Eleutherococcus senticosus as a crude medicine: Review of biological and pharmacological effects

Journal of Medicinal Plant Research

Volumn 5, Issue 25, 2011, Pages 5946-5952

  Yan Lin, Sun ^a   Lin De, Liu ^b   Soon Kwan, Hong ^a  

^a Kangwon National University   (South Korea)

^b LUDONG UNIVERSITY   (China)

Author keywords

Acanthopanax senticosus; Adaptogen; Biological activity; Eleutherococcus senticosus; Medicinal plant; Pharmacology

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ANTIHISTAMINIC AGENT; ANTINEOPLASTIC AGENT; ANTIPYRETIC AGENT; CIWUJIANOSIDE C1; CIWUJIANOSIDE D1; CROMOGLYCATE DISODIUM; ELEUTHEROCOCCUS SENTICOSUS EXTRACT; EN 3; IMMUNOGUARD; KANJANG; RESPIRATORY TRACT AGENT; SAPONIN; SYRINGIN; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; ANTIDIABETIC ACTIVITY; ANTIFATIGUE ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; BIOCHEMICAL COMPOSITION; BRADYKINESIA; BRONCHOSPASM; CARDIOVASCULAR DISEASE; DEPRESSION; DIABETES MELLITUS; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; FAMILIAL MEDITERRANEAN FEVER; FATIGUE; HUMAN; HYPERGLYCEMIA; HYPERLIPIDEMIA; IMMUNOMODULATION; LACTOBACILLUS; LACTOBACILLUS ACIDOPHILUS; LACTOBACILLUS BULARICUS; LACTOBACILLUS PARACASEI; LUNG CANCER; METASTASIS; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; OSTEOPOROSIS; PARKINSON DISEASE; PARKINSONISM; PHYTOCHEMISTRY; RECOMMENDED DRUG DOSE; RESPIRATORY TRACT INFECTION; REVIEW;

EID: 81855161483     PISSN: None     EISSN: 19960875     Source Type: Journal    
DOI: 10.5897/JMPR11.728     Document Type: Review

References (82)

