Validation of a phage display and computational algorithm by mapping a conformational epitope of Bla g 2

International Archives of Allergy and Immunology

Volumn 157, Issue 4, 2012, Pages 323-330

  Tiwari, Ruby ^a   Negi, Surendra S ^a   Braun, Benjamin ^a   Braun, Werner ^a   Pomés, Anna ^b   Chapman, Martin D ^b   Goldblum, Randall M ^a   Midoro Horiuti, Terumi ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b INDOOR Biotechnologies Inc   (United States)

Author keywords

Bla g 2; Cockroach allergen; Conformational epitope; EpiSearch; Monoclonal antibody; Random peptide phage display library

Indexed keywords

ALLERGEN; BLA G 2 ANTIGEN; EPITOPE; IMMUNOGLOBULIN E ANTIBODY; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ALGORITHM; AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; ANTIGEN BINDING; ANTIGEN STRUCTURE; ARTICLE; BINDING AFFINITY; COCKROACH; DATA ANALYSIS SOFTWARE; EPITOPE MAPPING; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN CONFORMATION; STRUCTURE ANALYSIS; VALIDATION STUDY;

ALGORITHMS; ANIMALS; ANTIBODIES, MONOCLONAL; ASPARTIC ACID ENDOPEPTIDASES; COCKROACHES; COMPUTATIONAL BIOLOGY; CRYSTALLIZATION; EPITOPE MAPPING; FEASIBILITY STUDIES; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; PEPTIDE LIBRARY; PROTEIN CONFORMATION;

EID: 82055200575     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000330108     Document Type: Article

References (33)

