Iptakalim, an ATP-sensitive potassium channel opener, confers neuroprotection against cerebral ischemia/reperfusion injury in rats by protecting neurovascular unit cells

Journal of Zhejiang University: Science B

Volumn 12, Issue 10, 2011, Pages 835-845

  Ran, Yu Hua ^a   Wang, Hai ^a,b  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b Thadweik Academy of Medicine   (China)

Author keywords

Apoptosis; ATP sensitive potassium channel opener; Cerebral ischemia reperfusion (I R) injury; Neuroprotection; Neurovascular unit

Indexed keywords

CASPASE 3; IPTAKALIM; LACTATE DEHYDROGENASE; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CELL; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL CULTURE; CELL DAMAGE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY;

ANIMALS; APOPTOSIS; BRAIN EDEMA; CEREBRAL INFARCTION; KATP CHANNELS; L-LACTATE DEHYDROGENASE; MALE; NEUROPROTECTIVE AGENTS; PROPYLAMINES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

RATTUS;

EID: 81855166205     PISSN: 16731581     EISSN: 18621783     Source Type: Journal    
DOI: 10.1631/jzus.B1100067     Document Type: Article

References (40)

1. K.M. Abdel-Hamid K.G. Baimbridge 1997 The effects of artificial calcium buffers on calcium responses and glutamate-mediated excitotoxicity in cultured hippocampal neurons Neuroscience 81 3 673 687 9316020 10.1016/S0306-4522(97) 00162-0 1:CAS:528:DyaK2sXmtlelsb4%3D (Pubitemid 27402515)
2. P.H. Chan 1996 Role of oxidants in ischemic brain damage Stroke 27 6 1124 1129 8650725 10.1161/01.STR.27.6.1124 1:CAS:528:DyaK28XktVegs7g%3D (Pubitemid 26177617)
3. Y.P. Chen C.R. Qiu H. Wang 2004 Cardiovascular pharmacological characterization of novel 2,3-dimethyl-2-butylamine derivatives in rats Life Sci. 75 17 2131 2142 15312756 10.1016/j.lfs.2004.06.003 1:CAS:528: DC%2BD2cXmsleqtb0%3D (Pubitemid 39092997)
4. Y.P. Chen W.Y. Cui H. Wang 2006 Selective actions of iptakalim on the subtypes of KATP channels Chin. Pharmacol. Bull 22 3 278 284 1:CAS:528:DC%2BD2sXnvVahurY%3D (Pubitemid 43953476)
5. 2+ concentration changes in cultured postnatal rat hippocampal neurons Neuroscience 93 3 1003 1016 10473265 10.1016/S0306-4522(99)00230-4 1:CAS:528:DyaK1MXltlKmt74%3D (Pubitemid 29341647)
6. F. Domoki B. Kis K. Nagy E. Farkas D.W. Busija F. Bari 2005 Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets Am. J. Physiol. 289 1 H368 H373 1:CAS:528: DC%2BD2MXmvVequro%3D
7. + channel in rat brain Brain Res. 814 1-2 41 54 9838037 10.1016/S0006-8993(98)00956-1 1:CAS:528: DyaK1cXnsFWltL0%3D (Pubitemid 29023410)
8. H.R. Girn S. Ahilathirunayagam A.I. Mavor S. Homer-Vanniasinkam 2007 Reperfusion syndrome: cellular mechanisms of microvascular dysfunction and potential therapeutic strategies Vasc. Endovascular Surg. 41 4 277 293 17704330 10.1177/1538574407304510 (Pubitemid 47258443)
9. S.H. Graham J. Chen 2001 Programmed cell death in cerebral ischemia J. Cereb. Blood Flow Metab. 21 2 99 109 11176275 10.1097/00004647-200102000-00001 1:CAS:528:DC%2BD3MXntFKjtbY%3D (Pubitemid 32143971)
10. D.R. Green J.C. Reed 1998 Mitochondria and apoptosis Science 281 5381 1309 1312 9721092 10.1126/science.281.5381.1309 1:CAS:528:DyaK1cXlvVegsLo%3D (Pubitemid 28406816)
11. B. Hamprecht F. Löffler 1985 Primary glial cultures as a model for studying hormone action Methods Enzymol. 109 341 345 2985921 10.1016/0076-6879(85)09097-8 1:CAS:528:DyaL2MXktlagsrY%3D (Pubitemid 15136041)