1. ®-a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra chinensis Bail and Glycyrrhiza glabra L. extracts in patients with familial Mediterranean fever. Phytomedicine, 10: 271-285.
2. Apers S, Naessens T, Van MS, Pieters L, Vlietinck A (2005). Quality control of roots of Eleutherococcus senticosus by HPLC. Phytochem. Anal., 16: 55-60. doi:10.1002.pca.811.
3. Bespalov VG, Aleksandrov VA, Yaremenko KV, Limarenko AY, Petrov AS, Troyan DN (1993). Inhibiting effect of the extract of Eleutherococcus senticosus Rupr. et Maxim. on the development of experimentally induced tumors of nervous system, cervix uteri and vagina. Pharm. Chem. J., 27: 358-361. doi:10.1007/BF00819969.
4. Bocharov EV, Kucherianu VG, Bocharova OA, Karpova RV (2008). Neuroprotective features of phytoadaptogens. Vestn. Ross. Akad. Med. Nauk., 4: 47-50.
5. Brekhman II (1968). Eleutherokokk (Eleutherococcus). Nauka Publishing House, Leningrad, USSR (in Russian).
6. Brekhman II (1976). Chelovek I biologicheski aktivnye vezshestva (Man and Biologically Active Substances). Nauka Publishing House, Leningrad, USSR (in Russian).
7. Brøsen K (1996). Drug-metabolizing enzymes and therapeutic drug monitoring in psychiatry. Ther. Drug Monit., 18: 393-396.
8. Choi HS, Kim YH, Han JH, Park SH (2008). Effects of Eleutherococcus senticosus and several oriental medicinal herbs extracts on serum lipid concentrations. Korean J. Food Nutr., 21: 210-217.
9. Choi JB, Shin YW, Paek NS, Kim YM (2004). Enfluence of herbal extract on lactic acid bacteria growth and cryoprotectants. Korean J. Food Nutr., 17: 286-293.
10. Choi YH, Kim JW (2002). Quantitative analysis of eleutherosides B and using HPLC-ESI/MS. Korean J. Pharmacogn., 33: 88-91.
11. Cicero AFG, Derosa G, Brillante R, Bernardi R, Nascetti S, Gaddi A (2004). Effects of Siberian ginseng (Eleutherococcus senticosus Maxim.) on elderly quality of life: a randomized clinical trial. Arch. Gerontol. Geriatr. Suppl., 9: 69-73.
12. Colas C, Popot MA, Garcia P, Bonnaire Y, Bouchonnet S (2008). Analysis of iridoids from Harpagophytum and eleutherosides from Eleutherococcus senticosus in horse urine. Biomed. Chromatogr., 22: 912-917. doi:10.1002/bmc.1030.
13. Davydov M, Krikorian AD (2000). Eleutherococcus senticosus (Rupr. and Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look. J. Ethnopharmacol., 72: 345-393.
14. Deyama T, Nishibe S, Nakazawa Y (2001). Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta Phamatcol. Sin., 22: 1057-1070.
15. Donovan JL, DeVane CL, Chavin KD, Taylor RM, Markowitz JS (2003). Siberian ginseng (Eleutherococcus senticosus) effects on CYP2D6 and CYP3A4 activity in normal volunteers. Drug Metab. Dispos., 31: 519-522. doi:10.1124/dmd.31.5.519.
16. Drozd J, Sawicka T, Prosinska J (2002). Estimation of humoral activity of Eleutherococcus senticosus. Acta Pol. Pharm. Drug Res., 59: 395-401.
17. Facchinetti F, Neri I, Tarabusi M (2002). Eleutherococcus senticosus reduces cardiovascular stress response in healthy subjects: a randomized, placebo-controlled trial. Stress Health, 18: 11-17. doi:10.1002/smi.914.
18. Fujikawa T, Kanada N, Shimada A, Ogata M, Suzuki I, Hayashi I, Nakashima K (2005). Effect of sesamin in Acanthopanax senticosus HARMS on behavioral dysfunction in rotenone-induced parkinsonian rats. Biol. Pharm. Bull., 28: 169-172.
19. Fujikawa T, Soya H, Hibasami H, Kawashima H, Takeda H, Nishibe S, Nakashima K (2002). Effect of Acanthopanax senticosus Harms on biogenic monoamine levels in the rat brain. Phytother. Res., 16: 474-478.doi:10.1002/ptr.1024.
