CD8 + T cell escape mutations in simian immunodeficiency virus SIVmac239 cause fitness defects in Vivo, and many revert after transmission

Journal of Virology

Volumn 85, Issue 23, 2011, Pages 12804-12810

  Mudd, Philip A ^a,b   Ericsen, Adam J ^a   Walsh, Andrew D ^a   León, Enrique J ^a   Wilson, Nancy A ^a,c   Maness, Nicholas J ^a   Friedrich, Thomas C ^c,d   Watkins, David I ^a,c  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF WISCONSIN   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ALLELE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; ESCAPE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS; IN VIVO STUDY; NONHUMAN; NOTE; PRIORITY JOURNAL; SIMIAN IMMUNODEFICIENCY VIRUS; VIRAL PHENOMENA AND FUNCTIONS; VIRUS FITNESS; VIRUS MUTATION; VIRUS TRANSMISSION;

AMINO ACID SEQUENCE; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MACACA MULATTA; MOLECULAR SEQUENCE DATA; MUTATION; SEQUENCE HOMOLOGY, AMINO ACID; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 81255163673     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.05841-11     Document Type: Note

References (43)

1. + T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution. J. Virol. 79:13239-13249.
2. Allen, T. M., et al. 2004. Selection, transmission, and reversion of an antigenprocessing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection. J. Virol. 78:7069-7078.
3. + lymphocytes from simian immunodeficiency virus-infected rhesus macaques recognize 14 different epitopes bound by the major histocompatibility complex class I molecule Mamu-A*01: implications for vaccine design and testing. J. Virol. 75:738-749.
4. Allen, T. M., et al. 2000. Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia. Nature 407:386-390.
5. Allen, T. M., et al. 1998. Characterization of the peptide binding motif of a rhesus MHC class I molecule (Mamu-A*01) that binds an immunodominant CTL epitope from simian immunodeficiency virus. J. Immunol. 160:6062-6071.
6. + T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection. J. Virol. 79:12952-12960.
7. Bimber, B. N., et al. 2010. Whole-genome characterization of human and simian immunodeficiency virus intrahost diversity by ultradeep pyrosequencing. J. Virol. 84:12087-12092.
8. Brockman, M. A., et al. 2007. Escape and compensation from early HLAB57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A. J. Virol. 81: 12608-12618.
9. Crawford, H., et al. 2007. Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLAB* 5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection. J. Virol. 81:8346-8351.
10. Daniel, M. D., et al. 1985. Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. Science 228:1201-1204.
11. Dzuris, J. L., et al. 2000. Conserved MHC class I peptide binding motif between humans and rhesus macaques. J. Immunol. 164:283-291.
12. Evans, D. T., et al. 2000. Definition of five new simian immunodeficiency virus cytotoxic T-lymphocyte epitopes and their restricting major histocompatibility complex class I molecules: evidence for an influence on disease progression. J. Virol. 74:7400-7410.
13. Evans, D. T., et al. 1999. Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef. Nat. Med. 5:1270-1276.
14. Friedrich, T. C., et al. 2004. Reversion of CTL escape-variant immunodeficiency viruses in vivo. Nat. Med. 10:275-281.
15. Friedrich, T. C., et al. 2004. Extraepitopic compensatory substitutions partially restore fitness to simian immunodeficiency virus variants that escape from an immunodominant cytotoxic-T-lymphocyte response. J. Virol. 78: 2581-2585.
16. Friedrich, T. C., et al. 2004. Consequences of cytotoxic T-lymphocyte escape: common escape mutations in simian immunodeficiency virus are poorly recognized in naive hosts. J. Virol. 78:10064-10073.
17. Gardner, M. B. 1996. The history of simian AIDS. J. Med. Primatol. 25:148-157.
18. Kawashima, Y., et al. 2009. Adaptation of HIV-1 to human leukocyte antigen class I. Nature 458:641-645.
19. Kelleher, A. D., et al. 2001. Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses. J. Exp. Med. 193:375-386.
20. Leslie, A. J., et al. 2004. HIV evolution: CTL escape mutation and reversion after transmission. Nat. Med. 10:282-289.
21. Li, B., et al. 2007. Rapid reversion of sequence polymorphisms dominates early human immunodeficiency virus type 1 evolution. J. Virol. 81:193-201.
22. + immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication. J. Virol. 82:1723-1738.
23. + T cells is unrelated to epitope specificity and is abrogated by viral escape. J. Virol. 81:2624-2634.
24. + T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation. PLoS One 2:e1152.
25. Loffredo, J. T., et al. 2007. Mamu-B*08-positive macaques control simian immunodeficiency virus replication. J. Virol. 81:8827-8832.
26. Loffredo, J. T., et al. 2009. Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B*08 and HLAB* 2705, bind peptides with sequence similarity. J. Immunol. 182:7763-7775.
27. + T cell epitopes restricted by the high frequency molecule, Mamu-A*02, and potential escape from CTL recognition. J. Immunol. 173:5064-5076.
28. + T lymphocytes against an immunodominant cryptic epitope select for viral escape. J. Exp. Med. 204:2505-2512.
29. Maness, N. J., et al. 2008. Comprehensive immunological evaluation reveals surprisingly few differences between elite controller and progressor Mamu-B*17-positive simian immunodeficiency virus-infected rhesus macaques. J. Virol. 82:5245-5254.
30. Mansfield, K. G., N. W. Lerch, M. B. Gardner, and A. A. Lackner. 1995. Origins of simian immunodeficiency virus infection in macaques at the New England Regional Primate Research Center. J. Med. Primatol. 24:116-122.
31. Matthews, P. C., et al. 2008. Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J. Virol. 82:8548-8559.
32. Miura, T., et al. 2009. HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers. J. Virol. 83:3407-3412.
33. Mothe, B. R., et al. 2002. Characterization of the peptide-binding specificity of Mamu-B*17 and identification of Mamu-B*17-restricted epitopes derived from simian immunodeficiency virus proteins. J. Immunol. 169:210-219.
34. Naidu, Y. M., et al. 1988. Characterization of infectious molecular clones of simian immunodeficiency virus (SIVmac) and human immunodeficiency virus type 2: persistent infection of rhesus monkeys with molecularly cloned SIVmac. J. Virol. 62:4691-4696.
35. O'Connor, D. H., et al. 2002. Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection. Nat. Med. 8:493-499.
36. +-T-lymphocyte selection in simian immunodeficiency virus sequence variation. J. Virol. 78:14012-14022.
37. Schneidewind, A., et al. 2009. Transmission and long-term stability of compensated CD8 escape mutations. J. Virol. 83:3993-3997.
38. Sette, A., et al. 2005. Characterization of the peptide-binding specificity of Mamu-A*11 results in the identification of SIV-derived epitopes and interspecies cross-reactivity. Immunogenetics 57:53-68.
39. Sidney, J., et al. 2000. Definition of the Mamu A*01 peptide binding specificity: application to the identification of wild-type and optimized ligands from simian immunodeficiency virus regulatory proteins. J. Immunol. 165: 6387-6399.
40. Valentine, L. E., et al. 2009. Infection with "escaped" virus variants impairs control of simian immunodeficiency virus SIVmac239 replication in Mamu-B*08-positive macaques. J. Virol. 83:11514-11527.
41. + T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1. J. Virol. 83:1845-1855.
42. + T cell escape variants of simian immunodeficiency virus. J. Virol. 85:530-541.
43. Yant, L. J., et al. 2006. The high-frequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication. J. Virol. 80:5074-5077.