Cardiovascular risk in systemic autoimmune diseases: Epigenetic mechanisms of immune regulatory functions

Clinical and Developmental Immunology

Volumn 2012, Issue , 2012, Pages

  López Pedrera, Chary ^a   Pérez Sánchez, Carlos ^a   Ramos Casals, Manuel ^b   Santos Gonzalez, Monica ^b   Rodriguez Ariza, Antonio ^a   José Cuadrado, Ma ^c  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b HOSPITAL CLÍNIC   (Spain)

^c ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; DNA; DNA METHYLTRANSFERASE 1; HISTONE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HYDRALAZINE; MICRORNA; MICRORNA 112; MICRORNA 141; MICRORNA 146A; MICRORNA 17 5P; MICRORNA 184; MICRORNA 196A; MICRORNA 383; MICRORNA 409 3P; PROCAINAMIDE; UNCLASSIFIED DRUG; MIRN146 MICRORNA, HUMAN;

ACUTE CORONARY SYNDROME; ANTIINFLAMMATORY ACTIVITY; ANTIPHOSPHOLIPID SYNDROME; AUTOIMMUNE DISEASE; CARDIOVASCULAR RISK; DNA METHYLATION; DNA MODIFICATION; DNA PACKAGING; DNA SEQUENCE; ENVIRONMENTAL FACTOR; EPIGENETICS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC REGULATION; HISTONE MODIFICATION; HUMAN; IMMUNOREGULATION; JUVENILE RHEUMATOID ARTHRITIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; SJOEGREN SYNDROME; SYSTEMIC DISEASE; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOGENESIS; THROMBOSIS; VASCULAR DISEASE; ACETYLATION; CARDIOVASCULAR DISEASE; FORECASTING; GENETIC EPIGENESIS; GENETICS; IMMUNOLOGY; METABOLISM; METHYLATION; PHYSIOLOGY; PROTEIN PROCESSING; RHEUMATIC DISEASE; RISK;

ACETYLATION; AUTOIMMUNE DISEASES; CARDIOVASCULAR DISEASES; DNA METHYLATION; EPIGENESIS, GENETIC; FORECASTING; HISTONE DEACETYLASE INHIBITORS; HISTONES; HUMANS; METHYLATION; MICRORNAS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RHEUMATIC DISEASES; RISK;

EID: 81555226689     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2012/974648     Document Type: Review

References (97)

1. Villalta D., Tozzoli R., Tonutti E., Bizzaro N., The laboratory approach to the diagnosis of autoimmune diseases: is it time to change? Autoimmunity Reviews 2007 6 6 359 365 (Pubitemid 46830688)
2. Vaudo G., Bocci E. B., Shoenfeld Y., Schillaci G., Wu R., Del Papa N., Vitali C., Delle Monache F., Marchesi S., Mannarino E., Gerli R., Precocious intima-media thickening in patients with primary Sjgren's syndrome Arthritis and Rheumatism 2005 52 12 3890 3897 (Pubitemid 41798228)
3. Sherer Y., Shoenfeld Y., Mechanisms of disease: atherosclerosis in autoimmune diseases Nature Clinical Practice Rheumatology 2006 2 2 99 106 (Pubitemid 43239209)
4. Rhew E. Y., Ramsey-Goldman R., Premature atherosclerotic disease in systemic lupus erythematosusrole of inflammatory mechanisms Autoimmunity Reviews 2006 5 2 101 105 (Pubitemid 43129536)
5. Lee P. Y., Li Y., Richards H. B., Chan F. S., Zhuang H., Narain S., Butfiloski E. J., Sobel E. S., Reeves W. H., Segal M. S., Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus Arthritis and Rheumatism 2007 56 11 3759 3769 (Pubitemid 350100709)
6. McMahon M., Hahn B. H., Atherosclerosis and systemic lupus erythematosusmechanistic basis of the association Current Opinion in Immunology 2007 19 6 633 639 (Pubitemid 350236815)
7. Crow M. K., George S., Paget S. A., Expression of an interferon-alpha gene program in SLE Arthritis Rheumatism 2002 46 S281
8. Bennett L., Palucka A. K., Arce E., Cantrell V., Borvak J., Banchereau J., Pascual V., Interferon and granulopoiesis signatures in systemic lupus erythematosus blood Journal of Experimental Medicine 2003 197 6 711 723 (Pubitemid 36350866)
