메뉴 건너뛰기




Volumn 87, Issue 4, 2011, Pages 199-213

2-Aminophenoxazine-3-one and 2-amino-4,4α-dihydro-4,7-dimethyl-3H-phenoxazine-3-one cause cellular apoptosis by reducing higher intracellular pH in cancer cells

Author keywords

Apoptosis; Cancer cells; Intracellular pH; Phenoxazines

Indexed keywords

2 AMINO 4,4ALPHA DIHYDRO 4ALPHA,7 DIMETHYL 3H PHENOXAZINE 3 ONE; 2-AMINO-4,4ALPHA-DIHYDRO-4ALPHA,7-DIMETHYL-3H-PHENOXAZINE-3-ONE; OXAZINE DERIVATIVE;

EID: 81455156197     PISSN: 03862208     EISSN: 13492896     Source Type: Journal    
DOI: 10.2183/pjab.87.199     Document Type: Article
Times cited : (34)

References (62)
  • 1
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg, O. (1956) On the origin of cancer cells. Science 24, 309-314.
    • (1956) Science , vol.24 , pp. 309-314
    • Warburg, O.1
  • 2
    • 52649107626 scopus 로고    scopus 로고
    • Cancer cell metabolism: Warburg and beyond
    • Hsu, P.P. and Sabatini, D.M. (2008) Cancer cell metabolism: Warburg and beyond. Cell 134, 703-707.
    • (2008) Cell , vol.134 , pp. 703-707
    • Hsu, P.P.1    Sabatini, D.M.2
  • 4
    • 77955458963 scopus 로고    scopus 로고
    • The combination of metformin and 2-deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells
    • Shara, I.B., Tanti, J.-F. and Bust, F. (2010) The combination of metformin and 2-deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells. Autophagy 6, 670-671.
    • (2010) Autophagy , vol.6 , pp. 670-671
    • Shara, I.B.1    Tanti, J.-F.2    Bust, F.3
  • 6
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review
    • Vaupel, P., Kallinowski, F. and Okunieff, P. (1989) Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res. 49, 6449-6465.
    • (1989) Cancer Res , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 7
    • 0014989053 scopus 로고
    • Effects of 2 3-diphosphoglycerate and other organic phosphate compounds on oxygen affinity and intracellular pH of human erythrocytes
    • Duhm, J. (1971) Effects of 2,3-diphosphoglycerate and other organic phosphate compounds on oxygen affinity and intracellular pH of human erythrocytes. Pflugers Arch. 326, 341-356.
    • (1971) Pflugers Arch , vol.326 , pp. 341-356
    • Duhm, J.1
  • 9
    • 0030013044 scopus 로고    scopus 로고
    • The chronic administration of drugs that inhibit the regulation of intracellular pH: in vitro and anti-tumor effects
    • Yamagata, M. and Tannock, I.F. (1996) The chronic administration of drugs that inhibit the regulation of intracellular pH: in vitro and anti-tumor effects. Br. J. Cancer 73, 1328-1334.
    • (1996) Br. J. Cancer , vol.73 , pp. 1328-1334
    • Yamagata, M.1    Tannock, I.F.2
  • 12
    • 0036174658 scopus 로고    scopus 로고
    • The changing face of the NaD/HD exchanger, NHE1: structure, regulation, and cellular actions
    • Putney, L.K., Denker, S.P. and Barber, B.L. (2002) The changing face of the NaD/HD exchanger, NHE1: structure, regulation, and cellular actions. Annu. Rev. Pharmacol. Toxicol. 42, 527-552.
    • (2002) Annu. Rev. Pharmacol. Toxicol. , vol.42 , pp. 527-552
    • Putney, L.K.1    Denker, S.P.2    Barber, B.L.3
  • 13
    • 0030698096 scopus 로고    scopus 로고
    • Role of intracellular pH in proliferation, transformation and apoptosis
    • Shrode, L.D., Tapper, H. and Grinstein, S. (1997) Role of intracellular pH in proliferation, transformation and apoptosis. J. Bioenerg. Biomembr. 29, 393-399.
