Mass spectrometry based approach to study the kinetics of O 6-alkylguanine DNA alkyltransferase-mediated repair of O 6-pyridyloxobutyl-2′-deoxyguanosine adducts in DNA

Chemical Research in Toxicology

Volumn 24, Issue 11, 2011, Pages 1966-1975

  Kotandeniya, Delshanee ^a   Murphy, Dan ^a   Seneviratne, Uthpala ^a   Guza, Rebecca ^a   Pegg, Anthony ^b   Kanugula, Sreenivas ^b   Tretyakova, Natalia ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; CYSTEINE; DOUBLE STRANDED DNA; O 6 PYRIDYLOXOBUTYL 2' DEOXYGUANOSINE; UNCLASSIFIED DRUG;

ARTICLE; CODON; DNA ADDUCT; DNA REPAIR; DNA SEQUENCE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; IN VITRO STUDY; ISOTOPE DILUTION ASSAY; KINETICS; NONHUMAN; ONCOGENE H RAS; PROTEIN PURIFICATION; PROTEIN SECRETION; RAT; SOLID PHASE EXTRACTION; VALIDATION PROCESS;

ANIMALS; CARCINOGENS; DEOXYGUANOSINE; DNA; DNA ADDUCTS; DNA DAMAGE; DNA REPAIR; GENES, RAS; HUMANS; KINETICS; NITROSAMINES; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PEPTIDE FRAGMENTS; RADIOISOTOPE DILUTION TECHNIQUE; RATS; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TOBACCO;

NICOTIANA TABACUM; RATTUS;

EID: 81755164040     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx2002993     Document Type: Article

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