SVO 2-guided resuscitation for experimental septic shock: Effects of fluid infusion and dobutamine on hemodynamics, inflammatory response, and cardiovascular oxidative stress

Shock

Volumn 36, Issue 6, 2011, Pages 604-612

  Rosário, André Loureiro ^a   Park, Marcelo ^a,b   Brunialti, Milena Karina ^c   Mendes, Marialice ^c   Rapozo, Marjorie ^c   Fernandes, Denise ^b   Salomão, Reinaldo ^c   Laurindo, Francisco Rafael ^b   Schettino, Guilherme Paula ^a   Azevedo, Luciano Cesar P ^a,b  

^a HOSPITAL SÍRIO LIBANÊS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

goal directed therapy; hemodynamic resuscitation; inflammatory response; mixed venous oxygen saturation; oxidative stress; Septic shock

Indexed keywords

3 NITROTYROSINE; AMIKACIN; CD14 ANTIGEN; DOBUTAMINE; GLUTATHIONE; INTERLEUKIN 6; METRONIDAZOLE; NITRATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CENTRAL VENOUS PRESSURE; CONTROLLED STUDY; ENZYME ACTIVITY; FLUID RESUSCITATION; HEART MUSCLE; HEMODYNAMICS; INFLAMMATION; MEAN ARTERIAL PRESSURE; MIXED VENOUS OXYGEN SATURATION; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; OXYGEN SATURATION; PROTEIN EXPRESSION; SEPTIC SHOCK; SWINE; URINE VOLUME;

ANIMALS; DOBUTAMINE; HEMODYNAMICS; NOREPINEPHRINE; OXIDATIVE STRESS; OXYGEN CONSUMPTION; RESUSCITATION; SHOCK, SEPTIC; SWINE;

EID: 81755166365     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3182336aa4     Document Type: Article

References (35)