20. Fujikawa T, Yamaguchi A, Morita I, Takeda H, Nishibe S (1996). Protective effects of Acanthopanax senticosus Harms from Hokkaido and its components on gastric ulcer in restrained cold water stressed rats. Biol. Pharm. Bull., 19: 1227-1230.
21. Gaffney BT, Hügel HM, Rich PA (2001a). The effects of Eleutherococcus senticosus and Panax ginseng on steroidal hormone indices of stress and lymphocyte subset numbers in endurance athletes. Life Sci., 70: 431-442.
22. Gaffney BT, Hügel HM, Rich PA (2001b). Panax ginseng and Eleutherococcus senticosus may exaggerate an already existing biphasic response to stress via inhibition of enzymes which limit the binding of stress hormones to their receptors. Med. Hypotheses, 56: 567-572. doi:10.1054/mehy.2000.1163.
23. Glatthaar-Saalmüller B, Sacher F, Esperester A (2001). Antiviral activity of an extract derived from roots of Eleutherococcus senticosus. Antiviral Res., 50: 223-228. doi:10.1016/S0166-3542(01)00143-7
24. Guo JF, Zhou JM, Zhang Y, Deng R, Liu JN, Feng GK, Liu ZC, Xiao DJ, Deng SZ, Zhu XF (2008). Rhabdastrellic acid-A inhibited P13K/Akt pathway and induced apoptosis in human leukemia HL-60 cells. Cell Biol. Int., 32: 48-54. doi:10.1016/j.cellbi.2007.08.009.
25. Hahn DR, Kim CJ, Kim JH (1985). A study on chemical constituents of Acanthopanax koreanum Nakai and its pharmaco-biological activities. Yakhak Hoeji, 29: 357-361.
26. Han JH, Jung IC, Cho HE, Park SH (2006). Total polyphenol, water soluble antioxidants contents and antioxidative activity from a composite with Eleutherococcus senticosus and several oriental medicinal herbs. Korean J. Ori. Physiol. Pathol., 20: 1275-1281.
27. Hibasami H, Fujikawa T, Takeda H, Nishibe S, Satoh T, Fujisawa T, Nakashima K (2000). Induction of apoptosis by Acanthopanax senticosus HARMS and its component, sesamin in human stomach cancer KATO III cells. Oncol. Rep., 4: 1213-1216.
28. Hikino H, Takahashi M, Otake K, Konno C (1986). Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots. J. Nat. Prod., 49: 293-297.
29. Huang LZ, Huang BK, Ye Q, Qin LP (2011b). Bioactivity-guide fractionation for anti-fatigue property of Acanthopanax senticosus. J. Ethnopharmacol., 133:213-219 doi:10.1013/j.jep.2010.09.032.
30. Huang LZ, Zhao HF, Huang BK, Zheng CJ, Peng W, Qin LP (2011a). Acanthopanax senticosus: review of botany, chemistry and pharmacology. Pharmazie, 66:83-97 doi:10.1691/ph.2011.0744.
31. Hwang SH, Ha ES, Yu KW, Shin KS, Lee SH, Lee JK, Lee KH (2003). Effect of the crude polysaccharides fraction from Eleutherococcus senicosus as a immunoadjuvant to soluble antigens (BSA and OVA). Yakhak Hoeji, 47: 167-175.
32. Jung CH, Jung H, Shin YC, Park JH, Jun CY, Kim HM, Yim HS, Shin MG, Bae HS, Kim SH, Ko SG (2007). Eleutherococcus senticosus extract attenuates LPS-induced iNOS expression through the inhibition of Akt and JNK pathways in murine macrophage. J. Ethnopharmacol., 113: 183-187. doi:10.1016/j.jep.2007.05.023.
33. Jung HJ, Park HJ, Kim RG, Shin KM, Ha J, Choi JW, Kim HJ, Lee YS, Lee KT (2003). In vivo anti-inflammatory and antinociceptive effects of liriodendrin isolated from the stem bark of Acanthopanax senticosus. Planta Med., 69: 610-616.
34. Kim JK, Kim SW, Kim HY, Lee BE, Ko SY (2007b). OPB, a water extract from Rehmannia glutinosa Libosch and Eleutherococcus senticosus Max, inhibits osteoclast differentiation and function. Int. J. Oral Biol., 32: 23-34.
