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Volumn 3, Issue 16, 2011, Pages 1983-1986

Research Spotlight: Iron chelation: Deciphering novel molecular targets for cancer therapy. the tip of the iceberg of a web of iron-regulated molecules

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CCAAT BINDING FACTOR; CYCLIN D1; DEFEROXAMINE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; JANUS KINASE; MIMOSINE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P21; SYNAPTOPHYSIN; THIOSEMICARBAZONE; UVOMORULIN; IRON; IRON CHELATING AGENT;

EID: 81855173468     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.11.154     Document Type: Article
Times cited : (6)

References (20)
  • 1
    • 80051615717 scopus 로고    scopus 로고
    • Deferoxamine for advanced hepatocellular carcinoma
    • Yamasaki T, Terai S, Sakaida I. Deferoxamine for advanced hepatocellular carcinoma N. Eng. J. Med. 365, 576-578 (2011).
    • (2011) N. Eng. J. Med. , vol.365 , pp. 576-578
    • Yamasaki, T.1    Terai, S.2    Sakaida, I.3
  • 2
    • 80053198672 scopus 로고    scopus 로고
    • Novel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor N-myc down-stream regulated gene 1: A new strategy for the treatment of pancreatic cancer
    • Kovacevic Z, Chikhani S, Lovejoy DB, Richardson DR. Novel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor N-myc down-stream regulated gene 1: A new strategy for the treatment of pancreatic cancer. Mol. Pharmacol. 80, 598-609 (2011).
    • (2011) Mol. Pharmacol. , vol.80 , pp. 598-609
    • Kovacevic, Z.1    Chikhani, S.2    Lovejoy, D.B.3    Richardson, D.R.4
  • 3
    • 80053926659 scopus 로고    scopus 로고
    • Bp44mT: An orally-active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy
    • doi:10.1111/j.1476-5381.2011.01526 Epub ahead of print
    • Yu Y, Rahmanto YS, Richardson D. Bp44mT: An orally-active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy. Br. J. Pharmacol. doi:10.1111/j.1476-5381.2011.01526 (2011) (Epub ahead of print).
    • (2011) Br. J. Pharmacol.
    • Yu, Y.1    Rahmanto, Y.S.2    Richardson, D.3
  • 4
    • 33749515083 scopus 로고    scopus 로고
    • A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics
    • USA
    • Whitnall M, Howard J, Ponka P, Richardson DR. A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics. Proc. Natl Acad. Sci. USA 103, 14901-14906 (2006).
    • (2006) Proc. Natl Acad. Sci. , vol.103 , pp. 14901-14906
    • Whitnall, M.1    Howard, J.2    Ponka, P.3    Richardson, D.R.4
  • 5
    • 4444248453 scopus 로고    scopus 로고
    • Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: In vitro and in vivo assessment
    • Yuan J, Lovejoy DB, Richardson DR. Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment, Blood 104, 1450-1458 (2004).
    • (2004) Blood , vol.104 , pp. 1450-1458
    • Yuan, J.1    Lovejoy, D.B.2    Richardson, D.R.3
  • 6
    • 29844457587 scopus 로고    scopus 로고
    • The evolution of iron chelators for the treatment of iron overload disease and cancer
    • Kalinowski DS, Richardson DR. The evolution of iron chelators for the treatment of iron overload disease and cancer, Pharmacol. Rev. 57 547-583 (2005).
    • (2005) Pharmacol. Rev. , vol.57 , pp. 547-583
    • Kalinowski, D.S.1    Richardson, D.R.2
  • 7
    • 69949108747 scopus 로고    scopus 로고
    • Thiosemicarbazones from the old to new: Iron chelators that are more than just ribonucleotide reductase inhibitors
    • Yu Y, Kalinowski DS, Kovacevic Z et al. Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors. J. Med. Chem. 52, 5271-5294 (2009).
    • (2009) J. Med. Chem. , vol.52 , pp. 5271-5294
    • Yu, Y.1    Kalinowski, D.S.2    Kovacevic, Z.3
  • 9
    • 77149125234 scopus 로고    scopus 로고
    • Iron chelator-mediated alterations in gene expression: Identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53
    • Saletta F, Rahmanto YS, Noulsri E, Richardson DR. Iron chelator-mediated alterations in gene expression: identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53. Mol. Pharmacol. 77, 443-458 (2010).
    • (2010) Mol. Pharmacol. , vol.77 , pp. 443-458
    • Saletta, F.1    Rahmanto, Y.S.2    Noulsri, E.3    Richardson, D.R.4
  • 10
    • 33845358660 scopus 로고    scopus 로고
    • The metastasis suppressor Ndrg-1: A new ally in the fight against cancer
    • Kovacevic Z, Richardson DR. The metastasis suppressor, Ndrg-1: A new ally in the fight against cancer. Carcinogenesis 27, 2355-2366 (2006).
    • (2006) Carcinogenesis , vol.27 , pp. 2355-2366
    • Kovacevic, Z.1    Richardson, D.R.2
  • 11
    • 80053914848 scopus 로고    scopus 로고
    • Cellular iron-depletion and the mechanisms involved in the iron-dependent regulation of the growth arrest and DNA damage family of genes
