Requirement for MLL3 in p53 regulation of hepatic expression of small heterodimer partner and bile acid homeostasis

Molecular Endocrinology

Volumn 25, Issue 12, 2011, Pages 2076-2083

  Kim, Dae Hwan ^a   Kim, Juhee ^a   Lee, Jae W ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYP8B1 PROTEIN; CYTOCHROME; FARNESOID X RECEPTOR; HISTONE H3; HISTONE METHYLTRANSFERASE; METHYLTRANSFERASE MIXED LINEAGE LEUKEMIA 3; PROTEIN P53; SMALL HETERODIMER PARTNER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE ACID SYNTHESIS; CATALYSIS; CONTROLLED STUDY; HISTONE METHYLATION; HOMEOSTASIS; HUMAN; HUMAN CELL; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSACTIVATION; UPREGULATION;

ANIMALS; BILE ACIDS AND SALTS; CHOLESTEROL 7-ALPHA-HYDROXYLASE; DNA DAMAGE; DNA-BINDING PROTEINS; DOXORUBICIN; GENE EXPRESSION; HEP G2 CELLS; HOMEOSTASIS; HUMANS; LIVER; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN BINDING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RESPONSE ELEMENTS; STEROID 12-ALPHA-HYDROXYLASE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 82055165711     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2011-1198     Document Type: Article

References (32)