9. Baechler E. C., Batliwalla F. M., Karypis G., Gaffney P. M., Ortmann W. A., Espe K. J., Shark K. B., Grande W. J., Hughes K. M., Kapur V., Gregersen P. K., Behrens T. W., Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus Proceedings of the National Academy of Sciences of the United States of America 2003 100 5 2610 2615 (Pubitemid 36297546)
10. Kirou K. A., Lee C., George S., Louca K., Papagiannis I. G., Peterson M. G. E., Ly N., Woodward R. N., Fry K. E., Lau A. Y. H., Prentice J. G., Wohlgemuth J. G., Crow M. K., Coordinate overexpression of interferon- -induced genes in systemic lupus erythematosus Arthritis and Rheumatism 2004 50 12 3958 3967 (Pubitemid 39643944)
11. Potti A., Bild A., Dressman H. K., Lewis D. A., Nevins J. R., Ortel T. L., Gene-expression patterns predict phenotypes of immune-mediated thrombosis Blood 2006 107 4 1391 1396 (Pubitemid 43242373)
12. Olsen N. J., Sokka T., Seehorn C. L., Kraft B., Maas K., Moore J., Aune T. M., A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells Annals of the Rheumatic Diseases 2004 63 11 1387 1392 (Pubitemid 39433940)
13. Edwards C. J., Feldman J. L., Beech J., Shields K. M., Stover J. A., Trepicchio W. L., Larsen G., Foxwell B. M. J., Brennan F. M., Feldmann M., Pittman D. D., Molecular profile of peripheral blood mononuclear cells from patients with rheumatoid arthritis Molecular Medicine 2007 13 1-2 40 58 (Pubitemid 46786833)
14. Hjelmervik T. O. R., Petersen K., Jonassen I., Jonsson R., Bolstad A. I., Gene expression profiling of minor salivary glands clearly distinguishes primary Sjgren's syndrome patients from healthy control subjects Arthritis and Rheumatism 2005 52 5 1534 1544 (Pubitemid 40663945)
15. Gottenberg J. E., Cagnard N., Lucchesi C., Letourneur F., Mistou S., Lazure T., Jacques S., Ba N., Ittah M., Lepajolec C., Labetoulle M., Ardizzone M., Sibilia J., Fournier C., Chiocchia G., Mariette X., Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjgren's syndrome Proceedings of the National Academy of Sciences of the United States of America 2006 103 8 2770 2775
16. Wakamatsu E., Nakamura Y., Matsumoto I., Goto D., Ito S., Tsutsumi A., Sumida T., DNA microarray analysis of labial salivary glands of patients with Sjgren's syndrome Annals of the Rheumatic Diseases 2007 66 6 844 845 (Pubitemid 46846717)
17. Devauchelle-Pensec V., Cagnard N., Pers J. O., Youinou P., Saraux A., Chiocchia G., Gene expression profile in the salivary glands of primary Sjgren's syndrome patients before and after treatment with rituximab Arthritis and Rheumatism 2010 62 8 2262 2271
18. Brooks W. H., Le Dantec C., Pers J. O., Youinou P., Renaudineau Y., Epigenetics and autoimmunity Journal of Autoimmunity 2010 34 3 J207 J219
19. Jngel A., Ospelt C., Gay S., What can we learn from epigenetics in the year 2009? Current Opinion in Rheumatology 2010 22 3 284 292
20. Cuthbert G. L., Daujat S., Snowden A. W., Erdjument-Bromage H., Hagiwara T., Yamada M., Schneider R., Gregory P. D., Tempst P., Bannister A. J., Kouzarides T., Histone deimination antagonizes arginine methylation Cell 2004 118 5 545 553 (Pubitemid 39179708)
21. Hu N., Qiu X., Luo Y., Yuan J., Li Y., Lei W., Zhang G., Zhou Y., Su Y., Lu Q., Abnormal histone modification patterns in lupus CD4+ T cells Journal of Rheumatology 2008 35 5 804 810 (Pubitemid 351747120)
