Engineering of bone marrow cells with fas-ligand proteinenhances donor-specific tolerance to solid organs

Transplantation Proceedings

Volumn 43, Issue 9, 2011, Pages 3545-3548

  Askenasy, E M ^a   Shushlav, Y ^a   Sun, Z ^b   Shirwan, H ^b   Yolcu, E S ^b   Askenasy, N ^a  

^a SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^b University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUSULFAN; FAS LIGAND;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CHIMERA; CONFERENCE PAPER; CONTROLLED STUDY; GRAFT SURVIVAL; HEART GRAFT; IMMUNOLOGICAL TOLERANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION; RAT; SKIN ALLOGRAFT; SKIN TRANSPLANTATION; SOLID ORGAN TRANSPLANTATION; TRANSPLANTATION; VASCULARIZATION;

ANIMALS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CHIMERISM; FAS LIGAND PROTEIN; GRAFT VS HOST DISEASE; HEART TRANSPLANTATION; IMMUNE SYSTEM; IMMUNE TOLERANCE; LYMPHOCYTES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; RATS; RATS, INBRED F344; RATS, INBRED LEW; SKIN TRANSPLANTATION; TRANSPLANTATION TOLERANCE;

EID: 81455132550     PISSN: 00411345     EISSN: 18732623     Source Type: Journal    
DOI: 10.1016/j.transproceed.2011.08.046     Document Type: Conference Paper

References (30)

