Disclosure of a pro-apoptotic glyceraldehyde-3-phosphate dehydrogenase promoter: Anti-dementia drugs depress its activation in apoptosis

Life Sciences

Volumn 74, Issue 26, 2004, Pages 3245-3258

  Tsuchiya, Katsumi ^a   Tajima, Hisao ^b   Yamada, Mitsunori ^c   Takahashi, Hitoshi ^c   Kuwae, Toyoyasu ^a   Sunaga, Katsuyoshi ^a   Katsube, Nobuo ^b   Ishitani, Ryoichi ^a  

^a JOSAI UNIVERSITY   (Japan)

^b ONO PHARMACEUTICAL CO   (Japan)

^c NIIGATA UNIVERSITY   (Japan)

Author keywords

Alzheimer's disease; Anti dementia drugs; Apoptosis; GAPDH; Nuclear aggregates; Promoter

Indexed keywords

CYTARABINE; DNA FRAGMENT; DONEPEZIL; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE (NADP); LUCIFERASE; MESSENGER RNA; NOOTROPIC AGENT; SELEGILINE; TACRINE;

ADULT; AGED; ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN REGION; CELL CULTURE; CEREBELLUM; CONTROLLED STUDY; DEMENTIA; ENZYME ACTIVITY; FEMALE; GENE ACTIVITY; GENE CONSTRUCT; GENE CONTROL; GENE DELETION; GENE EXPRESSION REGULATION; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MOLECULAR CLONING; MUTATIONAL ANALYSIS; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN EXPRESSION; RAT; REPORTER GENE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANIMALS; APOPTOSIS; CELL NUCLEUS; CELLS, CULTURED; CEREBELLUM; CLONING, MOLECULAR; CYTARABINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMANS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NOOTROPIC AGENTS; PREFRONTAL CORTEX; PROMOTER REGIONS (GENETICS); RATS; TRANSFECTION;

EID: 8144219547     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2003.11.029     Document Type: Article

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