    • (1997) J. Bioenerg. Biomembr. , vol.29 , pp. 393-399
    • Shrode, L.D.1    Tapper, H.2    Grinstein, S.3
  • 15
    • 0342948633 scopus 로고    scopus 로고
    • Relation between intracellular acidification and camptothecin-induced apoptosis in leukemia cells
    • Goossens, J.F., Henichrt, J.P., Dassonneville, L., Facompre, M. and Bailly, C. (2000) Relation between intracellular acidification and camptothecin-induced apoptosis in leukemia cells. Eur. J. Pharm. Sci. 10, 125-131.
    • (2000) Eur. J. Pharm. Sci. , vol.10 , pp. 125-131
    • Goossens, J.F.1    Henichrt, J.P.2    Dassonneville, L.3    Facompre, M.4    Bailly, C.5
  • 16
    • 0027278822 scopus 로고
    • Etoposide-induced apoptosis in human HL-60 cells is associated with intracellular acidification
    • Barry, M.A., Reynolds, J.E. and Eastman, A. (1993) Etoposide-induced apoptosis in human HL-60 cells is associated with intracellular acidification. Cancer Res. 53, 2349-2357.
    • (1993) Cancer Res , vol.53 , pp. 2349-2357
    • Barry, M.A.1    Reynolds, J.E.2    Eastman, A.3
  • 17
    • 47549104507 scopus 로고    scopus 로고
    • Suppression of the proliferation of cancer cell lines KB-3-1 and K562 cells preceded by a decrease in intracellular pH caused by phenoxazine derivatives
    • Che, X.F., Akiyama, S. and Tomoda, A. (2008) Suppression of the proliferation of cancer cell lines, KB-3-1 and K562 cells preceded by a decrease in intracellular pH caused by phenoxazine derivatives. Oncol. Rep. 19, 1253-1258.
    • (2008) Oncol. Rep. , vol.19 , pp. 1253-1258
    • Che, X.F.1    Akiyama, S.2    Tomoda, A.3
  • 18
    • 0028917643 scopus 로고
    • Intracellular alkalinization suppresses lovastatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease
    • Pérez-Sala, D., Collado-Escobar, D. and Mollinedo, F. (1995) Intracellular alkalinization suppresses lovastatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease. J. Biol. Chem. 270, 6235-6242.
    • (1995) J. Biol. Chem. , vol.270 , pp. 6235-6242
    • Pérez-Sala, D.1    Collado-Escobar, D.2    Mollinedo, F.3
  • 19
    • 0008003709 scopus 로고
    • Intracellular pH and growth control in eukaryotic cells
    • Academic Press, New York
    • Gillies, R.J. (1981) Intracellular pH and growth control in eukaryotic cells. In The Transformed Cell (ed. Cameron, I.L.). Academic Press, New York, pp. 348-382.
    • (1981) The Transformed Cell (ed. Cameron, I.L.) , pp. 348-382
    • Gillies, R.J.1
  • 20
    • 3042551563 scopus 로고    scopus 로고
    • Phenoxazine compounds produced by the reactions with bovine hemoglobin show antimicrobial activity against non-tuberculosis mycobacteria
    • Shimizu, S., Suzuki, M., Tomoda, A., Arai, S., Taguchi, H., Hanawa, T. and Kamiya, S. (2004) Phenoxazine compounds produced by the reactions with bovine hemoglobin show antimicrobial activity against non-tuberculosis mycobacteria. Tohoku J. Exp. Med. 203, 47-52.
    • (2004) Tohoku J. Exp. Med. , vol.203 , pp. 47-52
    • Shimizu, S.1    Suzuki, M.2    Tomoda, A.3    Arai, S.4    Taguchi, H.5    Hanawa, T.6    Kamiya, S.7
  • 21
    • 0035938414 scopus 로고    scopus 로고
    • An improved method for the rapid preparation of 2-amino-4,4,-dihydro-4,7-dimethyl-3H-phenoxazine-3-one, a novel antitumor agent
    • Tomoda, A., Arai, S., Ishida, R., Shimamoto, T. and Ohyashiki, K. (2001) An improved method for the rapid preparation of 2-amino-4,4,-dihydro-4,7-dimethyl-3H-phenoxazine-3-one, a novel antitumor agent. Bioorg. Med. Chem. Lett. 11, 1057-1058.
