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Volumn 43, Issue 12, 2011, Pages 844-853

Novel therapeutic agents for the treatment of gastroenteropancreatic neuroendocrine tumors

Author keywords

Angiogenesis inhibitors; Everolimus; Sunitinib; Targeted drugs; Tyrosine kinase inhibitors

Indexed keywords

2 METHOXYESTRADIOL; ALPHA2B INTERFERON; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CAPECITABINE; CIXUTUMUMAB; CYCLOPHOSPHAMIDE; DALOTUZUMAB; DOXORUBICIN; ENDOSTATIN; ERLOTINIB; EVEROLIMUS; FLUOROURACIL; GANITUMAB; GEFITINIB; MOTESANIB; OCTREOTIDE; PANITUMUMAB; PASIREOTIDE; PAZOPANIB; SOGRAZEPIDE; SORAFENIB; SUNITINIB; TELOTRISTAT ETHYL; TEMOZOLOMIDE; TEMSIROLIMUS; THALIDOMIDE; VASCULOTROPIN; VATALANIB;

EID: 82155166239     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0031-1291368     Document Type: Review
Times cited : (10)

References (71)
  • 1
    • 0025535786 scopus 로고
    • Pathophysiological and pharmacotherapeutic aspects of serotonin and serotonergic drugs
    • 03
    • van Zwieten P A, Blauw G J, van Brummelen P. Pathophysiological and pharmacotherapeutic aspects of serotonin and serotonergic drugs. Clin Physiol Biochem: 1990; 8 03 1 18
    • (1990) Clin Physiol Biochem , vol.8 , pp. 1-18
    • Van Zwieten, P.A.1    Blauw, G.J.2    Van Brummelen, P.3
  • 2
    • 0023055355 scopus 로고
    • Somatostatin analogue (SMS 201-995) in the management of gastroenteropancreatic tumors and diarrhea syndromes
    • Vinik A I, Tsai S T, Moattari A R, Cheung P, Eckhauser F E, Cho K. Somatostatin analogue (SMS 201-995) in the management of gastroenteropancreatic tumors and diarrhea syndromes. Am J Med: 1986; 81 23 40
    • (1986) Am J Med , vol.81 , pp. 23-40
    • Vinik, A.I.1    Tsai, S.T.2    Moattari, A.R.3    Cheung, P.4    Eckhauser, F.E.5    Cho, K.6
  • 3
    • 0021876171 scopus 로고
    • Treatment of patients with pancreatic endocrine tumours using a new long-acting somatostatin analogue symptomatic and peptide responses
    • Wood S M, Kraenzlin M E, Adrian T E, Bloom S R. Treatment of patients with pancreatic endocrine tumours using a new long-acting somatostatin analogue: symptomatic and peptide responses. Gut: 1985; 26 438 444 (Pubitemid 15064706)
    • (1985) Gut , vol.26 , Issue.5 , pp. 438-444
    • Wood, S.M.1    Kraenzlin, M.E.2    Adrian, T.E.3    Bloom, S.R.4
  • 4
    • 0020531637 scopus 로고
    • Effects of leukocyte interferon on clinical symptoms and hormone levels in patients with mid-gut carcinoid tumors and carcinoid syndrome
    • berg K, Funa K, Alm G. Effects of leukocyte interferon on clinical symptoms and hormone levels in patients with mid-gut carcinoid tumors and carcinoid syndrome. N Engl J Med: 1983; 309 129 133 (Pubitemid 13069520)
    • (1983) New England Journal of Medicine , vol.309 , Issue.3 , pp. 129-133
    • Oberg, K.1    Funa, K.2    Alm, G.3
  • 5
    • 0026530547 scopus 로고
    • Streptozocin-doxorubicin, streptozocin-fluorouracil or chlorozotocin in the treatment of advanced islet-cell carcinoma
    • Moertel C G, Lefkopoulo M, Lipsitz S, Hahn R G, Klaassen D. Streptozocin-doxorubicin, streptozocin-fluorouracil or chlorozotocin in the treatment of advanced islet-cell carcinoma. N Engl J Med: 1992; 326 519 523
    • (1992) N Engl J Med , vol.326 , pp. 519-523
    • Moertel, C.G.1    Lefkopoulo, M.2    Lipsitz, S.3    Hahn, R.G.4    Klaassen, D.5
  • 7
    • 47549101659 scopus 로고    scopus 로고
    • Treatment with combined streptozotocin and liposomal doxorubicin in metastatic endocrine pancreatic tumors
