Regulation and functions of ADAR in Drosophila

Current Topics in Microbiology and Immunology

Volumn 353, Issue 1, 2012, Pages 221-236

  Paro, Simona ^a   Li, Xianghua ^a   O'Connell, Mary A ^a   Keegan, Liam P ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

ADAR; Development; Drosophila; Genetics; RNA editing; RNA interference

Indexed keywords

ADAR PROTEIN; DOUBLE STRANDED RNA; GLUTAMATE RECEPTOR; ION CHANNEL; MEMBRANE PROTEIN; MICRORNA; PROTEIN; RECEPTOR SUBUNIT; RNA BINDING PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ADAR GENE; ARTICLE; CELL MUTANT; CENTRAL NERVOUS SYSTEM; DROSOPHILA MELANOGASTER; ELECTROPHYSIOLOGY; ENZYME INACTIVATION; GENE; GENE CONTROL; GENE FUNCTION; GENE LOCUS; GENETIC TRANSCRIPTION; INFORMATION; MUTANT; NERVE CELL; NERVE CELL EXCITABILITY; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA BINDING; RNA EDITING; RNA INTERFERENCE; RNA SEQUENCE; RNA SPLICING; TRANSPOSON;

ADENOSINE DEAMINASE; ANIMALS; DROSOPHILA; DROSOPHILA PROTEINS; RNA EDITING; RNA INTERFERENCE; TRANSCRIPTION, GENETIC;

DROSOPHILA MELANOGASTER; MAMMALIA;

EID: 81855172227     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/82_2011_152     Document Type: Article

References (47)