22. Zhang Z., Sullivan K. E., Maurer K., Perin J. C., Song L., Cytokine-induced monocyte characteristics in SLE Journal of Biomedicine and Biotechnology 2010 2010 13
23. Dubroff L. M., Reid R. J. Jr., Hydralazine-pyrimidine interactions may explain hydralazine-induced lupus erythematosus Science 1980 208 4442 404 406 (Pubitemid 10089454)
24. Lee B. H., Yegnasubramanian S., Lin X., Nelson W. G., Procainamide is a specific inhibitor of DNA methyltransferase 1 Journal of Biological Chemistry 2005 280 49 40749 40756 (Pubitemid 41780565)
25. Scheinbart L. S., Johnson M. A., Gross L. A., Edelstein S. R., Richardson B. C., Procainamide inhibits DNA methyltransferase in a human T cell line Journal of Rheumatology 1991 18 4 530 534
26. Gorelik G., Jing Y. F., Wu A., Sawalha A. H., Richardson B., Impaired T cell protein kinase C activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus Journal of Immunology 2007 179 8 5553 5563
27. Deng C., Kaplan M. J., Yang J., Decreased ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients Arthritis and Rheumatism 2001 44 2 397 407
28. Richardson B., Scheinbart L., Strahler J., Gross L., Hanash S., Johnson M., Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis Arthritis and Rheumatism 1990 33 11 1665 1673
29. Lu Q., Kaplan M., Ray D., Ray D., Zacharek S., Gutsch D., Richardson B., Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus Arthritis and Rheumatism 2002 46 5 1282 1291 (Pubitemid 34525836)
30. Oelke K., Lu Q., Richardson D., Wu A., Deng C., Hanash S., Richardson B., Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors Arthritis and Rheumatism 2004 50 6 1850 1860 (Pubitemid 38725098)
31. Lu Q., Wu A., Tesmer L., Ray D., Yousif N., Richardson B., Demethylation of CD40LG on the inactive X in T cells from women with lupus Journal of Immunology 2007 179 9 6352 6358
32. Kaplan M. J., Lu Q., Wu A., Attwood J., Richardson B., Demethylation of promoter regulatory elements contributes to perforin overexpression in CD4+ lupus T cells Journal of Immunology 2004 172 6 3652 3661 (Pubitemid 38337948)
33. Garaud S., Le Dantec C., Jousse-Joulin S., Hanrotel-Saliou C., Saraux A., Mageed R. A., Youinou P., Renaudineau Y., IL-6 Modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation Journal of Immunology 2009 182 9 5623 5632
34. Schwab J., Illges H., Silencing of CD21 expression in synovial lymphocytes is independent of methylation of the CD21 promoter CpG island Rheumatology International 2001 20 4 133 137 (Pubitemid 32449109)
35. Nile C. J., Read R. C., Akil M., Duff G. W., Wilson A. G., Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis Arthritis and Rheumatism 2008 58 9 2686 2693
36. Gonzlez S., Aguilera S., Urza U., Quest A. F. G., Molina C., Alliende C., Hermoso M., Gonzlez M. J., Mechanotransduction and epigenetic control in autoimmune diseases Autoimmunity Reviews 2010 10 3 175 179
37. Herrmann H., Br H., Kreplak L., Strelkov S. V., Aebi U., Intermediate filaments: from cell architecture to nanomechanics Nature Reviews Molecular Cell Biology 2007 8 7 562 573 (Pubitemid 46985377)
38. Pérez P., Anaya J. M., Aguilera S., Urza U., Munroe D., Molina C., Hermoso M. A., Cherry J. M., Alliende C., Olea N., Ruiz-Narvez E., Gonzlez M. J., Gene expression and chromosomal location for susceptibility to Sjgren's syndrome Journal of Autoimmunity 2009 33 2 99 108
