Tumour biology of gastroenteropancreatic neuroendocrine tumours

Neuroendocrinology

Volumn 80, Issue SUPPL. 1, 2004, Pages 8-11

  Grötzinger, Carsten ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Carcinoid; Gastroenteropancreatic neuroendocrine tumours; Growth factor; Proliferation; Tumour biology

Indexed keywords

SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANGIOGENESIS; AUTOCRINE EFFECT; CANCER GENETICS; CANCER GROWTH; CARCINOGENESIS; CARCINOID; CELL DIFFERENTIATION; CELL PROLIFERATION; CONFERENCE PAPER; GASTRINOMA; GASTROINTESTINAL TUMOR; GENE MUTATION; GENE OVEREXPRESSION; GENETIC CODE; GERM LINE; HORMONE RELEASE; HUMAN; INSULINOMA; INTESTINE CANCER; MITOGENESIS; MOLECULAR BIOLOGY; NEUROENDOCRINE TUMOR; PANCREAS TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION INITIATION; TUMOR SUPPRESSOR GENE; TUMOR VASCULARIZATION;

ANGIOGENESIS INDUCING AGENTS; BIOLOGY; DNA-BINDING PROTEINS; GASTROINTESTINAL NEOPLASMS; GROWTH SUBSTANCES; HUMANS; MODELS, BIOLOGICAL; NEUROENDOCRINE TUMORS; NUCLEAR PROTEINS; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS;

EID: 6044246300     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000080732     Document Type: Conference Paper

References (26)

