Dihydrotestosterone inhibits interleukin-1α or tumor necrosis factor α-induced proinflammatory cytokine production via androgen receptor-dependent inhibition of nuclear factor-κB activation in rheumatoid fibroblast-like synovial cell line

Biological and Pharmaceutical Bulletin

Volumn 34, Issue 11, 2011, Pages 1724-1730

  Xu, Jian ^a   Itoh, Yuka ^a   Hayashi, Hidetoshi ^a   Takii, Takemasa ^a   Miyazawa, Keiji ^b   Onozaki, Kikuo ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b KISSEI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Androgen; Interleukin 1 ; Interleukin 8; Rheumatoid arthritis; Synoviocyte; Tumor necrosis factor

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL STRAIN MH7A; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE; HUMAN; HUMAN CELL; IL 8 GENE; INHIBITION KINETICS; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; TRANSCRIPTION INITIATION;

ANDROGENS; ARTHRITIS, RHEUMATOID; CELL LINE; DIHYDROTESTOSTERONE; FEMALE; FIBROBLASTS; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1ALPHA; INTERLEUKIN-8; INTERLEUKINS; MALE; NF-KAPPA B; RECEPTORS, ANDROGEN; RNA, MESSENGER; SYNOVIAL FLUID; TRANSCRIPTIONAL ACTIVATION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 81455149501     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.34.1724     Document Type: Article

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