Dioxins interfere with differentiation of osteoblasts and osteoclasts

Bone

Volumn 44, Issue 6, 2009, Pages 1134-1142

  Korkalainen, Merja ^a   Kallio, Elise ^b   Olkku, Anu ^c   Nelo, Katri ^b   Ilvesaro, Joanna ^b   Tuukkanen, Juha ^b   Mahonen, Anitta ^c,d   Viluksela, Matti ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

AH receptor; Bone marrow stem cells; Osteoblast; Osteoclast; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ALKALINE PHOSPHATASE; AROMATIC HYDROCARBON RECEPTOR; OSTEOCALCIN; TRANSCRIPTION FACTOR RUNX2;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE REMODELING; CELL DIFFERENTIATION; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; OSTEOCLAST; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALKALINE PHOSPHATASE; ANIMALS; BLOTTING, WESTERN; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DIOXINS; ENVIRONMENTAL POLLUTANTS; MALE; MICE; MICE, INBRED C57BL; OSTEOBLASTS; OSTEOCALCIN; OSTEOCLASTS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS; TETRACHLORODIBENZODIOXIN;

EID: 67349107066     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.02.019     Document Type: Article

References (50)

1. Calvi L.M., Adams G.B., Weibrecht K.W., Weber J.M., Olson D.P., Knight M.C., et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425 (2003) 841-846
2. Kollet O., Dar A., Shivtiel S., Kalinkovich A., Lapid K., Sztainberg Y., et al. Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Nat. Med. 12 (2006) 657-664
3. Takayanagi H. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat. Rev., Immunol. 7 (2007) 292-304
4. Okey A.B. An aryl hydrocarbon receptor odyssey to the shores of toxicology: the Deichmann Lecture, International Congress of Toxicology-XI. Toxicol. Sci. 98 (2007) 5-38
5. Korkalainen M., Tuomisto J., and Pohjanvirta R. Primary structure and inducibility by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of aryl hydrocarbon receptor repressor in a TCDD-sensitive and a TCDD-resistant rat strain. Biochem. Biophys. Res. Commun. 315 (2004) 123-131
6. Jämsä T., Viluksela M., Tuomisto J.T., Tuomisto J., and Tuukkanen J. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on bone in two rat strains with different aryl hydrocarbon receptor structures. J. Bone Miner. Res. 16 (2001) 1812-1820
7. Miettinen H.M., Pulkkinen P., Jämsä T., Koistinen J., Simanainen U., Tuomisto J., et al. Effects of in utero and lactational TCDD exposure on bone development in differentially sensitive rat lines. Toxicol. Sci. 85 (2005) 1003-1012
8. Gierthy J.F., Silkworth J.B., Tassinari M., Stein G.S., and Lian J.B. 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits differentiation of normal diploid rat osteoblasts in vitro. J. Cell. Biochem. 54 (1994) 231-238
9. Ilvesaro J., Pohjanvirta R., Tuomisto J., Viluksela M., and Tuukkanen J. Bone resorption by aryl hydrocarbon receptor-expressing osteoclasts is not disturbed by TCDD in short-term cultures. Life Sci. 77 (2005) 1351-1366
10. Naruse M., Ishihara Y., Miyagawa-Tomita S., Koyama A., and Hagiwara H. 3-Methylcholanthrene, which binds to the arylhydrocarbon receptor, inhibits proliferation and differentiation of osteoblasts in vitro and ossification in vivo. Endocrinology 143 (2002) 3575-3581
11. Naruse M., Otsuka E., Naruse M., Ishihara Y., Miyagawa-Tomita S., and Hagiwara H. Inhibition of osteoclast formation by 3-methylcholanthrene, a ligand for arylhydrocarbon receptor: suppression of osteoclast differentiation factor in osteogenic cells. Biochem. Pharmacol. 67 (2004) 119-127
12. Voronov I., Heersche J.N., Casper R.F., Tenenbaum H.C., and Manolson M.F. Inhibition of osteoclast differentiation by polycyclic aryl hydrocarbons is dependent on cell density and RANKL concentration. Biochem. Pharmacol. 70 (2005) 300-307
13. Voronov I., Li K., Tenenbaum H.C., and Manolson M.F. Benzo[a]pyrene inhibits osteoclastogenesis by affecting RANKL-induced activation of NF-kappaB. Biochem. Pharmacol. 75 (2008) 2034-2044
14. Alhadlaq A., and Mao J.J. Mesenchymal stem cells: isolation and therapeutics. Stem Cells Dev. 13 (2004) 436-448
15. Marion N.W., and Mao J.J. Mesenchymal stem cells and tissue engineering. Methods Enzymol. 420 (2006) 339-361
16. Prockop D.J. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276 (1997) 71-74
17. Kong Y.Y., Yoshida H., Sarosi I., Tan H.L., Timms E., Capparelli C., et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397 (1999) 315-323
18. Rolink A.G., Massa S., Balciunaite G., and Ceredig R. Early lymphocyte development in bone marrow and thymus. Swiss Med. Wkly. 137 Suppl. 155 (2007) 20S-24S
19. Taichman R.S. Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche. Blood 105 (2005) 2631-2639
20. Lian J.B., and Stein G.S. The developmental stages of osteoblast growth and differentiation exhibit selective responses of genes to growth factors (TGF beta 1) and hormones (vitamin D and glucocorticoids). J. Oral Implantol. 19 (1993) 95-105 discussion 136-7
21. Stein G.S., and Lian J.B. Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype. Endocr. Rev. 14 (1993) 424-442