39. Gonzlez S., Aguilera S., Alliende C., Urza U., Quest A. F.G., Herrera L., Molina C., Hermoso M., Ewert P., Brito M., Romo R., Leyton C., Pérez P., Gonzlez M.-J., Alterations in type i hemidesmosome components suggestive of epigenetic control in the salivary glands of patients with sjgren's syndrome Arthritis and Rheumatism 2011 63 4 1106 1115
40. Koster J., Geerts D., Favre B., Borradori L., Sonnenberg A., Analysis of the interactions between BP180, BP230, plectin and the integrin 6 4 important for hemidesmosome assembly Journal of Cell Science 2003 116 2 387 399 (Pubitemid 36163879)
41. Litjens S. H. M., de Pereda J. M., Sonnenberg A., Current insights into the formation and breakdown of hemidesmosomes Trends in Cell Biology 2006 16 7 376 383 (Pubitemid 44062316)
42. Yin H., Zhao M., Wu X., Gao F., Luo Y., Ma L., Liu S., Zhang G., Chen J., Li F., Zuo X., Lu Q., Hypomethylation and overexpression of CD70 (TNFSF7) in CD4+ T cells of patients with primary Sjgren's syndrome Journal of Dermatological Science 2010 59 3 198 203
43. Shivdasani R. A., MicroRNAs: regulators of gene expression and cell differentiation Blood 2006 108 12 3646 3653 (Pubitemid 44864540)
44. Faltejskov P., Slab S., Hézov R., Michlek J., Role of microRNAs in the immune system Casopis Lekaru Ceskych 2010 149 1 10 15
45. Alevizos I., Illei G. G., MicroRNAs in Sjgren's syndrome as a prototypic autoimmune disease Autoimmunity Reviews 2010 9 9 618 621
46. Murata K., Yoshitomi H., Tanida S., Ishikawa M., Nishitani K., Ito H., Nakamura T., Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis Arthritis Research amp; Therapy 2010 12 3 R86
47. Nakasa T., Nagata Y., Yamasaki K., Ochi M., A mini-review: MicroRNA in arthritis Physiological Genomics 2011 43 10 566 570
48. Pauley K. M., Satoh M., Chan A. L., Bubb M. R., Reeves W. H., Chan E. K. L., Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients Arthritis Research and Therapy 2008 10 4, article R101
49. Stanczyk J., Pedrioli D. M., Brentano F., Sanchez-Pernaute O., Kolling C., Gay R. E., Detmar M., Gay S., Kyburz D., Altered expression of microRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis Arthritis and Rheumatism 2008 58 4 1001 1009 (Pubitemid 351564001)
50. Li J., Wan Y., Guo Q., Zou L., Zhang J., Fang Y., Zhang J., Zhang J., Fu X., Liu H., Lu L., Wu Y., Altered microRNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis Arthritis Research amp; Therapy 2010 12 R81
51. Niimoto T., Nakasa T., Ishikawa M., Okuhara A., Izumi B., Deie M., Suzuki O., Adachi N., Ochi M., MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients BMC Musculoskeletal Disorders 2010 11, article 209
52. Chatzikyriakidou A., Voulgari P. V., Georgiou I., Drosos A. A., A polymorphism in the 3'-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility Joint Bone Spine 2010 77 5 411 413
53. Guo M., Mao X., Ji Q., Lang M., Li S., Peng Y., Zhou W., Xiong B., Zeng Q., MiR-146a in PBMCs modulates Th1 function in patients with acute coronary syndrome Immunology and Cell Biology 2010 88 5 555 564
54. Dai Y., Huang Y. S., Tang M., Lv T. Y., Hu C. X., Tan Y. H., Xu Z. M., Yin Y. B., Microarray analysis of microRNA expression in peripheral blood cells of systemic lupus erythematosus patients Lupus 2007 16 12 939 946
55. Zhao X., Tang Y., Qu B., Cui H., Wang S., Wang L., Luo X., Huang X., Li J., Chen S., Shen N., MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus Arthritis and Rheumatism 2010 62 11 3425 3435
