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Volumn 86, Issue 6, 2011, Pages 436-443

Protective effect of L-carnitine on experimental lead toxicity in rats: A clinical, histopathological and immunohistochemical study

Author keywords

Hematology; Histopathology; Immunohistochemistry; L carnitine; Lead toxicity; Rat

Indexed keywords

CARNITINE; ENZYME; LEAD ACETATE; ORGANOMETALLIC COMPOUND; SUPEROXIDE DISMUTASE;

EID: 81255205048     PISSN: 10520295     EISSN: 14737760     Source Type: Journal    
DOI: 10.3109/10520295.2010.529825     Document Type: Article
Times cited : (30)

References (38)
  • 1
    • 0032798931 scopus 로고    scopus 로고
    • Lead intoxication: Antioxidant defenses and oxidative damage in rat brain
    • DOI 10.1016/S0300-483X(99)00051-7, PII S0300483X99000517
    • Adonaylo VN, Oteiza PI (1999) Lead intoxication: antioxidant defenses and oxidative damage in rat brain. Toxicology 135: 77-85. (Pubitemid 29333237)
    • (1999) Toxicology , vol.135 , Issue.2-3 , pp. 77-85
    • Adonaylo, V.N.1    Oteiza, P.I.2
  • 3
    • 0002498916 scopus 로고    scopus 로고
    • Kidney
    • Haschek WM, Ed 2nd ed. Academic Press, San Diego, CA
    • Alden CL, Khan KNM (2002) Kidney. In: Haschek WM, Ed. Handbook of Toxicologic Pathology , vol. 2. 2nd ed. Academic Press, San Diego, CA. pp. 255-336.
    • (2002) Handbook of Toxicologic Pathology , vol.2 , pp. 255-336
    • Alden, C.L.1    Khan, K.N.M.2
  • 4
    • 0026690988 scopus 로고
    • Carnitine and its acyl esters as secondary antioxidants?
    • Arduini A (1992) Carnitine and its acyl esters as secondary antioxidants? Am. Heart J. 123: 1726-1727.
    • (1992) Am Heart J. , vol.123 , pp. 1726-1727
    • Arduini, A.1
  • 5
    • 0034769470 scopus 로고    scopus 로고
    • Carnitine as a free radical scavenger in aging
    • DOI 10.1016/S0531-5565(01)00116-4, PII S0531556501001164
    • Arockia Rani PJ, Panneerselvam C (2001) L-carnitine as a free radical scavenger in aging. Exp. Gerontol . 36: 1713-1726. (Pubitemid 32982875)
    • (2001) Experimental Gerontology , vol.36 , Issue.10 , pp. 1713-1726
    • Arockia Rani, P.J.1    Panneerselvam, C.2
  • 6
    • 72149124486 scopus 로고    scopus 로고
    • Oxidative stress and immuno toxic effects of lead and their amelioration with myrrh (Commiphora molmol)emulsion
    • Ashry KM, El-Sayed YS, Khamiss RM, El-Ashmawy IM (2010) Oxidative stress and immuno toxic effects of lead and their amelioration with myrrh ( Commiphora molmol ) emulsion. Food Chem. Toxicol . 48: 236-241.
    • (2010) Food Chem. Toxicol. , vol.48 , pp. 236-241
    • Ashry, K.M.1    El-Sayed, Y.S.2    Khamiss, R.M.3    El-Ashmawy, I.M.4
  • 7
    • 0032585748 scopus 로고    scopus 로고
    • Fumosin B1-induced DNA damage in rat liver and spleen: Effect of pretreatment with coenzyme Q10, L-carnitine, a-tocoferol and selenium
    • Atroshi F, Rizzo A, Biese L, Veijalainen P, Saloniemi H, Sankari S, Andersson K (1999) Fumosin B1-induced DNA damage in rat liver and spleen: effect of pretreatment with coenzyme Q10, L-carnitine, a-tocoferol and selenium. Pharm. Res . 40: 459-467.
    • (1999) Pharm. Res. , vol.40 , pp. 459-467
    • Atroshi, F.1    Rizzo, A.2    Biese, L.3    Veijalainen, P.4    Saloniemi, H.5    Sankari, S.6    Andersson, K.7
  • 8
    • 0035976362 scopus 로고    scopus 로고
