Screening and optimization of ligand conjugates for lysosomal targeting

Bioconjugate Chemistry

Volumn 22, Issue 11, 2011, Pages 2271-2282

  Meerovich, Igor ^a   Koshkaryev, Alexander ^a   Thekkedath, Ritesh ^a   Torchilin, Vladimir P ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CONTROLLED DRUG DELIVERY; ENZYMES; FINITE DIFFERENCE METHOD; FLOW CYTOMETRY; LANTHANUM COMPOUNDS; LIGANDS; TARGETED DRUG DELIVERY;

ENZYME DEFICIENCIES; FLUORESCEIN ISOTHIOCYANATE DEXTRANS; LYSOSOMAL ENZYMES; LYSOSOMAL STORAGE DISORDER; LYSOSOMOTROPICS; OPTIMISATIONS; RHODAMINE-B; SUBCELLULAR FRACTIONATION; SYNTHESISED; THERAPEUTIC ENZYME;

LIPOSOMES;

BETA GALACTOSIDASE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; LIGAND; LIPOSOME; LYSOSOME ENZYME; NEUTRAL RED; RHODAMINE B;

ARTICLE; CELL FRACTIONATION; CELL ISOLATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; LYSOSOME; MACROPHAGE; PHENOTYPE; PROCESS OPTIMIZATION;

EID: 81255189116     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc200336j     Document Type: Article

References (27)

