Echogenic lipsomes for targeted drug delivery

Proceedings - 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009

Volumn , Issue , 2009, Pages 755-758

  Holland, Christy K ^a   McPherson, David D ^b  

^a University of Cincinnati   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACOUSTIC PRESSURES; BIO-EFFECTS; CONTRAST AGENT; ECHOGENIC; ECHOGENIC LIPOSOMES; IMMUNOLIPOSOMES; IN-VITRO; MECHANISTIC STUDIES; SONOTHROMBOLYSIS; STABLE CAVITATION; TARGETED DRUG DELIVERY; THROMBOLYSIS; TIME VARYING; TISSUE PLASMINOGEN ACTIVATOR; ULTRASOUND ENHANCED THROMBOLYSIS; ULTRASOUND FIELDS;

ACOUSTIC WAVES; BUBBLES (IN FLUIDS); CAVITATION; LIPOSOMES; PHOSPHOLIPIDS; STRATEGIC PLANNING; ULTRASONIC IMAGING; ULTRASONICS;

CONTROLLED DRUG DELIVERY;

EID: 70449344428     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/ISBI.2009.5193159     Document Type: Conference Paper

References (23)

1. A. D. Bangham, M. M. Standish, and J. C. Watkins, "Diffusion of univalent ions across the lamellae of swollen phospholipids," Journal of Molecular Biology, vol. 13, pp. 238-252, 1965.
2. H. Alkan-Onyuksel, S. M. Demos, G. M. Lanza, M. J. Vonesh, M. E. Klegerman, B. J. Kane, J. Kuszak, and D. D. McPherson, "Development of inherently echogenic liposomes as an ultrasonic contrast agent," Journal of Pharmaceutical Sciences, vol. 85, pp. 486-490, 1996.
3. S. L. Huang, A. J. Hamilton, A. Nagaraj, S. D. Tiukinhoy, M. E. Klegerman, D. D. McPherson, and R. C. Macdonald, "Improving ultrasound reflectivity and stability of echogenic liposomal dispersions for use as targeted ultrasound contrast agents," Journal of Pharmaceutical Sciences, vol. 90, pp. 1917-1926, 2001.
4. H. Alkan-Onyuksel, S. M. Demos, B. Kane, D. D. McPherson, M. E. Klegerman, and "Echogenic immunoliposomes as an ultrasound imaging agent," ICAST Proceedings, pp. 40-7, 1996.
5. S. L. Huang, A. J. Hamilton, E. Pozharski, A. Nagaraj, M. E. Klegerman, D. D. McPherson, and R. C. MacDonald, "Physical correlates of the ultrasonic reflectivity of lipid dispersions suitable as diagnostic contrast agents," Ultrasound in Medicine and Biology, vol. 28, pp. 339-348, 2002b.
6. F. J. Martin and T. D. Heath, "Covalent attachment of proteins to liposomes," in Liposomes: a practical approach, N. RRC, Ed. New York: IRL Press, 1990.
7. J. Leonetti, P. Machy, G. Degols, B. Lebleu, and L. Leserman, "Antibody-Targeted Lipsomes Containing Oligodeoxyribonucleotides Complementary to Viral RNA Selectively Inhibit Viral Replication," Proceedings of the National Academy of Sciences, vol. 87, pp. 2448-2451, April 1, 1990 1990.
8. A. Hamilton, M. Rabbat, P. Jain, N. Belkind, S. L. Huang, A. Nagaraj, M. Klegerman, R. Macdonald, and D. D. McPherson, "A physiologic flow chamber model to define intravascular ultrasound enhancement of fibrin using echogenic liposomes," Investigative Radiology, vol. 37, pp. 215-221, 2002.
9. G. M. Lanza, K. D. Wallace, M. J. Scott, W. P. Cacheris, D. R. Abendschein, D. H. Christy, A. M. Sharkey, J. G. Miller, P. J. Gaffney, and S. A. Wickline, "A novel site-targeted ultrasonic contrast agent with broad biomedical application," Circulation, vol. 94, pp. 3334-3340, 1996.
