Carbohydrates contribute to the interactions between cockroach allergen Bla g 2 and a monoclonal antibody

Journal of Immunology

Volumn 186, Issue 1, 2011, Pages 333-340

  Li, Mi ^a,b   Gustchina, Alla ^a   Glesner, Jill ^c   Wünschmann, Sabina ^c   Vailes, Lisa D ^c   Chapman, Martin D ^c   Pomés, Anna ^c   Wlodawer, Alexander ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c INDOOR Biotechnologies Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE DERIVATIVE; BLA G 2 ALLERGEN; CARBOHYDRATE; COCKROACH ALLERGEN; EPITOPE; GLUTAMINE DERIVATIVE; IMMUNOGLOBULIN E ANTIBODY; ISOLEUCINE; LYSINE DERIVATIVE; MEMBRANE ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 7C11; RECOMBINANT ALLERGEN; UNCLASSIFIED DRUG; WATER; ZINC ION;

AMINO TERMINAL SEQUENCE; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; COCKROACH; COCKROACH ALLERGY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEGLYCOSYLATION; HUMAN; IMMUNE COMPLEX DEPOSITION; IMMUNOREACTIVITY; INSECT ALLERGY; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS; SURFACE PROPERTY; X RAY CRYSTALLOGRAPHY;

ACETYLGLUCOSAMINE; ALLERGENS; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY REACTIONS; ASPARTIC ACID ENDOPEPTIDASES; COCKROACHES; CRYSTALLOGRAPHY, X-RAY; GLYCOSYLATION; MICE; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 79251583126     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1002318     Document Type: Article

References (41)

