Acoustic characterization of echogenic liposomes: Frequency-dependent attenuation and backscatter

Journal of the Acoustical Society of America

Volumn 130, Issue 5, 2011, Pages 3472-3481

  Kopechek, Jonathan A ^a   Haworth, Kevin J ^b   Raymond, Jason L ^a   Douglas Mast, T ^a   Perrin Jr , Stephen R ^a   Klegerman, Melvin E ^c   Huang, Shaoling ^c   Porter, Tyrone M ^d   McPherson, David D ^c   Holland, Christy K ^b  

^a 705 Engineering Research Center   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^d Boston University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACOUSTIC CHARACTERIZATION; ATTENUATION COEFFICIENT; BACKSCATTER COEFFICIENTS; BLOOD FLOW; DETECTION AND DIAGNOSIS; ECHOGENIC LIPOSOMES; ENHANCED CONTRAST; EXPERIMENTAL METHODS; FREQUENCY-DEPENDENT ATTENUATION; IMAGE CONTRASTS; INTRAVASCULAR ULTRASOUND; POLYDISPERSES; POLYSTYRENE MICRO-SPHERE; PULSE-ECHO TECHNIQUE; SCATTERING PROPERTY; THEORETICAL VALUES; ULTRASOUND CONTRAST AGENT; ULTRASOUND IMAGING; ULTRASOUND PARAMETERS;

IMAGE SEGMENTATION; LIPOSOMES; PHOSPHOLIPIDS; POLYDISPERSITY; POLYSTYRENES; ULTRASONIC IMAGING; ULTRASONICS;

BACKSCATTERING;

CONTRAST MEDIUM; LIPOSOME; MICROSPHERE; POLYSTYRENE DERIVATIVE;

ARTICLE; ELASTICITY; ENDOSCOPIC ECHOGRAPHY; INSTRUMENTATION; PARTICLE SIZE; PRESSURE; PRESSURE TRANSDUCER; RADIATION SCATTERING; REPRODUCIBILITY; SIGNAL PROCESSING; THEORETICAL MODEL; ULTRASOUND;

CONTRAST MEDIA; ELASTICITY; LIPOSOMES; MICROSPHERES; MODELS, THEORETICAL; PARTICLE SIZE; POLYSTYRENES; PRESSURE; REPRODUCIBILITY OF RESULTS; SCATTERING, RADIATION; SIGNAL PROCESSING, COMPUTER-ASSISTED; TRANSDUCERS, PRESSURE; ULTRASONICS; ULTRASONOGRAPHY, INTERVENTIONAL;

EID: 81355133041     PISSN: 00014966     EISSN: None     Source Type: Journal    
DOI: 10.1121/1.3626124     Document Type: Article

References (72)