    • Neuroprotective role of L-carnitine in the 3-nitropropionic acid induced neurotoxicity
    • DOI 10.1016/S0378-4274(01)00415-5, PII S0378427401004155
    • Binienda ZK, Ali SF (2001) Neuroprotective role of Lcarnitine in the 3-nitropropionic acid induced neurotoxicity. Toxicol. Lett . 125: 67-73. (Pubitemid 33043756)
    • (2001) Toxicology Letters , vol.125 , Issue.1-3 , pp. 67-73
    • Binienda, Z.K.1    Ali, S.F.2
  • 10
    • 0020376142 scopus 로고
    • Carnitine, carnitine acyltransferases, and rat brain function
    • DOI 10.1016/0014-4886(82)90047-4
    • Bresolin N, Freddo L, Vergani L, Angelini C (1982) Carnitine, carnitine acyltransferases, and rat brain function. Exp. Neurol . 78: 285-292. (Pubitemid 13253620)
    • (1982) Experimental Neurology , vol.78 , Issue.2 , pp. 285-292
    • Bresolin, N.1    Freddo, L.2    Vergani, L.3    Angelini, C.4
  • 11
    • 0018776894 scopus 로고
    • Hydroperoxide metabolism in mammalian organs
    • Chance B, Sies H, Boveris A (1979) Hydroperoxide metabolism in mammalian organs. Physiol. Rev. 59: 527-605. (Pubitemid 9236599)
    • (1979) Physiological Reviews , vol.59 , Issue.3 , pp. 527-605
    • Chance, B.1    Sies, H.2    Boveris, A.3
  • 13
    • 0036715482 scopus 로고    scopus 로고
    • L-Carnitine inhibits cisplatin-induced injury of the kidney and small intestine
    • DOI 10.1016/S0003-9861(02)00342-9, PII S0003986102003429
    • Chang B , Nishikawa M , Sato E , Utsumi K , Inoue M (2002) L-Carnitine inhibits cisplatin-induced injury of the kidney and small intestine. Arch. Biochem. Biophys. 405: 55-64. (Pubitemid 35026166)
    • (2002) Archives of Biochemistry and Biophysics , vol.405 , Issue.1 , pp. 55-64
    • Chang, B.1    Nishikawa, M.2    Sato, E.3    Utsumi, K.4    Inoue, M.5
  • 15
    • 0038327890 scopus 로고    scopus 로고
    • Beneficial effect of combined administration of some naturally occurring antioxidants (vitamins) and thiol chelators in the treatment of chronic lead intoxication
    • DOI 10.1016/S0009-2797(03)00025-5
    • Flora SJ, Pande M, Mehta A (2003) Beneficial effect of combined administration of some naturally occurring antioxidants (vitamins) and thiol chelators in the treatment of chronic lead intoxication. Chem. Biol. Interact . 145: 267-280. (Pubitemid 36549111)
    • (2003) Chemico-Biological Interactions , vol.145 , Issue.3 , pp. 267-280
    • Flora, S.J.S.1    Pande, M.2    Mehta, A.3
  • 17
    • 0028643643 scopus 로고
    • Hydroxyl radicals, iron, oxidative stress, and neurodegeneration
    • Gutteridge JMC (1995) Hydroxyl radicals, iron, oxidative stress, and neurodegeneration. Ann. NY Acad. Sci. 738: 201-213.
    • (1995) Ann. NY Acad. Sci. , vol.738 , pp. 201-213
    • Jmc, G.1
  • 18
    • 0021351203 scopus 로고
    • Oxygen toxicity, oxygen radicals, transition metals and disease
    • Halliwell B, Gutteridge JMC (1984) Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem. J. 219: 1.
    • (1984) Biochem. J. , vol.219 , pp. 1
    • Halliwell, B.1    Gutteridge, J.M.C.2
  • 19
    • 0020961009 scopus 로고    scopus 로고
    • Extra-neural lesions in experimental lead toxicosis of dogs
    • Hamir AN, Sullivan ND (2008) Extra-neural lesions in experimental lead toxicosis of dogs. J. Small Anim. Pract. 24: 437-444.
    • (2008) J. Small Anim. Pract. , vol.24 , pp. 437-444
    • Hamir, A.N.1    Sullivan, N.D.2
  • 21