22. Maniatopoulos C., Sodek J., and Melcher A.H. Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats. Cell Tissue Res. 254 (1988) 317-330
23. Asagiri M., and Takayanagi H. The molecular understanding of osteoclast differentiation. Bone 40 (2007) 251-264
24. Teitelbaum S.L. Bone resorption by osteoclasts. Science 289 (2000) 1504-1508
25. Väänänen H.K., Zhao H., Mulari M., and Halleen J.M. The cell biology of osteoclast function. J. Cell. Sci. 113 Pt 3 (2000) 377-381
26. Lakkakorpi P.T., and Väänänen H.K. Kinetics of the osteoclast cytoskeleton during the resorption cycle in vitro. J. Bone Miner. Res. 6 (1991) 817-826
27. Lakkakorpi P.T., and Väänänen H.K. Cytoskeletal changes in osteoclasts during the resorption cycle. Microsc. Res. Tech. 33 (1996) 171-181
28. Halleen J.M., Alatalo S.L., Suominen H., Cheng S., Janckila A.J., and Väänänen H.K. Tartrate-resistant acid phosphatase 5b: a novel serum marker of bone resorption. J. Bone Miner. Res. 15 (2000) 1337-1345
29. Minkin C. Bone acid phosphatase: tartrate-resistant acid phosphatase as a marker of osteoclast function. Calcif. Tissue Int. 34 (1982) 285-290
30. Halleen J.M., Räisänen S., Salo J.J., Reddy S.V., Roodman G.D., Hentunen T.A., et al. Intracellular fragmentation of bone resorption products by reactive oxygen species generated by osteoclastic tartrate-resistant acid phosphatase. J. Biol. Chem. 274 (1999) 22907-22910
31. Vääräniemi J., Halleen J.M., Kaarlonen K., Ylipahkala H., Alatalo S.L., Andersson G., et al. Intracellular machinery for matrix degradation in bone-resorbing osteoclasts. J. Bone Miner. Res. 19 (2004) 1432-1440
32. Selander K., Lehenkari P., and Väänänen H.K. The effects of bisphosphonates on the resorption cycle of isolated osteoclasts. Calcif. Tissue Int. 55 (1994) 368-375
33. Pohjanvirta R., Niittynen M., Lindén J., Boutros P.C., Moffat I.D., and Okey A.B. Evaluation of various housekeeping genes for their applicability for normalization of mRNA expression in dioxin-treated rats. Chem. Biol. Interact. 160 (2006) 134-149
34. Murray E., Provvedini D., Curran D., Catherwood B., Sussman H., and Manolagas S. Characterization of a human osteoblastic osteosarcoma cell line (SAOS-2) with high bone alkaline phosphatase activity. J. Bone Miner. Res. 2 (1987) 231-238
35. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
36. Korkalainen M., Tuomisto J., and Pohjanvirta R. Restructured transactivation domain in hamster AH receptor. Biochem. Biophys. Res. Commun. 273 (2000) 272-281
37. Takahashi N., Yamana H., Yoshiki S., Roodman G.D., Mundy G.R., Jones S.J., et al. Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology 122 (1988) 1373-1382
38. Lakkakorpi P., Tuukkanen J., Hentunen T., Järvelin K., and Väänänen K. Organization of osteoclast microfilaments during the attachment to bone surface in vitro. J. Bone Miner. Res. 4 (1989) 817-825
39. Lau C., Butenhoff J.L., and Rogers J.M. The developmental toxicity of perfluoroalkyl acids and their derivatives. Toxicol. Appl. Pharmacol. 198 (2004) 231-241
40. Tsukamoto Y., Ishihara Y., Miyagawa-Tomita S., and Hagiwara H. Inhibition of ossification in vivo and differentiation of osteoblasts in vitro by tributyltin. Biochem. Pharmacol. 68 (2004) 739-746
41. Ducy P., Zhang R., Geoffroy V., Ridall A.L., and Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89 (1997) 747-754
42. Marom R., Shur I., Solomon R., and Benayahu D. Characterization of adhesion and differentiation markers of osteogenic marrow stromal cells. J. Cell. Physiol. 202 (2005) 41-48
43. Ryan E.P., Holz J.D., Mulcahey M., Sheu T.J., Gasiewicz T.A., and Puzas J.E. Environmental toxicants may modulate osteoblast differentiation by a mechanism involving the aryl hydrocarbon receptor. J. Bone Miner. Res. 22 (2007) 1571-1580
44. Mimura J., Ema M., Sogawa K., and Fujii-Kuriyama Y. Identification of a novel mechanism of regulation of Ah (dioxin) receptor function. Genes Dev. 13 (1999) 20-25
45. Giannone J.V., Li W., Probst M., and Okey A.B. Prolonged depletion of AH receptor without alteration of receptor mRNA levels after treatment of cells in culture with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem. Pharmacol. 55 (1998) 489-497
46. Pollenz R.S. The aryl-hydrocarbon receptor, but not the aryl-hydrocarbon receptor nuclear translocator protein, is rapidly depleted in hepatic and nonhepatic culture cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Mol. Pharmacol. 49 (1996) 391-398
47. Tijet N., Boutros P.C., Moffat I.D., Okey A.B., Tuomisto J., and Pohjanvirta R. Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries. Mol. Pharmacol. 69 (2006) 140-153
48. Singh S.U., Casper R.F., Fritz P.C., Sukhu B., Ganss B., Girard Jr. B., et al. Inhibition of dioxin effects on bone formation in vitro by a newly described aryl hydrocarbon receptor antagonist, resveratrol. J. Endocrinol. 167 (2000) 183-195
49. Cheung R.C., Gray C., Boyde A., and Jones S.J. Effects of ethanol on bone cells in vitro resulting in increased resorption. Bone 16 (1995) 143-147
50. Dai J., Lin D., Zhang J., Habib P., Smith P., Murtha J., et al. Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice. J. Clin. Invest. 106 (2000) 887-895