To be or not to be accepted: The role of immunogenicity of neural stem cells following transplantation into the brain in animal and human studies

Seminars in Immunopathology

Volumn 33, Issue 6, 2011, Pages 619-626

  Capetian, Philipp ^a   Döbrössy, Máté ^a   Winkler, Christian ^a   Prinz, Marco ^a   Nikkhah, Guido ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Graft host interaction; Host defense system; Immuntolerance; Neural progenitor cells; Neural transplantation; Neurodegenerative diseases

Indexed keywords

CELL FATE; CELL FUNCTION; ENGRAFTMENT; GRAFT REJECTION; HOST RESISTANCE; HUMAN; HUNTINGTON CHOREA; IMMUNOGENICITY; IMMUNOMODULATION; NEURAL STEM CELL TRANSPLANTATION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW; STEM CELL NICHE; STEREOTACTIC PROCEDURE;

ANIMALS; BRAIN TISSUE TRANSPLANTATION; GRAFT REJECTION; HUMANS; IMMUNOMODULATION; NEURAL STEM CELLS; STEM CELL TRANSPLANTATION;

EID: 81855185600     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-011-0272-x     Document Type: Review

References (38)

1. A Björklund 1999 Transplanted precursors of nerve cells: Das and Altman and the revival of neural transplantation research Brain Res Bull 50 477 478 10643492 10.1016/S0361-9230(99)00142-2
2. A Morizane J Li P Brundin 2008 From bench to bed: the potential of stem cells for the treatment of Parkinson's disease Cell Tissue Res 331 323 336 18034267 10.1007/s00441-007-0541-0 (Pubitemid 50004907)
3. M Peschanski A Bachoud-Lévi P Hantraye 2004 Integrating fetal neural transplants into a therapeutic strategy: the example of Huntington's disease Brain 127 1219 1228 15047588 10.1093/brain/awh145 (Pubitemid 38745503)
4. RA Barker H Widner 2004 Immune problems in central nervous system cell therapy NeuroRx 1 472 481 15717048 10.1602/neurorx.1.4.472 (Pubitemid 46613779)
5. CF Barker RE Billingham 1977 Immunologically privileged sites Adv Immunol 25 1 54 345773 10.1016/S0065-2776(08)60930-X 1:STN:280:DyaE1c7ktFygsg%3D%3D
6. P Krystkowiak, et al. 2007 Alloimmunisation to donor antigens and immune rejection following foetal neural grafts to the brain in patients with Huntington's disease PLoS ONE 2 e166 17245442 10.1371/journal.pone.0000166
7. T Brabb 2000 In situ tolerance within the central nervous system as a mechanism for preventing autoimmunity J Exp Med 192 871 880 10993917 10.1084/jem.192.6.871 1:CAS:528:DC%2BD3cXmslGmtLk%3D
8. J Hori, et al. 2003 Neural progenitor cells lack immunogenicity and resist destruction as allografts Stem Cells 21 405 416 12832694 10.1634/stemcells.21-4-405 (Pubitemid 36798086)
9. WM Duan RM Cameron P Brundin H Widner 1997 Rat intrastriatal neural allografts challenged with skin allografts at different time points Exp Neurol 148 334 347 9398476 10.1006/exnr.1997.6656 1:STN:280:DyaK1c%2FmtlSnsg%3D%3D (Pubitemid 127445141)
10. J Odeberg J Piao E Samuelsson S Falci E Akesson 2005 Low immunogenicity of in vitro-expanded human neural cells despite high MHC expression J Neuroimmunol 161 1 11 15748938 10.1016/j.jneuroim.2004.11.016 1:CAS:528:DC%2BD2MXhvVCjtb0%3D (Pubitemid 40340868)
11. JH Kordower, et al. 1996 Functional fetal nigral grafts in a patient with Parkinson's disease: chemoanatomic, ultrastructural, and metabolic studies J Comp Neurol 370 203 230 8808731 10.1002/(SICI)1096-9861(19960624)370:2<203:: AID-CNE6>3.0.CO;2-6 1:STN:280:DyaK28vgsVGnuw%3D%3D (Pubitemid 26227146)
12. I Mendez, et al. 2005 Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease Brain 128 1498 1510 15872020 10.1093/brain/awh510 (Pubitemid 41373670)
13. J Li, et al. 2008 Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation Nat Med 14 501 503 18391963 10.1038/nm1746 1:CAS:528:DC%2BD1cXlsFCmsrs%3D (Pubitemid 351655211)
14. JH Kordower Y Chu RA Hauser TB Freeman CW Olanow 2008 Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease Nat Med 14 504 506 18391962 10.1038/nm1747 1:CAS:528:DC%2BD1cXlsFCmsrg%3D (Pubitemid 351655212)
15. TB Freeman, et al. 2000 Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology Proc Natl Acad Sci U S A 97 13877 13882 11106399 10.1073/pnas.97.25.13877 1:CAS:528:DC%2BD3cXoslynsb8%3D
16. P Capetian, et al. 2009 Histological findings on fetal striatal grafts in a Huntington's disease patient early after transplantation Neuroscience 160 661 675 19254752 10.1016/j.neuroscience.2009.02.035 1:CAS:528:DC%2BD1MXkslymtbs%3D
17. L Vignais, et al. 1993 Transplantation of oligodendrocyte precursors in the adult demyelinated spinal cord: migration and remyelination Int J Dev Neurosci 11 603 612 8116473 10.1016/0736-5748(93)90049-J 1:STN:280: DyaK2c7mtVygsA%3D%3D (Pubitemid 23352349)
18. S Das D Ghosh A Basu 2009 Japanese encephalitis virus induce immuno-competency in neural stem/progenitor cells PLoS ONE 4 e8134 19956550 10.1371/journal.pone.0008134