1. Akimaru H, Hou DX, Ishii S (1997) Drosophila CBP is required for dorsal-dependent twist gene expression. Nat Genet 17:211-214
2. Bhalla T, Rosenthal JJ, Holmgren M, Reenan R (2004) Control of human potassium channel inactivation by editing of a small mRNA hairpin. Nat Struct Mol Biol 11:950-956 (Pubitemid 39315298)
3. Czech B, Hannon GJ (2011) Small RNA sorting: matchmaking for Argonautes. Nat Rev Genet 12:19-31
4. Czech B, Malone CD, Zhou R, Stark A, Schlingeheyde C, Dus M, Perrimon N, Kellis M, Wohlschlegel JA, Sachidanandam R et al (2008) An endogenous small interfering RNA pathway in Drosophila. Nature 453:798-802 (Pubitemid 351793787)
5. Gallo A, Keegan LP, Ring GM, O'Connell MA (2003) An ADAR that edits transcripts encoding ion channel subunits functions as a dimer. Embo J 22:3421-3430 (Pubitemid 36834872)
6. Gan Z, Zhao L, Yang L, Huang P, Zhao F, Li W, Liu Y (2006) RNA editing by ADAR2 is metabolically regulated in pancreatic islets and beta-cells. J Biol Chem 281:33386-33394 (Pubitemid 46036720)
7. Grauso M, Reenan RA, Culetto E, Sattelle DB (2002) Novel putative nicotinic acetylcholine receptor subunit genes, Dalpha5, Dalpha6 and Dalpha7, in D. melanogaster identify a new and highly conserved target of adenosine deaminase acting on RNA-Mediated A-to-I Pre-mRNA Editing. Genetics 160:1519-1533 (Pubitemid 34454375)
8. Graveley BR, Brooks AN, Carlson JW, Duff MO, Landolin JM, Yang L, Artieri CG, van Baren MJ, Boley N, Booth BW et al (2011) The developmental transcriptome of Drosophila melanogaster. Nature 471:473-479
9. Hanrahan CJ, Palladino MJ, Ganetzky B, Reenan RA (2000) RNA editing of the Drosophila para Na(+) channel transcript. Evolutionary conservation and developmental regulation. Genetics 155:1149-1160 (Pubitemid 30463426)
10. Heale BS, Keegan LP, McGurk L, Michlewski G, Brindle J, Stanton CM, Caceres JF, O'Connell MA (2009a) Editing independent effects of ADARs on the miRNA/siRNA pathways. Embo J 28:3145-3156
11. Heale BS, Keegan LP, O'Connell MA (2009b) ADARs have effects beyond RNA editing. Cell Cycle 8:4011-4012
12. Higuchi M, Single FN, Kohler M, Sommer B, Sprengel R, Seeburg PH (1993) RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency. Cell 75:1361-1370 (Pubitemid 24021910)
13. Hoopengardner B, Bhalla T, Staber C, Reenan R (2003) Nervous system targets of RNA editing identified by comparative genomics. Science 301:832-836 (Pubitemid 36962624)
14. Ingleby L, Maloney R, Jepson J, Horn R, Reenan R (2009) Regulated RNA editing and functional epistasis in Shaker potassium channels. J Gen Physiol 133:17-27
15. Jepson JE, Reenan RA (2007) Genetic approaches to studying adenosine-to-inosine RNA editing. Methods Enzymol 424:265-287
16. Jepson JE, Reenan RA (2009) Adenosine-to-inosine genetic recoding is required in the adult stage nervous system for coordinated behavior in Drosophila. J Biol Chem 284:31391-31400
17. Jepson JE, Savva YA, Yokose C, Sugden AU, Sahin A, Reenan RA (2011) Engineered alterations in RNA editing modulate complex behavior in Drosophila: regulatory diversity of adenosine deaminase acting on RNA (ADAR) Targets. J Biol Chem 286:8325-8337
18. Jones AK, Buckingham SD, Papadaki M, Yokota M, Sattelle BM, Matsuda K, Sattelle DB (2009) Splice-variant-and stage-specific RNA editing of the Drosophila GABA receptor modulates agonist potency. J Neurosci 29:4287-4292
19. Kawahara Y, Zinshteyn B, Sethupathy P, Iizasa H, Hatzigeorgiou AG, Nishikura K (2007) Redirection of silencing targets by adenosine-to-inosine editing of miRNAs. Science 315: 1137-1140 (Pubitemid 46328026)
20. Kawahara Y, Megraw M, Kreider E, Iizasa H, Valente L, Hatzigeorgiou AG, Nishikura K (2008) Frequency and fate of microRNA editing in human brain. Nucleic Acids Res 36:5270-5280
21. Kawamura Y, Saito K, Kin T, Ono Y, Asai K, Sunohara T, Okada TN, Siomi MC, Siomi H (2008) Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells. Nature 453:793-797 (Pubitemid 351793781)
22. Keegan LP, Brindle J, Gallo A, Leroy A, Reenan RA, O'Connell MA (2005) Tuning of RNA editing by ADAR is required in Drosophila. Embo J 24:2183-2193 (Pubitemid 40961802)
23. Knight SW, Bass BL (2002) The role of RNA editing by ADARs in RNAi. Mol Cell 10:809-817 (Pubitemid 35335636)