35. Kim JK, Kim SW, Ko SY, Kim SN, Kwon JS, Hwang HH (2007a). The effect of combined Rehmannia glutinosa Libosch and Eleutherococcus senticosus Max (OPB) extracts on bone mineral density in ovariectomized rats. Int. J. Oral Biol., 32: 143-151.
36. Kim MJ, Kim NY, Kang WH, Choi WC, Yu CY (2002). In vitro antioxidant activity and anticancer effects of the extracts from Eleutherococcus senticosus Max. Korean J. Med. Crop Sci., 10: 269-272.
37. Kim MJ, Kwon YS, Yu CY (2005). Antioxidative compounds in extracts of Eleutherococcus senticosus Max. Plantlets. Korean J. Med. Crop Sci., 13: 194-198.
38. Kim MK, Jin YS, Heo SI, Shim TH, Sa JH, Wang MH (2006). Studies for component analysis and antioxidant effect, antimicrobial activity in Acanthopanax senticosus HARMS. Korean J. Pharmacogn., 37: 151-156.
39. Kimura Y, Sumiyoshi M (2004). Effects of various Eleutherococcus senticosus cortex on swimming time, natural killer activity and corticosterone level in forced swimming stressed mice. J. Ethnopharmacol., 95: 447-453. doi:10.1016/j.jep.2004.08.027.
40. Kormosh N, Laktionov K, Antoshechkina M (2006). Effect of a combination of extract from several plants on cell-mediated and humoral immunity of patients with advanced ovarian cancer. Phytother. Res., 20: 424-425. doi:10.1002/ptr.1889.
41. Kwan CY, Zhang WB, Sim SM, Deyama T, Nishibe S (2004). Vascular effects of Siberian ginseng (Eleutherococcus senticosus): endothelium-dependent NO-and EDHF-mediated relaxation depending on vessel size. Naunyn-Schmiedeberg's Arch. Pharmacol., 369: 473-480. doi: 10.1007/s00210-004-0927-4.
42. Lee S, Son D, Ryu J, Lee YS, Jung SH, Kang J, Lee SY, Kim HS, Shin KH (2004). Antioxidant activities of Acanthopanax senticosus stems and their lignin components. Arch. Pharm. Res., 27: 106-110.
43. Lee WT (1979). Distribution of Acanthopanax plants in Korea. Korean J. Pharmacol., 10: 103-107.
44. Li Q, Jia Y, Xu L, Wang XH, Shen ZD, Liu YL, Bi KS (2006). Simultaneous determination of protocatechuic acid, syringin, chlorogenic acid, caffeic acid, liriodendrin and isofraxidin in Acanthopanax senticosus HARMS by HPLC-DAD. Biol. Pharm. Bull., 29: 532-534.
45. Li XC, Barnes DL, Khan IA (2001). A new lignin glycoside from Eleutherococcus senticosus. Planta Med., 67: 776-778. doi:10.1055/s-2001-18352.
46. Lim SS, Lee JM, Park HS, Cho SH, Shin KH, Lee SH (2007). GC/MS analysis of volatile constituents from Acanthopanax senticosus. Korean J. Pharmacogn., 38: 327-333.
47. Liu KY, Wu YC, Liu IM, Yu WC, Cheng JT (2008). Release of acetylcholine by syringin, an active principle of Eleutherococcus senticosus, to raise insulin secretion in Wistar rats. Neurosci. Lett., 434: 195-199. doi:10.1013/j.neulet.2008.01.054.
48. ®) of herbal extracts containing Adhatoda vasica, Echinacea purpurea and Eleutherococcus senticosus in patients with upper respiratory tract infections. Phytomedicine, 12: 539-547. doi:10.1016/j.phymed.2004.10.001.
49. Nishibe S, Kinoshita H, Takeda H, Okano G (1990). Phenolic compounds from stem bark of Acanthopanax senticosus and their pharmacological effect in chronic swimming stressed rats. Chem. Pharm. Bull., 38: 1763-1765.
50. Nishiyama N, Kamegawa T, Iwai A, Saito H, Sanada S, Ida Y, Shoji J (1985). Effect of Eleutherococcus senticosus and its components on sex and learning-behaviors and tyrosine hydroxylase activity of adrenal gland and hypothalamic region in chronic stressed mice. Shoyakugaku Zasshi, 39: 238-242.
