Manganese-enhanced MRI reveals multiple cellular and vascular layers in normal and degenerated retinas

Journal of Magnetic Resonance Imaging

Volumn 34, Issue 6, 2011, Pages 1422-1429

  Nair, Govind ^a,b   Pardue, MacHelle T ^c,d   Kim, Moon ^c   Duong, Timothy Q ^e,f  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b EMORY UNIVERSITY   (United States)

^c ATLANTA VA MEDICAL CENTER   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Mays Cancer Center at UT Health San Antonio   (United States)

^f SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

high resolution imaging; magnetic resonance imaging; MEMRI; MRI microscopy; RCS; retinal degeneration

Indexed keywords

GADOLINIUM PENTETATE; MANGANESE CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOROID; CONTRAST ENHANCEMENT; CONTROLLED STUDY; EPIRETINAL MEMBRANE; HISTOLOGY; IMAGE ANALYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHOTORECEPTOR CELL; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RAT; RETINA; RETINA BIPOLAR GANGLION CELL; RETINA BLOOD VESSEL; RETINA DEBRIS LAYER; RETINA DEGENERATION; RETINA GANGLION CELL; RETINA INNER PLEXIFORM LAYER; RETINA NERVE CELL; THICKNESS;

ANIMALS; CHLORIDES; GADOLINIUM DTPA; IMAGE ENHANCEMENT; INJECTIONS, INTRAOCULAR; MAGNETIC RESONANCE IMAGING; MANGANESE COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RETINA; RETINAL DEGENERATION;

EID: 81755183117     PISSN: 10531807     EISSN: 15222586     Source Type: Journal    
DOI: 10.1002/jmri.22719     Document Type: Article

References (33)