24. Kondo T, Suzuki T, Ito S, Kono M, Negoro T, Tomita Y (2008) Dyschromatosis symmetrica hereditaria associated with neurological disorders. J Dermatol 35:662-666
25. Li C, Vagin VV, Lee S, Xu J, Ma S, Xi H, Seitz H, Horwich MD, Syrzycka M, Honda BM et al (2009) Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Cell 137:509-521
26. Ma E, Tucker MC, Chen Q, Haddad GG (2002) Developmental expression and enzymatic activity of pre-mRNA deaminase in Drosophila melanogaster. Brain Res Mol Brain Res 102:100-104 (Pubitemid 34607746)
27. Malone CD, Brennecke J, Dus M, Stark A, McCombie WR, Sachidanandam R, Hannon GJ (2009) Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell 137:522-535
28. Marcucci R, Romano M, Feiguin F, O'Connell MA, Baralle FE (2009) Dissecting the splicing mechanism of the Drosophila editing enzyme; dADAR. Nucleic Acids Res 37:1663-1671
29. Palladino MJ, Keegan LP, O'Connell MA, Reenan RA (2000a) dADAR, a Drosophila doublestranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing. RNA 6:1004-1018 (Pubitemid 30471137)
30. Palladino MJ, Keegan LP, O'Connell MA, Reenan RA (2000b) A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous systemfunction and integrity. Cell 102:437-449
31. Peng PL, Zhong X, Tu W, Soundarapandian MM, Molner P, Zhu D, Lau L, Liu S, Liu F, Lu Y (2006) ADAR2-dependent RNA editing of AMPA receptor subunit GluR2 determines vulnerability of neurons in forebrain ischemia. Neuron 49:719-733 (Pubitemid 43290131)
32. Peters NT, Rohrbach JA, Zalewski BA, Byrkett CM, Vaughn JC (2003)RNA editing and regulation of Drosophila 4f-rnp expression by sas-10 antisense readthrough mRNA transcripts. RNA 9:698-710 (Pubitemid 36618198)
33. Petschek JP, Mermer MJ, Scheckelhoff MR, Simone AA, Vaughn JC (1996) RNA editing in Drosophila 4f-rnp gene nuclear transcripts by multiple A-to-G conversions. J Mol Biol 259: 885-890 (Pubitemid 26229854)
34. Reenan RA (2005) Molecular determinants and guided evolution of species-specific RNA editing. Nature 434:409-413 (Pubitemid 40469187)
35. Roy S, Ernst J, Kharchenko PV, Kheradpour P, Negre N, Eaton ML, Landolin JM, Bristow CA, Ma L, Lin MF et al (2010) Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science 330:1787-1797
36. Ryan MY, Maloney R, Reenan R, Horn R (2008) Characterization of five RNA editing sites in Shab potassium channels. Channels (Austin) 2:202-209
37. Scadden AD (2005) The RISC subunit Tudor-SN binds to hyper-edited double-stranded RNA and promotes its cleavage. Nat Struct Mol Biol 12:489-496 (Pubitemid 43085878)
38. Scadden AD, Smith CW (2001) RNAi is antagonized by A I hyper-editing. EMBO Rep 2:1107-1111
39. Semenov EP, Pak WL (1999) Diversification of Drosophila chloride channel gene by multiple posttranscriptional mRNA modifications. J Neurochem 72:66-72 (Pubitemid 29013878)
40. Smith LA, Wang XJ, Peixoto AA, Neumann EK, Hall LM, Hall JC (1996) A Drosophila calcium channel a1 subunit gene maps to a genetic locus associated with behavioural and visual defects. J Neurosci 16:7868-7879 (Pubitemid 26405050)
41. Stapleton M, Carlson JW, Celniker SE (2006) RNA editing in Drosophila melanogaster: new targets and functional consequences. RNA 12:1922-1932 (Pubitemid 44771752)
42. Stefl R, Oberstrass FC, Hood JL, Jourdan M, Zimmermann M, Skrisovska L, Maris C, Peng L, Hofr C, Emeson RB, Allain FH (2010) The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific readout of the minor groove. Cell 143:225-237
43. Tian N, Wu X, Zhang Y, Jin Y (2008) A-to-I editing sites are a genomically encoded G: implications for the evolutionary significance and identification of novel editing sites. RNA 14:211-216 (Pubitemid 351171581)
44. Visel A, Blow MJ, Li Z, Zhang T, Akiyama JA, Holt A, Plajzer-Frick I, Shoukry M, Wright C, Chen F et al (2009) ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature 457:854-858
45. Vo N, Goodman RH (2001) CREB-binding protein and p300 in transcriptional regulation. J Biol Chem 276:13505-13508
46. Yang W, Wang Q, Howell KL, Lee JT, Cho DS, Murray JM, Nishikura K (2005) ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells. J Biol Chem 280: 3946-3953 (Pubitemid 40223864)
47. Yang Y, Lv J, Gui B, Yin H, Wu X, Zhang Y, Jin Y (2008) A-to-I RNA editing alters lessconserved residues of highly conserved coding regions: implications for dual functions in evolution. RNA 14:1516-1525