Mitochondrial oxidative stress and respiratory chain dysfunction account for liver toxicity during amiodarone but not dronedarone administration

Free Radical Biology and Medicine

Volumn 51, Issue 12, 2011, Pages 2234-2242

  Serviddio, Gaetano ^a   Bellanti, Francesco ^a   Giudetti, Anna Maria ^b   Gnoni, Gabriele Vincenzo ^b   Capitanio, Nazzareno ^a   Tamborra, Rosanna ^a   Romano, Antonino Davide ^a   Quinto, Maurizio ^a   Blonda, Maria ^a   Vendemiale, Gianluigi ^a,c   Altomare, Emanuele ^a  

^a UNIVERSITY OF FOGGIA   (Italy)

^b UNIVERSITY OF SALENTO   (Italy)

^c CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

Author keywords

Antioxidants; Drugs; Free radicals; Hepatotoxicity; Lipid peroxidation; Mitochondrial dysfunction

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; AMIODARONE; CARDIOLIPIN; DRONEDARONE; GLUTATHIONE; HYDROGEN PEROXIDE; MEMBRANE PHOSPHOLIPID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOENERGY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; LIPID PEROXIDATION; LIVER MITOCHONDRION; LIVER TOXICITY; LOADING DRUG DOSE; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RESPIRATORY CHAIN;

AMIODARONE; ANIMALS; DRUG-INDUCED LIVER INJURY; HYDROGEN PEROXIDE; LIVER; MALE; MITOCHONDRIA, LIVER; MITOCHONDRIAL MEMBRANES; OXIDATIVE STRESS; PHOSPHOLIPIDS; RATS; RATS, WISTAR;

RATTUS;

EID: 81855204957     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.09.004     Document Type: Article

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