Proteomic analysis of dopamine and α-synuclein interplay in a cellular model of Parkinson's disease pathogenesis

FEBS Journal

Volumn 277, Issue 23, 2010, Pages 4909-4919

  Alberio, Tiziana ^a   Bossi, Alessandra Maria ^b   Milli, Alberto ^b   Parma, Elisa ^a   Gariboldi, Marzia Bruna ^a   Tosi, Giovanna ^a   Lopiano, Leonardo ^c   Fasano, Mauro ^a  

^a UNIVERSITY OF INSUBRIA   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

synuclein; Dopamine; Network enrichment; NF B; Parkinson's disease; SH SY5Y

Indexed keywords

ALPHA SYNUCLEIN; DOPAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BIOINFORMATICS; CELL FUNCTION; CELL VIABILITY; CONTROLLED STUDY; CYTOSKELETON; DOWN REGULATION; ENERGY METABOLISM; ENZYME ACTIVATION; ENZYME SPECIFICITY; EXPERIMENTAL MODEL; FUNCTIONAL PROTEOMICS; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MITOCHONDRION; MOLECULAR MODEL; NERVE CELL PLASTICITY; NEUROPATHOLOGY; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ALPHA-SYNUCLEIN; CELL LINE; DOPAMINE; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GENE EXPRESSION; HUMANS; METABOLIC NETWORKS AND PATHWAYS; MODELS, NEUROLOGICAL; NF-KAPPA B; PARKINSON DISEASE; PROTEOMICS; TANDEM MASS SPECTROMETRY;

EID: 78449301168     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07896.x     Document Type: Article

References (47)

