A sequence within the Varicella-Zoster Virus (VZV) OriS is a negative regulator of DNA replication and is bound by a protein complex containing the VZV ORF29 protein

Journal of Virology

Volumn 85, Issue 23, 2011, Pages 12188-12200

  Khalil, Mohamed I ^a,d   Arvin, Ann ^b   Jones, Jeremy ^c   Ruyechan, William T ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^d NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; ORIGIN BINDING PROTEIN; PROTEIN ORF29; SINGLE STRANDED DNA BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; DNA FLANKING REGION; DNA REPLICATION; DNA SEQUENCE; DNA STRUCTURE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MUTATION; NONHUMAN; OPEN READING FRAME; PLASMID; PRIORITY JOURNAL; REGULATORY MECHANISM; VARICELLA ZOSTER VIRUS;

CELL NUCLEUS; DNA REPLICATION; DNA, VIRAL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENES, REPORTER; HERPESVIRUS 3, HUMAN; HUMANS; IMMEDIATE-EARLY PROTEINS; MELANOMA; OPEN READING FRAMES; PLASMIDS; REPLICATION ORIGIN; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; VIRAL ENVELOPE PROTEINS; VIRAL PROTEINS; VIRUS LATENCY; VIRUS REPLICATION;

HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 3; SIMPLEXVIRUS;

EID: 81255123476     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.05501-11     Document Type: Article

References (67)