51. Niu HS, Hsu FL, Liu IM (2008a). Role of sympathetic tone in the loss of syringin-induced plasma glucose lowering action in conscious Wistar rats. Neurosci. Lett., 445: 113-116. doi:10.1016/j.neulet.2008.08.066.
52. Niu HS, Liu IM, Cheng JT, Lin CL, Hsu FL (2008b). Hypoglycemic effect of syringin from Eleutherococcus senticosus in streptozotocininduced diabetic rats. Planta Med., 74: 109-113. doi:10.1055/s-2008-1034275.
53. Oh SY, Aryl DK, Kim YG, Kim HG (2007). Effects of R. glutinosa and E. senticosus on postmenopausal osteoporosis. Korean J. Physiol. Pharmacol., 11: 121-127.
54. Orr TSC, Cox JSG (1969). Disodium cromoglycate, an inhibitor of mast cell degranulation and histamine release induced by phospholipase A. Nature, 223: 197-198. doi:10.1038/223197b0.
55. Panossian A, Davtyan T, Gukassyan N, Gukasova G, Mamikonyan G, Gabrielian E, Wikman G (2002). Effect of andrographolide and Kan Jang-fixed combination of extract SHA-10 and extract SHE-3-on proliferation of human lymphocytes, production of cytokines and immune activation markers in the whole blood cells culture. Phytomedicine, 9: 598-605.
56. Park EJ, Nan JX, Zhao YZ, Lee SH, Kim YH, Nam JB, Lee JJ, Sohn DH (2004). Water-soluble polysaccharide from Eleutherococcus senticosus stems attenuates fulminant hepatic failure induced by Dgalactosamine and lipopolysaccharide in mice. Basic Clin. Pharmacol. Toxicol., 94: 298-304. doi:10.1111/j/1742-7843.2004.pto970607.x.
57. Park JS, Ahn BY, Koh HY, Choi DS (2003). Inhibitory effect of methanol extract of Eleutherococcus senticosus Maxim. on the direct mutagen mutagenicity. Korean J. Biotechnol. Bioeng., 18: 217-221.
58. Park JS, Oh CH, Koh HY, Choi DS (2002). Antimutagenic effect of extract of Eleutherococcus senticosus Maxim. Korean J. Food Sci. Technol., 34: 1110-1114.
59. Parvath S, Brindha R (2003). Ethnobotanical medicines of Animalai union. Ancient Sci. Life, 22: 14.
60. Protasova SF, Zykov MB (1984). Antiviral effect of Eleutherococcus in experimental influenza infection. Proceedings of the Second International Symposium on Eleutherococcus, Part II, Academy of Science or the USSR Far East Science Centre, Vladivostok, USSR, pp. 170-174.
61. Rawat RBS, Uniyal RC (2003). National medicinal plant board committed for overall development of the sector. Agro. Bios. Med. Plant, 1: 12-16.
62. Rhie SG, Won HR (2004). Effect of hot water soluble extract from Eleutherococcus senticosus and dietary carnitine on the lipid metabolism and antioxidant defense system of rats on hypercholesterol diet. Korean J. Comm. Living Sci., 15: 105-113.
63. Schmolz MW, Sacher F, Aicher B (2001). The synthesis of rantes, GCSF, IL-4, IL-5, IL-6, IL-12 and IL-13 in human whole-blood cultures in modulated by an extract from Eleutherococcus senticosus L. Roots. Phytother. Res., 15: 268-270. doi:10.1002/ptr.746.
64. Shao CJ, Kasai R, Xu JD, Tanaka O (1988). Saponins from leaves of Acanthopanax senticosus HARMS. Ciwujia: structure of ciwujianosides B, C1, C2, C3, C4, D1, D2, E. Chem. Pharm. Bull., 36: 601-608.
65. Slacanin I, Marston A, Hostettmann K, Guédon D, Abbe P (1991). The isolation of Eleutherococcus senticosus constituents by centrifugal partition chromatography and their quantitative determination by high performance liquid chromatography. Phytochem. Anal., 2: 137-142. doi:10.1002/pca.2800020310.