1. S. Vaina and C. Stefanadis, Detection of the vulnerable coronary atheromatous plaque. Where are we now?, Int. J. Cardiovasc. Intervent. 7, 75-87 (2005). (Pubitemid 41190678)
2. A. D. Bangham, M. M. Standish, and J. C. Watkins, Diffusion of univalent ions across the lamellae of swollen phospholipids., J. Mol. Biol. 13, 238-252 (1965).
3. S. M. Demos, H. Alkan-Onyuksel, B. J. Kane, K. Ramani, A. Nagaraj, R. Greene, M. Klegerman, and D. D. McPherson, In vivo targeting of acoustically reflective liposomes for intravascular and transvascular ultrasonic enhancement., J. Am. Coll. Cardiol. 33, 867-875 (1999).
4. A. J. Hamilton, S. L. Huang, D. Warnick, M. Rabbat, B. Kane, A. Nagaraj, M. Klegerman, and D. D. McPherson, Intravascular ultrasound molecular imaging of atheroma components in vivo., J. Am. Coll. Cardiol. 43, 453-460 (2004). (Pubitemid 38167708)
5. H. Alkan-Onyuksel, S. M. Demos, G. M. Lanza, M. J. Vonesh, M. E. Klegerman, B. J. Kane, J. Kuszak, and D. D. McPherson, Development of inherently echogenic liposomes as an ultrasonic contrast agent., J. Pharm. Sci. 85, 486-490 (1996). (Pubitemid 26150981)
6. H. Alkan-Onyuksel, S. M. Demos, B. Kane, D. D. Mcpherson, and R. C. MacDonald, Echogenic immunoliposomes as an ultrasound imaging agent., in ICAST Proceedings (1996), pp. 40-47.
7. S. L. Huang, A. J. Hamilton, A. Nagaraj, S. D. Tiukinhoy, M. E. Klegerman, D. D. McPherson, and R. C. Macdonald, Improving ultrasound reflectivity and stability of echogenic liposomal dispersions for use as targeted ultrasound contrast agents., J. Pharm. Sci. 90, 1917-1926 (2001). (Pubitemid 33144437)
8. S. L. Huang, A. J. Hamilton, E. Pozharski, A. Nagaraj, M. E. Klegerman, D. D. McPherson, and R. C. MacDonald, Physical correlates of the ultrasonic reflectivity of lipid dispersions suitable as diagnostic contrast agents., Ultrasound Med. Biol. 28, 339-348 (2002). (Pubitemid 34308914)
9. F. J. Martin and T. D. Heath, Covalent attachment of proteins to liposomes., in Liposomes: A Practical Approach, edited by, N. RRC, (IRL Press, New York, 1990), Chap..
10. J. P. Leonetti, P. Machy, G. Degols, B. Lebleu and L. Leserman, Antibody-targeted liposomes containing oligodeoxyribonucleotides complementary to viral RNA selectively inhibit viral replication., Proc. Natl. Acad. Sci. U.S.A. 87, 2448-2451 (1990).
11. M. E. Klegerman, Y. Zou, and D. D. McPherson, Fibrin targeting of echogenic liposomes with inactivated tissue plasminogen activator., J. Liposome Res. 18, 95-112 (2008). (Pubitemid 351874104)
12. G. M. Lanza, K. D. Wallace, M. J. Scott, W. P. Cacheris, D. R. Abendschein, D. H. Christy, A. M. Sharkey, J. G. Miller, P. J. Gaffney, and S. A. Wickline, A novel site-targeted ultrasonic contrast agent with broad biomedical application., Circulation 94, 3334-3340 (1996). (Pubitemid 26427506)
13. G. M. Lanza, D. R. Abendschein, C. S. Hall, M. J. Scott, D. E. Scherrer, A. Houseman, J. G. Miller, and S. A. Wickline, In vivo molecular imaging of stretch-induced tissue factor in carotid arteries with ligand-targeted nanoparticles., J. Am. Soc. Echocardiogr. 13, 608-614 (2000). (Pubitemid 30418897)
14. E. C. Unger, P. J. Lund, D. K. Shen, T. A. Fritz, D. Yellowhair, and T. E. New, Nitrogen-filled liposomes as a vascular US contrast agent: Preliminary evaluation., Radiology 185, 453-456 (1992).
15. E. C. Unger, T. P. McCreery, R. H. Sweitzer, D. Shen, and G. Wu, In vitro studies of a new thrombus-specific ultrasound contrast agent., Am. J. Cardiol. 81, 58G-61G (1998). (Pubitemid 28309282)
16. N. De Jong, M. Emmer, A. van Wamel, and M. Versluis, Ultrasonic characterization of ultrasound contrast agents., Med. Biol. Eng. Comput. 47, 861-873 (2009).