    • DOI 10.1159/000117575
    • Fjallskog M L, Janson E T, Falkmer U G, Vatn M H, Oberg K E, Eriksson B K. Treatment with combined streptozotocin and liposomal doxorubicin in metastatic endocrine pancreatic tumors. Neuroendocrinology: 2008; 88 53 58 (Pubitemid 352009119)
    • (2008) Neuroendocrinology , vol.88 , Issue.1 , pp. 53-58
    • Fjallskog, M.-L.H.1    Janson, E.T.2    Falkmer, U.G.3    Vatn, M.H.4    Oberg, K.E.5    Eriksson, B.K.6
  • 9
    • 70349146311 scopus 로고    scopus 로고
    • Liver resection versus other treatments for neuroendocrine tumours in patients with resectable liver metastases
    • CD007060
    • Gurusamy K S, Ramamoorthy R, Sharma D, Davidson B R. Liver resection versus other treatments for neuroendocrine tumours in patients with resectable liver metastases. Cochrane Database Syst Rev: 2009; 2 CD007060
    • (2009) Cochrane Database Syst Rev , Issue.2
    • Gurusamy, K.S.1    Ramamoorthy, R.2    Sharma, D.3    Davidson, B.R.4
  • 10
    • 67650083886 scopus 로고    scopus 로고
    • Palliative cytoreductive surgery versus other palliative treatments in patients with unresectable liver metastases from gastro-entero-pancreatic neuroendocrine tumours
    • CD007118
    • Gurusamy K S, Pamecha V, Sharma D, Davidson B R. Palliative cytoreductive surgery versus other palliative treatments in patients with unresectable liver metastases from gastro-entero-pancreatic neuroendocrine tumours. Cochrane Database Syst Rev: 2009; 1 CD007118
    • (2009) Cochrane Database Syst Rev , Issue.1
    • Gurusamy, K.S.1    Pamecha, V.2    Sharma, D.3    Davidson, B.R.4
  • 12
    • 72949085528 scopus 로고    scopus 로고
    • Review Article: Somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumors
    • Modlin I M, Pavel M E, Kidd M, Gustafsson B. Review Article: Somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumors. Alim Pharmacol Therap: 2010; 31 169 188
    • (2010) Alim Pharmacol Therap , vol.31 , pp. 169-188
    • Modlin, I.M.1    Pavel, M.E.2    Kidd, M.3    Gustafsson, B.4
  • 13
    • 70350442637 scopus 로고    scopus 로고
    • Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumour growth in patients with metastatic neuroendocrine midgut tumours: A report from the PROMID Study Group
    • PROMID study group
    • Rinke A, Mller H, Schade-Brittinger C, Klose K, Barth P, Wied M, Mayer C, Aminossadati B, Pape U, Blker M, Harder J, Arnold C, Gress T, Arnold R. PROMID study group Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumour growth in patients with metastatic neuroendocrine midgut tumours: a report from the PROMID Study Group. J Clin Oncol: 2009; 28 4656 4663
    • (2009) J Clin Oncol , vol.28 , pp. 4656-4663
    • Rinke, A.1    Mller, H.2    Schade-Brittinger, C.3    Klose, K.4    Barth, P.5    Wied, M.6    Mayer, C.7    Aminossadati, B.8    Pape, U.9    Blker, M.10    Harder, J.11    Arnold, C.12    Gress, T.13    Arnold, R.14
  • 15
    • 0043132282 scopus 로고    scopus 로고
    • Prospective, randomized, multicenter trial on the antiproliferative effect of lanreotide, interferon alfa, and their combination for therapy of metastatic neuroendocrine gastroenteropancreatic tumors - The International Lanreotide and Interferon Alfa Study Group
    • DOI 10.1200/JCO.2003.12.142