56. Tang Y., Luo X., Cui H., Ni X., Yuan M., Guo Y., Huang X., Zhou H., De Vries N., Tak P. P., Chen S., Shen N., MicroRNA-146a contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins Arthritis and Rheumatism 2009 60 4 1065 1075
57. Cuadrado M. J., Lpez-Pedrera C., Khamashta M. A., Camps M. T., Tinahones F., Torres A., Hughes G. R. V., Velasco F., Thrombosis in primary antiphospholipid syndrome: a pivotal role for monocyte tissue factor expression Arthritis and Rheumatism 1997 40 5 834 841 (Pubitemid 27199998)
58. Dobado-Berrios P. M., Lpez-Pedrera C., Velasco F., Aguirre M. A., Torres A., Cuadrado M. J., Increased levels of tissue factor mRNA in mononuclear blood cells of patients with primary antiphospholipid syndrome Thrombosis and Haemostasis 1999 82 6 1578 1582
59. Dobado-Berrios P. M., Lpez-Pedrera C., Velasco F., Cuadrado M. J., The role of tissue factor in the antiphospholipid syndrome Arthritis and Rheumatism 2001 44 11 2467 2476 (Pubitemid 33049324)
60. Lpez-Pedrera C., Buenda P., Cuadrado M. J., Siendones E., Aguirre M. A., Barbarroja N., Montiel-Duarte C., Torres A., Khamashta M., Velasco F., Antiphospholipid antibodies from patients with the antiphospholipid syndrome induce monocyte tissue factor expression through the simultaneous activation of NF- B/Rel proteins via the p38 mitogen-activated protein kinase pathway, and of the MEK-1/ERK pathway Arthritis and Rheumatism 2006 54 1 301 311 (Pubitemid 43122214)
61. Vega-Ostertag M., Casper K., Swerlick R., Ferrara D., Harris E. N., Pierangeli S. S., Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies Arthritis and Rheumatism 2005 52 5 1545 1554 (Pubitemid 40663946)
62. Teruel R., Pérez-Snchez C., Corral J., Identification of miRNAS as potential modulators of tissue factor expression in patients with systemic lupus erythematosus and antiphospholipid syndrome. Journal of Thrombosis and Haemostasis. In press
63. Lakkaraju A., Rodriguez-Boulan E., Itinerant exosomes: emerging roles in cell and tissue polarity Trends in Cell Biology 2008 18 5 199 209
64. Valadi H., Ekstrm K., Bossios A., Sjstrand M., Lee J. J., Ltvall J. O., Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells Nature Cell Biology 2007 9 6 654 659 (Pubitemid 47214727)
65. Michael A., Bajracharya S. D., Yuen P. S. T., Zhou H., Star R. A., Illei G. G., Alevizos I., Exosomes from human saliva as a source of microRNA biomarkers Oral Diseases 2010 16 1 34 38
66. Alevizos I., Alexander S., Turner R. J., Illei G. G., MicroRNA expression profiles as biomarkers of minor salivary gland inflammation and dysfunction in Sjgren's syndrome Arthritis and Rheumatism 2011 63 2 535 544
67. Mendell J. T., miRiad roles for the miR-17-92 Cluster in Development and Disease Cell 2008 133 2 217 222 (Pubitemid 351508308)
68. Xiao C., Srinivasan L., Calado D. P., Patterson H. C., Zhang B., Wang J., Henderson J. M., Kutok J. L., Rajewsky K., Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes Nature Immunology 2008 9 4 405 414 (Pubitemid 351405110)
69. Alevizos I., Illei G. G., MicroRNAs as biomarkers in rheumatic diseases Nature Reviews Rheumatology 2010 6 7 391 398
70. Lu Q., Renaudineau Y., Cha S., Ilei G., Brooks W. H., Selmi C., Tzioufas A., Pers J. O., Bombardieri S., Gershwin M. E., Gay S., Youinou P., Epigenetics in autoimmune disorders: highlights of the 10th Sjgren's syndrome symposium Autoimmunity Reviews 2010 9 9 627 630
