Mechanism of butyrate-induced hyperpolarization of cultured rat myenteric neurones

Neurogastroenterology and Motility

Volumn 16, Issue 5, 2004, Pages 597-604

  Hamodeh, S A ^a   Rehn, M ^a   Haschke, G ^a,b   Diener, M ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

Ca2+ release; K+ channels; Myenteric plexus (rat); Ryanodine receptors; Short chain fatty acids

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; BUTYRIC ACID; CALCIUM ACTIVATED POTASSIUM CHANNEL; CHARYBDOTOXIN; COLLAGENASE; FURA 2; HEPARIN; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; PHOSPHOLIPASE C; RECEPTOR BLOCKING AGENT; RUTHENIUM RED; RYANODINE RECEPTOR; SAPONIN; SHORT CHAIN FATTY ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL PERMEABILIZATION; ENZYME METABOLISM; HYPERPOLARIZATION; MYENTERIC PLEXUS; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SECOND MESSENGER;

ANIMALS; BUTYRATES; CALCIUM; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; INTESTINE, SMALL; MEMBRANE POTENTIALS; MYENTERIC PLEXUS; NEURONS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; RATS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL;

EID: 8144222937     PISSN: 13501925     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2004.00545.x     Document Type: Article

References (30)

1. Wood JD. Physiology of the enteric nervous system. In: Johnson LR, ed. Physiology of the Gastrointestinal Tract, 3rd edn. New York: Raven Press, 1994: 423-82.
2. Willard A. A vasoactive intestinal peptide-like cotransmitter at cholinergic synapses between rat myenteric neurons in cell culture. J Neurosci 1990; 100: 1025-34.
3. Baidan LV, Zholos AV, Wood JD. Modulation of calcium currents by G-proteins and adenosine receptors in myenteric neurones cultured from adult guinea-pig small intestine. Br J Pharmacol 1995; 116: 1882-6.
4. Schäfer KH, Saffrey MJ, Burnstock G, Mestres-Ventura P. A new method for the isolation of myenteric plexus from the newborn rat gastrointestinal tract. Brain Res Protoc 1997; 1: 109-13.
5. 2+ concentration in cultured rat myenteric neurons. Neurogastroenterol Motil 2002; 14: 133-42.
6. Bugaut M. Occurrence, absorption and metabolism of short chain fatty acids in the digestive tract of mammals. Comp Biochem Physiol 1987; 86B; 439-72.
7. von Engelhardt W, Rechkemmer G. Absorption of inorganic ions and short-chain fatty acids in the colon of mammals. In: Gilles-Baillien M, Gilles R, eds. Intestinal Transport Heidelberg: Springer, 1983: 26-45.
8. Mathews AG, Sutton AL, Scheidt AB, Patterson AJ, Kelly DT, Meyerholtz KA. Effect of galactan on selected microbial populations and pH and volatile fatty acids in the ileum of the weanling pig. J Anim Sci 1993; 71: 1503-9.
9. Neunlist M, Dobreva G, Schemann M. Characteristics of mucosally projecting myenteric neurones in the guinea-pig proximal colon. J Physiol (Lond) 1999; 517: 533-46.
10. Brown DA, Goldsworthy SM, Barnes AA et al. The orphan G protein-coupled receptor GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem 2003; 278: 1131-9.
11. Le Poul E, Loison C, Strufy S et al. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem 2003; 278: 23481-9.
12. Schulz I. Permeabilizing cells: some methods and applications for the study of intracellular processes. Methods Enzymol 1990; 192: 280-300.
13. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985; 260: 3440-50.
14. Cook NS, Quast U. Potassium channel pharmacology. In: Cook NS, ed. Potassium Channels. Structure, Classification, Function and Therapeutic Potential New York: Ellis Horwood, 1990: 181-255.
15. 2+ signalling: problems and pitfalls. Trends Pharmacol Sci 1998; 19: 370-5.
16. Bultynck G, Sienaert I, Parys JB et al. Pharmacology of inositol trisphosphate receptors. Pflügers Arch Eur J Physiol 2003; 445: 629-42.
17. Franzini-Amstrong C, Protasi F. Ryanodine receptors of striated muscles: a complex channel capable of multiple interactions. Physiol Rev 1997; 77: 699-729.
18. Kirichok Y, Krapivinsky G, Clapham DE. The mitochondrial calcium uniporter is a highly selective ion channel. Nature 2004; 427: 360-4.
19. 2+ uptake regulates the excitability of myenteric neurons. J Neurosci 2002; 22: 6962-71.
20. + channels. Effects of channel gating, voltage, and ionic strength. J Gen Physiol 1988; 91: 317-33.
21. - current in cultured myenteric neurons from murine proximal colon. Am J Physiol Cell Physiol 2003; 284: C839-47.
22. Rehn M, Hübschle T, Diener M. TNF-α hyperpolarises membrane potential and potentiates the response to nicotinic receptor stimulation in cultured rat myenteric neurons. Acta Physiol Scand 2004; 181: 13-22.
23. Sorrentino V. The ryanodine receptor family of intracellular calcium release channels. Adv Pharmacol 1996; 33: 67-90.
24. Lee HC. A unified mechanism of enzymatic synthesis of two calcium messengers: cyclic ADP-ribose and NAADP. Biol Chem 1999; 380: 785-93.
25. 2+ signalling in mouse submandibular acinar cells. Biochem J 2001; 353: 555-60.
26. Hillsley K, Kenyon JL, Smith TK. Ryanodine-sensitive stores regulate the excitability of AH neurons in the myenteric plexus of guinea-pig ileum. J Neurophysiol 2000; 84: 2777-85.
27. Vernia P, Gnaedinger A, Hauck W, Breuer RI. Organic anions and the diarrhea of inflammatory bowel disease. Dig Dis Sci 1988; 33: 1353-8.
28. Holtug K, Clausen MR, Hove H, Christiansen J, Mortensen PB. The colon in carbohydrate malabsorption: short-chain fatty acids, pH and omotic diarrhoea. Scand J Gastroenterol 1992; 27: 545-52.
29. Ramakrishna BS, Mathan VI. Colonic dysfunction in acute diarrhoea: the role of luminal short chain fatty acids. Gut 1993; 34: 1215-8.
30. i transients in HT29 cells. Pflügers Arch Eur J Physiol 1997; 434: 466-74.