    • Faiss S, Pape U F, Bohmig M, Drffel Y, Mansmann U, Golder W, Riecken E O, Wiedenmann B. and International Lanreotide and Interferon Alfa Study Group Prospective, randomized, multicenter trial on the antiproliferative effect of lanreotide, interferon alfa, and their combination for therapy of metastatic neuroendocrine gastroenteropancreatic tumors the International Lanreotide and Interferon Alfa Study Group. J Clin Oncol: 2003; 21 2689 2696 (Pubitemid 46606312)
    • (2003) Journal of Clinical Oncology , vol.21 , Issue.14 , pp. 2689-2696
    • Faiss, S.1    Pape, U.-F.2    Bohmig, M.3    Dorffel, Y.4    Mansmann, U.5    Golder, W.6    Riecken, E.O.7    Wiedenmann, B.8
  • 17
    • 77957575775 scopus 로고    scopus 로고
    • The inhibitory effect of a novel cytotoxic somatostatin analogue AN-162 on experimental glioblastoma
    • Pozsgai E, Schally A V, Halmos G, Rick F, Bellyei S. The inhibitory effect of a novel cytotoxic somatostatin analogue AN-162 on experimental glioblastoma. Horm Metab Res: 2010; 42 781 786
    • (2010) Horm Metab Res , vol.42 , pp. 781-786
    • Pozsgai, E.1    Schally, A.V.2    Halmos, G.3    Rick, F.4    Bellyei, S.5
  • 18
    • 24644503671 scopus 로고    scopus 로고
    • Phase II/III study of doxorubicin with fluorouracil compared with streptozocin with fluorouracil or dacarbazine in the treatment of advanced carcinoid tumors: Eastern Cooperative Oncology Group Study E1281
    • DOI 10.1200/JCO.2005.03.616
    • Sun W, Lipsitz S, Catalano P, Mailliard J A, Haller D G. Phase II/III study of doxorubicin with fluorouracil compared with streptozocin with fluorouracil or dacarbazine in the treatment of advanced carcinoid tumours: Eastern Cooperative Oncology Group Study E1281. J Clin Oncol: 2005; 23 4897 4904 (Pubitemid 46223995)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.22 , pp. 4897-4904
    • Sun, W.1    Lipsitz, S.2    Catalano, P.3    Mailliard, J.A.4    Haller, D.G.5
  • 19
    • 72549103551 scopus 로고    scopus 로고
    • Phase III trial of chemotherapy using 5-fluorouracil and streptozotocin compared with interferon alpha for advanced carcinoid tumors: FNCLCC-FFCD 9710
    • Fdration Francophone de Cancrologie Digestive (FFCD); Digestive Tumors Group of the Fdration Nationale des Centres de Lutte Contre le Cancer (FNCLCC)
    • Dahan L, Bonnetain F, Rougier P, Raoul J L, Gamelin E, Etienne P L, Cadiot G, Mitry E, Smith D, Cvitkovic F, Coudert B, Ricard F, Bedenne L, Seitz J F. Fdration Francophone de Cancrologie Digestive (FFCD); Digestive Tumors Group of the Fdration Nationale des Centres de Lutte Contre le Cancer (FNCLCC) Phase III trial of chemotherapy using 5-fluorouracil and streptozotocin compared with interferon alpha for advanced carcinoid tumors: FNCLCC-FFCD 9710. Endocr Rel Cancer: 2009; 16 1351 1361
    • (2009) Endocr Rel Cancer , vol.16 , pp. 1351-1361
    • Dahan, L.1    Bonnetain, F.2    Rougier, P.3    Raoul, J.L.4    Gamelin, E.5    Etienne, P.L.6    Cadiot, G.7    Mitry, E.8    Smith, D.9    Cvitkovic, F.10    Coudert, B.11    Ricard, F.12    Bedenne, L.13    Seitz, J.F.14
  • 21
    • 0037233574 scopus 로고    scopus 로고
    • Expression of somatostatin receptor subtypes 1 to 5 in tumor tissue and intratumoral vessels in malignant endocrine pancreatic tumors
    • DOI 10.1385/MO:20:1:59
    • Fjllskog M L, Ludvigsen E, Stridsberg M, Oberg K, Eriksson B, Janson E T. Expression of somatostatin receptor subtypes 1 to 5 in tumor tissue and intratumoral vessels in malignant endocrine pancreatic tumors. Med Oncol: 2003; 20 59 67 (Pubitemid 36344027)
    • (2003) Medical Oncology , vol.20 , Issue.1 , pp. 59-67