1. Thomas B & Beal MF (2007) Parkinson's disease. Hum Mol Genet 16 Spec. No. 2, R183-R194.
2. Devine MJ & Lewis PA (2008) Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2. FEBS J 275, 5748-5757.
3. Fasano M, Bergamasco B & Lopiano L (2006) Modifications of the iron-neuromelanin system in Parkinson's disease. J Neurochem 96, 909-916.
4. Fasano M & Lopiano L (2008) Alpha-synuclein and Parkinson's disease: a proteomic view. Expert Rev Proteomics 5, 239-248.
5. Henchcliffe C & Beal MF (2008) Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nat Clin Pract Neurol 4, 600-609.
6. Lesage S & Brice A (2009) Parkinson's disease: from monogenic forms to genetic susceptibility factors. Hum Mol Genet 18, R48-R59.
7. Colapinto M, Mila S, Giraudo S, Stefanazzi P, Molteni M, Rossetti C, Bergamasco B, Lopiano L & Fasano M (2006) Alpha-synuclein protects SH-SY5Y cells from dopamine toxicity. Biochem Biophys Res Commun 349, 1294-1300.
8. Cookson MR (2006) Hero versus antihero: the multiple roles of alpha-synuclein in neurodegeneration. Exp Neurol 199, 238-242.
9. Quilty MC, King AE, Gai WP, Pountney DL, West AK, Vickers JC & Dickson TC (2006) Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection. Exp Neurol 199, 249-256.
10. Lee HG, Zhu X, Takeda A, Perry G & Smith MA (2006) Emerging evidence for the neuroprotective role of alpha-synuclein. Exp Neurol 200, 1-7.
11. Fasano M, Bergamasco B & Lopiano L (2007) The proteomic approach in Parkinson's disease. Proteomics Clin Appl 1, 1428-1435.
12. Fasano M, Alberio T & Lopiano L (2008) Peripheral biomarkers of Parkinson's disease as early reporters of central neurodegeneration. Biomarker Med 2, 465-478.
13. Gómez-Santos C, Ferrer I, Santidrian AF, Barrachina M, Gil J & Ambrosio S (2003) Dopamine induces autophagic cell death and alpha-synuclein increase in human neuroblastoma SH-SY5Y cells. J Neurosci Res 73, 341-350.
14. Gómez-Santos C, Barrachina M, Giménez-Xavier P, Dalfó E, Ferrer I & Ambrosio S (2005) Induction of C/EBP beta and GADD153 expression by dopamine in human neuroblastoma cells. Relationship with alpha-synuclein increase and cell damage. Brain Res Bull 65, 87-95.
15. Gómez-Santos C, Francisco R, Giménez-Xavier P & Ambrosio S (2007) Dopamine induces TNFalpha and TNF-R1 expression in SH-SY5Y human neuroblastoma cells. Neuroreport 18, 1725-1728.
16. Antonov AV, Dietmann S, Rodchenkov I & Mewes HW (2009) PPI spider: A tool for the interpretation of proteomics data in the context of protein-protein interaction networks. Proteomics 9, 2740-2749.
17. Salminen A, Paimela T, Suuronen T & Kaarniranta K (2008) Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90. Immunol Lett 117, 9-15.
18. Brand IA & Heinickel A (1991) Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa Zn(2+)-binding protein (parathymosin). J Biol Chem 266, 20984-20989.
19. Petrak J, Ivanek R, Toman O, Cmejla R, Cmejlova J, Vyoral D, Zivny J & Vulpe CD (2008) Déjà vu in proteomics. A hit parade of repeatedly identified differentially expressed proteins. Proteomics 8, 1744-1749.
20. Mao L, Zabel C, Herrmann M, Nolden T, Mertes F, Magnol L, Chabert C, Hartl D, Herault Y, Delabar JM et al. (2007) Proteomic shifts in embryonic stem cells with gene dose modifications suggest the presence of balancer proteins in protein regulatory networks. PLoS ONE 2, e1218.
21. Shenton D, Smirnova JB, Selley JN, Carroll K, Hubbard SJ, Pavitt GD, Ashe MP & Grant CM (2006) Global translational responses to oxidative stress impact upon multiple levels of protein synthesis. J Biol Chem 281, 29011-29021.
22. Lev N, Ickowicz D, Barhum Y, Lev S, Melamed E & Offen D (2009) DJ-1 protects against dopamine toxicity. J Neural Transm 116, 151-160.
23. Celsi F, Pizzo P, Brini M, Leo S, Fotino C, Pinton P & Rizzuto R (2009) Mitochondria, calcium and cell death: a deadly triad in neurodegeneration. Biochim Biophys Acta 1787, 335-344.
24. Chan CS, Gertler TS & Surmeier DJ (2009) Calcium homeostasis, selective vulnerability and Parkinson's disease. Trends Neurosci 32, 249-256.
25. Van Laar VS, Mishizen AJ, Cascio M & Hastings TG (2009) Proteomic identification of dopamine-conjugated proteins from isolated rat brain mitochondria and SH-SY5Y cells. Neurobiol Dis 34, 487-500.