    • (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 1057-1058
    • Tomoda, A.1    Arai, S.2    Ishida, R.3    Shimamoto, T.4    Ohyashiki, K.5
  • 22
    • 0034906454 scopus 로고    scopus 로고
    • Antitumor effects of a novel phenoxazine derivative on human leukemia cell lines in vitro and in vivo
    • Shimamoto, T., Tomoda, A., Ishida, R. and Ohyashiki, K. (2001) Antitumor effects of a novel phenoxazine derivative on human leukemia cell lines in vitro and in vivo. Clin. Cancer Res. 704, 704-708.
    • (2001) Clin. Cancer Res. , vol.704 , pp. 704-708
    • Shimamoto, T.1    Tomoda, A.2    Ishida, R.3    Ohyashiki, K.4
  • 23
    • 0036323285 scopus 로고    scopus 로고
    • Antitumor activity of a phenoxazine compound, 2-amino-4,4,-dihydro-4,7-dimethyl-3H-phenoxazine-3-one against human B cell and T cell lymphoblastoid cell lines: induction of mixed types of cell death, apoptosis and necrosis
    • Koshibu-Koizumi, J., Akazawa, M., Iwamoto, T., Takasaki, M., Mizuno, F., Kobayashi, R., Abe, A., Tomoda, A., Hamatake, M. and Ishida, R. (2002) Antitumor activity of a phenoxazine compound, 2-amino-4,4,-dihydro-4,7-dimethyl-3H-phenoxazine-3-one against human B cell and T cell lymphoblastoid cell lines: induction of mixed types of cell death, apoptosis and necrosis. J. Cancer Res. Clin. Oncol. 128, 363-368.
    • (2002) J. Cancer Res. Clin. Oncol. , vol.128 , pp. 363-368
    • Koshibu-Koizumi, J.1    Akazawa, M.2    Iwamoto, T.3    Takasaki, M.4    Mizuno, F.5    Kobayashi, R.6    Abe, A.7    Tomoda, A.8    Hamatake, M.9    Ishida, R.10
  • 25
    • 37849034337 scopus 로고    scopus 로고
    • Phenoxazine derivatives induce caspaseindependent cell death in human glioblastoma cell lines A-172 and U-231 MG
    • Shirato, K., Imaizumi, K., Abe, A. and Tomoda, A. (2007) Phenoxazine derivatives induce caspaseindependent cell death in human glioblastoma cell lines, A-172 and U-231 MG. Oncol. Rep. 17, 201-208.
    • (2007) Oncol. Rep. , vol.17 , pp. 201-208
    • Shirato, K.1    Imaizumi, K.2    Abe, A.3    Tomoda, A.4
  • 26
    • 66349110927 scopus 로고    scopus 로고
    • Anticancer effects of phenoxazine derivatives revealed by inhibition of cell growth and viability, disregulation of cell cycle, and apoptosis induction in HTLV-1-positive leukemia cells
    • Miyano-Kurosaki, N., Ikegami, K., Kurosaki, K., Endo, T., Aoyagi, H., Hanami, M., Yasumoto, J. and Tomoda, A. (2009) Anticancer effects of phenoxazine derivatives revealed by inhibition of cell growth and viability, disregulation of cell cycle, and apoptosis induction in HTLV-1-positive leukemia cells. J. Pharmacol. Sci. 110, 87-97.
    • (2009) J. Pharmacol. Sci. , vol.110 , pp. 87-97
    • Miyano-Kurosaki, N.1    Ikegami, K.2    Kurosaki, K.3    Endo, T.4    Aoyagi, H.5    Hanami, M.6    Yasumoto, J.7    Tomoda, A.8
  • 27
    • 77149158781 scopus 로고    scopus 로고
    • 2-Aminophenoxazine-3-one induces cellular apoptosis by causing rapid intracellular acidification and generating reactive oxygen species in human lung adenocarcinoma cells
    • Zheng, C.L., Che, X.F., Akiyama, S., Miyazawa, K. and Tomoda, A. (2010) 2-Aminophenoxazine-3-one induces cellular apoptosis by causing rapid intracellular acidification and generating reactive oxygen species in human lung adenocarcinoma cells. Int. J. Oncol. 36, 641-650.