    • Fjallskog, M.-L.1    Ludvigsen, E.2    Stridsberg, M.3    Oberg, K.4    Eriksson, B.5    Janson, E.T.6
  • 22
    • 33845734120 scopus 로고    scopus 로고
    • Expression of tyrosine kinase receptors in malignant midgut carcinoid tumors
    • DOI 10.1159/000096294
    • Welin S, Fjllskog M L, Saras J, Eriksson B, Janson E T. Expression of tyrosine kinase receptors in malignant midgut carcinoid tumors. Neuroendocrinology: 2006; 84 42 48 (Pubitemid 44973686)
    • (2006) Neuroendocrinology , vol.84 , Issue.1 , pp. 42-48
    • Welin, S.1    Fjallskog, M.L.2    Saras, J.3    Eriksson, B.4    Janson, E.T.5
  • 23
    • 0027269918 scopus 로고
    • Expression of growth factor peptides and their receptors in neuroendocrine tumors of the digestive system
    • Chaudhry A, Funa K, Oberg K. Expression of growth factor peptides and their receptors in neuroendocrine tumors of the digestive system. Acta Oncol: 1993; 32 107 114 (Pubitemid 23188522)
    • (1993) Acta Oncologica , vol.32 , Issue.2 , pp. 107-114
    • Chaudhry, A.1    Funa, K.2    Oberg, K.3
  • 26
    • 0026526078 scopus 로고
    • Presence of IGF-I in human midgut carcinoid tumours an autocrine regulator of carcinoid tumour growth
    • Nilsson O, Wangberg B, Theodorsson E, Skottner A, Ahlman H. Presence of IGF-I in human midgut carcinoid tumours an autocrine regulator of carcinoid tumour growth? Int J Cancer: 1992; 51 195 203
    • (1992) Int J Cancer , vol.51 , pp. 195-203
    • Nilsson, O.1    Wangberg, B.2    Theodorsson, E.3    Skottner, A.4    Ahlman, H.5
  • 27
    • 25144432015 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and activated epidermal growth factor receptor expression in gastrointestinal carcinoids and pancreatic endocrine carcinomas
    • DOI 10.1038/modpathol.3800427, PII 3800427
    • Papouchado B, Erickson L A, Rohlinger A L, Hobday T J, Erlichman C, Ames M M, Lloyd R V. Epidermal growth factor receptor and activated epidermal growth factor receptor expression in gastrointestinal carcinoids and pancreatic endocrine carcinomas. Mod Pathol: 2005; 18 1329 1335 (Pubitemid 41348651)
    • (2005) Modern Pathology , vol.18 , Issue.10 , pp. 1329-1335
    • Papouchado, B.1    Erickson, L.A.2    Rohlinger, A.L.3    Hobday, T.J.4    Erlichman, C.5    Ames, M.M.6    Lloyd, R.V.7
  • 30
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • DOI 10.1016/j.ccr.2005.09.005, PII S1535610805002989
    • Casanovas O, Hicklin D J, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell: 2005; 8 299 309 (Pubitemid 41443415)
    • (2005) Cancer Cell , vol.8 , Issue.4 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 31
    • 34247162696 scopus 로고    scopus 로고
    • Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors
    • DOI 10.1002/cncr.22554
    • Zhang J, Jia Z, Li Q, Wang L, Rashid A, Zhu Z, Evans D B, Vauthey J N, Xie K, Yao J C. Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors. Cancer: 2007; 109 1478 1486 (Pubitemid 46595681)
    • (2007) Cancer , vol.109 , Issue.8 , pp. 1478-1486
    • Zhang, J.1    Jia, Z.2    Li, Q.3    Wang, L.4    Rashid, A.5    Zhu, Z.6    Evans, D.B.7    Vauthey, J.-N.8    Xie, K.9    Yao, J.C.10
  • 32
    • 17044402977 scopus 로고    scopus 로고
    • Circulating levels of angiogenic cytokines can predict tumour progression and prognosis in neuroendocrine carcinomas
    • Pavel M E, Hassler G, Baum U, Hahn E G, Lohmann T, Schuppan D. Circulating levels of angiogenic cytokines can predict tumour progression and prognosis in neuroendocrine carcinomas. Clin Endocrinol (Oxf): 2005; 62 434 443
