Statins discontinuation in compliant chronic users induces atherothrombotic profile despite baseline clinical setting and treatments

International Journal of Cardiology

Volumn 153, Issue 3, 2011, Pages 328-329

  Puccetti, Luca ^a   Pasqui, Anna Laura ^a   Scarpini, Francesca ^a   Cappellone, Roberta ^a   Ghezzi, Anna ^a   Ceccatelli, Linda ^a   Auteri, Alberto ^a  

^a UNIVERSITY OF SIENA   (Italy)

Author keywords

Atherothrombosis; Cholesterol; sCD40L; Statins discontinuation

Indexed keywords

ACETYLSALICYLIC ACID; APOLIPOPROTEIN A; APOLIPOPROTEIN B; ATORVASTATIN; C REACTIVE PROTEIN; CD40 LIGAND; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OXIDIZED LOW DENSITY LIPOPROTEIN; PADGEM PROTEIN; ROSUVASTATIN; SIMVASTATIN; TRIACYLGLYCEROL;

ADULT; ATHEROSCLEROSIS; ATHEROTHROMBOSIS; BLOOD ANALYSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORRELATIONAL STUDY; DYSLIPIDEMIA; FEMALE; HUMAN; HYPERTENSION; LETTER; MAJOR CLINICAL STUDY; MALE; PATIENT COMPLIANCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; THROMBOSIS; TREATMENT DURATION; TREATMENT WITHDRAWAL; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION;

EID: 81855194013     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2011.09.042     Document Type: Article

References (21)

1. Cholesterol Treatment Trialists' (CTT) Collaboration Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials Lancet 376 2010 1670 1681
2. A. Pineda, and L.X. Cubeddu Statin rebound or withdrawal syndrome: does it exist? Curr Atheroscler Rep 13 2011 23 30
3. M.C. Teixera Statins withdrawal, vascular complications, rebound effect and similitude Homeopathy 99 2010 255 262
4. C. Heeschen, C.W. Hhamm, U. Laufs, S. Snappin, M. Bohm, and H.D. White Platelet Receptor Inhibition in Ischemic Syndrome Management (PRISM) Investigators Circulation 105 2002 1446 1452
5. F.A. Spencer, G.C. Fonarow, and P.D. Frederick National Registry of Myocardial Infarction. Early withdrawal of statin therapy in patients with non-ST-segment elevation myocardial infarction Arch Intern Med 164 2004 2162 2168 (Pubitemid 39410807)
6. O. Schouten, S.E. Hoeks, and G. Welten Effect of statin withdrawal on frequency of cardiac events after vascular surgery Am J Cardiol 100 2007 316 320 (Pubitemid 47041993)
7. Y. Le Manach, G. Godet, and P. Coriat The impact of postoperative discontinuation or continuation of chronic statin therapy on cardiac outcome after major vascular surgery Anesth Analg 104 2007 1326 1333 (Pubitemid 46795280)
8. F. Colivicchi, A. Bassi, M. Santini, and C. Caltagirone Discontinuation of statin therapy and clinical outcome after ischemic stroke Stroke 38 2007 2652 2657 (Pubitemid 47493999)
9. M. Blanco, F. Nombela, and M. Castellanos Statin treatment withdrawal in ischemic stroke: a controlled randomized study Neurology 69 2007 904 910 (Pubitemid 47329591)
10. M.P. McGowan There is no evidence for an increase in acute coronary syndromes after short-term abrupt discontinuation of statins in stable cardiac patients Circulation 110 2004 2333 2335 (Pubitemid 39407335)
11. A.T. Hirsch, Z.J. Haskal, and N.R. Herttzner ACC/AHA 2005 guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): executive summary a collaborative report from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions Circulation 113 2006 463 654
12. T.G. Brott, J.L. Halperin, and S. Abbara 2011ASA/ACCF/AHA/AANN/AANS/ACR/ ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS. Guideline on the Management of Patients With Extracranial Carotid and Vertebral Artery Disease Circulation 2011 10.1161/CIR.0b013e31820d8d78
13. ICJME Sponsorship, authorship and accountability N Engl J Med 345 2001 825 828
14. L. Puccetti, A.L. Pasqui, and M. Pastorelli Platelet hyperactivity after statin treatment discontinuation Thromb Haemost 90 2003 476 482 (Pubitemid 37138773)
15. S. Riondino, F. Martini, F. La Farina, A. Spila, F. Guadagni, and P. Ferroni Increased plasma levels of soluble CD40 ligand correlate with platelet activation markers and underline the need for standardized pre-analytical conditions Clin Biochem 43 2010 666 670
16. S. Eichinger, G. Hron, M. Kollars, and P.A. Kyrle Prediction of recurrent venous thromboembolism by endogenous thrombin potential and D-dimer Clin Chem 54 2008 2042 2048 (Pubitemid 352774038)
17. L. Puccetti, F. Ciani, and A. Auteri Genetic involvement in statins induced myopathy. Preliminary data from an observational case-control study Atherosclerosis 211 2010 28 29
18. S.S. Daskalopoulou When statin therapy stops: implications for the patient Curr Opin Cardiol 24 2009 454 460
19. R.J. Simpson Jr., and P. Mendys The effects of adherence and persistence on clinical outcomes in patients treated with statins: a systematic review J Clin Lipidol 4 2010 462 471
20. C. Antoniades, C. Bakogiannis, D. Tousoulis, A.S. Antonopoulos, and C. Stefanadis The CD40/CD40 ligand system: linking inflammation with atherothrombosis J Am Coll Cardiol 54 2009 669 677
21. F. Santilli, S. Basili, P. Ferroni, and G. Davì CD40/CD40L system and vascular disease Intern Emerg Med 2 2007 256 268