17. C. X. Deng and F. L. Lizzi, A review of physical phenomena associated with ultrasonic contrast agents and illustrative clinical applications., Ultrasound Med. Biol. 28, 277-286 (2002). (Pubitemid 34326386)
18. R. A. Sigelman and J. A. Reid, Analysis and measurement of ultrasound backscattering from an ensemble of scatterers excited by sine-wave bursts., J. Acoust. Soc. Am. 53, 1351-1355 (1973).
19. L. Hoff, Acoustic Characterization of Contrast Agents for Medical Ultrasound Imaging (Kluwer Academic Publishers, Norwell, MA, 2001), pp. 89-141.
20. A. Bouakaz, N. De Jong, and C. Cachard, Standard properties of ultrasound contrast agents., Ultrasound Med. Biol. 24, 469-472 (1998). (Pubitemid 28164837)
21. P. J. Frinking and N. De Jong, Acoustic modeling of shell-encapsulated gas bubbles., Ultrasound Med. Biol. 24, 523-533 (1998). (Pubitemid 28252448)
22. S. Kaul, Myocardial contrast echocardiography: a 25-year retrospective., Circulation 118, 291-308 (2008).
23. S. L. Huang, D. D. McPherson, and R. C. Macdonald, A method to co-encapsulate gas and drugs in liposomes for ultrasound-controlled drug delivery., Ultrasound Med. Biol. 34, 1272-1280 (2008). (Pubitemid 352010460)
24. S. L. Huang, P. H. Kee, H. Kim, M. R. Moody, S. M. Chrzanowski, R. C. Macdonald, and D. D. McPherson, Nitric oxide-loaded echogenic liposomes for nitric oxide delivery and inhibition of intimal hyperplasia., J. Am. Coll. Cardiol. 54, 652-659 (2009).
25. G. L. Britton, H. Kim, P. H. Kee, J. Aronowski, C. K. Holland, D. D. McPherson, and S. L. Huang, In vivo therapeutic gas delivery for neuroprotection with echogenic liposomes., Circulation 122, 1578-1587 (2010).
26. J. J. Faran, Jr., Sound Scattering by Solid Cylinders and Spheres., J. Acoust. Soc. Am. 23, 405-418 (1951).
27. C. S. Hall, J. N. Marsh, M. S. Hughes, J. Mobley, K. D. Wallace, J. G. Miller, and G. H. Brandenburger, Broadband measurements of the attenuation coefficient and backscatter coefficient for suspensions: A potential calibration tool., J. Acoust. Soc. Am. 101, 1162-1171 (1997). (Pubitemid 27079899)
28. A. Hamilton, S. L. Huang, D. Warnick, A. Stein, M. Rabbat, T. Madhav, B. Kane, A. Nagaraj, M. Klegerman, R. MacDonald, and D. McPherson, Left ventricular thrombus enhancement after intravenous injection of echogenic immunoliposomes: Studies in a new experimental model., Circulation 105, 2772-2778 (2002). (Pubitemid 34615150)
29. I. Buttino, G. De Rosa, Y. Carotenuto, A. Ianora, A. Fontana, F. Quaglia, M. I. La Rotonda, and A. Miralto, Giant liposomes as delivery system for ecophysiological studies in copepods., J. Exp. Bio. 209, 801-809 (2006).
30. J. Guan and T. J. Matula, Using light scattering to measure the response of individual ultrasound contrast microbubbles subjected to pulsed ultrasound in vitro., J. Acoust. Soc. Am. 116, 2832-2842 (2004). (Pubitemid 39575532)
31. M. E. Klegerman, M. Wassler, S. L. Huang, Y. Zou, H. Kim, H. S. Shelat, C. K. Holland, Y. J. Geng, and D. D. McPherson, Liposomal modular complexes for simultaneous targeted delivery of bioactive gases and therapeutics., J. Control. Release 142, 326-331 (2010).
32. G. Korpanty, S. Chen, R. V. Shohet, J. Ding, B. Yang, P. A. Frenkel, and P. A. Grayburn, Targeting of VEGF-mediated angiogenesis to rat myocardium using ultrasonic destruction of microbubbles., Gene Therapy 12, 1305-1312 (2005). (Pubitemid 43084486)
33. J. Kotynska and Z. A. Figaszewski, Adsorption equilibria between liposome membrane formed of phosphatidylcholine and aqueous sodium chloride solution as a function of pH., Biochim. Biophys. Acta 1720, 22-27 (2006).
34. H. Takeuchi, Y. Matsui, H. Yamamoto, and Y. Kawashima, Mucoadhesive properties of carbopol or chitosan-coated liposomes and their effectiveness in the oral administration of calcitonin to rats., J. Control. Release 86, 235-242 (2003). (Pubitemid 36084273)