1. Torchilin, V. P. (2006) Recent approaches to intracellular delivery of drugs and DNA and organelle targeting Annu. Rev. Biomed. Eng. 8, 343-75 (Pubitemid 44314821)
2. Boddapati, S. V., DSouza, G. G., Erdogan, S., Torchilin, V. P., and Weissig, V. (2008) Organelle-targeted nanocarriers: specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo Nano Lett. 8, 2559-63
3. Ko, Y. T., Kale, A., Hartner, W. C., Papahadjopoulos-Sternberg, B., and Torchilin, V. P. (2009) Self-assembling micelle-like nanoparticles based on phospholipid-polyethyleneimine conjugates for systemic gene delivery J. Controlled Release 133, 132-8
4. Raas-Rothschild, A., Pankova-Kholmyansky, I., Kacher, Y., and Futerman, A. H. (2004) Glycosphingolipidoses: beyond the enzymatic defect Glycoconj. J. 21, 295-304 (Pubitemid 39439980)
5. Scriver, C. R., Sly, W. S., Childs, B., Beaudet, A. L., Valle, D., Kinzler, K. W., and Vogelstein, B. (2000) The Metabolic and Molecular Bases of Inherited Disease, 8 ed., McGraw-Hill Professional, New York.
6. Muro, S. (2010) New biotechnological and nanomedicine strategies for treatment of lysosomal storage diseases Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2, 189-204
7. Grabowsky, G. A. and Desnick, R. J. (1981) Enzyme replacement in genetic diseases, Enzymes as Drugs (Holcenberg, J. S. and Roberts, J., Eds.) Wiley, New York.
8. Butters, T. D. (2007) Pharmacotherapeutic strategies using small molecules for the treatment of glycolipid lysosomal storage disorders Expert Opin. Pharmacother. 8, 427-35 (Pubitemid 46416411)
9. Gregoriadis, G. (1978) Liposomes in the therapy of lysosomal storage diseases Nature 275, 695-6
10. Kirkegaard, T. and Jaattela, M. (2009) Lysosomal involvement in cell death and cancer Biochim. Biophys. Acta 1793, 746-54
11. Boya, P., Andreau, K., Poncet, D., Zamzami, N., Perfettini, J. L., Metivier, D., Ojcius, D. M., Jäättelä, M., and Kroemer, G. (2003) Lysosomal membrane permeabilization induces cell death in a mitochondriondependent fashion J. Exp. Med. 197, 1323-1334 (Pubitemid 36617779)
12. Horobin, R. W. (2002) Xanthenes. Conns Biological Stains: A Handbook of Dyes, Stains and Fluorochromes for Use in Biology and Medicine (Horobin, R. W., Kiernan, J. A., and Conn, H. J., Eds.) p 237, Chapter 16, BIOS Scientific Publishers, Oxford, U.K.
13. Minier, C. and Moore, M. N. (1996) Mar. Ecol.: Prog. Ser. 142, 165-173
14. Hoekstra, D., de Boer, T., Klappe, K., and Wilschut, J. (1984) Fluorescence method for measuring the kinetics of fusion between biological membranes Biochemistry 23, 5675-5681 (Pubitemid 15189719)
15. Kuwana, T., Mullock, B. M., and Luzio, J. P. (1995) Identification of a lysosomal protein causing lipid transfer, using a fluorescence assay designed to monitor membrane fusion between rat liver endosomes and lysosomes Biochem. J. 308, 937-946
16. Vult von Steyern, F., Josefsson, J. O., and Tagerud, S. (1996) Rhodamine B, a fluorescent probe for acidic organelles in denervated skeletal muscle J. Histochem. Cytochem. 44, 267-74 (Pubitemid 26081127)
17. Huth, U., Wieschollek, A., Garini, Y., Schubert, R., and Peschka-Suss, R. (2004) Fourier transformed spectral bio-imaging for studying the intracellular fate of liposomes Cytometry A 57, 10-21 (Pubitemid 38055710)
18. Koshkaryev, A., Thekkedath, R., Pagano, C., Meerovich, I., and Torchilin, V. P. (2011) Targeting of lysosomes by liposomes modified with octadecyl-rhodamine B. J. Drug Targeting, Epub ahead of print (DOI: 10.3109/1061186X.2010.550921).
19. Torchilin, V. P., Levchenko, T. S., Lukyanov, A. N., Khaw, B. A., Klibanov, A. L., Rammohan, R., Samokhin, G. P., and Whiteman, K. R. (2001) p-Nitrophenylcarbonyl-PEG-PE-liposomes: fast and simple attachment of specific ligands, including monoclonal antibodies, to distal ends of PEG chains via p-nitrophenylcarbonyl groups Biochim. Biophys. Acta 1511, 397-411 (Pubitemid 32250227)
20. Sundstrom, C. and Nilsson, K. (1976) Establishment and characterization of a human histiocytic lymphoma cell line (U-937) Int. J. Cancer 17, 565-77
21. Suzuki, K., Hirayama, E., Sugiyama, T., Yasuda, K., Okabe, H., and Citterio, D. (2002) Ionophore-based lithium ion film optode realizing multiple color variations utilizing digital color analysis Anal. Chem. 74, 5766-5773 (Pubitemid 35364831)
22. Derkacheva, V. M., Mikhalenko, S. A., Soloveva, L. I., Alekseeva, V. I., Marinina, L. E., Savina, L. P., Butenin, A. V., and Lukyanets, E. A. (2007) Phthalocyanines and related compounds: XLIV. Synthesis of conjugates of phthalocyanines with rhodamines Russian Journal of General Chemistry 77, 1117-1125
23. Plovins, A., Alvarez, A. M., Ibanez, M., Molina, M., and Nombela, C. (1994) Use of fluorescein-di-beta-D-galactopyranoside (FDG) and C12-FDG as substrates for beta-galactosidase detection by flow cytometry in animal, bacterial, and yeast cells Appl. Environ. Microbiol. 60, 4638-41 (Pubitemid 24370848)
24. Baek, Y. S., Haas, S., Hackstein, H., Bein, G., Hernandez-Santana, M., Lehrach, H., Sauer, S., and Seitz, H. (2009) Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cells BMC Immunol. 10, 18
25. Newburg, D. S., Shea, T. B., Yatziv, S., Raghavan, S. S., and McCluer, R. H. (1988) Macrophages exposed in vitro to conduritol B epoxide resemble Gaucher cells Exp. Mol. Pathol. 48, 317-23
26. Yatziv, S., Newburg, D. S., Livni, N., Barfi, G., and Kolodny, E. H. (1988) Gaucher-like changes in human blood-derived macrophages induced by beta-glucocerebrosidase inhibition J. Lab. Clin. Med. 111, 416-20
27. Manders, E. M. M., Verbeek, F. J., and Aten, J. A. (1993) Measurement of co-localisation of objects in dual-colour confocal images J. Microsc. 169, 375-382 (Pubitemid 23119681)