1. Rosenstreich, D. L., P. Eggleston, M. Kattan, D. Baker, R. G. Slavin, P. Gergen, H. Mitchell, K. McNiff-Mortimer, H. Lynn, D. Ownby, and F. Malveaux. 1997. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. N. Engl. J. Med. 336: 1356-1363.
2. Gruchalla, R. S., J. Pongracic, M. Plaut, R. Evans, III, C. M. Visness, M. Walter, E. F. Crain, M. Kattan, W. J. Morgan, S. Steinbach, et al. 2005. Inner City Asthma Study: relationships among sensitivity, allergen exposure, and asthma morbidity. J. Allergy Clin. Immunol. 115: 478-485.
3. Pomés, A., M. D. Chapman, L. D. Vailes, T. L. Blundell, and V. Dhanaraj. 2002. Cockroach allergen Bla g 2: structure, function, and implications for allergic sensitization. Am. J. Respir. Crit. Care Med. 165: 391-397.
4. Arruda, L. K., L. D. Vailes, B. J. Mann, J. Shannon, J. W. Fox, T. S. Vedvick, M. L. Hayden, and M. D. Chapman. 1995. Molecular cloning of a major cockroach (Blattella germanica) allergen, Bla g 2. Sequence homology to the aspartic proteases. J. Biol. Chem. 270: 19563-19568.
5. Satinover, S. M., A. J. Reefer, A. Pomés, M. D. Chapman, T. A. Platts-Mills, and J. A. Woodfolk. 2005. Specific IgE and IgG antibody-binding patterns to recombinant cockroach allergens. J. Allergy Clin. Immunol. 115: 803-809.
6. Dunn, B. M., M. M. Goodenow, A. Gustchina, and A. Wlodawer. 2002. Retroviral proteases. Genome Biol. 3: REVIEWS3006.
7. Wünschmann, S., A. Gustchina, M. D. Chapman, and A. Pomés. 2005. Cockroach allergen Bla g 2: an unusual aspartic proteinase. J. Allergy Clin. Immunol. 116: 140-145.
8. Tang, J., M. N. G. James, I. N. Hsu, J. A. Jenkins, and T. L. Blundell. 1978. Structural evidence for gene duplication in the evolution of the acid proteases. Nature 271: 618-621.
9. Burks, A. W., D. Shin, G. Cockrell, J. S. Stanley, R. M. Helm, and G. A. Bannon. 1997. Mapping and mutational analysis of the IgE-binding epitopes on Ara h 1, a legume vicilin protein and a major allergen in peanut hypersensitivity. Eur. J. Biochem. 245: 334-339.
10. Shreffler, W. G., K. Beyer, T. H. Chu, A. W. Burks, and H. A. Sampson. 2004. Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. J. Allergy Clin. Immunol. 113: 776-782.
11. Padlan, E. A. 1996. X-ray crystallography of antibodies. Adv. Protein Chem. 49: 57-133.
12. Gustchina, A., M. Li, S. Wünschmann, M. D. Chapman, A. Pomës, and A. Wlodawer. 2005. Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition. J. Mol. Biol. 348: 433-444.
13. Li, M., A. Gustchina, J. Alexandratos, A. Wlodawer, S. Wünschmann, C. L. Kepley, M. D. Chapman, and A. Pomés. 2008. Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody. J. Biol. Chem. 283: 22806-22814.
14. Pomés, A., L. D. Vailes, R. M. Helm, and M. D. Chapman. 2002. IgE reactivity of tandem repeats derived from cockroach allergen, Bla g 1. Eur. J. Biochem. 269: 3086-3092.
15. Otwinowski, Z., and W. Minor. 1997. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276: 307-326. (Pubitemid 27085611)
16. McCoy, A. J., R. W. Grosse-Kunstleve, P. D. Adams, M. D. Winn, L. C. Storoni, and R. J. Read. 2007. Phaser crystallographic software. J. Appl. Crystallogr. 40: 658-674.
17. Adams, P. D., R. W. Grosse-Kunstleve, L. W. Hung, T. R. Ioerger, A. J. McCoy, N. W. Moriarty, R. J. Read, J. C. Sacchettini, N. K. Sauter, and T. C. Terwilliger. 2002. PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr. D Biol. Crystallogr. 58: 1948-1954.
18. Murshudov, G. N., A. A. Vagin, and E. J. Dodson. 1997. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr. D Biol. Crystallogr. 53: 240-255.
19. Emsley, P., and K. Cowtan. 2004. Coot: model-building tools for molecular graphics. Acta Crystallogr. D Biol. Crystallogr. 60: 2126-2132.
20. Pollart, S. M., T. F. Smith, E. C. Morris, L. E. Gelber, T. A. Platts-Mills, and M. D. Chapman. 1991. Environmental exposure to cockroach allergens: analysis with monoclonal antibody-based enzyme immunoassays. J. Allergy Clin. Immunol. 87: 505-510.
21. Gelber, L. E., L. H. Seltzer, J. K. Bouzoukis, S. M. Pollart, M. D. Chapman, and T. A. Platts-Mills. 1993. Sensitization and exposure to indoor allergens as risk factors for asthma among patients presenting to hospital. Am. Rev. Respir. Dis. 147: 573-578.
22. Pollart, S. M., M. D. Chapman, G. P. Fiocco, G. Rose, and T. A. Platts-Mills. 1989. Epidemiology of acute asthma: IgE antibodies to common inhalant allergens as a risk factor for emergency room visits. J. Allergy Clin. Immunol. 83: 875-882.
