type: Article

References (22)

1. Scragg AH, Allan EJ. Quassia amara (Surinam Quassia): in vitro culture and the production of quassin. In: Bajaj YPS, editor. Biotechnology in agriculture and forestry, vol. 26. Berlin: Springer; 1994, p. 316-26.
2. Kupchan SM, Streelman DR. Quassimarin, a new antileukemic quassinoid from Quassia amara. J Org Chem 1976;41:3481-2.
3. Considine RT, Willingham Jr W, Chaney SG, Wyrick S, Hall IH, Lee KH. Structure-activity relationships for binding and inactivation of rabbit reticulocyte ribosomes by quassinoid antineoplastic agents. Eur J Biochem 1983;132:157-63.
4. Grieve, M. A modern herbal. London: Tiger Books International; 1992.
5. Jenson O. Pediculosis capitis treated with quassia tincture. Acta Derm Venereol 1978;58:557-9.
6. Jenson O. Treatment of head lice with quassia tincture. Ugeskr Laeger 1979;141:225-6.
7. Park MH, Maeda M, Komura H, Nakanishi K, Nomoto K. Acute insecticidal activity of quassin and its congeners against the American cockroach. Chem Pharm Bull (Tokyo) 1987;35:3082-5.
8. Evans DA, Raj RK. Larvicidal efficacy of Quassin against Culex quinquefasciatus. Indian J Med Res 1991;93:324-7.
9. Ajaiyeoba EO, Abalogu UI, Krebs HC, Oduola AM. In vivo antimalarial activities of Quassia amara and Quassia undulata plant extracts in mice. J Ethnopharmacol 1999;67:321-5.
10. Apers S, Cimanga K, Vanden Berghe D, Van Meenen E, Longanga AO, Foriers A, et al. Antiviral activity of simalikalactone D, a quassinoid from quassia africana. Planta Med 2002;68:20-4.
11. Dou J, Khan IA, McChesney JD, Burandt CL. Qualitative and quantitative high-performance liquid chromatography analysis of quassinoids in simaroubaceae plants. Pharm Anal 1996a;7:192-200.
12. Dou J, McChesney JD, Sindelar RD, Goins DK, Khan IA, Walker LA. A new quassinoid from crude quassin-extract of Quassia amara. Int J Pharmacognosy 1996;34:349-54.
13. Kitagawa I, Mahmud T, Yokota K, Nakagawa S, Mayumi T, Kobayashi M, et al. Indonesian medicinal plants. XVII. Characterization of quassinoids from the stems of Quassia indica. Chem Pharm Bull (Tokyo) 1996;44:2009-14.
14. Garcia Gonzalez M, Gonzalez Camacho SM, Pazos Sanou L. Pharmacologic activity of the aqueous wood extract from Quassia amara (Simarubaceae) on albino rats and mice. Rev Biol Trop 1997;44-45:47-50.
15. Njar VC, Alao TO, Okogun JI, Raji Y, Bolarinwa AF, Nduka EU. Antifertility activity of Quassia amara: quassin inhibits the steroidogenesis in rat Leydig cells in vitro. Planta Med 1995;61:180-2.
16. Raji Y, Bolarinwa AF. Antifertility activity of Quassia amara in male rats - in vivo study. Life Sci 1997;61:1067-74.
17. Rastogi RP, Mehrotra BN. Glossary of Indian medicinal plant toxins, vol. 1. New Delhi: Publication and Information Directorate CSIR; 1991.
18. Mortimer D. Practical laboratory andrology. Oxford: Oxford University Press; 1994.
19. Tenniswood M, Bird CE, Clark AF. Acid phosphatases: androgen dependent markers of rat prostate. Can J Biochem 1976;54:350-7.
20. Saffron M, Denstedt OF. A rapid method for the determination of citric acid. J Biol Chem 1948;175:849.
21. Foreman D, Gaylor L, Evans E, Trella C. A modification of the Roe procedure for the determination of fructose in tissues with increased specificity. Anal Chem 1973;56:584-90.
22. Tulsiani DRP, Orgebin-crist MC, Skudlarek MC. Role of luminal fluid glycosyltransferases and glycosidases in the modification of rat sperm plasma membrane glycoproteins during epididymal maturation. J Reprod Fertil 1998;53(Suppl):85-97.