Circulating angiopoietin-2 is elevated in patients with neuroendocrine tumours and correlates with disease burden and prognosis

Endocrine-Related Cancer

Volumn 16, Issue 3, 2009, Pages 967-976

  Srirajaskanthan, R ^a   Dancey, G ^b   Hackshaw, A ^c   Luong, T ^a   Caplin, M E ^a   Meyer, T ^b  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2;

ADULT; AGED; ARTICLE; CANCER GROWTH; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MARKER; DISTANT METASTASIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE LOCATION; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; NEUROENDOCRINE TUMOR; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN FUNCTION;

ADULT; AGED; AGED, 80 AND OVER; ANGIOPOIETIN-1; ANGIOPOIETIN-2; FEMALE; GASTROINTESTINAL NEOPLASMS; HUMANS; ILEAL NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; NEUROENDOCRINE TUMORS; PANCREATIC NEOPLASMS; PROGNOSIS; TUMOR BURDEN; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION; YOUNG ADULT;

EID: 72749109808     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1677/ERC-09-0089     Document Type: Article

References (34)

1. Ahmad SA, Liu W, Jung YD, Fan F, Wilson M, Reinmuth N, Shaheen RM, Bucana CD & Ellis LM 2001 The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer. Cancer Research 61 1255-1259. (Pubitemid 34292536)
2. Bach F, Uddin FJ & Burke D 2007 Angiopoietins inmalignancy. European Journal of Surgical Oncology 33 7-15.
3. Caplin ME, Buscombe JR, Hilson AJ, Jones AL, Watkinson AF & Burroughs AK 1998 Carcinoid tumour. Lancet 352 799-805.
4. Carmeliet P & Jain RK 2000 Angiogenesis in cancer and other diseases. Nature 407 249-257.
5. Davis S, Aldrich TH, Jones PF, Acheson A, Compton DL, Jain V, Ryan TE, Bruno J, Radziejewski C, Maisonpierre PC et al. 1996 Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 87 1161-1169. (Pubitemid 27010100)
6. Eriksson B, Oberg K & Stridsberg M 2000 Tumor markers in neuroendocrine tumors. Digestion 62 33-38.
7. Eriksson B, Kloppel G, Krenning E, Ahlman H, Plockinger U, Wiedenmann B, Arnold R, Auernhammer C, Korner M, Rindi G et al. 2008 Consensus guidelines for the management of patients with digestive neuroendocrine tumors - well-differentiated jejunal-ileal tumor/carcinoma. Neuroendocrinology 87 8-19. (Pubitemid 350308290)
8. Etoh T, Inoue H, Tanaka S, Barnard GF, Kitano S & Mori M 2001 Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases. Cancer Research 61 2145-2153. (Pubitemid 32692040)
9. Folkman J & Hanahan D 1991 Switch to the angiogenic phenotype during tumorigenesis. Princess Takamatsu Symposium 22 339-347.
10. Folkman J, Watson K, Ingber D & Hanahan D 1989 Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 339 58-61. (Pubitemid 19115892)
11. de Herder WW 2007 Biochemistry of neuroendocrine tumours. Best Practice & Research. Clinical Endocrinology & Metabolism 21 33-41.
12. Holash J, Wiegand SJ & Yancopoulos GD 1999 New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene 18 5356-5362. (Pubitemid 29462372)
13. Janson ET, Holmberg L, Stridsberg M, Eriksson B, Theodorsson E, Wilander E & Oberg K 1997 Carcinoid tumors: analysis of prognostic factors and survival in 301 patients from a referral center. Annals of Oncology 8 685-690. (Pubitemid 27372168)
14. Lee HJ, Cho CH, Hwang SJ, Choi HH, Kim KT, Ahn SY, Kim JH, Oh JL, Lee GM & Koh GY 2004 Biological characterization of angiopoietin-3 and angiopoietin-4. FASEB Journal 18 1200-1208.
15. Lind AJ, Wikstrom P, Granfors T, Egevad L, Stattin P & Bergh A 2005 Angiopoietin 2 expression is related to histological grade, vascular density, metastases, and outcome in prostate cancer. Prostate 62 394-399. (Pubitemid 40224144)
16. Machein MR, Knedla A, Knoth R, Wagner S, Neuschl E & Plate KH 2004 Angiopoietin-1 promotes tumor angiogenesis in a rat glioma model. American Journal of Pathology 165 1557-1570. (Pubitemid 39435155)
17. Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N et al. 1997 Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277 55-60. (Pubitemid 27450643)
18. Mi J, Sarraf-Yazdi S, Zhang X, Cao Y, Dewhirst MW, Kontos CD, Li CY & Clary BM 2006 A comparison of antiangiogenic therapies for the prevention of liver metastases. Journal of Surgical Research 131 97-104. (Pubitemid 43227590)
19. Mitsuhashi N, Shimizu H, Ohtsuka M, Wakabayashi Y, Ito H, Kimura F, Yoshidome H, Kato A, Nukui Y & Miyazaki M 2003 Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma. Hepatology 37 1105-1113. (Pubitemid 36538687)
20. Modlin IM, Lye KD & Kidd M 2003 A 5-decade analysis of 13,715 carcinoid tumors. Cancer 97 934-959. (Pubitemid 36173145)
21. Modlin IM, Oberg K, Chung DC, Jensen RT, de Herder WW, Thakker RV, Caplin M, Delle FG, Kaltsas GA, Krenning EP et al. 2008 Gastroenteropancreatic neuroendocrine tumours. Lancet Oncology 9 61-72.
22. Oliner J, Min H, Leal J, Yu D, Rao S, You E, Tang X, Kim H, Meyer S, Han SJ et al. 2004 Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell 6 507-516. (Pubitemid 39469986)
23. Park JH, Park KJ, Kim YS, Sheen SS, Lee KS, Lee HN, Oh YJ & Hwang SC 2007 Serum angiopoietin-2 as a clinical marker for lung cancer. Chest 132 200-206. (Pubitemid 47068222)
24. Rindi G, Kloppel G, Couvelard A, Komminoth P, Korner M, Lopes JM, McNicol AM, Nilsson O, Perren A, Scarpa A et al. 2007 TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system. Virchows Archiv 451 757-762. (Pubitemid 47497934)
25. Sfiligoi C, de LA, Cascone I, Sorbello V, Fuso L, Ponzone R, Biglia N, Audero E, Arisio R, Bussolino F et al. 2003 Angiopoietin-2 expression in breast cancer correlates with lymph node invasion and short survival. International Journal of Cancer 103 466-474. (Pubitemid 36020220)
26. Shim WS, Teh M, Bapna A, Kim I, Koh GY, Mack PO & Ge R 2002 Angiopoietin 1 promotes tumor angiogenesis and tumor vessel plasticity of human cervical cancer in mice. Experimental Cell Research 279 299-309. (Pubitemid 35217558)
27. Stoeltzing O, Ahmad SA, Liu W, McCarty MF, Wey JS, Parikh AA, Fan F, Reinmuth N, Kawaguchi M, Bucana CD et al. 2003 Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors. Cancer Research 63 3370-3377. (Pubitemid 36735897)
28. Suri C, Jones PF, Patan S, Bartunkova S, Maisonpierre PC, Davis S, Sato TN & Yancopoulos GD 1996 Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87 1171-1180. (Pubitemid 27010101)
29. Tait CR & Jones PF 2004 Angiopoietins in tumours: the angiogenic switch. Journal of Pathology 204 1-10.
30. Tanaka S, Sugimachi K, Yamashita Y, Shirabe K, Shimada M, Wands JR & Sugimachi K 2003 Angiogenic switch as a molecular target of malignant tumors. Journal of Gastroenterology 38 93-97. (Pubitemid 36442895)
31. Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, Verweij J, Van GM, van Oosterom AT, Christian MC et al. 2000 New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. Journal of the National Cancer Institute 92 205-216.
32. Wang J, Wu K, Zhang D, Tang H, Xie H, Hong L, Pan Y, Lan M, Hu S, Ning X et al. 2005 Expressions and clinical significances of angiopoietin-1, -2 and Tie2 in human gastric cancer. Biochemical and Biophysical Research Communications 337 386-393.
33. Wong MP, Chan SY, Fu KH, Leung SY, Cheung N, Yuen ST & Chung LP 2000 The angiopoietins, tie2 and vascular endothelial growth factor are differentially expressed in the transformation of normal lung to non-small cell lung carcinomas. Lung Cancer 29 11-22. (Pubitemid 30398555)
34. Yu Q & Stamenkovic I 2001 Angiopoietin-2 is implicated in the regulation of tumor angiogenesis. American Journal of Pathology 158 563-570. (Pubitemid 32158617)