Effects of controlled released BMP-7 on markers of inflammation and degradation during the cultivation of human osteoarthritic chondrocytes

Journal of Biomaterials Applications

Volumn 26, Issue 4, 2011, Pages 419-433

  Gavenis, Karsten ^a   Pufe, Thomas ^b   Brandenburg, Lars Ove ^b   Schiffl, Katharina ^b   Schmidt Rohlfing, Bernhard ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

BMP 7; inflammation; osteoarthritic chondrocyte; PGLA microspheres

Indexed keywords

ARTICULAR CHONDROCYTES; BMP-7; CHONDROCYTES; COLLAGEN GELS; CONTROLLED RELEASE; CONTROLLED RELEASED; IMMUNOHISTOCHEMICAL STAINING; INFLAMMATION; INFLAMMATORY CYTOKINES; MATRIX; MATRIX SYNTHESIS; OSTEOARTHRITIC CHONDROCYTE; POLYLACTIDE MICROSPHERES; TREATMENT GROUP; UNTREATED CONTROL;

BODY FLUIDS; COLLAGEN; DEGRADATION; GELS; MICROSPHERES; ORGANIC POLYMERS; PATHOLOGY;

GENE EXPRESSION;

AUTACOID; BIOLOGICAL MARKER; BMP7 PROTEIN, HUMAN; COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGENASE 3; CYTOKINE; IL6 PROTEIN, HUMAN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MICROSPHERE; MMP13 PROTEIN, HUMAN; OSTEOGENIC PROTEIN 1; RECOMBINANT PROTEIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ARTICLE; CARTILAGE CELL; CULTURE TECHNIQUE; DELAYED RELEASE FORMULATION; DRUG EFFECT; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE; OSTEOARTHRITIS; PATHOLOGY;

BASE SEQUENCE; BIOLOGICAL MARKERS; BONE MORPHOGENETIC PROTEIN 7; CELL CULTURE TECHNIQUES; CHONDROCYTES; COLLAGEN TYPE I; COLLAGEN TYPE II; CYTOKINES; DELAYED-ACTION PREPARATIONS; GENE EXPRESSION; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; INTERLEUKIN-6; MATRIX METALLOPROTEINASE 13; MICROSPHERES; OSTEOARTHRITIS; RECOMBINANT PROTEINS; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 81255168538     PISSN: 08853282     EISSN: 15308022     Source Type: Journal    
DOI: 10.1177/0885328210374671     Document Type: Article

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