71. McMahon M., Hahn B. H., Atherosclerosis and systemic lupus erythematosus-mechanistic basis of the association Current Opinion in Immunology 2007 19 6 633 639 (Pubitemid 350236815)
72. Lpez-Pedrera C., Aguirre M. A., Barbarroja N., Cuadrado M. J., Accelerated atherosclerosis in systemic lupus erythematosus: role of proinflammatory cytokines and therapeutic approaches Journal of Biomedicine and Biotechnology 2010 2010 13
73. Denny M. F., Thacker S., Mehta H., Somers E. C., Dodick T., Barrat F. J., McCune W. J., Kaplan M. J., Interferon- promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis Blood 2007 110 8 2907 2915 (Pubitemid 350006944)
74. Csiszr A., Nagy G., Gergely P., Pozsonyi T., Pcsik E., Increased interferon-gamma (IFN- ), IL-10 and decreased IL-4 mRNA expression in peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE) Clinical and Experimental Immunology 2000 122 3 464 470 (Pubitemid 32002208)
75. Schneider P., Mackay F., Steiner V., Hofmann K., Bodmer J. L., Holler N., Ambrose C., Lawton P., Bixler S., Acha-Orbea H., Valmori D., Romero P., Werner-Favre C., Zubler R. H., Browning J. L., Tschopp J., BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth Journal of Experimental Medicine 1999 189 11 1747 1756 (Pubitemid 29272691)
76. Moore P. A., Belvedere O., Orr A., Pieri K., LaFleur D. W., Feng P., Soppet D., Charters M., Gentz R., Parmelee D., Li Y., Galperina O., Giri J., Roschke V., Nardelli B., Carrell J., Sosnovtseva S., Greenfield W., Ruben S. M., Olsen H. S., Fikes J., Hilbert D. M., BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator Science 1999 285 5425 260 263 (Pubitemid 29330000)
77. Shu H. B., Johnson H., B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1 Proceedings of the National Academy of Sciences of the United States of America 2000 97 16 9156 9161 (Pubitemid 30626690)
78. Rho Y. H., Chung C. P., Oeser A., Solus J., Raggi P., Gebretsadik T., Shintani A., Stein C. M., Novel cardiovascular risk factors in premature coronary atherosclerosis associated with systemic lupus erythematosus Journal of Rheumatology 2008 35 9 1789 1794
79. Roman M. J., Shanker B. A., Davis A., Lockshin M. D., Sammaritano L., Simantov R., Crow M. K., Schwartz J. E., Paget S. A., Devereux R. B., Salmon J. E., Prevalence and correlates of accelerated atherosclerosis in systemic lupus erythematosus New England Journal of Medicine 2003 349 25 2399 2406 (Pubitemid 37542988)
80. Wong C. K., Lit L. C. W., Tam L. S., Li E. K. M., Wong P. T. Y., Lam C. W. K., Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity Clinical Immunology 2008 127 3 385 393
81. Crispn J. C., Oukka M., Bayliss G., Cohen R. A., Van Beek C. A., Stillman I. E., Kyttaris V. C., Juang Y. T., Tsokos G. C., Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys Journal of Immunology 2008 181 12 8761 8766
82. Eid R. E., Rao D. A., Zhou J., Lo S. F. L., Ranjbaran H., Gallo A., Sokol S. I., Pfau S., Pober J. S., Tellides G., Interleukin-17 and interferon- Are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells Circulation 2009 119 10 1424 1432
83. Del Rincn I., Freeman G. L., Haas R. W., O'Leary D. H., Escalante A., Relative contribution of cardiovascular risk factors and rheumatoid arthritis clinical manifestations to atherosclerosis Arthritis and Rheumatism 2005 52 11 3413 3423 (Pubitemid 41612207)