19. JS Fink, et al. 2000 Porcine xenografts in Parkinson's disease and Huntington's disease patients: preliminary results Cell Transplant 9 273 278 10811399 1:STN:280:DC%2BD3czosVOmtQ%3D%3D (Pubitemid 30252692)
20. U Galili 1993 Interaction of the natural anti-Gal antibody with alpha-galactosyl epitopes: a major obstacle for xenotransplantation in humans Immunol Today 14 480 482 7506033 10.1016/0167-5699(93)90261-I 1:CAS:528:DyaK2cXltFyksQ%3D%3D (Pubitemid 23300997)
21. P Brundin H Widner OG Nilsson RE Strecker A Björklund 1989 Intracerebral xenografts of dopamine neurons: the role of immunosuppression and the blood-brain barrier Exp Brain Res 75 195 207 2495977 10.1007/BF00248542 1:CAS:528:DyaL1MXktVSgtLc%3D (Pubitemid 19084701)
22. A Brandis, et al. 1998 Time-dependent expression of donor- and host-specific major histocompatibility complex class I and II antigens in allogeneic dopamine-rich macro- and micrografts: comparison of two different grafting protocols Acta Neuropathol 95 85 97 9452826 10.1007/s004010050769 1:CAS:528:DyaK1cXmtlCitg%3D%3D (Pubitemid 28075931)
23. RD Broadwell BJ Baker P Ebert WF Hickey J Villegas 1992 Intracerebral grafting of solid tissues and cell suspensions: the blood-brain barrier and host immune response Prog Brain Res 91 95 102 1410441 10.1016/S0079-6123(08)62323-7 1:STN:280:DyaK3s%2FivFCmsw%3D%3D
24. K Takei, et al. 1990 Immunological rejection of grafted tissue in xenogeneic neural transplantation Prog Brain Res 82 103 109 1705353 10.1016/S0079-6123(08)62596-0 1:STN:280:DyaK3M7kvFGrsg%3D%3D (Pubitemid 20299607)
25. BJ Baker-Cairns DJ Sloan RD Broadwell M Puklavec HM Charlton 1996 Contributions of donor and host blood vessels in CNS allografts Exp Neurol 142 36 46 8912897 10.1006/exnr.1996.0177 1:STN:280:DyaK2s%2FmvF2itQ%3D%3D (Pubitemid 26381379)
26. J Oertel M Samii GF Walter 2004 Fetal allogeneic dopaminergic cell suspension grafts in the ventricular system of the rat: characterization of transplant morphology and graft-host interactions Acta Neuropathol 107 421 427 14872256 10.1007/s00401-004-0823-5 1:STN:280:DC%2BD2c7ovVCjtw%3D%3D (Pubitemid 38559251)
27. DJ Sloan BJ Baker M Puklavec HM Charlton 1990 The effect of site of transplantation and histocompatibility differences on the survival of neural tissue transplanted to the CNS of defined inbred rat strains Prog Brain Res 82 141 152 1981274 10.1016/S0079-6123(08)62599-6 1:STN:280:DyaK3M7kvFGrtg%3D%3D (Pubitemid 20299610)
28. S Kida A Pantazis RO Weller 1993 CSF drains directly from the subarachnoid space into nasal lymphatics in the rat. Anatomy, histology and immunological significance Neuropathol Appl Neurobiol 19 480 488 7510047 10.1111/j.1365-2990.1993.tb00476.x 1:STN:280:DyaK2c7ms12gug%3D%3D (Pubitemid 24010674)
29. K Vass H Lassmann 1990 Intrathecal application of interferon gamma. Progressive appearance of MHC antigens within the rat nervous system Am J Pathol 137 789 800 2121041 1:CAS:528:DyaK3MXit1Wrug%3D%3D (Pubitemid 20337794)
30. S Pluchino, et al. 2003 Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis Nature 422 688 694 12700753 10.1038/nature01552 1:CAS:528:DC%2BD3sXivFGhsLg%3D (Pubitemid 36514101)
31. S Pluchino, et al. 2005 Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism Nature 436 266 271 16015332 10.1038/nature03889 1:CAS:528:DC%2BD2MXmtVers7k%3D (Pubitemid 41021278)
32. S Pluchino, et al. 2009 Immune regulatory neural stem/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell function PLoS ONE 4 e5959 19543526 10.1371/journal.pone.0005959
33. S Pluchino, et al. 2009 Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates Ann Neurol 66 343 354 19798728 10.1002/ana.21745 1:CAS:528:DC%2BD1MXhtlCgt7fK
34. M Aharonowiz, et al. 2008 Neuroprotective effect of transplanted human embryonic stem cell-derived neural precursors in an animal model of multiple sclerosis PLoS ONE 3 e3145 18773082 10.1371/journal.pone.0003145
35. Krebs S (2011) Immune response after striatal engraftment of fetal neuronal cells in patients with Huntington's disease: consequences for cerebral transplantation programs. Clinical and Experimental Neuroimmunology (in press)
36. C Winkler D Kirik A Björklund 2005 Cell transplantation in Parkinson's disease: how can we make it work? Trends Neurosci 28 86 92 15667931 10.1016/j.tins.2004.12.006 1:CAS:528:DC%2BD2MXmslKmtg%3D%3D (Pubitemid 40178925)
37. G Nikkhah, et al. 2009 Microtransplantation of dopaminergic cell suspensions: further characterization and optimization of grafting parameters Cell Transplant 18 119 133 19499701 10.3727/096368909788341324
38. M Döbrössy, et al. 2010 Neurorehabilitation with neural transplantation Neurorehabil Neural Repair 24 692 701 20647502 10.1177/1545968310363586