    • (2010) Int. J. Oncol. , vol.36 , pp. 641-650
    • Zheng, C.L.1    Che, X.F.2    Akiyama, S.3    Miyazawa, K.4    Tomoda, A.5
  • 28
    • 0034652007 scopus 로고    scopus 로고
    • Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the NaD/HD exchanger
    • Rich, I.N., Worthington-White, D., Garden, O.A. and Musk, P. (2000) Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the NaD/HD exchanger. Blood 95, 1427-1434.
    • (2000) Blood , vol.95 , pp. 1427-1434
    • Rich, I.N.1    Worthington-White, D.2    Garden, O.A.3    Musk, P.4
  • 29
    • 0017327949 scopus 로고
    • Glycolysis of red cell suspended in solutions of impermeable solutes: Intracellular pH and glycolysis
    • Tomoda, A., Tsuda-Hirota, S. and Minakami, S. (1977) Glycolysis of red cell suspended in solutions of impermeable solutes: Intracellular pH and glycolysis. J. Biochem. 81, 697-701.
    • (1977) J. Biochem. , vol.81 , pp. 697-701
    • Tomoda, A.1    Tsuda-Hirota, S.2    Minakami, S.3
  • 30
    • 17644433925 scopus 로고
    • Actinomycin D for Wilms's tumor
    • Ward, H.W.C. (1973) Actinomycin D for Wilms's tumor. Br. Med. J. 2, 661.
    • (1973) Br. Med. J. , vol.2 , pp. 661
    • Ward, H.W.C.1
  • 32
    • 77951713348 scopus 로고    scopus 로고
    • Anticancer activity of phenoxazines produced by bovine erythrocytes on colon cancer cells
    • Nakachi, T., Tabuchi, T., Takasaki, A., Arai, S., Miyazawa, K. and Tomoda, A. (2010) Anticancer activity of phenoxazines produced by bovine erythrocytes on colon cancer cells. Oncol. Rep. 23, 1517-1522.
    • (2010) Oncol. Rep. , vol.23 , pp. 1517-1522
    • Nakachi, T.1    Tabuchi, T.2    Takasaki, A.3    Arai, S.4    Miyazawa, K.5    Tomoda, A.6
  • 33
    • 78651367220 scopus 로고    scopus 로고
    • Rapid decrease of intracellular pH associated with inhibition of NaD/HD exchanger precedes apoptotic events in the MNK and MNK74 gastric cancer cell lines treated with 2-aminophenoxazine-3-one
    • Nagata, H., Che, X.-F., Miyazawa, K., Tomoda, A., Konishi, M., Ubukata, H. and Tabuchi, T. (2011) Rapid decrease of intracellular pH associated with inhibition of NaD/HD exchanger precedes apoptotic events in the MNK and MNK74 gastric cancer cell lines treated with 2-aminophenoxazine-3-one. Oncol. Rep. 25, 341-346.
    • (2011) Oncol. Rep. , vol.25 , pp. 341-346
    • Nagata, H.1    Che, X.-F.2    Miyazawa, K.3    Tomoda, A.4    Konishi, M.5    Ubukata, H.6    Tabuchi, T.7
  • 36
    • 21144435075 scopus 로고    scopus 로고
    • 2-Aminophenoxazine-3-one attenuates glucose-induced augmentation of embryonic form of myosin heavy chain, endothelin-1 and plasminogen activator inhibitor-1 in human umbilical vein endothelial cells
    • Fukuda, G., Yoshitake, N., Khan, Z.A., Kanazawa, M., Notoya, Y., Che, X.-F., Akiyama, S., Tomoda, A., Chakrabarti, S. and Odawara, M. (2005) 2-Aminophenoxazine-3-one attenuates glucose-induced augmentation of embryonic form of myosin heavy chain, endothelin-1 and plasminogen activator inhibitor-1 in human umbilical vein endothelial cells. Biol. Pharm. Bull. 28, 797-801.