    • (2005) Clin Endocrinol (Oxf) , vol.62 , pp. 434-443
    • Pavel, M.E.1    Hassler, G.2    Baum, U.3    Hahn, E.G.4    Lohmann, T.5    Schuppan, D.6
  • 33
    • 72749109808 scopus 로고    scopus 로고
    • Circulating angiopoietin-2 is elevated in patients with neuroendocrine tumours and correlates with disease burden and prognosis
    • Srirajaskanthan R, Dancey G, Hackshaw A, Luong T, Caplin M E, Meyer T. Circulating angiopoietin-2 is elevated in patients with neuroendocrine tumours and correlates with disease burden and prognosis. Endocr Relat Cancer: 2009; 16 967 976
    • (2009) Endocr Relat Cancer , vol.16 , pp. 967-976
    • Srirajaskanthan, R.1    Dancey, G.2    Hackshaw, A.3    Luong, T.4    Caplin, M.E.5    Meyer, T.6
  • 38
    • 41649114168 scopus 로고    scopus 로고
    • Targeting vascular endothelial growth factor in advanced carcinoid tumor: A random assignment phase II study of depot octreotide with bevacizumab and pegylated interferon alpha-2b
    • Yao J C, Phan A, Hoff P M, Chen H X, Charnsangavej C, Yeung S C, Hess K, Ng C, Abbruzzese J L, Ajani J A. Targeting vascular endothelial growth factor in advanced carcinoid tumor: a random assignment phase II study of depot octreotide with bevacizumab and pegylated interferon alpha-2b. J Clin Oncol: 2008; 26 1316 1323
    • (2008) J Clin Oncol , vol.26 , pp. 1316-1323
    • Yao, J.C.1    Phan, A.2    Hoff, P.M.3    Chen, H.X.4    Charnsangavej, C.5    Yeung, S.C.6    Hess, K.7    Ng, C.8    Abbruzzese, J.L.9    Ajani, J.A.10
  • 41
    • 64349087319 scopus 로고    scopus 로고
    • Phase II trial of FOLFOX plus bevacizumab in advanced, progressive neuroendocrine tumors
    • (suppl; abstr 15545)
    • Venook A P, Ko A H, Tempero M A, Uy J, Weber T, Korn M, Bergsland E K. Phase II trial of FOLFOX plus bevacizumab in advanced, progressive neuroendocrine tumors. J Clin Oncol: 2008; 26 (suppl; abstr 15545)
    • (2008) J Clin Oncol , pp. 26
    • Venook, A.P.1    Ko, A.H.2    Tempero, M.A.3    Uy, J.4    Weber, T.5    Korn, M.6    Bergsland, E.K.7
  • 43
    • 38049008967 scopus 로고    scopus 로고
    • Phase II study of thalidomide in patients with metastatic carcinoid and islet cell tumors
    • Varker K A, Campbell J, Shah M H. Phase II study of thalidomide in patients with metastatic carcinoid and islet cell tumors. Cancer Chemother Pharmacol: 2008; 61 661 668
    • (2008) Cancer Chemother Pharmacol , vol.61 , pp. 661-668
    • Varker, K.A.1    Campbell, J.2    Shah, M.H.3
  • 45
    • 64349123204 scopus 로고    scopus 로고
    • Open-label, nonrandomized, multicenter phase II study evaluating the angiogenesis inhibitor PTK787/ZK222584 (PTK/ZK) in patients with advanced neuroendocrine carcinomas (NEC)
    • Pavel M E, Bartel C, Heuck F, Neumann F, Tiling N, Pape U F, Plckinger U, Wiedenmann B. Open-label, nonrandomized, multicenter phase II study evaluating the angiogenesis inhibitor PTK787/ZK222584 (PTK/ZK) in patients with advanced neuroendocrine carcinomas (NEC). Proc Am Soc Clin Oncol: 2008; 26 14684
    • (2008) Proc Am Soc Clin Oncol , vol.26 , pp. 14684
    • Pavel, M.E.1    Bartel, C.2    Heuck, F.3    Neumann, F.4    Tiling, N.5    Pape, U.F.6    Plckinger, U.7    Wiedenmann, B.8
  • 47
    • 41349094931 scopus 로고    scopus 로고
    • Sorafenib MC044h, a phase II trial of sorafenib in patients (pts) with metastatic neuroendocrine tumors (NET): A Phase II Consortium (P2C) study
    • ASCO Annual Meeting Proceedings 2007; Part I. Vol 25, No. 18S (Suppl: 4504)