1. Advani, S. J., R. R. Weichselbaum, and B. Roizman. 2000. E2F proteins are posttranslationally modified concomitantly with a reduction in nuclear binding activity in cells infected with herpes simplex virus 1. J. Virol. 74:7842-7850.
2. Ambagala, A. P., T. Krogmann, J. Qin, L. Pesnicak, and J. I. Cohen. 2010. A varicella-zoster virus mutant impaired for latency in rodents, but not impaired for replication in cell culture. Virology 399:194-200.
3. Balliet, J. W., and P. A. Schaffer. 2006. Point mutations in herpes simplex virus type 1 oriL, but not in OriS, reduce pathogenesis during acute infection of mice and impair reactivation from latency. J. Virol. 80:440-450.
4. Boucaud, D., H. Yoshitake, J. Hay, and W. T. Ruyechan. 1998. The varicellazoster virus (VZV) open-reading frame 29 protein acts as a modulator of a late VZV gene promoter. J. Infect. Dis. 178:S34-S38.
5. Chattopadhyay, S., and S. K. Weller. 2006. DNA binding activity of the herpes simplex virus type 1 origin binding protein, UL9, can be modulated by sequences in the N terminus: correlation between transdominance and DNA binding. J. Virol. 80:4491-4500.
6. Chattopadhyay, S., and S. K. Weller. 2007. Direct interaction between the Nand C-terminal portions of the herpes simplex virus type 1 origin binding protein UL9 implies the formation of a head-to-tail dimer. J. Virol. 81: 13659-13667.
7. Chen, D., and P. D. Olivo. 1994. Expression of the variella-zoster virus origin-binding protein and analysis of its site-specific DNA-binding properties. J. Virol. 68:3841-3849.
8. Cohen, J. I., E. Cox, L. Pesnicak, S. Srinivas, and T. Krogmann. 2004. The varicella-zoster virus open reading frame 63 latency-associated protein is critical for establishment of latency. J. Virol. 78:11833-11840.
9. Cohen, J. I., D. Heffel, and K. Seidel. 1993. The transcriptional activation domain of varicella-zoster virus open reading frame 62 protein is not conserved with its herpes simplex virus homolog. J. Virol. 67:4246-4251.
10. Cohen, J. I., T. Krogmann, S. Bontems, C. Sadzot-Delvaux, and L. Pesnicak. 2005. Regions of the varicella-zoster virus open reading frame 63 latencyassociated protein important for replication in vitro are also critical for efficient establishment of latency. J. Virol. 79:5069-5077.
11. Cohen, J. I., T. Krogmann, L. Pesnicak, and M. A. Ali. 2007. Absence or overexpression of the varicella-zoster virus (VZV) ORF29 latency-associated protein impairs late gene expression and reduces VZV latency in a rodent model. J. Virol. 81:1586-1591.
12. Cohen, J. I., S. E. Straus, and A. M. Arvin. 2007. Varicella-zoster virus, p. 2773-2818. In D. M. Knipe et al. (ed.), Fields virology, 5th ed. Lippincott Williams & Wilkins, Philadelphia, PA.
13. Davison, A. J., and J. E. Scott. 1985. DNA sequence of the major inverted repeat in the varicella-zoster virus genome. J. Gen. Virol. 66:207-220.
14. Davison, A. J., and J. E. Scott. 1986. The complete DNA sequence of varicella-zoster virus. J. Gen. Virol. 67:1759-1816.
15. Deb, S., and M. Doelberg. 1988. A 67-base-pair segment from the Ori-S region of herpes simplex virus type 1 encodes origin function. J. Virol. 62:2516-2519.
16. Desloges, N., M. Rahaus, and M. H. Wolff. 2005. The varicella-zoster virusmediated delayed host shutoff: open reading frame 17 has no major function, whereas immediate-early 63 protein represses heterologous gene expression. Microbes Infect. 7:1519-1529.
17. Ehmann, G. L., H. A. Burnett, and S. L. Bachenheimer. 2001. Pocket protein p130/Rb2 is required for efficient herpes simplex virus type 1 gene expression and viral replication. J. Virol. 75:7149-7160.
18. Gomi, Y., et al. 2002. Comparison of the complete DNA sequences of the Oka varicella vaccine and its parental virus. J. Virol. 76:11447-11459.
19. Grose, C., et al. 2004. Complete DNA sequence analyses of the first two varicella-zoster virus glycoprotein E (D150N) mutant viruses found in North America: evolution of genotypes with an accelerated cell spread phenotype. J. Virol. 78:6799-6807.
20. Hay, J., and W. T. Ruyechan. 2007. Alphaherpesvirus DNA replication, p. 138-143. In A. Arvin et al. (ed.), Human herpesviruses: biology, therapy, and immunoprophylaxis, vol. 1. Cambridge University Press, Cambridge, MA.
21. He, H., D. Boucaud, J. Hay, and W. T. Ruyechan. 2001. Cis and trans elements regulating expression of the varicella zoster virus gI gene. Arch. Virol. Suppl. 17:57-70.