    • (2005) Biol. Pharm. Bull. , vol.28 , pp. 797-801
    • Fukuda, G.1    Yoshitake, N.2    Khan, Z.A.3    Kanazawa, M.4    Notoya, Y.5    Che, X.-F.6    Akiyama, S.7    Tomoda, A.8    Chakrabarti, S.9    Odawara, M.10
  • 38
    • 19644366708 scopus 로고    scopus 로고
    • Suppression of proliferation of poliovirus and porcine parvovirus by novel phenoxazines, 2-amino-4,4,-dihydro-4,7-dimethyl-3H-phenoxazine-3-one and 3-amino-1,4,-dihydro-4 8-dimethyl-2H-phenoxazine-2-one. Biol
    • Iwata, A., Yamaguchi, T., Sato, K., Yoshitake, N. and Tomoda, A. (2005) Suppression of proliferation of poliovirus and porcine parvovirus by novel phenoxazines, 2-amino-4,4,-dihydro-4,7-dimethyl-3H-phenoxazine-3-one and 3-amino-1,4,-dihydro-4,8-dimethyl-2H-phenoxazine-2-one. Biol. Pharm. Bull. 28, 9905-9907.
    • (2005) Pharm. Bull. , vol.28 , pp. 9905-9907
    • Iwata, A.1    Yamaguchi, T.2    Sato, K.3    Yoshitake, N.4    Tomoda, A.5
  • 39
    • 28944433947 scopus 로고    scopus 로고
    • Clamydia pneumoniae growth inhibition in human monocytic THP-1 cells and human epithelial HEp-2 cells by a novel phenoxazine derivative
    • Uruma, T., Yamaguchi, H., Fukuda, M., Kawakami, H., Goto, H., Kishimoto, T., Yamamoto, Y., Tomoda, A. and Kamiya, S. (2005) Clamydia pneumoniae growth inhibition in human monocytic THP-1 cells and human epithelial HEp-2 cells by a novel phenoxazine derivative. J. Med. Microbiol. 54, 1143-1149.
    • (2005) J. Med. Microbiol. , vol.54 , pp. 1143-1149
    • Uruma, T.1    Yamaguchi, H.2    Fukuda, M.3    Kawakami, H.4    Goto, H.5    Kishimoto, T.6    Yamamoto, Y.7    Tomoda, A.8    Kamiya, S.9
  • 41
    • 0013882352 scopus 로고
    • The effect of active cation transport, pH and inorganic phosphate concentration on erythrocyte glycolysis
    • Minakami, S. and Yoshikawa, H. (1966) The effect of active cation transport, pH and inorganic phosphate concentration on erythrocyte glycolysis. J. Biochem. 59, 145-150.
    • (1966) J. Biochem. , vol.59 , pp. 145-150
    • Minakami, S.1    Yoshikawa, H.2
  • 42
    • 26444434434 scopus 로고    scopus 로고
    • Role of HER-2/neu signaling in sensitivity to tumor necrosis factorrelated apoptosis-inducing ligand: Enhancement of TRAIL-mediated apoptosis by amiloride
    • Kim, K.M. and Lee, Y.J. (2005) Role of HER-2/neu signaling in sensitivity to tumor necrosis factorrelated apoptosis-inducing ligand: Enhancement of TRAIL-mediated apoptosis by amiloride. J. Cell. Biochem. 96, 376-389.
    • (2005) J. Cell. Biochem. , vol.96 , pp. 376-389
    • Kim, K.M.1    Lee, Y.J.2
  • 43
    • 15844401134 scopus 로고
    • Regulation of energy metabolism in normal and tumor tissues
    • Plenum, New York
    • Wenner, C. (1975) Regulation of energy metabolism in normal and tumor tissues. In Cancer: A Comprehensive Treatise (ed. Becker, F.F.). Plenum, New York, pp. 389-403.
    • (1975) Cancer: A Comprehensive Treatise (ed. Becker, F.F.) , pp. 389-403
    • Wenner, C.1
  • 44
    • 0014026436 scopus 로고
    • A role of phosphofructokinase in pH dependent regulation of glycolysis
    • Ui, M. (1966) A role of phosphofructokinase in pH dependent regulation of glycolysis. Biochim. Biophys. Acta 124, 310-322.
    • (1966) Biochim. Biophys. Acta , vol.124 , pp. 310-322
    • Ui, M.1
  • 45
    • 0027477597 scopus 로고
    • Therapeutic intracellular pH as a possible mechanism of tumor selective therapy
    • Maidorn, R.P., Cragoe, E.J. and Tannock, I.F. (1993) Therapeutic intracellular pH as a possible mechanism of tumor selective therapy. Br. J. Cancer 67, 297-303.
