Kinetically controlled drug resistance: How penicillium brevicompactum survives mycophenolic acid

Journal of Biological Chemistry

Volumn 286, Issue 47, 2011, Pages 40595-40600

  Sun, Xin E ^a,c   Hansen, Bjarne Gram ^b,d   Hedstrom, Lizbeth ^a  

^a BRANDEIS UNIVERSITY   (United States)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c USA   (United States)

^d NOVOZYMES A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; COVALENT ENZYME INTERMEDIATES; DRUG RESISTANCE; FILAMENTOUS FUNGI; IMMUNOSUPPRESSIVE DRUGS; MYCOPHENOLIC ACIDS; PENICILLIUM BREVICOMPACTUM; POTENT INHIBITOR; RATE LIMITING;

LEAD;

ENZYMES;

INOSINATE DEHYDROGENASE; INOSINATE DEHYDROGENASE A; INOSINATE DEHYDROGENASE B; INOSINE PHOSPHATE; MYCOPHENOLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG RESISTANCE; DRUG SENSITIVITY; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME KINETICS; NONHUMAN; PENICILLIUM BREVICOMPACTUM; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CRICETINAE; DRUG RESISTANCE, FUNGAL; ENZYME INHIBITORS; IMP DEHYDROGENASE; KINETICS; MODELS, MOLECULAR; MYCOPHENOLIC ACID; PENICILLIUM; PROTEIN CONFORMATION; RIBONUCLEOTIDES;

EUKARYOTA; FUNGI; PENICILLIUM BREVICOMPACTUM;

EID: 81755189068     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.305235     Document Type: Article

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