Baicalin interferes with iron accumulation in C6 glioma cells

Neural Regeneration Research

Volumn 6, Issue 30, 2011, Pages 2352-2356

  Guo, Chunyan ^a   Chen, Xin ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Baicalin; Iron; Iron chelation; Neuroprotection; Parkinson's disease

Indexed keywords

BAICALIN; FERRIC AMMONIUM CITRATE; IRON; LACTATE DEHYDROGENASE; MALONALDEHYDE; TRANSFERRIN;

ARTICLE; BIOACCUMULATION; CELL CULTURE; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG STRUCTURE; DRUG TARGETING; GLIOMA CELL; IRON CHELATION; LIPID PEROXIDATION; NERVE CELL NECROSIS; NEUROPROTECTION; PH; REACTION TIME;

EID: 81755168943     PISSN: 16735374     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1673-5374.2011.30.006     Document Type: Article

References (25)

1. Song YW, Chen X, Li CH, et al. Divalent metal transporter 1 expression and iron deposition in the substantia nigra of a rat model of Parkinson's disease. Neural Regen Res. 2010;5(22): 1701-1705.
2. Wang J, Jiang H, Xie JX. The relationship between iron metabolism of CNS and PD. Shengli Kexue Jinzhan. 2003;34(1): 67.
3. Jiang H, Chen WF, Xie JX. The relationship between dopamine of PD rats and iron. Sheng Li Xue Bao. 2001;53(5):334-338.
4. th ed. Beijing: People's Medical Publishing House. 2002:176-177.
5. Chen X, Zhang N, Zou HY. Baicalin to protect DA of SN in rotenone-induced PD rats. Zhongguo Zhongxiyi Jiehe Zazhi. 2008;25(2):174-177.
6. Chen X, Zhang N, Zou HY. Baicalin to protect MPTP-induced PD mouse. Zhongguo Zhongxiyi Jiehe Zazhi. 2007;27(11): 1010-1012.
7. Perez CA, Wei YB, Guo ML. Iron-binding and anti-Fenton properties of baicalein and baicalin. J Inorg Biochem. 2008;11(3): 1-33.
8. Hei MY, Kuang SJ, Yin P. The change of newborn rats in hypoxic-ischemic brain tissue iron. Zhongguo Dangdai Erke Zazhi. 2002;4(6):445.
9. He BC, Zhou QX, Yang JQ. Iron metabolism and neurodegeneration. Sichuan Shengli Ke Xue Zazhi. 2004;26(1): 34-38.
10. Koeppen AH. A brief history of brain iron research. J Neurol Sci. 2003;207(1-2):95-97.
11. Jiang H, Xie JX. The effect of brain high iron in PD disease. Zhongguo Shenjing Ke Xue Zazhi. 2001;17(2):201-204.
12. Chen X, Zhang N, Li C, et al. Parallel relationship between microglial activation and substantia nigra damage in a rotenone- induced Parkinson's disease rat model. Neural Regen Res. 2010; 5(4):245-250.
13. Youdim MBH, Stephenson G, Ben Shachar D. Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators - A lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28. Ann NY Acad Sci. 2004;1012: 306-325.
14. Kaur D, Yantiri F, Rajagopalan S, et al. Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: A novel therapy for Parkinson's disease. Neuron. 2003;37(6):899-909.
15. Luan Z. Neuroprotective effects of iron chelator desferal on dopaminergic neurons in the substantia nigra of rats. Qingdao: Qingdao University. 2005.
16. Youdim MB, Grunblatt E, Levites-Royak Y, et al. Drugs to prevent cell death in Parkinson's disease. Neuroprotection against oxidative stress and inflammatory gene expression. Adv Neurol. 2001;86:115-124.
17. Almli LM, Hamrick SE, Koshy AA, et al. Multiple pathways of neuroprotection against oxidative stress and excitotoxic injury in immature primary hippocampal neurons. Brain Res Dev Brain Res. 2001;132(2):121-129.
18. Sangchot P, Sharma S, Chetsawang B, et al. Deferoxamine attenuates iron-induced oxidative stress and prevents mitochondrial aggregation and alpha-synuclein translocation in SK-N-SH cells in culture. Dev Neurosci. 2002;24(2-3):143-153.
19. Richardson DR, Ponka P. The iron metabolism of the human neuroblastoma cell: lack of relationship between the efficacy of iron chelation and the inhibition of DNA synthesis. J Lab din Med. 1994;124(5):660-671.
20. Zhang LJ, Du LJ. The Distribution Law of BI in the Nuclei and BI Affects on the Brain. Beijing: Tsinghua University. 2007.
21. Zhang SM, He CX. The photometric method research of Quercetin-iron compounds. Guangpu Shiyanshi. 2001;18(3): 328-331.
22. Feng JM, Xu LF, Cai CZ, et al. The synthesis and characterization of Baicalin-Zinc. Nanjing Tiedao Yixueyuan Xuebao. 1988;7(2): 9-10.
23. Jia ZX, Wu Q. The research of Baicalin-Copper (II) compounds synthesis and super oxide anion activity. Wuji Hua Xue Xuebao. 1990;6(1):106-108.
24. Li SR, Dong HR, Bi PY. The synthesis and characterization of Baicalin-Fe (II) compounds. Beijing Huagong Daxue Xuebao. 2006;33(2):97-101.
25. Deng Y, Zhao AH, Yin LP, et al. The synthesis and characterization of Baicalin-Chromium (III). Zhongguo Tianran Yaowu. 2007;5(1):38-41.