    • (1993) Br. J. Cancer , vol.67 , pp. 297-303
    • Maidorn, R.P.1    Cragoe, E.J.2    Tannock, I.F.3
  • 46
    • 0038175031 scopus 로고    scopus 로고
    • Paclitaxel induces apoptosis via protein kinase A- and p38 mitogen-activated proteindependent inhibition of the NaD/HD exchanger (NHE) NHE isoform 1 in human breast cancer cells
    • Reshkin, S.J., Bellizi, A., Cardone, R.A., Tommashino, M., Casavola, V. and Paradiso, A. (2003) Paclitaxel induces apoptosis via protein kinase A- and p38 mitogen-activated proteindependent inhibition of the NaD/HD exchanger (NHE) NHE isoform 1 in human breast cancer cells. Clin. Cancer Res. 9, 2366-2373.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 2366-2373
    • Reshkin, S.J.1    Bellizi, A.2    Cardone, R.A.3    Tommashino, M.4    Casavola, V.5    Paradiso, A.6
  • 47
    • 0034523187 scopus 로고    scopus 로고
    • Mitochondriadependent apoptosis and cellular pH regulation
    • Matsuyama, S. and Reed, J.C. (2000) Mitochondriadependent apoptosis and cellular pH regulation. Cell Death Differ. 7, 1155-1165.
    • (2000) Cell Death Differ , vol.7 , pp. 1155-1165
    • Matsuyama, S.1    Reed, J.C.2
  • 48
    • 0033776271 scopus 로고    scopus 로고
    • Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis
    • Matsuyama, S., Liopis, J., Deveraux, Q.L., Tsien, R.Y. and Reed, J.C. (2000) Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat. Cell Biol. 2, 318-325.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 318-325
    • Matsuyama, S.1    Liopis, J.2    Deveraux, Q.L.3    Tsien, R.Y.4    Reed, J.C.5
  • 49
    • 4544246352 scopus 로고    scopus 로고
    • Alterations of intracellular pH homeostasis in apoptosis: origins and roles
    • Lagadic-Gossmann, D., Hue, L. and Lecureur, V. (2004) Alterations of intracellular pH homeostasis in apoptosis: origins and roles. Cell Death Differ. 11, 953-961.
    • (2004) Cell Death Differ , vol.11 , pp. 953-961
    • Lagadic-Gossmann, D.1    Hue, L.2    Lecureur, V.3
  • 50
    • 37849042569 scopus 로고    scopus 로고
    • Apoptosis induction preceded by mitochondrial depolarization in multiple myeloma cell line U266 by 2-aminophenoxazine-3-one
    • Shirato, K., Imaizumi, K., Miyazawa, K., Takasaki, A., Mizuguchi, J., Che, X.-F., Akiyama, S. and Tomoda, A. (2008) Apoptosis induction preceded by mitochondrial depolarization in multiple myeloma cell line U266 by 2-aminophenoxazine-3-one. Biol. Pharm. Bull. 31, 62-67.
    • (2008) Biol. Pharm. Bull. , vol.31 , pp. 62-67
    • Shirato, K.1    Imaizumi, K.2    Miyazawa, K.3    Takasaki, A.4    Mizuguchi, J.5    Che, X.-F.6    Akiyama, S.7    Tomoda, A.8
  • 51
    • 69249088130 scopus 로고    scopus 로고
    • Mitochondrial depolarization and apoptosis associated with sustained activation of c-jun-N-terminal kinase in the human multiple myeloma cell line U266 induced by 2-aminophenoxazine-3-one
    • Takasaki, A., Hanyu, H., Iwamoto, T., Shirato, K., Izumi, R., Toyota, H., Mizuguchi, J., Miyazawa, K. and Tomoda, A. (2009) Mitochondrial depolarization and apoptosis associated with sustained activation of c-jun-N-terminal kinase in the human multiple myeloma cell line U266 induced by 2-aminophenoxazine-3-one. Mol. Med. Report. 2, 199-203.
