Nm23-H1 Protein Binds to APE1 at AP Sites and Stimulates AP Endonuclease Activity Following Ionizing Radiation of the Human Lung Cancer A549 Cells

Cell Biochemistry and Biophysics

Volumn 61, Issue 3, 2011, Pages 561-572

  Zhang, Zhi Min ^a   Yang, Xue Qin ^a   Wang, Dong ^a   Wang, Ge ^a   Yang, Zhen Zhou ^a   Qing, Yi ^a   Yang, Zhi Xiang ^a   Li, Meng Xia ^a   Xiang, De Bing ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

APE1; BER pathway; DNA repair; Ionizing radiation; Nm23 H1

Indexed keywords

APEX1 PROTEIN, HUMAN; DNA; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; NUCLEOSIDE DIPHOSPHATE KINASE NM23;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HUMAN; INTRACELLULAR SPACE; LUNG TUMOR; METABOLISM; PATHOLOGY; PROTEIN BINDING; PROTEIN TRANSPORT; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; TIME; TUMOR CELL LINE; X RAY;

CELL LINE, TUMOR; DNA; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DOSE-RESPONSE RELATIONSHIP, RADIATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTRACELLULAR SPACE; LUNG NEOPLASMS; MODELS, MOLECULAR; NM23 NUCLEOSIDE DIPHOSPHATE KINASES; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN TRANSPORT; RADIATION TOLERANCE; TIME FACTORS; X-RAYS;

EID: 81155152597     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12013-011-9238-9     Document Type: Article

References (37)