1. Rindi G, Villanacci V, Ubiali A: Biological and molecular aspects of gastroenteropancreatic neuroendocrine tumors. Digestion 2000;62(suppl 1):19-26.
2. Bartsch D, Hahn SA, Danichevski KD, Ramaswamy A, Bastian D, Galehdari H, Barth P, Schmiegel W, Simon B, Rothmund M: Mutations of the DPC4/Smad4 gene in neuroendocrine pancreatic tumors. Oncogene 1999;18:2367-2371.
3. Muscarella P, Melvin WS, Fisher WE, Foor J, Ellison EC, Herman JG, Schirmer WJ, Hitchcock CL, DeYoung BR, Weghorst CM: Genetic alterations in gastrinomas and nonfunctioning pancreatic neuroendocrine tumors: An analysis of p16/MTS1 tumor suppressor gene inactivation. Cancer Res 1998;58:237-240.
4. Lubomierski N, Kersting M, Bert T, Muench K, Wulbrand U, Schuermann M, Bartsch D, Simon B: Tumor suppressor genes in the 9p21 gene cluster are selective targets of inactivation in neuroendocrine gastroenteropancreatic tumors. Cancer Res 2001;61:5905-5910.
5. Lollgen RM, Hessman O, Szabo E, Westin G, Akerstrom G: Chromosome 18 deletions are common events in classical midgut carcinoid tumors. Int J Cancer 2001;92:812-815.
6. Jensen RT: Carcinoid and pancreatic endocrine tumors: Recent advances in molecular pathogenesis, localization, and treatment. Curr Opin Oncol 2000;12:368-377.
7. Agarwal SK, Guru SC, Heppner C, Erdos MR, Collins RM, Park SY, Saggar S, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ, Burns AL: Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell 1999;96:143-152.
8. Calender A: Molecular genetics of neuroendocrine tumors. Digestion 2000;62(suppl 1):3-18.
9. Ichihara M, Murakumo Y, Takahashi M: RET and neuroendocrine tumors. Cancer Lett 2004;204:197-211.
10. Ludwig L, Kessler H, Hoang-Vu C, Dralle H, Adler G, Boehm BO, Schmid RM: Grap-2, a novel RET binding protein, is involved in RET mitogenic signaling. Oncogene 2003;22:5362-5366.
11. Rindi G, Capella C, Solcia E: Cell biology, clinicopathological profile, and classification of gastro-enteropancreatic endocrine tumors. J Mol Med 1998;76:413-420.
12. Wiedenmann B, John M, Ahnert-Hilger G, Riecken EO: Molecular and cell biological aspects of neuroendocrine tumors of the gastroenteropancreatic system. J Mol Med 1998;76:637-647.
13. Bast RC, Kufe DW, Pollock RE, et al: Neoplasms of the Endocrine Glands. Cancer Medicine, ed 5. Hamilton, BC Decker Inc, 2000.
14. Modlin IM, Sandor A: An analysis of 8,305 cases of carcinoid tumors. Cancer 1997;79:813-829.
15. John M, Meyerhof W, Richter D, Waser B, Schaer JC, Scherubl H, Boese-Landgraf J, Neuhaus P, Ziske C, Molling K, Riecken EO, Reubi JC, Wiedenmann B: Positive somatostatin receptor scintigraphy correlates with the presence of somatostatin receptor subtype 2. Gut 1996;38:33-39.
16. Schaer JC, Waser B, Mengod G, Reubi JC: Somatostatin receptor subtypes sst1, sst2, sst3 and sst5 expression in human pituitary, gastroentero-pancreatic and mammary tumors: Comparison of mRNA analysis with receptor autoradiography. Int J Cancer 1997;70:530-537.
17. Kulaksiz H, Eissele R, Rossler D, Schulz S, Hollt V, Cetin Y, Arnold R: Identification of somatostatin receptor subtypes 1, 2A, 3, and 5 in neuroendocrine tumours with subtype-specific antibodies. Gut 2002;50:52-60.
18. Reubi JC, Waser B: Concomitant expression of several peptide receptors in neuroendocrine tumours: Molecular basis for in vivo multireceptor tumour targeting. Eur J Nucl Med Mol Imaging 2003;30:781-793.
19. von Wichert G, Jehle PM, Hoeflich A, Koschnick S, Dralle H, Wolf E, Wiedenmann B, Boehm BO, Adler G, Seufferlein T: Insulin-like growth factor-I is an autocrine regulator of chromogranin A secretion and growth in human neuroendocrine tumor cells. Cancer Res 2000;60:4573-4581.
20. Chaudhry A, Oberg K, Gobl A, Heldin CH, Funa K: Expression of transforming growth factors beta 1, beta 2, beta 3 in neuroendocrine tumors of the digestive system. Anticancer Res 1994;14:2085-2091.
21. Chaudhry A, Papanicolaou V, Oberg K, Heldin CH, Funa K: Expression of platelet-derived growth factor and its receptors in neuroendocrine tumors of the digestive system. Cancer Res 1992;52:1006-1012.
22. Chaudhry A, Funa K, Oberg K: Expression of growth factor peptides and their receptors in neuroendocrine tumors of the digestive system. Acta Oncol 1993;32:107-114.
23. Peghini PL, Iwamoto M, Raffeld M, Chen YJ, Goebel SU, Serrano J, Jensen RT: Overexpression of epidermal growth factor and hepatocyte growth factor receptors in a proportion of gastrinomas correlates with aggressive growth and lower curability. Clin Cancer Res 2002;8:2273-2285.
24. Wulbrand U, Wied M, Zofel P, Goke B, Arnold R, Fehmann H: Growth factor receptor expression in human gastroenteropancreatic neuroendocrine tumours. Eur J Clin Invest 1998;28:1038-1049.
25. Wimmel A, Wiedenmann B, Rosewicz S: Autocrine growth inhibition by transforming growth factor beta-1 (TGFbeta-1) in human neuroendocrine tumour cells. Gut 2003;52:1308-1316.
26. von Marschall Z, Scholz A, Cramer T, Schafer G, Schirner M, Oberg K, Wiedenmann B, Hocker M, Rosewicz S: Effects of interferon alpha on vascular endothelial growth factor gene transcription and tumor angiogenesis. J Natl Cancer Inst 2003;95:437-448.