1. Akinbami LJ, Moorman JE, Liu X: Asthma prevalence, health care use, and mortality: United States, 2005-2009. Natl Health Stat Report 2011;(32):1-14.
2. Reed SD, Lee TA, McCrory DC: The economic burden of allergic rhinitis: a critical evaluation of the literature. Pharmacoeconomics 2004; 22: 345-361. (Pubitemid 38609812)
3. Bukstein D: The Obama dilemma: allergic rhinitis (animal dander allergy) -the great burden of illness. Allergy Asthma Proc 2009; 30: 567-572.
4. Meltzer EO, Blaiss MS, Derebery MJ, Mahr TA, Gordon BR, Sheth KK, Simmons AL, Wingertzahn MA, Boyle JM: Burden of allergic rhinitis: results from the Pediatric Allergies in America survey. J Allergy Clin Immunol 2009; 124:S43-S70.
5. Rihs HP, Chen Z, Rueff F, Petersen A, Rozynek P, Heimann H, Baur X: IgE binding of the recombinant allergen soybean profilin (rGly m 3) is mediated by conformational epitopes. J Allergy Clin Immunol 1999; 104: 1293-1301. (Pubitemid 30004994)
6. Van Regenmortel MHV: Mapping epitope structure and activity: from one-dimensional prediction to four-dimensional description of antigenic specificity. Methods 1996; 9: 465-472. (Pubitemid 26273467)
7. Aalberse RC: Structural biology of allergens. J Allergy Clin Immunol 2000; 106: 228-238. (Pubitemid 30644995)
8. Barlow DJ, Edwards MS, Thornton JM: Continuous and discontinuous protein antigenic determinants. Nature 1986; 322: 747-748. (Pubitemid 16074126)
9. Satoh R, Koyano S, Takagi K, Nakamura R, Teshima R: Identification of an IgE-binding epitope of a major buckwheat allergen, BWp16, by SPOTs assay and mimotope screening. Int Arch Allergy Immunol 2010; 153: 133-140.
10. Smith AM, Chapman MD, Taketomi EA, Platts-Mills TA, Sung SS: Recombinant allergens for immunotherapy: a Der p 2 variant with reduced IgE reactivity retains T-cell epitopes. J Allergy Clin Immunol 1998; 101: 423-425. (Pubitemid 28146366)
11. Garman SC, Kinet JP, Jardetzky TS: Crystal structure of the human high-affinity IgE receptor. Cell 1998; 95: 951-961. (Pubitemid 29019047)
12. Wan T, Beavil RL, Fabiane SM, Beavil AJ, Sohi MK, Keown M, Young RJ, Henry AJ, Owens RJ, Gould HJ, Sutton BJ: The crystal structure of IgE Fc reveals an asymmetrically bent conformation. Nat Immunol 2002; 3: 681-686. (Pubitemid 34752478)
13. Ivanciuc O, Mathura V, Midoro-Horiuti T, Braun W, Goldblum RM, Schein CH: Detecting potential IgE-reactive sites on food proteins using a sequence and structure database, SDAP-Food. J Agric Food Chem 2003; 51: 4830-4837.
14. Chapman MD, Pomés A, Breiteneder H, Ferreira F: Nomenclature and structural biology of allergens. J Allergy Clin Immunol 2007; 119: 414-420.
15. Niemi M, Jylha S, Laukkanen ML, Soderlund H, Makinen-Kiljunen S, Kallio JM, Hakulinen N, Haahtela T, Takkinen K, Rouvinen J: Molecular interactions between a recombinant IgE antibody and the beta-lactoglobulin allergen. Structure 2007; 15: 1413-1421. (Pubitemid 350051924)
16. Padavattan S, Schirmer T, Schmidt M, Akdis C, Valenta R, Mittermann I, Soldatova L, Slater J, Mueller U, Markovic-Housley Z: Identification of a B-cell epitope of hyaluronidase, a major bee venom allergen, from its crystal structure in complex with a specific Fab. J Mol Biol 2007; 368: 742-752. (Pubitemid 46527617)
17. Mirza O, Henriksen A, Ipsen H, Larsen JN, Wissenbach M, Spangfort MD, Gajhede M: Dominant epitopes and allergic cross-reactivity: complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen Bet v 1. J Immunol 2000; 165: 331-338. (Pubitemid 30429524)
18. Padavattan S, Flicker S, Schirmer T, Madritsch C, Randow S, Reese G, Vieths S, Lupinek C, Ebner C, Valenta R, Markovic-Housley Z: High-affinity IgE recognition of a conformational epitope of the major respiratory allergen Phl p 2 as revealed by X-ray crystallography. J Immunol 2009; 182: 2141-2151.
19. Li M, Gustchina A, Alexandratos J, Wlodawer A, Wunschmann S, Kepley CL, Chapman MD, Pomés A: Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody. J Biol Chem 2008; 283: 22806-22814.
20. Li M, Gustchina A, Glesner J, Wunschmann S, Vailes LD, Chapman MD, Pomés A, Wlodawer A: Carbohydrates contribute to the interactions between cockroach allergen Bla g and a monoclonal antibody. J Immunol 2011; 186: 333-340.
21. Tordesillas L, Pacios LF, Palacin A, Cuesta-Herranz J, Madero M, Diaz-Perales A: Characterization of IgE epitopes of Cuc m 2, the major melon allergen, and their role in crossreactivity with pollen profilins. Clin Exp Allergy 2010; 40: 174-181.
22. Untersmayr E, Szalai K, Riemer AB, Hemmer W, Swoboda I, Hantusch B, Scholl I, Spitzauer S, Scheiner O, Jarisch R, Boltz-Nitulescu G, Jensen-Jarolim E: Mimotopes identify conformational epitopes on parvalbumin, the major fish allergen. Mol Immunol 2006; 43: 1454-1461. (Pubitemid 43356385)
23. Pacios LF, Tordesillas L, Cuesta-Herranz J, Compes E, Sanchez-Monge R, Palacin A, Salcedo G, Diaz-Perales A: Mimotope mapping as a complementary strategy to define allergen IgE-epitopes: peach Pru p 3 allergen as a model. Mol Immunol 2008; 45: 2269-2276.
24. Negi SS, Braun W: Automated detection of conformational epitopes using phage display peptide sequences. Bioinform Biol Insights 2009; 3: 71-81.
25. Woodard CS, Splawski JB, Goldblum RM, Denney RM: Characterization of epitopes of human secretory component on free secretory component, secretory IgA, and membrane-associated secretory component. J Immunol 1984; 133: 2116-2125. (Pubitemid 14035319)
26. Venkatarajan MS, Braun W: New quantitative descriptors of amino acids based on multidimensional scaling of a large number of physical-chemical properties. J Mol Model 2001; 7: 445-453. (Pubitemid 36153531)
27. Negi SS, Schein CH, Oezguen N, Power TD, Braun W: InterProSurf: a web server for predicting interacting sites on protein surfaces. Bioinformatics 2007; 23: 3397-3399. (Pubitemid 350238897)
28. Lee H, Jeong KY, Shin KH, Yi MH, Gantulaga D, Hong CS, Yong TS: Reactivity of German cockroach allergen, Bla g 2, peptide fragments to IgE antibodies in patients' sera. Korean J Parasitol 2008; 46: 243-246.
29. Gustchina A, Li M, Wunschmann S, Chapman MD, Pomés A, Wlodawer A: Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition. J Mol Biol 2005; 348: 433-444. (Pubitemid 40462107)
30. Sampson HA: Update on food allergy. J Allergy Clin Immunol 2004; 113: 805-819. (Pubitemid 38608586)
31. Chatchatee P, Jarvinen KM, Bardina L, Beyer K, Sampson HA: Identification of IgE-and IgG-binding epitopes on alpha(s1)-casein: differences in patients with persistent and transient cow's milk allergy. J Allergy Clin Immunol 2001; 107: 379-383. (Pubitemid 32173919)
32. Cooke SK, Sampson HA: Allergenic properties of ovomucoid in man. J Immunol 1997; 159: 2026-2032. (Pubitemid 127484194)
33. Jarvinen KM, Beyer K, Vila L, Bardina L, Mishoe M, Sampson HA: Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy. Allergy 2007; 62: 758-765. (Pubitemid 46934359)