1. Jin, L., Liu, G., Zhang, C. H., et al. (2009). Nm23-H1 regulates the proliferation and differentiation of the human chronic myeloid leukemia K562 cell line: A functional proteomics study. Life Sciences, 84, 458-467.
2. Jung, H., Seong, H. A., & Ha, H. (2007). Nm23-H1 tumor suppressor and its interacting partner STRAP activate p53 function. The Journal of Biological Chemistry, 282, 35293-35307.
3. Biggs, J., Hersperger, E., Steeg, P. S., Liotta, L. A., & Shearn, A. A. (1990). Drosophila gene that is homologous to a mammalian gene associated with tumor metastasis codes for a nucleoside diphosphate kinase. Cell, 63, 933-940.
4. Hartsough, M. T., Morrison, D. K., Salerno, M., et al. (2002). Nm23-H1 metastasis suppressor of Ras via a histidine protein kinase pathway. The Journal of Biological Chemistry, 277, 32389-32399.
5. Bosnar, M. H., Dubravčic′, K., Bago, R., & Pavelic′, J. (2008). Head and neck tumor cells exhibit altered proliferation upon overexpression of nm23 genes. Croatica Chemica Acta, 81, 183-189.
6. Cipollini, G., Berti, A., Fiore, L., et al. (1997). Down-regulation of the nm23-H1 gene inhibits cell proliferation. International Journal of Cancer, 73, 297-302.
7. Kimura, N., Shimada, N., Fukuda, M., et al. (2000). Regulation of cellular functions by nucleoside diphosphate kinases in mammals. Journal of Bioenergetics and Biomembranes, 32, 309-315.
8. Parlanti, E., Locatelli, G., Maga, G., & Dogliotti, E. (2007). Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins. Nucleic Acids Research, 35, 1569-1577.
9. Wilson, D. M., 3rd, & Bohr, V. A. (2007). The mechanics of base excision repair, and its relationship to aging and disease. DNA Repair, 6, 544-559.
10. Evans, A. R., Limp-Foster, M., & Kelley, M. R. (2000). Going APE over ref-1. Mutation Research, 461, 83-108.
11. Chowdhury, D., Beresford, P. J., Zhu, P., et al. (2006). The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. Molecular Cell, 23, 133-142.
12. Fan, Z., Beresford, P. J., Zhang, D., et al. (2003). Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. Nature Immunology, 4, 145-153.
13. Yan, N., Cherepanov, P., Daigle, J. E., Engelman, A., & Lieberman, J. (2009). The SET complex acts as a barrier to autointegration of HIV-1. PLoS Pathogens, 5, e1000327.
14. Chowdhury, D., & Lieberman, J. (2008). Death by a thousand cuts: Granzyme pathways of programmed cell death. Annual Review of Immunology, 26, 389-420.
15. Zhao, Y., Seefeldt, T., Chen, W., et al. (2009). Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation. Free Radical Biology and Medicine, 47, 176-183.
16. Zhou, Q., Yang, X., Zhu, D., et al. (2007). Double mutant P96S/S120G of Nm23-H1 abrogates its NDPK activity and motility-suppressive ability. Biochemical and Biophysical Research Communications, 356, 348-353.
17. Dai, N., Wang, D., Li, M. X., et al. (2009). Construction, purification and functional characterization of hAPE1 and fusion protein. Acta Academiae Medicinae Militaris Tertiae, 31, 1123-1126.
18. Li, M. X., Wang, D., Zhong, Z. Y., et al. (2008). Targeting truncated APE1 in mitochondria enhances cell survival after oxidative stress. Free Radical Biology and Medicine, 45, 592-601.
19. Wang, D., Xiang, D. B., Yang, X. Q., et al. (2009). APE1 overexpression is associated with cisplatin resistance in non-small cell lung cancer and targeted inhibition of APE1 enhances the activity of cisplatin in A549 cells. Lung Cancer, 66, 298-304.
20. Xiang, D. B., Chen, Z. T., Wang, D., et al. (2008). Chimeric adenoviral vector Ad5/F35-mediated APE1 siRNA enhances sensitivity of human colorectal cancer cells to radiotherapy in vitro and in vivo. Cancer Gene Therapy, 15, 625-635.
21. Wang, Y. F., Chen, J. Y., Chang, S. Y., et al. (2008). Nm23-H1 expression of metastatic tumors in the lymph nodes is a prognostic indicator of oral squamous cell carcinoma. International Journal of Cancer, 122, 377-386.
22. Neyton, S., Lespinasse, F., Lahaye, F., Staccini, P., Paquis-Flucklinger, V., & Santucci-Darmanin, S. (2007). CRM1-dependent nuclear export and dimerization with hMSH5 contribute to the regulation of hMSH4 subcellular localization. Experimental Cell Research, 313, 3680-3693.
23. Fan, Z., Beresford, P. J., Oh, D. Y., Zhang, D., & Lieberman, J. (2003). Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis and the nucleosome assembly protein SET is its inhibitor. Cell, 112, 659-672.
24. Wong, H. K., Muftuoglu, M., Beck, G., Imam, S. Z., Bohr, V. A., & Wilson, D. M., 3rd. (2007). Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates. Nucleic Acids Research, 35, 4103-4113.
25. Belzile, J. P., Choudhury, S. A., Cournoyer, D., & Chow, T. Y. (2006). Targeting DNA repair proteins: A promising avenue for cancer gene therapy. Current Gene Therapy, 6, 111-123.
26. Ding, J., Miao, Z. H., Meng, L. H., & Geng, M. Y. (2006). Emerging cancer therapeutic opportunities target DNA-repair systems. Trends in Pharmacological Sciences, 27, 338-344.
27. Madhusudan, S., & Middleton, M. R. (2005). The emerging role of DNA repair proteins as predictive, prognostic and therapeutic targets in cancer. Cancer Treatment Review, 31, 603-617.
28. Kaetzel, D. M., Zhang, Q., Yang, M., McCorkle, J. R., Ma, D., & Craven, R. J. (2006). Potential roles of 3′-5′ exonuclease activity of NM23-H1 in DNA repair and malignant progression. Journal of Bioenergetics and Biomembranes, 38, 163-167.
29. Lu, Q., Zhang, X., Almaula, N., Mathews, C. K., & Inouye, M. (1995). The gene for nucleoside diphosphate kinase functions as a mutator gene in Escherichia coli. Journal of Molecular Biology, 254, 337-341.
30. Fabbro, M., & Henderson, B. R. (2003). Regulation of tumor suppressors by nuclear-cytoplasmic shuttling. Experimental Cell Research, 282, 59-69.
31. Henderson, B. R. (2005). Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking. BioEssays, 27, 884-893.
32. Simeonov, A., Kulkarni, A., Dorjsuren, D., et al. (2009). Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One, 4, e5740.
33. Ma, D., McCorkle, J. R., & Kaetzel, D. M. (2004). The metastasis suppressor NM23-H1 possesses 3′-5′ exonuclease activity. The Journal of Biological Chemistry, 279, 18073-18084.
34. Postel, E. H. (2003). Multiple biochemical activities of Nm23/NDP kinase in gene regulation. Journal of Bioenergetics and Biomembranes, 35, 31-40.
35. Zou, Y., Crowley, D. J., & van Houten, B. (1998). Involvement of molecular chaperonins in nucleotide excision repair: Dna K leads to increased thermal stability of UvrA, catalytic UvrB loading, enhanced repair and increased UV resistance. The Journal of Biological Chemistry, 273, 12887-12892.
36. Chow, K. C., & Tung, W. L. (2000). Magnetic field exposure enhances DNA repair through the induction of DnaK/J synthesis. FEBS Letters, 478, 133-136.
37. Wilson, D. M., 3rd, Takeshita, M., & Demple, B. (1997). Abasic site binding by the human apurinic endonuclease, Ape, and determination of the DNA contact sites. Nucleic Acids Research, 25, 933-939.