    • 0035004676 scopus 로고    scopus 로고
    • Effect of carnitine on stress-induced lipid peroxidation in rat gastric mucosa
    • DOI 10.1007/s005350170108
    • Izg ü t-Uysal VN, Aga ç A, Derin N (2001) Effect of carnitine on stress-induced lipid peroxidation in rat gastric mucosa. J. Gastroenterol. 36: 231-236. (Pubitemid 32427787)
    • (2001) Journal of Gastroenterology , vol.36 , Issue.4 , pp. 231-236
    • Izgut-Uysal, V.N.1    Agac, A.2    Derin, N.3
  • 22
    • 0032844857 scopus 로고    scopus 로고
    • Histochemical characterization of renal phosphatases in rats treated with lead
    • DOI 10.1080/109158199225378
    • Jarrar BM, Mahmoud, ZN (1999a) Histochemical characterization of renal phosphatases in rats treated with lead. Int. J. Toxicol. 18: 231-238. (Pubitemid 29409286)
    • (1999) International Journal of Toxicology , vol.18 , Issue.4 , pp. 231-238
    • Jarrar, B.M.1    Mahmoud, Z.N.2
  • 23
    • 70350424287 scopus 로고    scopus 로고
    • Histochemical demonstration of changes in the activity of hepatic phosphatases induced by experimental lead poisoning in male white rats ( Rattus norvegicus )
    • Jarrar BM, Mahmoud ZN (1999b) Histochemical demonstration of changes in the activity of hepatic phosphatases induced by experimental lead poisoning in male white rats ( Rattus norvegicus ). Toxicol. Iindust. Health 15: 1-9.
    • (1999) Toxicol. Iindust. Health , vol.15 , pp. 1-9
    • Jarrar, B.M.1    Mahmoud, Z.N.2
  • 24
    • 70350432675 scopus 로고    scopus 로고
    • Histochemical alterations in the activities of hepatic dehydrogenases induced by lead in male albino rats ( Rattus norvegicus )
    • Jarrar BM, Zuhair NM, Al-Enazi M, Taib NT (2006) Histochemical alterations in the activities of hepatic dehydrogenases induced by lead in male albino rats ( Rattus norvegicus ). Egypt. J. Zool . 46: 217-225.
    • (2006) Egypt. J. Zool. , vol.46 , pp. 217-225
    • Jarrar, B.M.1    Zuhair, N.M.2    Al-Enazi, M.3    Taib, N.T.4
  • 25
    • 67349215135 scopus 로고    scopus 로고
    • The protective effects of a fermented substance from Saccharomyces cerevisiae on carbon tetrachloride-induced liver damage in rats
    • Lai JT, Hsieh WT, Fang HL, Lin WC (2009) The protective effects of a fermented substance from Saccharomyces cerevisiae on carbon tetrachloride- induced liver damage in rats. Clin. Nutr. 28: 338-345.
    • (2009) Clin. Nutr. , vol.28 , pp. 338-345
    • Lai, J.T.1    Hsieh, W.T.2    Fang, H.L.3    Lin, W.C.4
  • 27
    • 0026196069 scopus 로고
    • Clinical and laboratory findings in small companion animals with lead poisoning
    • Morgan RV, Moore FM (1991) Clinical and laboratory findings in small companion animals with lead poisoning . J. Am. Vet. Med. Assoc . 199: 93-97.
    • (1991) J. Am. Vet. Med. Assoc , vol.199 , pp. 93-97
    • Morgan, R.V.1    Moore, F.M.2
  • 29
    • 0022411491 scopus 로고
    • Effects of lead on the heme biosynthetic pathway in rat kidney
    • Oskarsson A, Fowler BA (1985) Effects of lead on the heme biosynthetic pathway in rat kidney. Exp. Molec. Pathol . 43: 397-408.
    • (1985) Exp. Molec. Pathol. , vol.43 , pp. 397-408
    • Oskarsson, A.1    Fowler, B.A.2
  • 30
    • 33645816554 scopus 로고    scopus 로고
    • Lead toxicity, a review of the literature. Part I: Exposure, evaluation and treatment
