Iron overload: What is the role of public health?

American Journal of Preventive Medicine

Volumn 41, Issue 6 SUPPL.4, 2011, Pages

  Hulihan, Mary M ^a   Sayers, Cindy A ^a   Grosse, Scott D ^a   Garrison, Cheryl ^b   Grant, Althea M ^a  

^a NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES   (United States)

^b Iron Disorders Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; FERROPORTIN 1; HEMOJUVELIN; HEPCIDIN; IRON; PROTON PUMP INHIBITOR; TRANSFERRIN RECEPTOR 2;

ALCOHOL LIVER DISEASE; ARTHROPATHY; ARTICLE; COST EFFECTIVENESS ANALYSIS; DEGENERATIVE DISEASE; EARLY DIAGNOSIS; FERRITIN BLOOD LEVEL; FOOD INTAKE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; HEALTH EDUCATION; HEMOCHROMATOSIS; HEPATITIS C; HUMAN; IRON INTAKE; IRON OVERLOAD; MOLECULAR GENETICS; MORBIDITY; MORTALITY; PHLEBOTOMY; PORPHYRIA CUTANEA TARDA; PUBLIC HEALTH; QUALITY OF LIFE; SELF REPORT; SICKLE CELL ANEMIA;

EID: 81355124013     PISSN: 07493797     EISSN: 18732607     Source Type: Journal    
DOI: 10.1016/j.amepre.2011.09.020     Document Type: Review

References (42)