    • (2009) Mol. Med. Report. , vol.2 , pp. 199-203
    • Takasaki, A.1    Hanyu, H.2    Iwamoto, T.3    Shirato, K.4    Izumi, R.5    Toyota, H.6    Mizuguchi, J.7    Miyazawa, K.8    Tomoda, A.9
  • 54
    • 1842682286 scopus 로고    scopus 로고
    • The phenoxazine derivative Phx-1 suppresses IgEmediated degranulation in rat basophilic leukemia RBL-2H3 cells
    • Enoki, E., Sada, K., Qu, X., Kyo, S., Miah, S.M.S., Hanani, T., Tomoda, A. and Yamamura, H. (2004) The phenoxazine derivative Phx-1 suppresses IgEmediated degranulation in rat basophilic leukemia RBL-2H3 cells. J. Pharmacol. Sci. 94, 329-333.
    • (2004) J. Pharmacol. Sci. , vol.94 , pp. 329-333
    • Enoki, E.1    Sada, K.2    Qu, X.3    Kyo, S.4    Miah, S.M.S.5    Hanani, T.6    Tomoda, A.7    Yamamura, H.8
  • 57
    • 0023139370 scopus 로고
    • 2,7-Diamino-3,8-dimethylphenazine as the major mutagenic product from the reaction of 2 4-diaminotoluene with hydrogen peroxide
    • Watanabe, T., Ono, M., Hirayama, T. and Fukui, S. (1987) 2,7-Diamino-3,8-dimethylphenazine as the major mutagenic product from the reaction of 2,4-diaminotoluene with hydrogen peroxide. Mutat. Res. 190, 113-117.
    • (1987) Mutat. Res. , vol.190 , pp. 113-117
    • Watanabe, T.1    Ono, M.2    Hirayama, T.3    Fukui, S.4
  • 58
    • 0021205089 scopus 로고
    • Involvement of oxidoreactive reactions of intracellular haemoglobin in the metabolism of 3-hydroxyanthranilic acid in human erythrocytes
    • Tomoda, A., Shirasawa, E., Nagano, S., Minami, M. and Yoneyama, Y. (1984) Involvement of oxidoreactive reactions of intracellular haemoglobin in the metabolism of 3-hydroxyanthranilic acid in human erythrocytes. Biochem. J. 222, 755-760.
    • (1984) Biochem. J. , vol.222 , pp. 755-760
    • Tomoda, A.1    Shirasawa, E.2    Nagano, S.3    Minami, M.4    Yoneyama, Y.5
  • 59
    • 0023095424 scopus 로고
    • Oxidative reactivity of the tryptophan metabolites 3-hydroxyanthranilate, cinnabarinate, quinolinate and picolinate
    • Dykens, J., Sullivan, S.G. and Stern, A. (1987) Oxidative reactivity of the tryptophan metabolites 3-hydroxyanthranilate, cinnabarinate, quinolinate and picolinate. Biochem. Pharmacol. 36, 211-217.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 211-217
    • Dykens, J.1    Sullivan, S.G.2    Stern, A.3
  • 60
    • 0016315511 scopus 로고
    • Actinomycin. Chemistry and mechanism of action
    • Hollstein, U. (1974) Actinomycin. Chemistry and mechanism of action. Chem. Rev. 74, 625-652.
    • (1974) Chem. Rev , vol.74 , pp. 625-652
    • Hollstein, U.1
  • 61
    • 0033783095 scopus 로고    scopus 로고
    • Antitumor activity of 2-amino-4,4,-dihydro-4 7-dimethyl-3H-phenoxazine-3-one against Meth A tumor transplanted into BALB/c mice
    • Mori, H., Honda, K., Ishida, R., Nohira, T. and Tomoda, A. (2000) Antitumor activity of 2-amino-4,4,-dihydro-4,7-dimethyl-3H-phenoxazine-3-one against Meth A tumor transplanted into BALB/c mice. Anticancer Drugs 11, 653-657.
    • (2000) Anticancer Drugs , vol.11 , pp. 653-657
    • Mori, H.1    Honda, K.2    Ishida, R.3    Nohira, T.4    Tomoda, A.5
  • 62
    • 0024379967 scopus 로고
    • Acid pH in tumors and its potential for therapeutic exploitation
    • Tannock, I.F. and Rotin, D. (1989) Acid pH in tumors and its potential for therapeutic exploitation. Cancer Res. 49, 4373-4384.
    • (1989) Cancer Res , vol.49 , pp. 4373-4384
    • Tannock, I.F.1    Rotin, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.