35. Z. Xing, H. Ke, J. Wang, B. Zhao, X. Yue, Z. Dai and J. Liu, Novel ultrasound contrast agent based on microbubbles generated from surfactant mixtures of Span 60 and polyoxyethylene 40 stearate., Acta Biomater. 6, 3542-3549 (2010).
36. K. D. Buchanan, S. Huang, H. Kim, R. C. Macdonald, and D. D. McPherson, Echogenic liposome compositions for increased retention of ultrasound reflectivity at physiologic temperature., J. Pharm. Sci. 97, 2242-2249 (2008).
37. A. Bouakaz, M. Versluis, and N. De Jong, High-speed optical observations of contrast agent destruction., Ultrasound Med. Biol. 31, 391-399 (2005). (Pubitemid 40327228)
38. D. A. Smith, T. M. Porter, J. Martinez, S. Huang, R. C. MacDonald, D. D. McPherson, and C. K. Holland, Destruction thresholds of echogenic liposomes with clinical diagnostic ultrasound., Ultrasound Med. Biol. 33, 797-809 (2007). (Pubitemid 46654545)
39. J. E. Chomas, P. Dayton, J. Allen, K. Morgan, and K. W. Ferrara, Mechanisms of contrast agent destruction., IEEE Trans. Ultrason. Ferroelectr. Freq. Control 48, 232-248 (2001). (Pubitemid 32191199)
40. C. C. Coussios, C. K. Holland, L. Jakubowska, S. L. Huang, R. C. MacDonald, A. Nagaraj, and D. D. McPherson, In vitro characterization of liposomes and Optison by acoustic scattering at 3.5 MHz., Ultrasound Med. Biol. 30, 181-190 (2004). (Pubitemid 38293270)
41. J. N. Marsh, M. S. Hughes, C. S. Hall, S. H. Lewis, R. L. Trousil, H. Levene, and J. G. Miller, Frequency and concentration dependence of the backscatter coefficient of the ultrasound contrast agent Albunex., J. Acoust. Soc. Am. 104, 1654-1666 (1998).
42. X. Chen, D. Phillips, K. Q. Schwarz, J. G. Mottley, and K. J. Parker, The measurement of backscatter coefficient from a broadband pulse-echo system: a new formulation., IEEE Trans. Ultrason. Ferroelectr. Freq. Control 44, 515-525 (1997). (Pubitemid 127771236)
43. J. N. Marsh, M. S. Hughes, G. H. Brandenburger, and J. G. Miller, Broadband measurement of the scattering-to-attenuation ratio for Albunex at 37 degrees C., Ultrasound Med. Biol. 25, 1321-1324 (1999). (Pubitemid 29465805)
44. R. Hickling, Analysis of echoes from a solid elastic sphere in water., J. Acoust. Soc. Am. 34, 1582-1592 (1962).
45. A. E. Hay and A. S. Schaafsma, Resonance scattering in suspensions., J. Acoust. Soc. Am. 85, 1124-1138 (1989).
46. A. D. Pierce, Acoustics: An Introduction to its Physical Principles and Applications (Acoustical Society of America, Melville, NY, 1989), p. 428.
47. A. E. Hay and D. G. Mercer, On the theory of sound scattering and viscous absorption in aqueous suspensions at medium and short wavelengths., J. Acoust. Soc. Am. 78, 1761-1771 (1985).
48. D. S. Hughes, E. B. Blankenship, and R. L. Mims, Variation of elastic moduli and wave velocity with pressure and temperature in plastics., J. Appl. Phys. 21, 294-297 (1950).
49. J. A. Rinde, Poisson's ratio for rigid plastic foams., J. Appl. Polym. Sci. 14, 1913-1926 (1970).
50. C. C. Church, The effects of an elastic solid surface layer on the radial pulsations of gas bubbles., J. Acoust. Soc. Am. 97, 1510-1521 (1995).
51. D. E. Goertz, N. De Jong, and A. F. van der Steen, Attenuation and size distribution measurements of Definity and manipulated Definity populations., Ultrasound Med. Biol. 33, 1376-1388 (2007). (Pubitemid 47302197)
52. J. Miones, Jr., J. M. Rodrguez Patino, O. Conde, C. Carrera, and R. Seoane, The effect of polar groups on structural characteristics of phospholipid monolayers spread at the air-water interface., Colloids Surf. A: Physicochem. Eng. Aspects 203, 273-286 (2002). (Pubitemid 34224864)
53. T. T. Jansson, T. D. Mast, and R. C. Waag, Measurements of differential scattering cross section using a ring transducer., J. Acoust. Soc. Am. 103, 3169-3179 (1998). (Pubitemid 28274938)