1. EASL clinical practice guidelines for HFE hemochromatosis J Hepatol 53 2010 3 22
2. L.C. Gurrin, N.A. Bertalli, and G.W. Dalton HFE C282Y/H63D compound heterozygotes are at low risk of hemochromatosis-related morbidity Hepatology 50 2009 94 101
3. K.K. Steinberg, M.E. Cogswell, and J.C. Chang Prevalence of C282Y and H63D mutations in the hemochromatosis (HFE) gene in the United States JAMA 285 2001 2216 2222 (Pubitemid 32416767)
4. M.A. van Bokhoven, C.T. van Deursen, and D.W. Swinkels Diagnosis and management of hereditary haemochromatosis BMJ 342 2011 c7251
5. J. Waalen, B.G. Nordestgaard, and E. Beutler The penetrance of hereditary hemochromatosis Best Pract Res Clin Haematol 18 2005 203 220 (Pubitemid 40298365)
6. E.P. Whitlock, B.A. Garlitz, and E.L. Harris Screening for hereditary hemochromatosis: a systematic review for the U.S. Preventive Services Task Force Ann Intern Med 145 2006 209 223 (Pubitemid 46780566)
7. K.J. Allen, L.C. Gurrin, and C.C. Constantine Iron-overload-related disease in HFE hereditary hemochromatosis N Engl J Med 358 2008 221 230
8. G. Willis, J.Z. Wimperis, and K.C. Smith Haemochromatosis gene C282Y homozygotes in an elderly male population Lancet 354 1999 221 222 (Pubitemid 29329167)
9. M.O. Van Aken, A.J. De Craen, and J. Gussekloo No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85-plus study Eur J Clin Invest 32 2002 750 754 (Pubitemid 35334970)
10. P.C. Adams, D.M. Reboussin, and J.C. Barton Hemochromatosis and iron-overload screening in a racially diverse population N Engl J Med 352 2005 1769 1778 (Pubitemid 40570925)
11. L.R. Zacharski, D.L. Ornstein, and S. Woloshin Association of age, sex, and race with body iron stores in adults: analysis of NHANES III data Am Heart J 140 2000 98 104 (Pubitemid 30471247)
12. L.R. Zacharski, B.K. Chow, and P.S. Howes Reduction of iron stores and cardiovascular outcomes in patients with peripheral arterial disease: a randomized controlled trial JAMA 297 2007 603 610
13. J.L. Sullivan Iron and the sex difference in heart disease risk Lancet 1 1981 1293 1294 (Pubitemid 11111356)
14. L.R. Zacharski, B.K. Chow, and P.S. Howes Decreased cancer risk after iron reduction in patients with peripheral arterial disease: results from a randomized trial J Natl Cancer Inst 100 2008 996 1002 (Pubitemid 352019800)
15. L.C. Gurrin, N.J. Osborne, and C.C. Constantine The natural history of serum iron indices for HFE C282Y homozygosity associated with hereditary hemochromatosis Gastroenterology 135 2008 1945 1952
16. G.J. Carroll, W.H. Breidahl, and M.K. Bulsara Hereditary hemochromatosis is characterized by a clinically definable arthropathy that correlates with iron load Arthritis Rheum 63 2011 286 294
17. J.C. Barton Chelation therapy for iron overload Curr Gastroenterol Rep 9 2007 74 82 (Pubitemid 46487028)
18. P. Phatak, P. Brissot, and M. Wurster A phase 1/2, dose-escalation trial of deferasirox for the treatment of iron overload in HFE-related hereditary hemochromatosis Hepatology 52 2010 1671 1679
19. J.C. Barton, S.M. McDonnell, and P.C. Adams Management of hemochromatosis Hemochromatosis Management Working Group Ann Intern Med 129 1998 932 939
20. G. Papanikolaou, M.E. Samuels, and E.H. Ludwig Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis Nat Genet 36 2004 77 82 (Pubitemid 38056211)
21. A. Roetto, G. Papanikolaou, and M. Politou Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis Nat Genet 33 2003 21 22 (Pubitemid 36068676)
22. C. Camaschella, A. Roetto, and A. Cali The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22 Nat Genet 25 2000 14 15 (Pubitemid 30257027)
23. O.T. Njajou, N. Vaessen, and M. Joosse A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis Nat Genet 28 2001 213 214 (Pubitemid 32626019)
24. G. Montosi, A. Donovan, and A. Totaro Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene J Clin Invest 108 2001 619 623 (Pubitemid 32777742)
25. J. Kato, K. Fujikawa, and M. Kanda A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload Am J Hum Genet 69 2001 191 197 (Pubitemid 32614030)
26. V.R. Gordeuk, D.M. Reboussin, and C.E. McLaren Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population Am J Hematol 83 2008 618 626
27. P.B. Walter, P. Harmatz, and E. Vichinsky Iron metabolism and iron chelation in sickle cell disease Acta Haematol 122 2009 174 183
28. J. Gao, N. Zhao, and M.D. Knutson The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells J Biol Chem 283 2008 21462 21468
29. B. Benyamin, M.A. Ferreira, and G. Willemsen Common variants in TMPRSS6 are associated with iron status and erythrocyte volume Nat Genet 41 2009 1173 1175
30. R.T. Acton, B.M. Snively, and J.C. Barton A genome-wide linkage scan for iron phenotype quantitative trait loci: the HEIRS Family Study Clin Genet 71 2007 518 529 (Pubitemid 46831946)
31. J.C. Barton, C. Leiendecker-Foster, and H. Li HAMP promoter mutation nc.-153C>T in 785 HEIRS Study participants Haematologica 94 2009 1465 1466
32. J.K. Olynyk, D.J. Cullen, and S. Aquilia A population-based study of the clinical expression of the hemochromatosis gene N Engl J Med 341 1999 718 724 (Pubitemid 29407371)
33. A.G. Mainous III, B.J. Wells, and C.J. Everett Association of ferritin and lipids with C-reactive protein Am J Cardiol 93 2004 559 562 (Pubitemid 38293058)
34. J. Waalen, V. Felitti, and T. Gelbart Prevalence of hemochromatosis- related symptoms among individuals with mutations in the HFE gene Mayo Clin Proc 77 2002 522 530 (Pubitemid 34587340)
35. G.D. McLaren, C.E. McLaren, and P.C. Adams Clinical manifestations of hemochromatosis in HFE C282Y homozygotes identified by screening Can J Gastroenterol 22 2008 923 930
36. P.D. Phatak, H.L. Bonkovsky, and K.V. Kowdley Hereditary hemochromatosis: time for targeted screening Ann Intern Med 149 2008 270 272
37. E.M. Jacobs, J.C. Hendriks, and C.T. van Deursen Severity of iron overload of proband determines serum ferritin levels in families with HFE-related hemochromatosis: the HEmochromatosis FAmily Study J Hepatol 50 2009 174 183
38. E.M. Jacobs, J.C. Hendriks, and J.J. Marx Morbidity and mortality in first-degree relatives of C282Y homozygous probands with clinically detected haemochromatosis compared with the general population: the HEmochromatosis FAmily Study (HEFAS) Neth J Med 65 2007 425 433
39. W.H. Rogowski The cost-effectiveness of screening for hereditary hemochromatosis in Germany: a remodeling study Med Decis Making 29 2009 224 238
40. M.A. Hall, J.C. Barton, and P.C. Adams Genetic screening for iron overload: no evidence of discrimination at 1 year J Fam Pract 56 2007 829 834 (Pubitemid 350072156)
41. N.J. Shaheen, L.B. Lawrence, and B.R. Bacon Insurance, employment, and psychosocial consequences of a diagnosis of hereditary hemochromatosis in subjects without end organ damage Am J Gastroenterol 98 2003 1175 1180 (Pubitemid 36733784)
42. P.R. Billings, C. Barash, and L.N. Geller Screening for hemochromatosis N Engl J Med 329 1993 2037 2038