Release of acetylcholine by syringin, an active principle of Eleutherococcus senticosus, to raise insulin secretion in Wistar rats

Neuroscience Letters

Volumn 434, Issue 2, 2008, Pages 195-199

  Liu, Ko Yu ^a   Wu, Yang Chang ^a   Liu, I Min ^b   Yu, Wen Chen ^c   Cheng, Juei Tang ^c,d  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b TAJEN UNIVERSITY   (Taiwan)

^c HUNGKUANG UNIVERSITY   (Taiwan)

^d NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Acetylcholine; Insulin; Muscarinic M3 receptors; Syringin; Wistar rats

Indexed keywords

4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; ACETYLCHOLINE; C PEPTIDE; ELEUTHEROCOCCUS SENTICOSUS EXTRACT; HEMICHOLINIUM 3; HEXAMETHONIUM; INSULIN; PENTOLONIUM TARTRATE; SYRINGIN; VESAMICOL;

ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; ELEUTHEROCOCCUS SENTICOSUS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; INSULIN BLOOD LEVEL; INSULIN RELEASE; MALE; NERVE ENDING; NONHUMAN; PANCREAS CELL; PRIORITY JOURNAL; RAT;

ACETYLCHOLINE; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; ELEUTHEROCOCCUS; GLUCOSIDES; INSULIN; MALE; MUSCARINIC ANTAGONISTS; PHENYLPROPIONATES; PHYTOTHERAPY; PIPERIDINES; RATS; RECEPTOR, MUSCARINIC M3;

EID: 40849118099     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.01.054     Document Type: Article

References (21)

1. Anderson D.C., King S.C., and Parsons S.M. Pharmacological characterization of the acetylcholine transport system in purified Torpedo electric organ synaptic vesicles. Mol. Pharmacol. 24 (1983) 48-54
2. Aquilonius S.M., and Hartvig P. Clinical pharmacokinetics of cholinesterase inhibitors. Clin. Pharmacokinet. 11 (1986) 236-249
3. Barlow R.B., McMillen L.S., and Veale M.A. The use of 4-diphenylacetoxy-N-(2-chloroethyl)-piperidine (4-DAMP mustard) for estimating the apparent affinities of some agonists acting at muscarinic receptors in guinea-pig ileum. Br. J. Pharmacol. 102 (1991) 657-662
4. Cho J.Y., Nam K.H., Kim A.R., Park J., Yoo E.S., Baik K.U., Yu Y.H., and Park M.H. In vitro and in vivo immunomodulatory effects of syringin. J. Pharm. Pharmacol. 53 (2001) 1287-1294
5. Davydov M., and Krikorian A.D. Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look. J. Ethnopharmacol. 72 (2000) 345-393
6. Duttaroy A., Zimliki C.L., Gautam D., Cui Y., Mears D., and Wess J. Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in m3 muscarinic acetylcholine receptor-deficient mice. Diabetes 53 (2004) 1714-1720
7. Fischbach G.D., Frank E., Jessell T.M., Rubin L.L., and Schuetze S.M. Accumulation of acetylcholine receptors and acetylcholinesterase at newly formed nerve-muscle synapses. Pharmacol. Rev. 30 (1978) 411-428
8. Free R.B., and McKay D.B. Receptor protection studies to characterize neuronal nicotinic receptors: tubocurarine prevents alkylation of adrenal nicotinic receptors. Brain Res. 891 (2001) 176-184
9. Gautam D., Han S.J., Hamdan F.F., Jeon J., Li B., Li J.H., Cui Y., Mears D., Lu H., Deng C., Heard T., and Wess J. A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab. 3 (2006) 449-461
10. Gilon P., and Henquin J.C. Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function. Endocr. Rev. 22 (2001) 565-604
11. Hikino H., Takahashi M., Otake K., Konn C., and Isolation. hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots. J. Nat. Prod. 49 (1986) 293-297
12. Iismaa T.P., Kerr E.A., Wilson J.R., Carpenter L., Sims N., and Biden T.J. Quantitative and functional characterization of muscarinic receptor subtypes in insulin secreting cell lines and rat pancreatic islets. Diabetes 49 (2000) 392-398
13. Jeffcoate S.L. Diabetes control and complications: the role of glycated haemoglobin, 25 years on. Diabetes Med. 21 (2004) 657-665
14. Kahn S.E. Clinical review 135: the importance of beta-cell failure in the development and progression of type 2 diabetes. J. Clin. Endocrinol. Metab. 86 (2001) 4047-4058
15. Korytkowski M.T. Sulfonylurea treatment of type 2 diabetes mellitus: focus on glimepiride. Pharmacotherapy 24 (2004) 606-620
16. Kwan C.Y., Zhang W.B., Sim S.M., Deyama T., and Nishibe S. Vascular effects of Siberian ginseng (Eleutherococcus senticosus): endothelium-dependent NO- and EDHF-mediated relaxation depending on vessel size. Naunyn Schmiedebergs Arch. Pharmacol. 369 (2004) 473-480
17. Lindstrom J., Louheranta A., Mannelin M., Rastas M., Salminen V., Eriksson J., Uusitupa M., Tuomilehto J., and Finnish Diabetes Prevention Study Group. The Finnish Diabetes Prevention Study (DPS): lifestyle intervention and 3-year results on diet and physical activity. Diabetes Care 26 (2003) 3230-3236
18. Polonsky K.S., Pugh W., Jaspan J.B., Cohen D.M., Karrison T., Tager H.S., and Rubenstein A.H. C-peptide and insulin secretion. Relationship between peripheral concentrations of C-peptide and insulin and their secretion rates in the dog. J. Clin. Invest. 74 (1984) 1821-1829
19. Prado M.A., Gomez M.V., and Collier B. Mobilization of the readily releasable pool of acetylcholine from a sympathetic ganglion by tityustoxin in the presence of vesamicol. J. Neurochem. 59 (1992) 544-552
20. Ruijun Z., Jinkang Q., Gnanghua Y., Baozhen W., and Xiulan W. Medicinal protection with Chinese herb-compound against radiation damage. Aviat. Space Environ. Med. 61 (1990) 729-731
21. Zhao X. Effect of HC-3 on electroacupuncture-induced immunoregulation. Zhen. Ci. Yan. Jiu. 20 (1995) 59-62