54. N. De Jong and L. Hoff, Ultrasound scattering properties of Albunex microspheres., Ultrasonics 31, 175-181 (1993).
55. K. Sarkar, W. T. Shi, D. Chatterjee, and F. Forsberg, Characterization of ultrasound contrast microbubbles using in vitro experiments and viscous and viscoelastic interface models for encapsulation., J. Acoust. Soc. Am. 118, 539-550 (2005). (Pubitemid 40981508)
56. L. Hoff, P. C. Sontum and J. M. Hovem, Oscillations of polymeric microbubbles: effect of the encapsulating shell., J. Acoust. Soc. Am. 107, 2272-2280 (2000). (Pubitemid 30194382)
57. C. Greis, Technology overview: SonoVue (Bracco, Milan)., Eur. Radiol. 14, 11-15 (2004).
58. S. L. Huang and R. C. MacDonald, Acoustically active liposomes for drug encapsulation and ultrasound-triggered release., Biochim. Biophys. Acta 1665, 134-141 (2004). (Pubitemid 39303578)
59. S. Datta, C. C. Coussios, A. Y. Ammi, T. D. Mast, G. M. de Courten-Myers, and C. K. Holland, Ultrasound-enhanced thrombolysis using Definity as a cavitation nucleation agent., Ultrasound Med. Biol. 34, 1421-1433 (2008).
60. W. T. Shi, F. Forsberg, A. Tornes, J. Ostensen, and B. B. Goldberg, Destruction of contrast microbubbles and the association with inertial cavitation., Ultrasound Med. Biol. 26, 1009-1019 (2000).
61. M. D. Santin, D. A. King, J. Foiret, A. Haak, W. D. O'Brien, Jr., and S. L. Bridal, Encapsulated contrast microbubble radial oscillation associated with postexcitation pressure peaks., J. Acoust. Soc. Am. 127, 1156-1164 (2010).
62. K. E. Hitchcock and C. K. Holland, Ultrasound-assisted thrombolysis for stroke therapy: Better thrombus break-up with bubbles., Stroke 41, S50-S53 (2010).
63. S. Datta, C. C. Coussios, L. E. McAdory, J. Tan, T. Porter, G. De Courten-Myers, and C. K. Holland, Correlation of cavitation with ultrasound enhancement of thrombolysis., Ultrasound Med. Biol. 32, 1257-1267 (2006). (Pubitemid 44093792)
64. G. A. Husseini, M. A. Diaz de la Rosa, E. S. Richardson, D. A. Christensen, and W. G. Pitt, The role of cavitation in acoustically activated drug delivery., J. Control. Release 107, 253-261 (2005). (Pubitemid 41316288)
65. N. McDannold, N. Vykhodtseva, and K. Hynynen, Targeted disruption of the blood-brain barrier with focused ultrasound: Association with cavitation activity., Phys. Med. Biol. 51, 793-807 (2006).
66. Y. Zhou, J. Cui, and C. X. Deng, Dynamics of sonoporation correlated with acoustic cavitation activities., Biophys. J. 94, L51-L53 (2008).
67. K. E. Hitchcock, D. N. Caudell, J. T. Sutton, M. E. Klegerman, D. Vela, G. J. Pyne-Geithman, T. Abruzzo, P. E. Cyr, Y. J. Geng, D. D. McPherson, and C. K. Holland, Ultrasound-enhanced delivery of targeted echogenic liposomes in a novel ex vivo mouse aorta model., J. Control. Release 144, 288-295 (2010).
68. C. K. Holland and D. D. McPherson, Echogenic Lipsomes for Targeted Drug Delivery., Proc. IEEE Int. Symp. Biomed. Imaging 2009, 755-758 (2009).
69. G. J. Shaw, J. M. Meunier, S. L. Huang, C. J. Lindsell, D. D. McPherson, and C. K. Holland, Ultrasound-enhanced thrombolysis with tPA-loaded echogenic liposomes., Thromb. Res. 124 (3), 306-310 (2009).
70. D. A. Smith, S. S. Vaidya, J. A. Kopechek, S. L. Huang, M. E. Klegerman, D. D. McPherson, and C. K. Holland, Ultrasound-triggered release of recombinant tissue-type plasminogen activator from echogenic liposomes., Ultrasound. Med. Biol. 36, 145-157 (2010).
71. J. A. Kopechek, T. M. Abruzzo, B. Wang, S. M. Chrzanowski, D. A. Smith, P. H. Kee, S. Huang, J. H. Collier, D. D. McPherson, and C. K. Holland, Ultrasound-mediated release of hydrophilic and lipophilic agents from echogenic liposomes., J. Ultrasound. Med. 27, 1597-1606 (2008).
72. S. L. Huang, Liposomes in ultrasonic drug and gene delivery., Adv. Drug Deliv. Rev. 60, 1167-1176 (2008).