Current challenges for the creation of effective vaccines against drugs of abuse

Expert Review of Vaccines

Volumn 10, Issue 12, 2011, Pages 1637-1639

  Moreno, Amira Y ^a   Janda, Kim D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

adjuvant; cocaine; drug addiction; hapten; heroin; nicotine; vaccine

Indexed keywords

CANNABIS; COCAINE; COCAINE VACCINE; DIAMORPHINE; NICOTINE VACCINE; PLACEBO; PSYCHEDELIC AGENT; UNCLASSIFIED DRUG; VACCINE; VARENICLINE; WART VIRUS VACCINE;

COCAINE DEPENDENCE; DISEASE SEVERITY; DRUG DEPENDENCE; DRUG FORMULARY; DRUG SAFETY; EUPHORIA; HUMAN; IMMUNOGENICITY; MENTAL DISEASE; NEUROLOGIC DISEASE; NONHUMAN; PLEASURE; PRIORITY JOURNAL; REHABILITATION CARE; REVIEW; TOBACCO DEPENDENCE;

CLINICAL TRIALS AS TOPIC; COCAINE; HAPTENS; HUMANS; STREET DRUGS; SUBSTANCE-RELATED DISORDERS; VACCINATION; VACCINES;

EID: 81355134869     PISSN: 14760584     EISSN: 17448395     Source Type: Journal    
DOI: 10.1586/erv.11.145     Document Type: Review

References (12)

1. Pleis JR, Ward BW, Lucas JW. Summary health statistics for U.S. adults: National health interview survey, 2009. National Center for Health Statistics. Vital Health Stat. 10(249), 1-207 (2010).
2. US Substance Abuse and Mental Health Services Administration. Results from the 2010 National Survey on Drug Use and Health: Summary of National Findings NSDUH Series H-41 HHS Publication No. (SMA) 11-4658 (2011).
3. McLellan AT, Lewis DC, O'Brian CP, Kleber H. Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation. J. Am. Med. Assoc. 284(13), 1689-1695 (2000).
4. Jorenby DE, Hays JT, Rigotti NA et al. Efficacy of varenicline, an a4b2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial. J. Am. Med. Assoc. 296, 56-63 (2006).
5. Hatsukami DK, Jorenby D, Gonzales D et al. Immunogenicity and smokingcessation outcomes for a novel nicotine immunotherapeutic. Clin. Pharmacol. Ther. 89(3), 392-399 (2011).
6. Martell BA, Orson FM, Poling J et al. Cocaine vaccine for the treament of cocaine dependence in methadonemaintained patients: a randomized, doubleblind, placebo-controlled efficacy trial. Arch. Gen. Psychiat. 66(10), 1116-1123 (2009).
7. Carrera MR, Ashley JA, Wirsching P, Koob GF, Janda KD. A second-generation vaccine protects against the psychoactive effects of cocaine. Proc. Natl Acad. Sci. 98, 1988-1992 (2001). (Pubitemid 32165610)
8. Stowe GN, Vendruscolo LF, Edwards S et al. A vaccine strategy that induces protective immunity against heroin. J. Med. Chem. 54(14), 5195-5204 (2011).
9. Meijler MM, Matsushita H, Atobell LJ, Wirshing P, Janda KD. A new strategy for improved nicotine vaccines using conformationally constrained haptens. J. Am. Chem. Soc. 125, 7164-7165 (2003). (Pubitemid 36798951)
10. Moreno AY, Mayorov AV, Janda KD. Impact of distinct chemical structures for the development of a methamphetamine vaccine. J. Am. Chem. Soc. 133(17), 6587-6595 (2011).
11. Duryee MJ, Bevins RA, Reichel CM et al. Immune response to methamphetamine by active immunization with peptide-based, molecular adjuvant-containing vaccines. Vaccine 27, 2981-2988 (2009).
12. Carroll FI, Blough BE, Pidaparthi RR et al. Synthesis of mercapto-(+)- methamphetamine haptens and their use for obtaining improved epitope density on (+)-methamphetamine conjugate vaccines. J. Med. Chem. 54(14), 5221-5228 (2011).