22. Hernandez, T. R., R. E. Dutch, I. R. Lehman, C. Gustafsson, and P. Elias. 1991. Mutations in a herpes simplex virus type 1 origin that inhibit interaction with origin-binding protein also inhibit DNA replication. J. Virol. 65: 1649-1652.
23. Hilton, M. J., et al. 1995. Induction by herpes simplex virus of free and heteromeric forms of E2F transcription factor. Virology 213:624-638.
24. Ito, H., et al. 2003. Promoter sequences of varicella-zoster virus glycoprotein I targeted by cellular transactivating factors Sp1 and USF determine virulence in skin and T cells in SCIDhu mice in vivo. J. Virol. 77:489-498.
25. Jackers, P., et al. 1992. Characterization of regulatory functions of the varicella-zoster virus gene 63-encoded protein. J. Virol. 66:3899-3903.
26. Jones, J. O., M. Sommer, S. Stamatis, and A. M. Arvin. 2006. Mutational analysis of the varicella-zoster virus ORF62/63 intergenic region. J. Virol. 80:3116-3121.
27. Kennedy, P. G., and R. J. Cohrs. 2010. Varicella-zoster virus human ganglionic latency: a current summary. J. Neurovirol. 16:411-418.
28. Khalil, M. I., J. Hay, and W. T. Ruyechan. 2008. The cellular transcription factors Sp1 and Sp3 suppress varicella zoster virus origin-dependent DNA replication. J. Virol. 82:11723-11733.
29. Kinchington, P. R., J. K. Hougland, A. M. Arvin, W. T. Ruyechan, and J. Hay. 1992. The varicella-zoster virus immediate-early protein IE62 is a major component of virus particles. J. Virol. 66:359-366.
30. Kinchington, P. R., et al. 1988. Identification and characterization of a varicella-zoster virus DNA-binding protein by using antisera directed against a predicted synthetic oligopeptide. J. Virol. 62:802-809.
31. Kinchington, P. R., J. P. Vergnes, P. Defechereux, J. Piette, and S. E. Turse. 1994. Transcriptional mapping of the varicella-zoster virus regulatory genes encoding open reading frames 4 and 63. J. Virol. 68:3570-3581.
32. Kinchington, P. R., J. P. Vergnes, and S. E. Turse. 1995. Transcriptional mapping of varicella-zoster virus regulatory proteins. Neurology 45:S33-S35.
33. Kost, R. G., H. Kupinsky, and S. E. Straus. 1995. Varicella-zoster virus gene 63: transcript mapping and regulatory activity. Virology 209:218-224.
34. Link, M. A., and P. A. Schaffer. 2007. Herpes simplex virus type 1 C-terminal variants of the origin binding protein (OBP), OBPC-1 and OBPC-2, cooperatively regulate viral DNA levels in vitro, and OBPC-2 affects mortality in mice. J. Virol. 81:10699-10711.
35. Link, M. A., L. A. Silva, and P. A. Schaffer. 2007. Cathepsin B mediates cleavage of herpes simplex virus type 1 origin binding protein (OBP) to yield OBPC-1, and cleavage is dependent upon viral DNA replication. J. Virol. 81:9175-9182.
36. Lungu, O., C. A. Panagiotidis, P. W. Annunziato, A. A. Gershon, and S. J. Silverstein. 1998. Aberrant intracellular localization of varicella-zoster virus regulatory proteins during latency. Proc. Natl. Acad. Sci. U. S. A. 95:7080-7085.
37. Lynch, J. M., T. K. Kenyon, C. Grose, J. Hay, and W. T. Ruyechan. 2002. Physical and functional interaction between the varicella zoster virus IE63 and IE62 proteins. Virology 302:71-82.
38. Martin, D. W., S. P. Deb, J. S. Klauer, and S. Deb. 1991. Analysis of the herpes simplex virus type 1 OriS sequence: mapping of functional domains. J. Virol. 65:4359-4369.
39. Merrikh, H., C. Machon, W. H. Grainger, A. D. Grossman, and P. Soultanas. 2011. Co-directional replication-transcription conflicts lead to replication restart. Nature 470:554-557.
40. Mirkin, E. V., and S. M. Mirkin. 2007. Replication fork stalling at natural impediments. Microbiol. Mol. Biol. Rev. 71:13-35.
41. Moriuchi, H., M. Moriuchi, and J. I. Cohen. 1995. The varicella-zoster virus immediate-early 62 promoter contains a negative regulatory element that binds transcriptional factor NF-Y. Virology 214:256-258.
42. Moriuchi, M., H. Moriuchi, S. E. Straus, and J. I. Cohen. 1994. Varicellazoster virus (VZV) virion-associated transactivator open reading frame 62 protein enhances the infectivity of VZV DNA. Virology 200:297-300.
43. Nguyen-Huynh, A. T., and P. A. Schaffer. 1998. Cellular transcription factors enhance herpes simplex virus type 1 OriS-dependent DNA replication. J. Virol. 72:3635-3645.
44. Olgiate, J., G. L. Ehmann, S. Vidyarthi, M. J. Hilton, and S. L. Bachenheimer. 1999. Herpes simplex virus induces intracellular redistribution of E2F4 and accumulation of E2F pocket protein complexes. Virology 258:257-270.