    • Hobday T, Rubin J, Holen K, Picus J, Donehower R, Marschke R, Maples W, Lloyd R, Mahoney M, Erlichman C. Sorafenib MC044h, a phase II trial of sorafenib in patients (pts) with metastatic neuroendocrine tumors (NET): A Phase II Consortium (P2C) study. J Clin Oncol: 2007; ASCO Annual Meeting Proceedings 2007; Part I. Vol 25, No. 18S (Suppl: 4504)
    • (2007) J Clin Oncol
    • Hobday, T.1    Rubin, J.2    Holen, K.3    Picus, J.4    Donehower, R.5    Marschke, R.6    Maples, W.7    Lloyd, R.8    Mahoney, M.9    Erlichman, C.10
  • 48
    • 79960201832 scopus 로고    scopus 로고
    • (GETNE). Sorafenib and bevacizumab combination targeted therapy in advanced neuroendocrine tumor: A phase II study of the Spanish Neuroendocrine Tumor Group (GETNE0801)
    • Spanish Neuroendocrine Tumor Group (suppl; abstr 4113)
    • Castellano D E, Capdevila J, Salazar R, Sastre J, Alonso V, Llanos M, Garcia-Carbonero R, Abad A, Sevilla I, Duran I. Spanish Neuroendocrine Tumor Group (GETNE). Sorafenib and bevacizumab combination targeted therapy in advanced neuroendocrine tumor: A phase II study of the Spanish Neuroendocrine Tumor Group (GETNE0801). J Clin Oncol: 2011; 29 (suppl; abstr 4113)
    • (2011) J Clin Oncol , vol.29
    • Castellano, D.E.1    Capdevila, J.2    Salazar, R.3    Sastre, J.4    Alonso, V.5    Llanos, M.6    Garcia-Carbonero, R.7    Abad, A.8    Sevilla, I.9    Duran, I.10
  • 53
    • 78049425681 scopus 로고    scopus 로고
    • A prospective, multi-institutional phase II study of GW786034 (pazopanib) and depot octreotide (sandostatin LAR) in advanced low-grade neuroendocrine carcinoma (LGNEC)
    • (suppl; abstr 4001)
    • Phan A T, Yao J C, Fogelman D R, Hess K R, Ng C S, Bullock S A, Malinowski P, Regan E, Kulke M. A prospective, multi-institutional phase II study of GW786034 (pazopanib) and depot octreotide (sandostatin LAR) in advanced low-grade neuroendocrine carcinoma (LGNEC). J Clin Oncol: 2010; 28 15s (suppl; abstr 4001)
    • (2010) J Clin Oncol , vol.28
    • Phan, A.T.1    Yao, J.C.2    Fogelman, D.R.3    Hess, K.R.4    Ng, C.S.5    Bullock, S.A.6    Malinowski, P.7    Regan, E.8    Kulke, M.9
  • 55
    • 79951812671 scopus 로고    scopus 로고
    • A phase II clinical trial of MK-0646, an insulin-like growth factor-1 receptor inhibitor (IGF-1R), in patients with metastatic well-differentiated neuroendocrine tumors (NETs)
    • (suppl; abstr 4163)
    • Reidy D L, Hollywood E, Segal M, Saltz L. A phase II clinical trial of MK-0646, an insulin-like growth factor-1 receptor inhibitor (IGF-1R), in patients with metastatic well-differentiated neuroendocrine tumors (NETs). J Clin Oncol: 2010; 28 15s (suppl; abstr 4163)
    • (2010) J Clin Oncol , vol.28
    • Reidy, D.L.1    Hollywood, E.2    Segal, M.3    Saltz, L.4
  • 59
    • 78650443861 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled multicenter phase III trial of everolimus + octreotide LAR vs. placebo + octreotide LAR in patients with advanced neuroendocrine tumors (NET) (RADIANT-2)
    • 08 LBA8
    • Pavel M, Hainsworth J D, Baudin E, Peeters M, Hoersch D, Anthony L, Hoosen S St., Peter J, Jehl V, Yao J C. A randomized, double-blind, placebo-controlled multicenter phase III trial of everolimus + octreotide LAR vs. placebo + octreotide LAR in patients with advanced neuroendocrine tumors (NET) (RADIANT-2). Ann Oncol: 2010; 21 08 viii1 viii12 LBA8
    • (2010) Ann Oncol , vol.21