12. X.L. Hu T. Olsson I.M. Johansson T. Brannstrom P. Wester 2004 Dynamic changes of the anti- and pro-apoptotic proteins Bcl-w, Bcl-2, and Bax with Smac/Diablo mitochondrial release after photothrombotic ring stroke in rats Eur. J. Neurosci. 20 5 1177 1188 15341589 10.1111/j.1460-9568.2004.03554.x (Pubitemid 39233571)
13. + channels in rat aorta and brain microvascular endothelial cells Am. J. Physiol. 265 3Pt1 C812 C821 8214038 1:CAS:528:DyaK3sXms1Ohtrw%3D
14. B. Kis H. Kaiya R. Nishi M.A. Deli C.S. Abraham T. Yanagita T. Isse S. Gotoh H. Kobayashi A. Wada, et al. 2002 Cerebral endothelial cells are a major source of adrenomedullin J. Neuroendocrinol. 14 4 283 293 11963825 10.1046/j.1365-2826.2002.00778.x 1:CAS:528:DC%2BD38XivVCiuro%3D (Pubitemid 34285297)
15. B. Kis J.A. Snipes S.A. Simandle D.W. Busija 2005 Acetaminophen-sensitive prostaglandin production in rat cerebral endothelial cells Am. J. Physiol. 288 4 R897 R902 1:CAS:528:DC%2BD2MXjtlOqsL4%3D
16. A.J. Kowaltowski R.F. Castilho A.E. Vercesi 2001 Mitochondrial permeability transition and oxidative stress FEBS Lett. 495 1-2 12 15 11322939 10.1016/S0014-5793(01)02316-X 1:CAS:528:DC%2BD3MXivFehu7o%3D (Pubitemid 32367965)
17. G. Kroemer 2003 Mitochondrial control of apoptosis: an introduction Biochem. Biophys. Res. Commun. 304 3 433 435 12729576 10.1016/S0006-291X(03) 00614-4 1:CAS:528:DC%2BD3sXjt1Kisr8%3D (Pubitemid 36511397)
18. P. Li D. Nijhawan I. Budihardjo S.M. Srinivasula M. Ahmad E.S. Alnemri X. Wang 1997 Cytochrome C and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade Cell 91 4 479 489 9390557 10.1016/S0092-8674(00)80434-1 1:CAS:528:DyaK2sXnsFGls70%3D (Pubitemid 27508237)
19. Y. Li M. Chopp N. Jiang F. Yao C. Zaloga 1995 Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat J. Cereb. Blood Flow Metab. 15 3 389 397 7713996 10.1038/jcbfm.1995.49 1:CAS:528:DyaK2MXlslClt7s%3D
20. M.D. Linnik R.H. Zobrist M.D. Hatfield 1993 Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats Stroke 24 12 2002 2008 8248983 10.1161/01.STR.24.12.2002 1:STN:280:DyaK2c%2FmvFGrsQ%3D%3D
21. B. Liss R. Bruns J. Roeper 1999 Alternative sulfonylurea receptor expression defines metabolic sensitivity of KATP channels in dopaminergic midbrain neurons EMBO J. 18 4 833 846 10022826 10.1093/emboj/18.4.833 1:CAS:528:DyaK1MXhs1Wrtbw%3D (Pubitemid 29082263)
22. E.H. Lo G.A. Rosenberg 2009 The neurovascular unit in health and disease: introduction Stroke 40 3 S2 S3 19064779 10.1161/STROKEAHA.108.534404
23. R. Makins A. Ballinger 2003 Gastrointestinal side effects of drugs Expert Opin. Drug Saf. 2 4 421 429 12904098 10.1517/14740338.2.4.421 1:CAS:528:DC%2BD3sXmsVSlsrs%3D
24. M.P. Mattson W. Duan W.A. Pedersen C. Culmsee 2001 Neurodegenerative disorders and ischemic brain diseases Apoptosis 6 1-2 69 81 11321043 10.1023/A:1009676112184 1:CAS:528:DC%2BD3MXivVGrsL0%3D (Pubitemid 32233956)
25. M. Mederos y Schnitzler C. Derst J. Daut R. Preisig-Müller 2000 ATP-sensitive potassium channels in capillaries isolated from guinea-pig heart J. Physiol. 525 2 307 317 10835035 10.1111/j.1469-7793.2000.t01-1-00307.x (Pubitemid 30398362)
26. R.L. Roof G.P. Schielke X. Ren E.D. Hall 2001 A comparison of long-term functional outcome after 2 middle cerebral artery occlusion models in rats Stroke 32 11 2648 2657 11692030 10.1161/hs1101.097397 1:STN:280: DC%2BD3MnktFenug%3D%3D (Pubitemid 33055320)
27. T. Sato N. Sasaki B. O'Rourke E. Marban 2000 Nicorandil, a potent cardioprotective agent, acts by opening mitochondrial ATP-dependent potassium channels J. Am. Coll. Cardiol. 35 2 514 518 10676702 10.1016/S0735-1097(99) 00552-5 1:CAS:528:DC%2BD3cXhs1elsLc%3D (Pubitemid 30125546)