66. Smalinskiene A, Lesauskaite V, Zitkevicius V, Savickiene N, Savickas A, Ryselis S, Sadauskiene I, Ivanov L (2009). Estimation of the combined effect of Eleutherococcus senticosus extract and cadmium on liver cells. Natural compounds and their role in apoptotic cell signaling pathways: Ann. N. Y. Acad. Sci., 1171: 314-320. doi:10.1111/j.1749-6632.2009.04678.x.
67. Song YJ, Han DS, Oh SW, Paik IY, Park TS (2002). Effect of dietary supplementation of Eleutherococcus senticosus, taurine and carnitine on endurance exercise performance in rats. Korean J. Nutr., 35: 825-833.
68. Steinmann GG, Esperester A, Joller P (2001). Immunopharmacological in vitro effects of Eleutherococcus senticosus extracts. Drug Res., 51: 76-83.
69. Sui DY, Lu ZZ, Li SH, Cai Y (1994a). Hypoglycemic effect of saponin isolated from leaves of Acanthoganax senticosus (Rupr. et Maxin.) Harms. Zhongguo Zhong Yao Za Zhi, 19: 683-685, 703.
70. Sui DY, Lu ZZ, Ma LN, Fan ZG (1994b). Effects of the leaves of Acanthopanax senticosus (Rupr. et Maxim.) Harms. on myocardial infarct size in acute ischemic dogs. Zhongguo Zhong Yao Za Zhi, 19: 746-747, 764.
71. Sung JY, Yoon TJ, Yu KW, Lee KH, Lee H (2006). Enhancement of immunological activities in mice by oral administration of pectic polysaccharides from Eleutherococcus senticosus. Food Sci. Biotechnol., 15: 117-121.
72. Szolomicki S, Samochowiec L, Wójcicki J, Drozdzik M (2000). The influence of active components of Eleutherococcus senticosus on cellular defence and physical fitness in man. Phytother. Res., 14: 30-35.
73. Takasugi N, Moriguchi T, Fuwa T, Sanada S, Ida Y, Shoji J (1985). Effect of Eleutherococcus senticosus and its components on rectal temperature, body and grip tones, motorcoordination, and exploratory and spontaneous movements in acute stressed mice. Shoyakugaku Zasshi, 39: 232-237.
74. Tohda C, Ichimura M, Bai YJ, Tanaka K, Zhu S, Komatsu K (2008). Inhibitory effects of Eleutherococcus senticosus extracts on amyloid β (25-35)-induced neuritic atrophy and synaptic loss. J. Pharmacol. Sci., 107: 329-339. doi:10.1254/jphs.08046FP.
75. Tolonen A, Joutsamo T, Mattlla S, Kämäräinen T, Jalonen J (2002). Identification of isomeric dicaffeoyquinic acids from Eleutherococcus senticosus using HPLC-ESI/TOF/MS and 1H-NMR methods. Phytochem. Anal., 13: 316-328. doi.10.1002/pca.663.
76. Umeyama A, Shoji N, Takei M, Endo K, Arihara S (1992). Ciwujianosides D1 and C1: powerful inhibitors of histamine release induced by anti-immunoglobulin E from rat peritoneal mast cells. J. Pharm. Sci., 81: 661-662.
77. Wiegant FAC, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, Post JA (2009). Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology, 10: 27-42. doi:10.1007/s10522-008-9151-9.
78. Winston D, Maimes S (2007). Adaptogens: Herbs for Strength, Stamina, and Stress Relief. Healing Arts Press, Rochester, Vermont, Pp. 85-86.
79. Yang DS, Cha MH, Kang BJ, Oh SW, Kim YE, Yoon YS (2003). A study on the longitudinal bone growth of growth-stimulating material with Eleutherococcus senticosus. Korean J. Food Sci. Technol., 35: 702-707.
80. Yang SJ, Shin JS, Kang CH (2004). Extraction of acanthoside-D from Acanthopanax cortex using supercritical carbon dioxide. Korean J. Biotechnol. Bioeng., 19: 284-287.
81. Yi JM, Hong SH, Kim JH, Kim HK, Song HJ, Kim HM (2002). Effect of Acanthopanax senticosus stem on mast cell-dependent anaphylaxis. J. Ethnopharm., 79: 347-352.
82. Yu CY, Kim SH, Lim JD, Kim MJ, Chung IM (2003). Intraspecific relationship analysis by DNA markers and in vitro cytotoxic and antioxidant activity in Eleutherococcus senticosus. Toxicol. Vitro, 17: 229-236.