    • Pavel, M.1    Hainsworth, J.D.2    Baudin, E.3    Peeters, M.4    Hoersch, D.5    Anthony, L.6    St., H.S.7    Peter, J.8    Jehl, V.9    Yao, J.C.10
  • 60
    • 0036111856 scopus 로고    scopus 로고
    • SOM230: A novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile
    • Bruns C, Lewis I, Briner U, Meno-Tetang G, Weckbecker G. SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile. Eur J Endocrinol: 2002; 146 707 716 (Pubitemid 34552506)
    • (2002) European Journal of Endocrinology , vol.146 , Issue.5 , pp. 707-716
    • Bruns, C.1    Lewis, I.2    Briner, U.3    Meno-Tetang, G.4    Weckbecker, G.5
  • 61
    • 65349180440 scopus 로고    scopus 로고
    • The SOM230 Carcinoid Study Group. Safety and efficacy of pasireotide (SOM230) in patients with metastatic carcinoid tumors refractory or resistant to octreotide LAR: Results of a phase II study
    • ASCO Annual Meeting Proceedings Part I. Vol 24, No. 18S (Suppl): 4082
    • Kvols L, Wiedenmann B, Oberg K, Glusman J E, Odorisio T M, De Herder W, Gao B, Arnold R, Anthony L. The SOM230 Carcinoid Study Group. Safety and efficacy of pasireotide (SOM230) in patients with metastatic carcinoid tumors refractory or resistant to octreotide LAR: Results of a phase II study. J Clin Oncol: 2006; ASCO Annual Meeting Proceedings Part I. Vol 24, No. 18S (Suppl): 4082
    • (2006) J Clin Oncol
    • Kvols, L.1    Wiedenmann, B.2    Oberg, K.3    Glusman, J.E.4    Odorisio, T.M.5    De Herder, W.6    Gao, B.7    Arnold, R.8    Anthony, L.9
  • 62
    • 58149385408 scopus 로고    scopus 로고
    • Glycemic control in patients with insulinoma treated with everolimus
    • Kulke M H, Bergsland E K, Yao J C. Glycemic control in patients with insulinoma treated with everolimus. N Engl J Med: 2009; 360 195 197
    • (2009) N Engl J Med , vol.360 , pp. 195-197
    • Kulke, M.H.1    Bergsland, E.K.2    Yao, J.C.3
  • 63
    • 77951654565 scopus 로고    scopus 로고
    • Therapies for the medical management of persistent hypoglycaemia in two cases of inoperable malignant insulinoma
    • Ong G S, Henley D E, Hurley D, Turner J H, Claringbold P G, Fegan P G. Therapies for the medical management of persistent hypoglycaemia in two cases of inoperable malignant insulinoma. Eur J Endocrinol: 2010; 162 1001 1008
    • (2010) Eur J Endocrinol , vol.162 , pp. 1001-1008
    • Ong, G.S.1    Henley, D.E.2    Hurley, D.3    Turner, J.H.4    Claringbold, P.G.5    Fegan, P.G.6
  • 64
    • 79959596899 scopus 로고    scopus 로고
    • Everolimus induces rapid plasma glucose normalization in insulinoma patients by effects on tumor as well as normal tissues
    • Fiebrich H B, Siemerink E J, Brouwers A H, Links T P, Remkes W S, Hospers G A, de Vries E G. Everolimus induces rapid plasma glucose normalization in insulinoma patients by effects on tumor as well as normal tissues. Oncologist: 2011; 16 783 787
    • (2011) Oncologist , vol.16 , pp. 783-787
    • Fiebrich, H.B.1    Siemerink, E.J.2    Brouwers, A.H.3    Links, T.P.4    Remkes, W.S.5    Hospers, G.A.6    De Vries, E.G.7
  • 65
    • 79959239083 scopus 로고    scopus 로고
    • Everolimus resolving hypoglycemia, producing hyperglycemia, and necessitating insulin use in a patient with diabetes and nonresectable malignant insulinoma
    • Ferrer-Garca J C, Tolosa-Torrns M, Hernando-Meli C, Arribas-Palomar L, Snchez-Juan C. Everolimus resolving hypoglycemia, producing hyperglycemia, and necessitating insulin use in a patient with diabetes and nonresectable malignant insulinoma. Endocr Pract: 2011; 17 e17 e20
