Panax ginseng and eleutherococcus senticosus may exaggerate an already existing biphasic response to stress via inhibition of enzymes which limit the binding of stress hormones to their receptors

Medical Hypotheses

Volumn 56, Issue 5, 2001, Pages 567-572

  Gaffney, B T ^a   Hugel H M ^a   Rich, P A ^a  

^a RMIT UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CATECHOL METHYLTRANSFERASE; ELEUTHEROCOCCUS SENTICOSUS EXTRACT; ELEUTHEROSIDE B; ELEUTHEROSIDE E; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RG 1; GINSENOSIDE RG 2; GLYCYRRHIZIC ACID; NORADRENALIN; NORMETADRENALIN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DRUG MECHANISM; DRUG STRUCTURE; ENERGY; ENZYME INHIBITION; GINSENG; GINSENOSIDE RF; HORMONE METABOLISM; HORMONE RECEPTOR INTERACTION; NEGATIVE FEEDBACK; PHYSICAL ACTIVITY; POSITIVE FEEDBACK; PRIORITY JOURNAL; RECEPTOR OCCUPANCY; STRESS;

ELEUTHEROCOCCUS SENTICOSUS; PANAX GINSENG;

EID: 0034980498     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1054/mehy.2000.1163     Document Type: Article

References (40)

1. Medicinal uses of Ginseng and related plants in the Soviet Union: Recent trends in the Soviet Literature
2. Ginseng and hypothalamic-pituitary control of stress
3. Pharmacological investigation of glycosides from Ginseng and Eleutherococcus
4. Effect of Eleutherococcus on Alarm Phase of Stress
5. Phenolic compounds from stem bark of Acanthopanax senticosus and their pharmacological effect in chronic swimming stressed rats
6. A comparative evaluation of some anti-stress agents of plant origin
7. New substances of plant origin which increase nonspecific resistance
8. Plant adaptogens
9. Studies on adaptation
10. The general adaptation syndrome and the diseases of adaptation
11. Stimulating effect of the roots of Panax ginseng C. A. Meyer on the incorporation of labeled precursors into rat liver RNA
12. Synthesis and characterization of nuclear RNA induced by Radix ginseng extract in rat liver
13. Stimulating effect of Panax ginseng on RNA polymerase activity in rat fiver nuclei
14. Effect of Eleutherococcus glucosides on RNA polymerase activity in nuclei from skeletal muscles and fiver after physical strain
15. Incorporation of phosphorous-32 into rat liver RNA during physical exercise and under the effect of glycosides from Eleutherococcus senticosus
16. Effect of ginseng on the brain biogenic monoamines and 3′5′-AMP system: Experiments on rats
17. Effects of Panax ginseng root on the vertical and horizontal motor activities and on brain monoamine-related substances in mice
18. Effect of Panax ginseng on age-related changes in the spontaneous motor activity and dopaminergic nervous system in the rat
19. Panax ginseng and Eleutherococcus senticosus extracts - In vitro studies on binding to steroid receptors
20. Ginsenoside-Rg1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor
21. Inhibition of cyclic AMP phosphodiesterase by lignans
22. Ginsenoside Rg1 inhibits the brain cAMP phosphodiesterase activity in young and aged rats
23. Ginsenosides are potent and selective inhibitors of some calmodulin-dependant phosphodiesterase isozymes
24. Panax ginseng pharmacology: A nitric oxide link?
25. Inhibition of stress-induced plasma corticosterone levels by ginsenosides in mice: Involvement of nitric oxide
26. In the rat, endogenous nitric oxide modulates the response of the hypothalamic-pituitary-adrenal axis to interleukin- 1 beta, vasopressin and oxytocin
27. Stimulation of pituitary-adrenocortical system by ginseng saponin
28. Features of ginseng saponin-induced corticosterone secretion
29. Influence of Ginseng on the stress mechanism
30. Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age
31. On the role of brain mineralocorticoid (type I) and glucocorticoid (type II) receptors in neuroendocrine regulation
32. Facilitation of feedback inhibition through blockade of glucocorticoid receptors in the hippocampus
33. Brain corticosteroid receptor balance and homeostatic control
34. Glucocorticoid receptor, mineralocorticoid receptors, 11 -hydroxysteroid dehydrogenase - 1 and -24 expression in rat brain and kidney: In situ studies
35. The role of alpha-2-adrenoceptors in the control of ACTH secretion; interaction with the opioid system
36. Adrenergic control of the secretion of anterior pituitary hormones
37. The concepts of stress and stress system disorders: Overview of physical and behavioral homeostasis