1. O. Bohana-Kashtan, and C.I. Civin Fas ligand as a tool for immunosuppression and generation of immune tolerance Stem Cells 22 2004 908
2. N. Askenasy, E.S. Yolcu, and I. Yaniv Fas-ligand as a double-edged immunomodulator to induce transplantation tolerance Blood 105 2005 1396
3. H. Matsue, K. Matsue, and M. Walters Induction of antigen-specific immunosuppression by CD95L cDNA-transfected "killer" dendritic cells Nat Med 5 1999 930
4. H.G. Zhang, X. Su, and D. Liu Induction of specific T cell tolerance by Fas ligand-expressing antigen-presenting cells J Immunol 162 1999 1423
5. W.P. Min, R. Gorczynski, and X.Y. Huang Dendritic cells genetically engineered to express Fas ligand induce donor-specific hyporesponsiveness and prolong allograft survival J Immunol 164 2000 161
6. E.S. Yolcu, X. Gu, and C. Lacelle Induction of tolerance to cardiac allografts using donor splenocytes engineered to display on their surface an exogenous fas ligand protein J Immunol 181 2008 931
7. M. Pearl-Yafe, E.S. Yolcu, and J. Stein Expression of Fas and Fas-ligand in donor hematopoietic stem and progenitor cells is dissociated from the sensitivity to apoptosis Exp Hematol 35 2007 1601
8. M. Pearl-Yafe, J. Stein, and E.S. Yolcu Fas transduces dual apoptotic and trophic signals in hematopoietic progenitors Stem Cells 25 2007 3194
9. M. Pearl-Yafe, E.S. Yolcu, and J. Stein Fas ligand enhances hematopoietic cell engraftment through abrogation of alloimmune responses and nonimmunogenic interactions Stem Cells 25 2007 1448
10. E.S. Yolcu, N. Askenasy, and N.P. Singh Cell membrane modification for rapid display of proteins as a novel means of immunomodulation: FasL-decorated cells prevent islet graft rejection Immunity 17 2002 795
11. N.P. Singh, E.S. Yolcu, and N. Askenasy ProtEx™: a novel technology to display exogenous proteins on the cell surface for immunomodulation Ann N Y Acad Sci 1056 2005 344
12. N. Askenasy, H. Shirwan, and Z. Wang Cardiac allograft acceptance after localized bone marrow transplantation by isolated limb perfusion in non-myeloablated recipients Stem Cells 21 2003 200
13. N. Askenasy Localized bone marrow transplantation leads to skin allograft acceptance in non- myeloablated recipients: comparison of intra-bone marrow and isolated limb perfusion Stem Cells 20 2002 86
14. J.S. Gammie, and S.M. Pham Simultaneous donor bone marrow and cardiac transplantation: can tolerance be induced with the development of chimerism? Curr Opin Cardiol 14 1999 126
15. K.Y. Chiang, and H.M. Lazarus Should we be performing more combined hematopoietic stem cell plus solid organ transplants? Bone Marrow Transplant 31 2003 633
16. I. Yaniv, S. Ash, and D.L. Farkas Consideration of strategies for hematopoietic cell transplantation J Autoimmun 33 2009 255
17. N. Askenasy, E. Yolcu, and Z. Wang Display of Fas-ligand protein on cardiac vasculature as a novel means of regulating allograft rejection Circulation 107 2003 1525
18. M. Pearl-Yafe, E.S. Yolcu, and I. Yaniv The dual role of Fas-ligand as an injury effector and defense strategy in diabetes and islet transplantation BioEssays 28 2006 211
19. A. Kaminitz, K. Mizrahi, and I. Yaniv Low levels of allogeneic but not syngeneic hematopoietic chimerism reverse autoimmune insulitis in prediabetic NOD mice J Autoimmun 33 2009 83
20. M.B. Baker, N.H. Altman, and E.R. Podack The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice J Exp Med 183 1996 2645
21. M.B. Baker, R.L. Riley, and E.R. Podack Graft-versus-host-disease- associated lymphoid hypoplasia and B cell dysfunction is dependent upon donor T cell-mediated Fas-ligand function, but not perforin function Proc Natl Acad Sci USA 94 1997 1366
22. Z. Jiang, E. Podack, and R.B. Levy Major histocompatibility complex-mismatched allogeneic bone marrow transplantation using perforin and/or Fas ligand double-defective CD4(+) donor T cells: involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host disease pathogenesis Blood 98 2001 390
23. T. Iwasaki, T. Hamano, and K. Saheki Effect of graft-versus-host disease (GVHD) on host hematopoietic progenitor cells is mediated by Fas-Fas ligand interactions but this does not explain the effect of GVHD on donor cells Cell Immunol 197 1999 30
24. D.R. Goldstein, J.M. Thomas, and J.K. Kirklin Indefinite allograft survival mediated by donor bone marrow is dependent on the presence of a functional CD95 (Fas) gene in recipients J Heart Lung Transplant 20 2001 1132
25. J.F. George, S.D. Sweeney, and J.K. Kirklin An essential role for Fas ligand in transplantation tolerance induced by donor bone marrow Nat Med 4 1998 333
26. D.R. Goldstein, T. Chang, and S.D. Sweeney Enhanced allograft survival induced by posttransplant donor spleen cell infusion occurs via a mechanism that is distinct from the mechanism of enhancement by donor bone marrow Transplantation 69 2000 1020
27. Y. Itabashi, S. Narumi, and K. Hakamada Allogeneic chimerism established with a mixture of low dose bone marrow cells and splenocytes in sublethally irradiated mice Transpl Immunol 10 2002 25
28. Y. Jin, Q. Zhang, and J. Hao Simultaneous administration of a low-dose mixture of donor bone marrow cells and splenocytes plus adenovirus containing the CTLA4Ig gene result in stable mixed chimerism and long-term survival of cardiac allograft in rats Immunology 110 2003 275
29. A. Kaminitz, K. Mizrahi, and I. Yaniv Immunosuppressive therapy exacerbates autoimmunity in NOD mice and diminishes the protective activity of regulatory T cells J Autoimmun 35 2010 145
30. E.M. Askenasy, N. Askenasy, and J.J. Askenasy Does lymphopenia preclude restoration of immune homeostasis? The particular case of type 1 diabetes Autoimmun Rev 9 2010 687