45. Olsson, M., et al. 2009. Stepwise evolution of the herpes simplex virus origin binding protein and origin of replication. J. Biol. Chem. 284:16246-16255.
46. Orlov, S. V., et al. 2007. Novel repressor of the human FMR1 gene-identi-fication of p56 human (GCC)(n)-binding protein as a Krüppel-like transcription factor ZF5. FEBS J. 274:4848-4862.
47. Peng, H., H. He, J. Hay, and W. T. Ruyechan. 2003. Interaction between the varicella zoster virus IE62 major transactivator and cellular transcription factor Sp1. J. Biol. Chem. 278:38068-38075.
48. Perera, L. P., J. D. Mosca, W. T. Ruyechan, and J. Hay. 1992. Regulation of varicella-zoster virus gene expression in human T lymphocytes. J. Virol. 66:5298-5304.
49. Perera, L. P., et al. 1993. A major transactivator of varicella-zoster virus, the immediate-early protein IE62, contains a potent N-terminal activation domain. J. Virol. 67:4474-4483.
50. Peters, G. A., et al. 2006. A full-genome phylogenetic analysis of varicellazoster virus reveals a novel origin of replication-based genotyping scheme and evidence of recombination between major circulating clades. J. Virol. 80:9850-9860.
51. Pomerantz, R. T., and M. O'Donnell. 2010. What happens when replication and transcription complexes collide? Cell Cycle 9:2537-2543.
52. Reichelt, M., J. Brady, and A. M. Arvin. 2009. The replication cycle of varicella-zoster virus: analysis of the kinetics of viral protein expression, genome synthesis, and virion assembly at the single-cell level. J. Virol. 83: 3904-3918.
53. Roberts, C. R., A. C. Weir, J. Hay, S. E. Straus, and W. T. Ruyechan. 1985. DNA-binding proteins present in varicella-zoster virus-infected cells. J. Virol. 55:45-53.
54. Sakamoto, K., Y. Tamamura, K. Katsube, and A. Yamaguchi. 2008. Zfp64 participates in Notch signaling and regulates differentiation in mesenchymal cells. J. Cell Sci. 121:1613-1623.
55. Sato, B., et al. 2003. Mutational analysis of open reading frames 62 and 71, encoding the varicella-zoster virus immediate-early transactivating protein, IE62, and effects on replication in vitro and in skin xenografts in the SCID-hu mouse in vivo. J. Virol. 77:5607-5620.
56. Spengler, M. L., W. T. Ruyechan, and J. Hay. 2000. Physical interaction between two varicella zoster virus gene regulatory proteins, IE4 and IE62. Virology 272:375-381.
57. Stow, N. D., and A. J. Davison. 1986. Identification of a varicella-zoster virus origin of DNA replication and its activation by herpes simplex virus type 1 gene products. J. Gen. Virol. 67:1613-1623.
58. Stow, N. D., and E. C. McMonagle. 1983. Characterization of the TRS/IRS origin of DNA replication of herpes simplex virus type 1. Virology 130:427-438.
59. Stow, N. D., H. M. Weir, and E. C. Stow. 1990. Analysis of the binding sites for the varicella-zoster virus gene 51 product within the viral origin of DNA replication. Virology 177:570-577.
60. Summers, B. C., and D. A. Leib. 2002. Herpes simplex virus type 1 origins of DNA replication play no role in the regulation of flanking promoters. J. Virol. 76:7020-7029.
61. Weir, H. M., and N. D. Stow. 1990. Two binding sites for the herpes simplex virus type 1 UL9 protein are required for efficient activity of the oriS replication origin. J. Gen. Virol. 71:1379-1385.
62. White, K., H. Peng, J. Hay, and W. T. Ruyechan. 2010. Role of the IE62 consensus binding site in transactivation by the varicella-zoster virus IE62 protein. J. Virol. 84:3767-3779.
63. Workman, A., and C. Jones. 2010. Productive infection and bICP0 early promoter activity of bovine herpesvirus 1 are stimulated by E2F1. J. Virol. 84:6308-6317.
64. Yang, M., J. Hay, and W. T. Ruyechan. 2004. The DNA element controlling expression of the varicella-zoster virus open reading frame 28 and 29 genes consists of two divergent unidirectional promoters which have a common USF site. J. Virol. 78:10939-10952.
65. Zerboni, L., M. Reichelt, and A. Arvin. 2010. Varicella-zoster virus neurotropism in SCID mouse-human dorsal root ganglia xenografts. Curr. Top. Microbiol. Immunol. 342:255-276.
66. Zerboni, L., et al. 2007. Aberrant infection and persistence of varicella-zoster virus in human dorsal root ganglia in vivo in the absence of glycoprotein I. Proc. Natl. Acad. Sci. U. S. A. 104:14086-14091.
67. Zuranski, T., et al. 2005. Cell-type-dependent activation of the cellular EF-1alpha promoter by the varicella-zoster virus IE63 protein. Virology 338:35-42.