23. King, E. M., L. D. Vailes, A. Tsay, S. M. Satinover, and M. D. Chapman. 2007. Simultaneous detection of total and allergen-specific IgE by using purified allergens in a fluorescent multiplex array. J. Allergy Clin. Immunol. 120: 1126-1131.
24. Brünger, A. T., P. D. Adams, G. M. Clore, W. L. DeLano, P. Gros, R. W. Grosse-Kunstleve, J. S. Jiang, J. Kuszewski, M. Nilges, N. S. Pannu, et al. 1998. Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr. D Biol. Crystallogr. 54: 905-921.
25. Sundberg, E. J., and R. A. Mariuzza. 2003. Molecular recognition in antibody-antigen complexes. In Advances in Protein Chemistry, vol. 61. J. Janin and S. J. Wodak eds. Elsevier Science, Burlington, MA, p. 119-160.
26. Lawrence, M. C., and P. M. Colman. 1993. Shape complementarity at protein/protein interfaces. J. Mol. Biol. 234: 946-950.
27. Pomés, A., M. Li, J. Glesner, S. Wünschmann, E. M. King, M. D. Chapman, A. Wlodawer, and A. Gustchina. 2009. The X-ray crystal structure of two complexes of the cockroach allergen Bla g 2 with fragments of monoclonal antibodies defines two non-overlapping epitopes. J. Allergy Clin. Immunol. 123: S229.
28. Munk, K., E. Pritzer, E. Kretzschmar, B. Gutte, W. Garten, and H. D. Klenk. 1992. Carbohydrate masking of an antigenic epitope of influenza virus haemagglutinin independent of oligosaccharide size. Glycobiology 2: 233-240.
29. Helle, F., A. Goffard, V. Morel, G. Duverlie, J. McKeating, Z. Y. Keck, S. Foung, F. Penin, J. Dubuisson, and C. Voisset. 2007. The neutralizing activity of antihepatitis C virus antibodies is modulated by specific glycans on the E2 envelope protein. J. Virol. 81: 8101-8111. (Pubitemid 47101496)
30. Takai, T., T. Kato, H. Yasueda, K. Okumura, and H. Ogawa. 2005. Analysis of the structure and allergenicity of recombinant pro- and mature Der p 1 and Der f 1: major conformational IgE epitopes blocked by prodomains. J. Allergy Clin. Immunol. 115: 555-563.
31. Zdanov, A., Y. Li, D. R. Bundle, S. J. Deng, C. R. MacKenzie, S. A. Narang, N. M. Young, and M. Cygler. 1994. Structure of a single-chain antibody variable domain (Fv) fragment complexed with a carbohydrate antigen at 1.7-A resolution. Proc. Natl. Acad. Sci. USA 91: 6423-6427.
32. Calarese, D. A., C. N. Scanlan, M. B. Zwick, S. Deechongkit, Y. Mimura, R. Kunert, P. Zhu, M. R. Wormald, R. L. Stanfield, K. H. Roux, et al. 2003. Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. Science 300: 2065-2071.
33. Ramsland, P. A., W. Farrugia, T. M. Bradford, P. Mark Hogarth, and A. M. Scott. 2004. Structural convergence of antibody binding of carbohydrate determinants in Lewis Y tumor antigens. J. Mol. Biol. 340: 809-818.
34. Farrugia, W., A. M. Scott, and P. A. Ramsland. 2009. A possible role for metallic ions in the carbohydrate cluster recognition displayed by a Lewis Y specific antibody. PLoS One 4: e7777.
35. Ekiert, D. C., G. Bhabha, M. A. Elsliger, R. H. Friesen, M. Jongeneelen, M. Throsby, J. Goudsmit, and I. A. Wilson. 2009. Antibody recognition of a highly conserved influenza virus epitope. Science 324: 246-251.
36. Aalberse, R. C. 1998. Clinical relevance of carbohydrate allergen epitopes. Allergy 53(45, Suppl)54-57.
37. Seppälä, U., D. Selby, R. Monsalve, T. P. King, C. Ebner, P. Roepstorff, and B. Bohle. 2009. Structural and immunological characterization of the N-glycans from the major yellow jacket allergen Ves v 2: the N-glycan structures are needed for the human antibody recognition. Mol. Immunol. 46: 2014-2021.
38. Malik, A., S. A. Arif, S. Ahmad, and E. Sunderasan. 2008. A molecular and in silico characterization of Hev b 4, a glycosylated latex allergen. Int. J. Biol. Macromol. 42: 185-190.
39. van der Veen, M. J., R. van Ree, R. C. Aalberse, J. Akkerdaas, S. J. Koppelman, H. M. Jansen, and J. S. van der Zee. 1997. Poor biologic activity of cross-reactive IgE directed to carbohydrate determinants of glycoproteins. J. Allergy Clin. Immunol. 100: 327-334.
40. Foetisch, K., S. Westphal, I. Lauer, M. Retzek, F. Altmann, D. Kolarich, S. Scheurer, and S. Vieths. 2003. Biological activity of IgE specific for cross-reactive carbohydrate determinants. J. Allergy Clin. Immunol. 111: 889-896.
41. Altmann, F. 2007. The role of protein glycosylation in allergy. Int. Arch. Allergy Immunol. 142: 99-115.