10. G. M. Lanza, D. R. Abendschein, C. S. Hall, M. J. Scott, D. E. Scherrer, A. Houseman, J. G. Miller, and S. A. Wickline, "In vivo molecular imaging of stretch-induced tissue factor in carotid arteries with ligand-targeted nanoparticles," Journal of the American Society of Echocardiography, vol. 13, pp. 608-614, 2000.
11. E. C. Unger, T. P. McCreery, R. H. Sweitzer, D. Shen, and G. Wu, "In vitro studies of a new thrombus-specific ultrasound contrast agent," American Journal of Cardiology, vol. 81, pp. 58G-61G, 1998.
12. E. C. Unger, P. J. Lund, D. K. Shen, T. A. Fritz, D. Yellowhair, and T. E. New, "Nitrogen-filled liposomes as a vascular US contrast agent: Preliminary evaluation," Radiology, vol. 185, pp. 453-456, 1992.
13. D. R. Groothuis, "The blood-brain and blood-tumor barriers: A review of strategies for increasing drug delivery," Neuro-oncol, vol. 2, pp. 45-59, January 1, 2000 2000.
14. D. S. Eccleston, M. C. Horrigan, and S. G. Ellis, "Rationale for local drug delivery," Seminars in interventional cardiology : SIIC, vol. 1, pp. 8-16, 1996.
15. K. E. Hitchcock, J. T. Sutton, D. N. Caudell, G. J. Pyne-Geithman, M. E. Klegerman, S. Huang, D. Vela, D. D. McPherson, and C. K. Holland, "Delivery of targeted echogenic liposomes in an exvivo mouse aorta model," J Acoust Soc Am, vol. 125, p. 2713, 2009.
16. C. K. Holland, S. S. Vaidya, S. Datta, C. C. Coussios, and G. J. Shaw, "Ultrasoundenhanced tissue plasminogen activator thrombolysis in an in vitro porcine clot model," Thromb Res, vol. 121, pp. 663-73, 2008.
17. J. M. Meunier, C. K. Holland, C. J. Lindsell, and G. J. Shaw, "Duty Cycle Dependence of Ultrasound Enhanced Thrombolysis in a Human Clot Model," Ultrasound in Medicine and Biology, vol. 33, pp. 576-583, 2007a.
18. S. Datta, C. C. Coussios, L. E. McAdory, J. Tan, T. Porter, G. De Courten-Myers, and C. K. Holland, "Correlation of cavitation with ultrasound enhancement of thrombolysis," Ultrasound in Medicine and Biology, vol. 32, pp. 1257-1267, 2006.
19. S. Datta, C.-C. Coussios, A. Y. Ammi, T. D. Mast, G. M. de Courten-Myers, and C. K. Holland, "Ultrasound-enhanced thrombolysis using Definity® as a cavitation nucleation agent," Ultrasound in medicine & biology, vol. In Press, 2008.
20. D. A. B. Smith, S. Vaidya, J. A. Kopechek, K. E. Hitchcock, S. L. Huang, D. D. McPherson, and C. K. Holland, "Echogenic liposomes loaded with recombinant tissue-type plasminogen activatory (rt-PA) for image-guided, ultrasound-triggered drug release," Journal of the Acoustical Society of America, vol. 122, p. 3007, 2007b.
21. S. D. Tiukinhoy-Laing, K. Buchanan, D. Parikh, S. Huang, R. C. Macdonald, D. D. McPherson, and M. E. Klegerman, "Fibrin targeting of tissue plasminogen activatorloaded echogenic liposomes," Journal of Drug Targeting, vol. 15, pp. 109-114, 2007a.
22. M. E. Klegerman, Y. Zou, and D. D. McPherson, "Fibrin-targeting of echogenic liposomes with inactivated tissue plasminogen activator," J Liposome Res, p. In press, 2008a.
23. G. J. Shaw, J. M. Meunier, S. L. Huang, C. J. Lindsell, D. D. McPherson, and C. K. Holland, "Ultrasound-enhanced thrombolysis with tPA-loaded echogenic liposomes," Thromb Res, In Press, 2009.