28. S. Seino T. Miki 2004 Gene targeting approach to clarification of ion channel function: studies of Kir6.x null mice J. Physiol. 554 2 295 300 12826653 10.1113/jphysiol.2003.047175 1:CAS:528:DC%2BD2cXhtFGrtbY%3D (Pubitemid 38181344)
29. K. Shimizu Z. Lacza N. Rajapakse T. Horiguchi J. Snipes D.W. Busija 2002 MitoKATP opener, diazoxide, reduces neuronal damage after middle cerebral artery occlusion in the rat Am. J. Physiol. 283 3 H1005 H1011 1:CAS:528: DC%2BD38XntFOgtbo%3D
30. J.M. Simard M. Chen 2004 Regulation by sulfanylurea receptor type 1 of a non-selective cation channel involved in cytotoxic edema of reactive astrocytes J. Neurosurg. Anesthesiol. 16 1 98 99 14676579 10.1097/00008506-200401000-00021 (Pubitemid 38057409)
31. R.A. Swanson F.R. Sharp 1994 Infarct measurement methodology J. Cereb. Blood Flow Metab. 14 4 697 698 7516936 10.1038/jcbfm.1994.88 1:STN:280:DyaK2c3osVeisw%3D%3D (Pubitemid 24198416)
32. D. Tsuchiya S. Hong Y. Matsumori H. Shiina T. Kayama R.A. Swanson W.H. Dillman J. Liu S.S. Panter P.R. Weinstein 2003 Overexpression of rat heat shock protein 70 is associated with reduction of early mitochondrial cytochrome C release and subsequent DNA fragmentation after permanent focal ischemia J. Cereb. Blood Flow Metab. 23 6 718 727 12796720 10.1097/01.WCB.0000054756.97390. F7 1:CAS:528:DC%2BD3sXks1yqsLY%3D (Pubitemid 36713677)
33. H. Wang Y.L. Zhang X.C. Tang H.S. Feng G. Hu 2004 Targeting ischemic stroke with a novel opener of ATP-sensitive potassium channels in the brain Mol. Pharmacol. 66 5 1160 1168 15304552 10.1124/mol.104.003178 1:CAS:528: DC%2BD2cXptVKmt7Y%3D (Pubitemid 39411056)
34. H. Wang Y. Tang L. Wang C.L. Long Y.L. Zhang 2007 ATP-sensitive potassium channel openers and 2,3-dimethyl-2-butylamine derivatives Curr. Med. Chem. 14 2 133 155 17266574 10.2174/092986707779313390 (Pubitemid 46043910)
35. K. Yamada J.J. Ji H. Yuan T. Miki S. Sato N. Horimoto T. Shimizu S. Seino N. Inagaki 2001 Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure Science 292 5521 1543 1546 11375491 10.1126/science.1059829 1:CAS:528:DC%2BD3MXktVyqsrk%3D (Pubitemid 32493422)
36. H. Yanamoto I. Nagata N. Hashimoto H. Kikuchi 1998 Three-vessel occlusion using a micro-clip for the proximal left middle cerebral artery produces a reliable neocortical infarct in rats Brain Res. Brain Res. Protoc. 3 2 209 220 9813332 10.1016/S1385-299X(98)00042-7 1:STN:280:DyaK1M%2FjtlWhuw%3D%3D (Pubitemid 28527103)
37. G.Y. Yang A.L. Betz 1994 Reperfusion-induced injury to the blood-brain barrier after middle cerebral artery occlusion in rats Stroke 25 8 1658 1664 8042219 10.1161/01.STR.25.8.1658 1:STN:280:DyaK2czhslWqsA%3D%3D
38. H. Yoshida J.E. Feig A. Morrissey I.A. Ghiu M. Artman W.A. Coetzee 2004 KATP channels of primary human coronary artery endothelial cells consist of a heteromultimeric complex of Kir6.1, Kir6.2, and SUR2B subunits J. Mol. Cell. Cardiol. 37 4 857 869 15380676 10.1016/j.yjmcc.2004.05.022 1:CAS:528: DC%2BD2cXnslOjsL8%3D (Pubitemid 39232076)
39. S. Zhang F. Zhou J.H. Ding X.Q. Zhou X.L. Sun G. Hu 2007 ATP-sensitive potassium channel opener iptakalim protects against MPP-induced astrocytic apoptosis via mitochondria and mitogen-activated protein kinase signal pathways J. Neurochem. 103 2 569 579 17635669 10.1111/j.1471-4159.2007.04775.x 1:CAS:528:DC%2BD2sXht1KqsLzF (Pubitemid 47498023)
40. H.L. Zhu W.Q. Luo H. Wang 2008 Iptakalim protects against hypoxic brain injury through multiple pathways associated with ATP-sensitive potassium channels Neuroscience 157 4 884 894 18951957 10.1016/j.neuroscience.2008.09.033 1:CAS:528:DC%2BD1cXhsVGgsrzO