26. Xun Z, Sowell RA, Kaufman TC & Clemmer DE (2007) Lifetime proteomic profiling of an A30P alpha-synuclein Drosophila model of Parkinson's disease. J Proteome Res 6, 3729-3738.
27. Tseng Y, Kole TP, Lee JS, Fedorov E, Almo SC, Schafer BW & Wirtz D (2005) How actin crosslinking and bundling proteins cooperate to generate an enhanced cell mechanical response. Biochem Biophys Res Commun 334, 183-192.
28. Monastyrskaya K, Babiychuk EB & Draeger A (2009) The annexins: spatial and temporal coordination of signaling events during cellular stress. Cell Mol Life Sci 66, 2623-2642.
29. Sousa VL, Bellani S, Giannandrea M, Yousuf M, Valtorta F, Meldolesi J & Chieregatti E (2009) α-Synuclein and its A30P mutant affect actin cytoskeletal structure and dynamics. Mol Biol Cell 20, 3725-3739.
30. Birbach A (2008) Profilin, a multi-modal regulator of neuronal plasticity. Bioessays 30, 994-1002.
31. Andersen SS (2000) Spindle assembly and the art of regulating microtubule dynamics by MAPs and Stathmin/Op18. Trends Cell Biol 10, 261-267.
32. Broers JL, Ramaekers FC, Bonne G, Yaou RB & Hutchison CJ (2006) Nuclear lamins: laminopathies and their role in premature ageing. Physiol Rev 86, 967-1008.
33. Nakamura M, Morisawa H, Imajoh-Ohmi S, Takamura C, Fukuda H & Toda T (2009) Proteomic analysis of protein complexes in human SH-SY5Y neuroblastoma cells by using blue-native gel electrophoresis: an increase in lamin A/C associated with heat shock protein 90 in response to 6-hydroxydopamine-induced oxidative stress. Exp Gerontol 44, 375-382.
34. Shi M, Bradner J, Bammler TK, Eaton DL, Zhang J, Ye Z, Wilson AM, Montine TJ, Pan C & Zhang J (2009) Identification of glutathione S-transferase pi as a protein involved in Parkinson disease progression. Am J Pathol 175, 54-65.
35. Whitworth AJ, Theodore DA, Greene JC, Benes H, Wes PD & Pallanck LJ (2005) Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease. Proc Natl Acad Sci USA 102, 8024-8029.
36. Smeyne M, Boyd J, Raviie Shepherd K, Jiao Y, Pond BB, Hatler M, Wolf R, Henderson C & Smeyne RJ (2007) GSTpi expression mediates dopaminergic neuron sensitivity in experimental parkinsonism. Proc Natl Acad Sci USA 104, 1977-1982.
37. Werner CJ, Heyny-von Haussen R, Mall G & Wolf S (2008) Proteome analysis of human substantia nigra in Parkinson's disease. Proteome Sci 6, 8.
38. Takashima A (2009) Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: role of GSK-3beta in adult brain. J Pharmacol Sci 109, 174-178.
39. Cole AR, Causeret F, Yadirgi G, Hastie CJ, McLauchlan H, McManus EJ, Hernández F, Eickholt BJ, Nikolic M & Sutherland C (2006) Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. J Biol Chem 281, 16591-16598.
40. Duka T, Duka V, Joyce JN & Sidhu A (2009) Alpha-synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease models. FASEB J 23, 2820-2830.
41. Halvorsen EM, Dennis J, Keeney P, Sturgill TW, Tuttle JB & Bennett JB Jr (2002) Methylpyridinium (MPP(+))- and nerve growth factor-induced changes in pro- and anti-apoptotic signaling pathways in SH-SY5Y neuroblastoma cells. Brain Res 952, 98-110.
42. Yuan Y, Jin J, Yang B, Zhang W, Hu J, Zhang Y & Chen NH (2008) Overexpressed alpha-synuclein regulated the nuclear factor-kappaB signal pathway. Cell Mol Neurobiol 28, 21-33.
43. Cookson MR & Van Der Brug M (2008) Cell systems and the toxic mechanism(s) of alpha- synuclein. Exp Neurol 209, 5-11.
44. Sarnico I, Lanzillotta A, Benarese M, Alghisi M, Baiguera C, Battistin L, Spano P & Pizzi M (2009) NF-kappaB dimers in the regulation of neuronal survival. Int Rev Neurobiol 85, 351-362.
45. Blum D, Torch S, Nissou MF, Benabid AL & Verna JM (2000) Extracellular toxicity of 6-hydroxydopamine on PC12 cells. Neurosci Lett 283, 193-196.
46. Görg A, Obermaier C, Boguth G, Harder A, Scheibe B, Wildgruber R & Weiss W (2000) The current state of two-dimensional electrophoresis with immobilized pH gradients. Electrophoresis 21, 1037-1053.
47. Gromova I & Celis JE (2006) Protein detection in gels by silver staining: A procedure compatible with mass-spectrometry. In Cell Biology: A Laboratory Handbook (Celis JE, Carter N, Hunter T, Simons K, Small JV & Shotton D eds), pp. 219-224. Academic Press, New York.