    • Patrick L (2006) Lead toxicity, a review of the literature. Part I: Exposure, evaluation and treatment. Altern. Med. Rev. 11: 2-22.
    • (2006) Altern. Med. Rev. , vol.11 , pp. 2-22
    • Patrick, L.1
  • 31
    • 0025828592 scopus 로고
    • Statisticaily signifi-cant hematopoietic effects of low blood lead levels
    • Pounds JG, Long GJ, Rosen JF (1991) Statisticaily signifi-cant hematopoietic effects of low blood lead levels. Env. Health Perspec . 91: 17-32.
    • (1991) Env. Health Perspec. , vol.91 , pp. 17-32
    • Pounds, J.G.1    Long, G.J.2    Rosen, J.F.3
  • 32
    • 77955401235 scopus 로고    scopus 로고
    • Influence of vitamin C supplementation on lead-induced histopathological alterations in male rats
    • [e-published before print] Journal home
    • Shaban El-Neweshy M , Said El-Sayed Y (2010) Influence of vitamin C supplementation on lead-induced histopathological alterations in male rats. Exp. Toxicol. Pathol. [e-published before print]. Journal home page: www.elsevier.de/etp.
    • (2010) Exp. Toxicol. Pathol.
    • Shaban El-Neweshy, M.1    Said El-Sayed, Y.2
  • 33
    • 10044257785 scopus 로고    scopus 로고
    • Amelioration of lead toxicity on rat liver with Vitamin C and silymarin supplements
    • DOI 10.1016/j.tox.2004.07.006, PII S0300483X0400397X
    • Shalan MG, Mostafa MS, Hassouna MM, Hassab El-Nabi SE, El-Refaie A (2005) Amelioration of lead toxicity on rat liver with vitamin C and silymarin supplements. Toxicology 206: 1-15. (Pubitemid 39601041)
    • (2005) Toxicology , vol.206 , Issue.1 , pp. 1-15
    • Shalan, M.G.1    Mostafa, M.S.2    Hassouna, M.M.3    El-Nabi, S.E.H.4    El-Refaie, A.5
  • 34
    • 1642458570 scopus 로고    scopus 로고
    • Lead Intoxication: Histological and Oxidative Damage in Rat Cerebrum and Cerebellum
    • DOI 10.1002/jtra.10052
    • Sidhu P, Nehru B (2004) Lead intoxication: histological and oxidative damage in rat cerebrum and cerebellum. J. Trace Elem. Exp. Med. 17: 45-53. (Pubitemid 38129761)
    • (2004) Journal of Trace Elements in Experimental Medicine , vol.17 , Issue.1 , pp. 45-53
    • Sidhu, P.1    Nehru, B.2
  • 35
    • 84985570313 scopus 로고
    • Biochemistry of oxidative stress
    • Sies H (1986) Biochemistry of oxidative stress. Angew. Chem. Int. Ed. 25: 1058-1071.
    • (1986) Angew. Chem. Int. Ed. , vol.25 , pp. 1058-1071
    • Sies, H.1
  • 36
    • 37649015380 scopus 로고    scopus 로고
    • Ultrastructural alterations in hepatic tissues of white rats ( Rattus norvegicus ) induced by lead experimental toxicity
    • Taib NT, BM Jarrar, Mubarak M (2004) Ultrastructural alterations in hepatic tissues of white rats ( Rattus norvegicus ) induced by lead experimental toxicity. Saudi J. Biol. Sci. 11: 11-20.
    • (2004) Saudi J. Biol. Sci. , vol.11 , pp. 11-20
    • Taib, N.T.1    Jarrar, B.M.2    Mubarak, M.3
  • 38
    • 48849113099 scopus 로고    scopus 로고
    • Protective effect of L-carnitine against diclofenac sodium toxicity in mice
    • Yapar K, Atakisi O, Uzlu E, Citil M, Uzun M, Metin-Erdogan H (2008) Protective effect of L-carnitine against diclofenac sodium toxicity in mice. Rev. M é d. V é t. 159: 363-367.
    • (2008) Rev.Méd.Vét , vol.159 , pp. 363-367
    • Yapar, K.1    Atakisi, O.2    Uzlu, E.3    Citil, M.4    Uzun, M.5    Metin-Erdogan, H.6


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