A randomised, double-blind, placebo-controlled trial of atovaquone-proguanil vs. sulphadoxine-pyrimethamine in the treatment of malarial anaemia in Zambian children

Tropical Medicine and International Health

Volumn 11, Issue 11, 2006, Pages 1643-1652

  Mulenga, Modest ^a,b   Malunga, Fidelis ^a   Bennett, Steve ^b   Thuma, Philip E ^c   Shulman, Caroline ^b   Fielding, Katherine ^b   Alloueche, Ali ^b   Greenwood, Brian M ^b  

^a TROPICAL DISEASES RESEARCH CENTRE   (Zambia)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c Malaria Institute   (Zambia)

Author keywords

Atovaquone proguanil; Malaria anaemia; Sulphadoxine pyrimethamine; Zambian children

Indexed keywords

ATOVAQUONE PLUS PROGUANIL; FANSIDAR; FOLIC ACID; PLACEBO; QUININE;

ANEMIA; ANTIMALARIAL AGENT; BLOOD; CHILD HEALTH; COMPARATIVE STUDY; DISEASE INCIDENCE; DISEASE RESISTANCE; MALARIA; NAPHTHALENE; PROTOZOAN;

AFRICA; ANEMIA; ANOREXIA; ARTICLE; BLOOD EXAMINATION; BLOOD TRANSFUSION; CHILD; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVULSION; COUGHING; DEHYDRATION; DIARRHEA; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FATALITY; DRUG TREATMENT FAILURE; FEMALE; HEMATOCRIT; HUMAN; HYPOGLYCEMIA; LETHARGY; MAJOR CLINICAL STUDY; MALARIA; MALE; MEASLES; PARASITEMIA; PARASITOLOGY; PLASMODIUM FALCIPARUM; PNEUMONIA; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY DISTRESS; RISK; VOMITING; WEAKNESS; ZAMBIA;

ANEMIA; ANTIMALARIALS; ATOVAQUONE; CHILD; CHILD, PRESCHOOL; CHLOROGUANIDE; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; FEMALE; HUMANS; INFANT; MALARIA, FALCIPARUM; MALE; PARASITEMIA; PREVALENCE; PYRIMETHAMINE; SULFADOXINE; TIME FACTORS; TREATMENT FAILURE; ZAMBIA;

AFRICA; SOUTHERN AFRICA; SUB-SAHARAN AFRICA; ZAMBIA;

PLASMODIUM FALCIPARUM;

EID: 33750296002     PISSN: 13602276     EISSN: 13653156     Source Type: Journal    
DOI: 10.1111/j.1365-3156.2006.01726.x     Document Type: Article

References (20)

1. Biemba G, Dolmans D, Thuma PE, Weiss G & Gordeuk VR (2000) Severe anaemia in Zambian children with Plasmodium falciparum malaria. Tropical Medicine and International Health 5, 9-16.
2. Bijl HM, Kager J, Koetsier DW & van der Werf TS (2000) Chloroquine- and sulfadoxine-pyrimethamine-resistant falciparum malaria in vivo - a pilot study in rural Zambia. Tropical Medicine and International Health 5, 692-695.
3. Bloland PB, Lackritz EM, Kazembe PN, Were JBO, Steketee R & Cambell CC (1993) Beyond chloroquine: implications of drug resistance for evaluating malaria therapy efficacy and treatment policy in Africa. Journal of Infectious Diseases 167, 932-937.
4. Bloland PB, Ettling M, Ruebush T, Mulenga M, Kinkese D & Nkunika S (1995) Efficacy of chloroquine therapy for Plasmodium falciparum in Zambia: findings from studies in Chipata District. Environmental Health Report, USAID Activity Report No 15, 47-61.
5. Boele van Hensbroek MB, Morris-Jones S, Meisner S et al. (1995) Iron, but not folic acid, combined with effective antimalarial therapy promotes haematological recovery in African children after acute falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 89, 672-676.
6. Bojang KA, Palmer A, Boele van Hensbroek M, Banya WAS & Greenwood BM (1997) Management of severe malaria anaemia in Gambian children. Transactions of the Royal Society of Tropical Medicine and Hygiene 91, 557-561.
7. Carter JY, Loolpapit MP, Lema OE, Tome JL, Nagelkerke NJD & Watkins WM (2005) Folic acid supplementation reduces the efficacy of antifolate antimalarial therapy. American Journal of Tropical Medicine and Hygiene 73, 166-170.
8. Dacie JV & Lewis SM (1991) Practical Haematology. Longman, London.
9. Duraisingh MT, Curtis J & Warhurst DC (1998) Plasmodium falciparum: detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion. Experimental Parasitology 89, 1-8.
10. ter Kuile F, White NJ, Holloway PA, Pasvol G & Krishna S (1993) Plasmodium falciparum: in vitro studies of the pharmacodynamic properties of drugs used for the treatment of severe malaria. Experimental Parasitology 76, 85-95.
11. Lelijveld J & Kortmann H (1970) The eosin colour test of Dill and Glazko: a simple field test to detect chloroquine in urine. Bulletin of the World Health Organization 42, 477-479.
12. Mulenga M, Sukwa TY, Canfield JC & Hutchinson DBA (1999) Atovaquone and proguanil versus pyrimethamine/sulfadoxine for the treatment of acute falciparum malaria in Zambia. Clinical Therapeutics 21, 841-852.
13. Mulenga M, Malunga P, Bennett S et al. (2005) Factors associated with severe anaemia in Zambian children admitted with Plasmodium falciparum malarial anaemia. Annals of Tropical Hygiene 25, 87-90.
14. Mulenga M, Malunga P, Bennett S et al. (2006) Folic acid treatment of Zambian children with moderate to severe malaria anemia. American Journal of Tropical Medicine and Hygiene 74, 986-990.
15. Oyediran AB & Heisler MH (1998) Malarone Donation Program. Journal of Travel Medicine 6, S28-S30.
16. Oyediran AB, Ddumba EM, Ochola SA, Lucas AO, Koporc K & Dowdle WR (2002) A public-private partnership for malaria control: lessons from the Malarone Donation Programme. Bulletin of the World Health Organization 80, 817-821.
17. Scott T, Chulay JD, Zeman A, Beerahee M & Garris C (1998) Malarone (atovaquone/proguanil): Clinical Investigator's Brochure. Glaxo Wellcome Research and Development, USA.
18. Snounou G (2002) Genotyping of Plasmodium spp. Nested PCR. Methods in Molecular Medicine 72, 103-116.
19. Watkins WM, Sixsmith DG, Chulay JD & Spencer HC (1985) Antagonism of sufadoxine and pyrimethamine antimalarial activity in vitro by p-aminobenzoic acid, p-aminobenzoylglutamic acid and folic acid. Molecular and Biochemical Parasitology 14, 55-61.
20. World Health Organization (2000) Severe falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 94 (Suppl. 1), S1-90.