A novel fused 1,2,4-triazine aryl derivative as antioxidant and nonselective antagonist of adenosine A 2A receptors in ethanol-activated liver stellate cells

Chemico-Biological Interactions

Volumn 195, Issue 1, 2012, Pages 18-24

  Szuster Ciesielska, Agnieszka ^a   Sztanke, Krzysztof ^b   Kandefer Szerszeń, Martyna ^a  

^a MARIA CURIE SK ODOWSKA UNIVERSITY   (Poland)

^b MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

Antagonist of A 2A receptors; Cytokines; Liver stellate cell; New triazine derivative; Oxidative stress; Signal transduction pathway

Indexed keywords

1,2,4 TRIAZINE ARYL DERIVATIVE; 1,2,4 TRIAZINE DERIVATIVE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; ALCOHOL; ALPHA SMOOTH MUSCLE ACTIN; ANTIOXIDANT; COLLAGEN; GELATINASE A; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; SMAD3 PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL ACTIVATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME SYNTHESIS; NONHUMAN; OXIDATIVE STRESS; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; STELLATE CELL;

ACTINS; ADENOSINE A2 RECEPTOR AGONISTS; ADENOSINE A2 RECEPTOR ANTAGONISTS; ANIMALS; ANTIOXIDANTS; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL LINE; CYTOKINES; ETHANOL; HEPATIC STELLATE CELLS; HYDRAZINES; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OXIDATIVE STRESS; PYRIMIDINES; RATS; REACTIVE OXYGEN SPECIES; RECEPTOR, ADENOSINE A2A; SIGNAL TRANSDUCTION; TRIAZOLES;

RATTUS;

EID: 82055200074     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2011.10.004     Document Type: Article

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