The immunomodulatory effects of cordyceps sinensis on dendritic cells derived from chronic myelogenous leukemia (CML)

Journal of Medicinal Plant Research

Volumn 5, Issue 24, 2011, Pages 5925-5932

  Huang, Zhi liang ^a   Jin, Jie ^a   Tong, Xiang min ^a   Yang, Qun zheng ^b   Gu, Bao luo ^c   Wang, Jian chao ^d   Yuedi shen, ^e   Xie, Jun jun ^e  

^a ZHEJIANG UNIVERSITY   (China)

^b Department of Hematology   (China)

^c Department of Clinical Laboratory   (China)

^d The Xinhua Hospital   (China)

^e The Second People's Hospital of Hangzhou   (China)

Author keywords

Chronic myeloid leukemia; Cordyceps sinensis; Dendritic cells; Differentiation

Indexed keywords

CORDYCEPS SINENSIS EXTRACT; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 4; POLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL FUNCTION; CELL ISOLATION; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; IN VITRO STUDY; INCUBATION TIME; MALE; MIXED LYMPHOCYTE REACTION; MONONUCLEAR CELL; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE;

EID: 82055169099     PISSN: None     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Akaki J, Matsui Y, Kojima H, Nakajima S, Kamei K, Tamesada M (2009). Structural analysis of monocyte activation constituents in cultured mycelia of Cordyceps sinensis. Fitoterapia, 80(3): 182-187.
2. Bonnefont-Rebeix C, De CCM, Bernaud J, Chabanne L, Marchal TR (2006). DCD86 molecule is a specific marker for canine monocyte-derived dendritic cells. Vet. Immunol. Immunopathol., 109(1-2): 167-176.
3. Brady MT, Lee J, Ferrone S, Wang ES, Wetzler M (2011). Interferon-γ secretion by t(9;22) acute lymphoblastic leukemia-derived dendritic cells. Leuk. Res., 35(2): 275-277.
4. Byeon SE, Lee J, Yoo BC, Sung GH, Kim TW, Park HJ, Cho JY (2011). p38-targeted inhibition of interleukin-12 expression by ethanol extract from Cordyceps bassiana in lipopolysaccharide-activated macrophages. Immuno-pharmacol. Immunotoxicol., 33(1): 90-96.
5. Chen J, Zhang W, Lu T, Li J, Zheng Y, Kong L (2006). Morphological and genetic characterization of a cultivated Cordyceps sinensis fungus and its polysaccharide component possessing antioxidant property in H22 tumor-bearing mice. Life Sci., 78(23): 2742-2748.
6. Cheung JK, Li J, Cheung AW, Zhu Y, Zheng KY, Bi CW, Duan R, Choi RC, Lau DT, Dong TT, Lau BW, Tsim KW (2009). Cordysinocan, a polysaccharide isolated from cultured Cordyceps, activates immune responses in cultured T-lymphocytes and macrophages: signaling cascade and induction of cytokines. J. Ethnopharmacol., 124(1): 61-68.
7. Choudhury A, Gajewski JL, Liang JC (1997). Use of leukemic dendritic cells for the generation of antileukemic cellular cytotoxicity against Philadelphia chromosome-positive chronic myelogenous leukemia. Blood, 89(4): 1133-1142.
8. Gabriele L, Borghi P, Rozera C, Sestili P, Andreotti M, Guarini A Montefusco E, Foa R, Belardelli F (2004). IFN-alpha promotes the rapid differentiation of monocytes from patients with chronic myeloid leukemia into activated dendritic cells tuned to undergo full maturation after LPS treatment Blood, 103(3): 980-987.
9. Jeong JW, Jin CY, Kim GY, Lee JD, Park C, Kim GD, Kim WJ, Jung WK, Seo SK, Choi IW, Choi YH (2010). Anti-inflammatory effects of cordycepin via suppression of inflammatory mediators in BV2 microglial cells. Int. Immunopharmacol., 10(12): 1580-1586.