1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the Unites States: analysis of incidence, outcome and associated costs of care. Crit Care Med 29(7):1303-1310, 2001. (Pubitemid 32641789)
2. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, et al.; International Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases; European Society of Intensive Care Medicine; European Respiratory Society; International Sepsis Forum; Japanese Association for Acute Medicine; Japanese Society of Intensive Care Medicine; Society of Critical Care Medicine; Society of Hospital Medicine; Surgical Infection Society; World Federation of Societies of Intensive and Critical Care Medicine: Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 36(1):296-327, 2008.
3. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M; Early Goal-Directed Therapy Collaborative Group: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345(19):1368-1377, 2001.
4. Russell JA: Management of sepsis. N Engl J Med 355(16):1699-1713, 2006. (Pubitemid 44583960)
5. Martins PS, Brunialti MKC, Fernandes ML, Martos LS, Gomes NE, Rigato O, Salomao R: Bacterial recognition and induced cell activation in sepsis. Endocr Metab Immune Disord Drug Targets 6(2):183-191, 2006. (Pubitemid 43881031)
6. Salomão R, Martins PS, Brunialti MKC, Fernandes Mda L, Martos LS, Mendes ME, Gomes NE, Rigato O: TLR signaling pathway in patients with sepsis. Shock 30(Suppl 1):73-77, 2008.
7. Azevedo LC, Janiszewski M, Soriano FG, Laurindo FR: Redox mechanisms of vascular cell dysfunction in sepsis. Endocr Metab Immune Disord Drug Targets 6(2):159-164, 2006. (Pubitemid 43881028)
8. Azevedo LC, Park M, Noritomi DT, Maciel AT, Brunialti MK, Salomão R: Characterization of an animal model of severe sepsis associated with respiratory dysfunction. Clinics 62(4):491-498, 2007.
9. Martins PS, Kallas EG, Cendoroglo-Neto M, Dalboni MA, Blecher S, Salomão R: Upregulation of reactive oxygen species generation and phagocytosis, and increased apoptosis in human neutrophils during severe sepsis and septic shock. Shock 20(3):208-212, 2003.
10. Martins PS, Brunialti MK, Martos LS, Machado FR, Assunçao MS, Blecher S, Salomao R: Expression of cell surface receptors and oxidative metabolism modulation in the clinical continuum of sepsis. Critical Care 12(1):R25, 2008.
11. Fernandes DC, Wosniak J Jr, Pescatore LA, Bertoline MA, Liberman M, Laurindo FR, Santos CX: Analysis of dihydroethidium-derived oxidation products by HPLC in the assessment of superoxide production and NADPH oxidase activity in vascular systems. Am J Physiol Cell Physiol 292(1):C413-C422, 2007. (Pubitemid 46115149)
12. Hiraku Y, Murata M, Kawanishi S: Determination of intracellular glutathione and thiols by high performance liquid chromatography with a gold electrode at the femtomole level: comparison with a spectroscopic assay. Biochim Biophys Acta 1570(1):47-52, 2002. (Pubitemid 34311893)
13. Rivers EP, Coba V, Visbal A, Whitmill M, Amponsah D: Management of sepsis: early resuscitation. Clin Chest Med 29(4):689-704, 2008.
14. Rady MY, Rivers EP, Nowak RM: Resuscitation of the critically ill in the ED: responses of blood pressure, heart rate, shock index, central venous oxygen saturation, and lactate. Am J Emerg Med 14(2):218-225, 1996. (Pubitemid 26090212)
15. Ramos FJ, Azevedo LC: Hemodynamic and perfusion endpoints for volemic resuscitation in sepsis. Shock 34(Suppl 1):34-39, 2010.
16. Nevière R, Chagnon JL, Vallet B, Lebleu N, Marechal X, Mathieu D, Wattel F, Dupuis B: Dobutamine improves gastrointestinal mucosal blood flow in a porcine model of endotoxic shock. Crit Care Med 25(8):1371-1377, 1997. (Pubitemid 27347303)
17. Cunha-Goncalves D, Perez-de-Sa V, Larsson A, Thörne J, Blomquist S: Inotropic support during experimental endotoxemic shock: part II. A comparison of levosimendan with dobutamine. Anesth Analg 109(5):1576-1583, 2009.
18. Rivers EP, Kruse JA, Jacobsen G, Shah K, Loomba M, Otero R, Childs EW: The influence of early hemodynamic optimization on biomarker patterns of severe sepsis and septic shock. Crit Care Med 35(9):2016-2024, 2007. (Pubitemid 47326436)
19. Santry HP, Alam HB. Fluid resuscitation: past, present and the future. Shock 33(3):229-241, 2010.
20. Cotton BA, Guy JS, Morris JA Jr, Abumrad NN: The cellular, metabolic and systemic consequences of aggressive fluid resuscitation strategies. Shock 26(2): 115-121, 2006. (Pubitemid 44162495)
21. Brandt S, Regueira T, Bracht H, Porta F, Djafarzadeh S, Takala J, Gorrasi J, Borotto E, Krejci V, Hiltebrand LB, et al.: Effect of fluid resuscitation on mortality and organ function in experimental sepsis models. Crit Care 13(6): R186, 2009.
22. The National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network: Comparison of two fluidmanagement strategies in acute lung injury. N Engl J Med 354(24):2564-2575, 2006.
23. Perel A: Bench-to-bedside review: the initial hemodynamic resuscitation of the septic patient according to Surviving Sepsis Campaign guidelinesVdoes one size fit all? Crit Care 12(5):223, 2008.
24. Puskarich MA, Marchick MR, Kline JA, Steuerwald MT, Jones AE: One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: a before and after study. Crit Care 13(5):R167, 2009.
25. Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA: Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA 303(8):739-746, 2010.
26. Peake SL, Bailey M, Bellomo R, Cameron PA, Cross A, Delaney A, Finfer S, Higgins A, Jones DA, Myburgh JA, et al.; ARISE Investigators, for the Australian and New Zealand Intensive Care Society Clinical Trials Group: Australasian resuscitation of sepsis evaluation (ARISE): a multi-centre, prospective, inception cohort study. Resuscitation 80(7):811-818, 2009.
27. Bozza FA, Carnevale R, Japiassu AM, Castro-Faria-Neto HC, Angus DC, Salluh JI. Early fluid resuscitation in sepsis: evidence and perspectives. Shock 34(Suppl 1):40-43, 2010.
28. Rahal L, Garrido AG, Cruz RJ Jr, Silva E, Poli-de-Figueiredo LF: Fluid replacement with hypertonic or isotonic solutions guided by mixed venous oxygen saturation in experimental hypodynamic sepsis. J Trauma 67(6):1205-1212, 2009.
29. Trzeciak S, Jones AE, Shapiro NI, Pusateri AE, Arnold RC, Rizzuto M, Arora T, Parrillo JE, Dellinger RP: A prospective multicenter cohort study of the association between global tissue hypoxia and coagulation abnormalities during early sepsis resuscitation. Crit Care Med 38(4):1092-1100, 2010.
30. Younger JG, Bracho DO, Chung-Esaki HM, Lee M, Rana GK, Sen A, Jones AE: Complement activation in emergency department patients with severe sepsis. Acad Emerg Med 17(4):353-359, 2010.
31. Jhanji S, Vivian-Smith A, Lucena-Amaro S, Watson D, Hinds CJ, Pearse RM: Haemodynamic optimisation improves tissue microvascular flow and oxygenation after major surgery: a randomised controlled trial. Crit Care 14(4):R151, 2010.
32. Anas A, van der Poll T, de Vos AF: Role of CD14 in lung inflammation and infection. Crit Care 14(2):209, 2010.
33. Brunialti MK, Martins PS, Carvalho HB, Machado FR, Barbosa LM, Salomao R: TLR2, TLR4, CD14, CD11B, and CD11C expressions on monocytes surface and cytokine production in patients with sepsis. Shock 25(4):351-357, 2006.
34. Hiki N, Berger D, Prigl C, Boelke E, Wiedeck H, Seidelmann M, Staib L, Kaminishi M, Oohara T, Beger HG: Endotoxin binding and elimination by monocytes: secretion of soluble CD14 represents an inducible mechanism counteracting reduced expression of membrane CD14 in patients with sepsis and in a patient with paroxysmal nocturnal hemoglobinuria. Infect Immun 66(3): 1135-1141, 1998. (Pubitemid 28101157)
35. Javesghani D, Hussain SN, Scheidel J, Quinn MT, Magder SA: Superoxide production in the vasculature of lipopolysaccharide-treated rats and pigs. Shock 19(5):486-493, 2003. (Pubitemid 44305178)