84. Kerekes G., Szekanecz Z., Dér H., Sndor Z., Lakos G., Muszbek L., Csip I., Sipka S., Seres I., Paragh G., Kappelmayer J., Szomjk E., Veres K., Szegedi G., Shoenfeld Y., Soltész P., Endothelial dysfunction and atherosclerosis in rheumatoid arthritis: a multiparametric analysis using imaging techniques and laboratory markers of inflammation and autoimmunity Journal of Rheumatology 2008 35 3 398 406 (Pubitemid 351374411)
85. Ahmed H. M., Youssef M., Mosaad Y. M., Antibodies against oxidized low-density lipoprotein are associated with subclinical atherosclerosis in recent-onset rheumatoid arthritis Clinical Rheumatology 2010 29 11 1237 1243
86. Zal B., Kaski J. C., Arno G., Akiyu J. P., Xu Q., Cole D., Whelan M., Russell N., Madrigal J. A., Dodi I. A., Baboonian C., Heat-Shock Protein 60-Reactive CD4+CD28null T Cells in Patients with Acute Coronary Syndromes Circulation 2004 109 10 1230 1235 (Pubitemid 38372781)
87. Szekanecz Z., Kerekes G., Dér H., Sndor Z., Szab Z., Végvri A., Simkovics E., Sos L., Szentpétery.., Besenyei T., Szcs G., Sznt S., Tamsi L., Szegedi G., Shoenfeld Y., Soltész P., Accelerated atherosclerosis in rheumatoid arthritis Annals of the New York Academy of Sciences 2007 1108 349 358 (Pubitemid 47528747)
88. Divekar A. A., Dubey S., Gangalum P. R., Singh R. R., Dicer insufficiency and microRNA-155 overexpression in lupus regulatory T cells: an apparent paradox in the setting of an inflammatory milieu Journal of Immunology 2011 186 2 924 930
89. Wang G., Tam L. S., Li E. K. M., Kwan B. C. H., Chow K. M., Luk C. C. W., Li P. K. T., Szeto C. C., Serum and urinary cell-free MiR-146a and MiR-155 in patients with systemic lupus erythematosus Journal of Rheumatology 2010 37 12 2516 2522
90. Chan E. K. L., Satoh M., Pauley K. M., Contrast In aberrant microRNA expression In systemic lupus erythematosus and rheumatoid arthritis: is microRNA-146 all we need? Arthritis and Rheumatism 2009 60 4 912 915
91. Pan W., Zhu S., Yuan M., Cui H., Wang L., Luo X., Li J., Zhou H., Tang Y., Shen N., MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1 Journal of Immunology 2010 184 12 6773 6781
92. Zhao S., Wang Y., Liang Y., Zhao M., Long H., Ding S., Yin H., Lu Q., MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1 Arthritis and Rheumatism 2011 63 5 1376 1386
93. Ballestar E., Esteller M., Richardson B. C., The epigenetic face of systemic lupus erythematosus Journal of Immunology 2006 176 12 7143 7147 (Pubitemid 43849013)
94. Mishra N., Reilly C. M., Brown D. R., Ruiz P., Gilkeson G. S., Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse Journal of Clinical Investigation 2003 111 4 539 552 (Pubitemid 36228011)
95. Reilly C. M., Mishra N., Miller J. M., Joshi D., Ruiz P., Richon V. M., Marks P. A., Gilkeson G. S., Modulation of renal disease in MRL/lpr mice by suberoylanilide hydroxamic acid Journal of Immunology 2004 173 6 4171 4178 (Pubitemid 39280783)
96. Vojinovic J., Damjanov N., D'Urzo C., Furlan A., Susic G., Pasic S., Iagaru N., Stefan M., Dinarello C. A., Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis Arthritis and Rheumatism 2011 63 5 1452 1458
97. Mazari L., Ouarzane M., Zouali M., Subversion of B lymphocyte tolerance by hydralazine, a potential mechanism for drug-induced lupus Proceedings of the National Academy of Sciences of the United States of America 2007 104 15 6317 6322 (Pubitemid 47186092)