10. Jeong JW, Jin CY, Park C, Hong SH, Kim GY, Jeong YK, Lee JD, Yoo YH, Choi YH (2011). Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells. Toxicol. In vitro. 25(4): 817-824.
11. Kim HS, Kim JY, Kang JS, Kim HM, Kim YO, Hong IP, Lee MK, Hong JT, Kim Y, Han SB (2010). Cordlan polysaccharide isolated from mushroom Cordyceps militaris induces dendritic cell maturation through toll-like receptor 4 signalings. Food Chem. Toxicol., 48(7): 1926-1933.
12. Ko WS, Hsu SL, Chyau CC, Chen KC, Peng RY (2010). Compound Cordyceps TCM-700C exhibits potent hepatoprotective capability in animal model. Fitoterapia, 81(1): 1-7.
13. Kolb HJ, Rank A, Chen X, Woiciechowsky A, Roskrow M, Schmid C, Tischer J, Ledderose G (2004). In-vivo generation of leukaemiaderived dendritic cells. Best Practise Res. Clin. Haematol., 17(3): 439-451.
14. Kufner S, Zitzelsberger H, Kroell T, Pelka-Fleischer R, Salem A, Valle F, Schweiger C, Nuessler V, Schmid C, Kolb HJ, Schmetzer HM (2005). Leukemia-derived dendritic cells can be generated from blood or bone marrow cells from patients with acute myeloid leukaemia: a methodological approach under serum-free culture conditions. Scand. J. Immunol., 62(1): 86-98.
15. Leung PH, Zhang QX, Wu JY (2006). Mycelium cultivation, chemical composition and antitumour activity of a Tolypocladium sp. Fungus isolated from wild Cordyceps sinensis. J. Appl. Microbiol., 101(2): 275-278.
16. Martin M, Sharpe A, Clements JD, Michalek SM (2002). Role of B7 costimulatory molecules in the adjuvant activity of the heat-labile enterotoxin of Escherichia coli. J. Immunol., 169(4): 1744-1752.
17. Ng TB, Wang HX (2005). Pharmacological actions of Cordyceps, a prized folk medicine. J. Pharm. Pharmacol., 57(12): 1509-1519.
18. Park C, Hong SH, Lee JY, Kim GY, Choi BT, Lee YT, Park DI, Park YM, Jeong YK, Choi YH (2005). Growth inhibition of U937 leukemia cells by aqueous extract of Cordyceps militaris through induction of apoptosis. Oncol. Rep., 13(6): 1211-1216.
19. Raymond CR, Wilkie BN (2004). Th-1/Th-2 type cytokine profiles of pig T-cells cultured with antigen-treated monocyte-derived dendritic cells. Vaccine, 22(8): 1016-1023.
20. Tanosaki R, Tobinai K (2010). Adult T-cell leukemia-lymphoma: current treatment strategies and novel immunological approaches. Expert Rev. Hematol., 3(6): 743-753.
21. Tong XM, Yao HP, Qian WB, Zhu LF, Fu ZH, Huang ZL, Jin J (2008).The biological characteristics of dendritic cells derived in vitro from myelogeneous leukemia cells and healthy donor cells. Int. J. Lab. Hematol., 30(5): 372-381.
22. Tsai BY, Lin YL, Chiang BL (2009). Application of interleukin-12 expressing dendritic cells for the treatment of animal model of leukemia. Exp. Biol. Med. (Maywood), 234(8): 952-960.
23. Tsang KY, Zhu M, Even J, Gulley J, Arlen P, Schlom J (2001).The infection of human dendritic cells with recombinant avipox vectors expressing a costimulatory molecule transgene (CD80) to enhance the activation of antigen-specific cytolytic T lymphocytes. Cancer Res., 61(20): 7568-7576.
24. Wang C, Al-Omar HM, Radvanyi L, Banerjee A, Bouman D, Squire J, Messner HA (1999). Clonal heterogeneity of dendritic cells derived from patients with chronic myeloid leukemia and enhancement of their t-cells stimulatory activity by IFN-α. Exp. Hematol., 27(7): 1176-1184.
25. Zhang W, Li J, Qiu S, Chen J, Zheng Y (2008). Effects of the exopolysaccharide fraction (EPSF) from a cultivated Cordyceps sinensis on immunocytes of H22 tumor bearing mice. Fitoterapia, 79(3): 168-173.