1. Shilatifard A 2006 Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. Annu Rev Biochem 75:243-269
2. Malik S, Bhaumik SR 2010 Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human. FEBS J 277:1805-1821
3. Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW 2003 Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. Mol Cell Biol 23:140-149
4. Lee S, Lee DK, Dou Y, Lee J, Lee B, Kwak E, Kong YY, Lee SK, Roeder RG, Lee JW 2006 Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc Natl Acad Sci USA 103:15392-15397
5. Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K 2007 PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem 282:20395-20406
6. Issaeva I, Zonis Y, Rozovskaia T, Orlovsky K, Croce CM, Nakamura T, Mazo A, Eisenbach L, Canaani E 2007 Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. Mol Cell Biol 27:1889-1903
7. Lee S, Lee J, Lee SK, Lee JW 2008 Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferases MLL3 and MLL4 to the liver X receptors. Mol Endocrinol 22:1312-1319
8. Lee J, Saha PK, Yang QH, Lee S, Park JY, Suh Y, Lee SK, Chan L, Roeder RG, Lee JW 2008 Targeted inactivation of MLL3 histone H3-lysine-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proc Natl Acad Sci USA 105: 19229-19234
9. Kim DH, Lee J, Lee B, Lee JW 2009 ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity. Mol Endocrinol 23:1556-1562
10. Lee J, Kim DH, Lee S, Yang QH, Lee DK, Lee SK, Roeder RG, Lee JW 2009 A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4. Proc Natl Acad Sci USA 106:8513-8518
11. Swigut T, Wysocka J 2007 H3K27 demethylases, at long last. Cell 131:29-32
12. Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW 1999 A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for liganddependent transactivation by nuclear receptors in vivo. J Biol Chem 274:34283-34293
13. Patel SR, Kim D, Levitan I, Dressler GR 2007 The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Dev Cell 13:580-592
14. Dreijerink KM, Mulder KW, Winkler GS, Hoppener JW, Lips CJ, Timmers HT 2006 Menin links estrogen receptor activation to histone H3K4 trimethylation, Cancer Res 66:4929-4935
15. Sierra J, Yoshida T, Joazeiro CA, Jones KA 2006 The APC tumor suppressor counteracts β-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev 20:586-600
16. Dou Y, Milne TA, Tackett AJ, Smith ER, Fukuda A, Wysocka J, Allis CD, Chait BT, Hess JL, Roeder RG 2005 Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell 121:873-885
17. Wysocka J, Herr W 2003 The herpes simplex virus VP16-induced complex: the makings of a regulatory switch. Trends Biochem Sci 28:294-304
18. Zhang Y, Hagedorn CH, Wang L 2011 SHP review. Role of nuclear receptor SHP in metabolism and cancer. Biochim Biophys Acta 1812:893-908
19. Ananthanarayanan M, Li Y, Surapureddi S, Balasubramaniyan N, Ahn J, Goldstein JA, Suchy FJ 2011 Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis. Am J Physiol Gastrointest Liver Physiol 300:G771-G781
20. Kim DH, Lee JW 2011 The tumor suppressor p53 regulates bile acid homeostasis via small heterodimer partner. Proc Natl Acad Sci USA 108:12266-12270
21. Dou Y, Milne TA, Ruthenburg AJ, Lee S, Lee JW, Verdine GL, Allis CD, Roeder RG 2006 Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol Biol 13:713-719
22. Patel A, Vought VE, Dharmarajan V, Cosgrove MS 2008 A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex. J Biol Chem 283:32162-32175
23. Patel A, Dharmarajan V, Vought VE, Cosgrove MS 2009 On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. J Biol Chem 284: 24242-24256
24. Patel A, Dharmarajan V, Cosgrove MS 2008 Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide. J Biol Chem 283:32158-32161
25. Song JJ, Kingston RE 2008 WDR5 interacts with mixed-lineage leukemia (MLL) protein via the histone H3 binding pocket. J Biol Chem 283:35258-35264
26. Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC, Boca SM, Carter H, Samayoa J, Bettegowda C, Gallia GL, Jallo GI, Binder ZA, Nikolsky Y, Hartigan J, Smith DR, Gerhard DS, Fults DW, VandenBerg S, Berger MS, Marie SK, Shinjo SM, Clara C, Phillips PC, Minturn JE, Biegel JA, Judkins AR, Resnick AC, Storm PB, Curran T, He Y, Rasheed BA, Friedman HS, Keir ST, McLendon R, Northcott PA, Taylor MD, Burger PC, Riggins GJ, Karchin R, Parmigiani G, Bigner DD, Yan H, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE 2011 The genetic landscape of the childhood cancer medulloblastoma. Science 331:435-439
27. Wang XX, Fu L, Li X, Wu X, Zhu Z, Fu L, Dong JT 2011 Somatic mutations of the mixed-lineage leukemia 3 (MLL3) gene in primary breast cancers. Pathol Oncol Res 17:429-433
28. Balakrishnan A, Bleeker FE, Lamba S, Rodolfo M, Daniotti M, Scarpa A, van Tilborg AA, Leenstra S, Zanon C, Bardelli A 2007 Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma. Cancer Res 67:3545-3550
29. van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C, Edkins S, Hardy C, O'Meara S, Teague J, Butler A, Hinton J, Latimer C, Andrews J, Barthorpe S, Beare D, Buck G, Campbell PJ, Cole J, Forbes S, Jia M, Jones D, Kok CY, Leroy C, Lin ML, McBride DJ, Maddison M, Maquire S, McLay K, Menzies A, Mironenko T, Mulderrig L, Mudie L, Pleasance E, Shepherd R, Smith R, Stebbings L, Stephens P, Tang G, Tarpey PS, Turner R, Turrell K, Varian J, West S, Widaa S, Wray P, Collins VP, Ichimura K, Law S, Wong J, Yuen ST, Leung SY, Tonon G, DePinho RA, Tai YT, Anderson KC, Kahnoski RJ, Massie A, Khoo SK, Teh BT, Stratton MR, Futreal PA 2009 Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet 41:521-523
30. Jung YS, Qian Y, Chen X 2010 Examination of the expanding pathways for the regulation of p21 expression and activity. Cell Signal 22:1003-1012
31. Chen WD, Wang YD, Zhang L, Shiah S, Wang M, Yang F, Yu D, Forman BM, Huang W 2010 Farnesoid X receptor alleviates agerelated proliferation defects inregenerating mouse livers by activating forkhead box m1b transcription. Hepatology 51:953-962
32. Kanamaluru D, Xiao Z, Fang S, Choi SE, Kim DH, Veenstra TD, Kemper JK 2011 Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner. Mol Cell Biol 31:1540-1550