    • Saletta F, Suryo Rahmanto Y, Siafakas AR, Richardson DR. Cellular iron-depletion and the mechanisms involved in the iron-dependent regulation of the growth arrest and DNA damage family of genes. J. Biol. Chem. 286, 35396-35406 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 35396-35406
    • Saletta, F.1    Suryo Rahmanto, Y.2    Siafakas, A.R.3    Richardson, D.R.4
  • 12
    • 79955462543 scopus 로고    scopus 로고
    • Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways dissociation of ASK1- thioredoxin and activation of ASK1
    • Yu Y, Richardson DR. Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1- thioredoxin and activation of ASK1. J. Biol. Chem. 286, 15413-15427 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 15413-15427
    • Yu, Y.1    Richardson, D.R.2
  • 13
    • 34547137681 scopus 로고    scopus 로고
    • Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1 by iron depletion
    • Fu D, Richardson DR. Iron chelation and regulation of the cell cycle: 2 mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1/WAF1 by iron depletion. Blood 110, 752-761 (2007).
    • (2007) Blood , vol.110 , pp. 752-761
    • Fu, D.1    Richardson, D.R.2
  • 14
    • 34247373460 scopus 로고    scopus 로고
    • Iron chelation regulates cyclin D1 expression via the proteasome: A link to iron deficiency-mediated growth suppression
    • Nurtjahja-Tjendraputra E, Fu D, Phang JM, Richardson DR. Iron chelation regulates cyclin D1 expression via the proteasome: A link to iron deficiency-mediated growth suppression. Blood 109, 4045-4054 (2007).
    • (2007) Blood , vol.109 , pp. 4045-4054
    • Nurtjahja-Tjendraputra, E.1    Fu, D.2    Phang, J.M.3    Richardson, D.R.4
  • 15
    • 0034079520 scopus 로고    scopus 로고
    • The p53/p63/p73 family of transcription factors: Overlapping and distinct functions
    • Levrero M, De Laurenzi V, Costanzo A, Gong J, Wang JY, Melino G. The p53/p63/p73 family of transcription factors: overlapping and distinct functions. J. Cell Sci. 113(Pt 10), 1661-1670 (2000).
    • (2000) J. Cell Sci. , vol.113 , Issue.10 , pp. 1661-1670
    • Levrero, M.1    De Laurenzi, V.2    Costanzo, A.3    Gong, J.4    Wang, J.Y.5    Melino, G.6
  • 16
    • 0034671837 scopus 로고    scopus 로고
    • CHOP gene expression in response to endoplasmic-reticular stress requires NFY interaction with different domains of a conserved DNA-binding element
    • Ubeda M, Habener JF. CHOP gene expression in response to endoplasmic-reticular stress requires NFY interaction with different domains of a conserved DNA-binding element. Nucleic Acids Res. 28, 4987-4997 (2000).
    • (2000) Nucleic Acids Res. , vol.28 , pp. 4987-4997
    • Ubeda, M.1    Habener, J.F.2
  • 17
    • 58149140268 scopus 로고    scopus 로고
    • Involvement of endoplasmic reticulum stress and activation of MAP kinases in beta-lapachone-induced human prostate cancer cell apoptosis
    • Lien YC, Kung HN, Lu KS, Jeng CJ, Chau YP. Involvement of endoplasmic reticulum stress and activation of MAP kinases in beta-lapachone-induced human prostate cancer cell apoptosis. Histol. istopathol. 23, 1299-1308 (2008).
    • (2008) Histol. istopathol. , vol.23 , pp. 1299-1308
    • Lien, Y.C.1    Kung, H.N.2    Lu, K.S.3    Jeng, C.J.4    Chau, Y.P.5
  • 18
    • 4744359324 scopus 로고    scopus 로고
    • Arsenic trioxide causes redistribution of cell cycle caspase activation and GADD expression in human colonic breast and pancreatic cancer cells
    • Li X, Ding X, Adrian TE. Arsenic trioxide causes redistribution of cell cycle, caspase activation, and GADD expression in human colonic, breast, and pancreatic cancer cells, Cancer Invest. 22, 389-400 (2004).
    • (2004) Cancer Invest. , vol.22 , pp. 389-400
    • Li, X.1    Ding, X.2    Adrian, T.E.3
  • 19
    • 7244239197 scopus 로고    scopus 로고
    • Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: A link between iron metabolism and proliferation
    • Le NT, Richardson DR. Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: A link between iron metabolism and proliferation. Blood 104, 2967-2975 (2004).
    • (2004) Blood , vol.104 , pp. 2967-2975
    • Le, N.T.1    Richardson, D.R.2
  • 20
    • 79955770381 scopus 로고    scopus 로고
    • The metastasis suppressor N-myc downstream regulated gene 1 NDRG1 upregulates p21 via p53- independent mechanisms
    • Kovacevic Z, Sivagurunathan S, Mangs H, Chikhani S, Zhang D, Richardson DR. The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), upregulates p21 via p53- independent mechanisms. Carcinogenesis 32, 732-740 (2011).
    • (2011) Carcinogenesis , vol.32 , pp. 732-740
    • Kovacevic, Z.1    Sivagurunathan, S.2    Mangs, H.3    Chikhani, S.4    Zhang, D.5    Richardson, D.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.