1. Wassle H, Boycott BB,. Functional architecture of the mammalian retina. Physiol Rev 1991; 1: 447-480.
2. Yu D-Y, Cringle SJ,. Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in the animal models of retinal disease. Prog Retinal Eye Res 2001; 20: 175-208.
3. Cotzias G, Horiuchi M, Fuenzalida S, Mena I,. Clearance of tissue manganese concentrations with persistence of the neurological picture. Neurology 1968; 18: 376-382.
4. Takeda A, Kodama Y, Ishiwatari S, Okada S,. Manganese transport in the neural circuit of rat CNS. Brain Res Bull 1998; 45: 149-152.
5. Lee JH, Silva AC, Merkle H, Koretsky AP,. Manganese-enhanced magnetic resonance imaging of mouse brain after systemic administration of MnCl2: dose-dependent and temporal evolution of T1 contrast. Magn Reson Med 2005; 53: 640-648.
6. Aoki I, Wu YJ, Silva AC, Lynch RM, Koretsky AP,. In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI. Neuroimage 2004; 22: 1046-1059.
7. Berkowitz BA, Roberts R, Goebel DJ, Luan H,. Noninvasive and simultaneous imaging of layer-specific retinal functional adaptation by manganese-enhanced MRI. Invest Ophthalmol Vis Sci 2006; 47: 2668-2674.
8. Cheng H, Nair G, Walker TA, et al. Structural and functional MRI reveals multiple retinal layers. Proc Natl Acad Sci U S A 2006; 103: 17525-17530.
9. Wang S, Villegas-Perez MP, Holmes T, et al. Evolving neurovascular relationships in the RCS rat with age. Curr Eye Res 2003; 27: 183-196.
10. Strupp JP,. Stimulate: a GUI based fMRI analysis software package. Neuroimage 1996; 3: S607.
11. Duong TQ, Muir ER. Magnetic resonance imaging of the retina. Japanese J of Ophthalmology 2009;53:352-367.
12. Duong TQ, Pardue MT, Thule PM, et al. Layer-specific anatomical, physiological and functional MRI of the retina NMR Biomed 2008; 21: 978-996.
13. Shen Q, Cheng H, Pardue MT, et al. Magnetic resonance imaging of tissue and vascular layers in the cat retina. J Magn Reson Imaging 2006; 23: 465-472.
14. Ollivier FJ, Samuelson DA, Brooks DE, Lewis PA, Kallberg ME, Komaromy AM,. Comparative morphology of the tapetum lucidum (among selected species). Vet Ophthalmol 2004; 7: 11-22.
15. Lin GP, Tseng WYI, Cheng HC, Cheng JH,. Validation of diffusion tensor magnetic resonance axonal fiber imaging with registered manganese-enhanced optic tracts. Neuroimage 2001; 14: 1035-1047.
16. Pautler R, Silva A, Koretsky A,. In vivo neuronal tract tracing using manganese-enhanced magnetic resonance imaging. Magn Reson Med 1998; 40: 740-748.
17. Chan KC, Fu QL, Hui ES, So KF, Wu EX,. Evaluation of the retina and optic nerve in a rat model of chronic glaucoma using in vivo manganese-enhanced magnetic resonance imaging. Neuroimage 2008; 40: 1166-1174.
18. Chan KC, Li J, Kau P, et al. In vivo retinotopic mapping of superior colliculus using manganese-enhanced magnetic resonance imaging. Neuroimage 2010; 54: 389-395.
19. Thuen M, Berry M, Pedersen TB, et al. Manganese-enhanced MRI of the rat visual pathway: acute neural toxicity, contrast enhancement, axon resolution, axonal transport, and clearance of Mn(2+). J Magn Reson Imaging 2008; 28: 855-865.
20. Thuen M, Singstad TE, Pedersen TB, et al. Manganese-enhanced MRI of the optic visual pathway and optic nerve injury in adult rats. J Magn Reson Imaging 2005; 22: 492-500.
21. Lin Y-J, Koretsky AP,. Manganese ion enhances T1-weighted MRI during brain activation: an approach to direct imaging of brain function. Magn Reson Med 1997; 38: 378-398.
22. Duong TQ, Silva AC, Lee S-P, Kim S-G,. Functional MRI of calcium-dependent synaptic activity: cross correlation with CBF and BOLD measurements. Magn Reson Med 2000; 43: 383-392.
23. Yu D-Y, Cringle SJ, Su E-N, Yu PK,. Intraretinal oxygen levels before and after photoreceptor loss in the RCS rat. Invest Ophthalmol Vis Sci 2000; 41: 3999-4006.
24. Toprak AB, Ozbilgin K, Toprak V, Tuglu I, Guler C,. A histological analysis of the protective effect of ischemic preconditioning in the rat retina. Curr Eye Res 2002; 24: 234-239.
25. Joly S, Pernet V, Dorfman AL, Chemtob S, Lachapelle P,. Light-induced retinopathy: comparing adult and juvenile rats. Invest Ophthalmol Vis Sci 2006; 47: 3202-3212.
26. Jolly C, Jeanny JC, Behar-Cohen F, Laugier P, Saied A,. High-resolution ultrasonograophy of subretinal structure and assessment of retina degeneration in rat. Exp Eye Res 2005; 81: 592-601.
27. Thomas BB, Arai S, Ikai Y, et al. Retinal transplants evaluated by optical coherence tomography in photoreceptor degenerate rats. J Neurosci Methods 2006; 151: 186-193.
28. Sho K, Takahashi K, Fukuchi T, Matsumura M,. Quantitative evaluation of ischemia-reperfusion injury by optical coherence tomography in the rat retina. Jpn J Ophthalmol 2005; 49: 109-113.
29. Steinle JJ, Krizsan-Agbas D, Smith PG,. Regional regulation of choroidal blood flow by autonomic innervation in the rat. Am J Physiol Regul Integr Comp Physiol 2000; 279: 202-209.
30. Zhang Y, Peng Q, Kiel JW, Rosende CA, Duong TQ,. Magnetic resonance imaging of vascular oxygenation changes during hyperoxia and carbogen challenges in the human retina. Invest Ophthalmol Vis Sci 2011; 52: 286-291.
31. Maleki N, Dai W, Alsop DC,. Blood flow quantification of the human retina with MRI. NMR Biomed 2011; 24: 104-111.
32. Peng Q, Zhang Y, Nateras OS, van Osch MJ, Duong TQ,. MRI of blood flow of the human retina. Magn Reson Med 2011; 65: 1768-1775.
33. Zhang Y, Oscar San Emeterio Nateras O, Peng Q, et al. Lamina-specific anatomical magnetic resonance imaging of the human retina. Invest Ophthalmol Vis Sci 2011; 52: 7232-7237.