Parallel relationship between microglial activation and substantia nigra damage in a rotenone-induced Parkinson's disease rat model

Neural Regeneration Research

Volumn 5, Issue 4, 2010, Pages 245-250

  Chen, Xin ^a   Zhang, Nan ^a   Li, Chun ^a   Song, Yangwen ^a   Yu, Siyuan ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Microglia; Neural regeneration; Neurodegenerative disease; Parkinson's disease; Parkinson's models; Rotenone

Indexed keywords

COMPLEMENT RECEPTOR; LIPID EMULSION; ROTENONE; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL DAMAGE; CELL LOSS; CEREBELLUM; COGNITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOPAMINERGIC ACTIVITY; DOPAMINERGIC NERVE CELL; DOSE RESPONSE; DRUG INDUCED DISEASE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; NERVE CELL DEGENERATION; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; OUTCOME ASSESSMENT; PARKINSON DISEASE; RAT; SCORING SYSTEM; STAINING; STRIATONIGRAL DEGENERATION; SUBSTANTIA NIGRA;

EID: 77949409210     PISSN: 16735374     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1673-5374.2010.04.001     Document Type: Article

References (23)

1. Teismann P, Schulz JB. Cellular pathology of Parkinson's disease: astrocytes, microglia and inflammation. Cell Tissue Res. 2004;318(1):149-161.
2. Kohutnicka M, Lewandowska E, Kurkowska-Jastrzebska I, et al. Microglial and astrocytic involvement in a murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Immunopharmacology. 1998;39(3):167-80.
3. Hirsch EC, Hunot S, Damier P, et al. Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration? Ann Neurol. 1998;44(3 Suppl 1):S115-20.
4. Ling Z, Zhu Y, Tong C, et al. Progressive dopamine neuron loss following supra-nigral lipopolysaccharide (LPS) infusion into rats exposed to LPS prenatally. Exp Neurol. 2006;199(2):499-512.
5. Klegeris A, McGeer EG, McGeer PL. Therapeutic approaches to inflammation in neurodegenerative disease. Curr Opin Neurol. 2007;20(3):351-357.
6. Wersinger C, Sidhu A. An inflammatory pathomechanism for Parkinson's disease? Curr Med Chem. 2006;13(5):591-602.
7. Sawada M, Imamura K, Nagatsu T. Role of cytokines in inflammatory process in Parkinson's disease. J Neural Transm Suppl. 2006;(70):373-381.
8. Kim YS, Joh TH. Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease. Exp Mol Med. 2006;38(4):333-347.
9. Liu B. Modulation of microglial pro-inflammatory and neurotoxic activity for the treatment of Parkinson's disease. AAPS J. 2006;8(3):E606-621.
10. Dong ZJ. The dopaminergic neurons toxicity of rotenone and Parkinson's disease. Guowai Yixue: Shenjing Bing Xue Fence. 2001;28(5):357-360.
11. Han W, Sun LZ, Chen JF, et al. Mechanisms of rotenone-induced neurotoxicity in PC 12 cells. Neural Regen Res. 2008;3(12):1281-1285.
12. Betarbet R, Sherer TB, MacKenzie G, et al. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci. 2000;3(12):1301-1306.
13. Chen X, Zhang N, Zhao H, et al. The relations of behavioral features and loss of Nigrostriatum on the model of Parkinson's disease induced by rotenone on rats. Zhongguo Shenjing Jingshen Jibing Zazhi. 2008;34(4):232-234.
14. Li C, Chen X, Zhang N, et al. Changes of expression of apoptosis-related proteins Bcl-2 and Bax in Parkinson's disease rat induced by rotenone. Zhongguo Shiyan Dongwu Xuebao. 2009;17(1):50-52.
15. Chen X, Zhang N, Zhao H, et al. The protect effect of Baicalin on the substantial nigra dopaminergic neuron in Parkinson's rats induced by rotenone. Zhongfeng yu Shenjing Jibing Zazhi. 2008;25(2):174-177.
16. Gomes MZ, Raisman-Vozari R, Del Bel EA. A nitric oxide synthase inhibitor decreases 6-hydroxydopamine effects on tyrosine hydroxylase and neuronal nitric oxide synthase in the rat nigrostriatal pathway. Brain Res. 2008;1203:160-169.
17. Hawlitschka A, Haas SJ, Schmitt O, et al. Effects of systemic PSI administration on catecholaminergic cells in the brain, adrenal medulla and carotid body in Wistar rats. Brain Res. 2007;1173:137-144.
18. Jiménez JJ, Bernal JL, del Nozal MJ, et al. Determination of rotenone residues in raw honey by solid-phase extraction and high-performance liquid chromatography. J Chromatogr A. 2000;871(1-2):67-73.
19. He Y, Appel S, Le W. Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum. Brain Res. 2001;909(1-2):187-193.
20. Depino AM, Earl C, Kaczmarczyk E, et al. Microglial activation with atypical proinflammatory cytokine expression in a rat model of Parkinson's disease. Eur J Neurosci. 2003;18(10):2731-2742.
21. Cicchetti F, Brownell AL, Williams K, et al. Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemiatry and PET imaging. Eur J Neurosci. 2002;15(6):991-998.
22. Kim WG, Mohney RP, Wilson B, et al. Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. J Neurosci. 2000;20(16):6309-6316.
23. Sherer TB, Betarbet R, Kim JH, et al. Selective microglial activation in the rat rotenone model of Parkinson's disease. Neurosci Lett. 2003;341(2):87-90.