    • (2011) Endocr Pract , vol.17
    • Ferrer-Garca, J.C.1    Tolosa-Torrns, M.2    Hernando-Meli, C.3    Arribas-Palomar, L.4    Snchez-Juan, C.5
  • 66
    • 81255174910 scopus 로고    scopus 로고
    • Effect of everolimus treatment on chromogranin A, neuron-specific enolase, gastrin, and glucagon levels in patients with advanced pancreatic neuroendocrine tumors (pNET): Phase III RADIANT-3 study results
    • (suppl; abstr 10624)
    • De Vries E, Anthony L B, Sideris L, Chen L, Lebrec J, Tsuchihashi Z, Winkler R E, Yao J C, berg K. Effect of everolimus treatment on chromogranin A, neuron-specific enolase, gastrin, and glucagon levels in patients with advanced pancreatic neuroendocrine tumors (pNET): Phase III RADIANT-3 study results. J Clin Oncol: 2011; 29 (suppl; abstr 10624)
    • (2011) J Clin Oncol , vol.29
    • De Vries, E.1    Anthony, L.B.2    Sideris, L.3    Chen, L.4    Lebrec, J.5    Tsuchihashi, Z.6    Winkler, R.E.7    Yao, J.C.8    Berg, K.9
  • 67
    • 82155199641 scopus 로고    scopus 로고
    • Effect of everolimus plus octreotide LAR treatment on chromogranin A and 5-hydroxyindoleacetic acid levels in patients with advanced neuroendocrine tumors: Phase III RADIANT-2 study results
    • (suppl; abstr 10527)
    • Baudin E, Wolin E M, Castellano D E, Kaltsas G, Lebrec J, Tsuchihashi Z, Klimovsky J, Saletan S, Yao J C, Gross D. Effect of everolimus plus octreotide LAR treatment on chromogranin A and 5-hydroxyindoleacetic acid levels in patients with advanced neuroendocrine tumors: Phase III RADIANT-2 study results. J Clin Oncol: 2011; 29 (suppl; abstr 10527)
    • (2011) J Clin Oncol , vol.29
    • Baudin, E.1    Wolin, E.M.2    Castellano, D.E.3    Kaltsas, G.4    Lebrec, J.5    Tsuchihashi, Z.6    Klimovsky, J.7    Saletan, S.8    Yao, J.C.9    Gross, D.10
  • 69
    • 77953609118 scopus 로고    scopus 로고
    • Compensatory activation of Akt in response to mTOR and Raf inhibitors a rationale for dual-targeted therapy approaches in neuroendocrine tumor disease
    • Zitzmann K, Rden J, Brand S, Gke B, Lichtl J, Spttl G, Auernhammer C J. Compensatory activation of Akt in response to mTOR and Raf inhibitors a rationale for dual-targeted therapy approaches in neuroendocrine tumor disease. Cancer Lett: 2010; 295 100 109
    • (2010) Cancer Lett , vol.295 , pp. 100-109
    • Zitzmann, K.1    Rden, J.2    Brand, S.3    Gke, B.4    Lichtl, J.5    Spttl, G.6    Auernhammer, C.J.7
  • 70
    • 79951864002 scopus 로고    scopus 로고
    • Survival benefit with proapoptotic molecular and pathologic responses from dual targeting of mammalian target of rapamycin and epidermal growth factor receptor in a preclinical model of pancreatic neuroendocrine carcinogenesis
    • Chiu C W, Nozawa H, Hanahan D. Survival benefit with proapoptotic molecular and pathologic responses from dual targeting of mammalian target of rapamycin and epidermal growth factor receptor in a preclinical model of pancreatic neuroendocrine carcinogenesis. J Clin Oncol: 2010; 28 4425 4433
    • (2010) J Clin Oncol , vol.28 , pp. 4425-4433
    • Chiu, C.W.1    Nozawa, H.2    Hanahan, D.3
  • 71
    • 6044246300 scopus 로고    scopus 로고
    • Tumour biology of gastroenteropancreatic neuroendocrine tumours
    • 01
    • Grtzinger C. Tumour biology of gastroenteropancreatic neuroendocrine tumours. Neuroendocrinology: 2004; 80 01 8 11
    • (2004) Neuroendocrinology , vol.80 , pp. 8-11
    • Grtzinger, C.1


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