Ibuprofen improves functional outcome after axotomy and immediate repair in the peripheral nervous system

Journal of Plastic, Reconstructive and Aesthetic Surgery

Volumn 64, Issue 12, 2011, Pages 1641-1646

  Madura, Tomas ^a,b   Tomita, Koichi ^a   Terenghi, Giorgio ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Axonal regrowth; Cytoskeleton; Ibuprofen; Nerve injury; NSAIDs; Regeneration; Rho

Indexed keywords

IBUPROFEN; MYELIN; PHOSPHATE BUFFERED SALINE; RHO FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; MORPHOMETRICS; NERVE CONDUCTION; NERVE FIBER; NERVE FIBER TRANSECTION; NERVE FUNCTION; NERVE POTENTIAL; NERVE REGENERATION; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NONHUMAN; OSMOTIC PUMP; PERIPHERAL NERVE INJURY; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; RAT; TIBIAL NERVE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AXOTOMY; ELECTROPHYSIOLOGY; FEMALE; IBUPROFEN; NERVE REGENERATION; NEURAL CONDUCTION; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; RHO GTP-BINDING PROTEINS; TIBIAL NERVE; TREATMENT OUTCOME;

EID: 81155150155     PISSN: 17486815     EISSN: 18780539     Source Type: Journal    
DOI: 10.1016/j.bjps.2011.07.014     Document Type: Article

References (30)

1. S. Etienne-Manneville, and A. Hall Rho GTPases in cell biology Nature 420 2002 629 635 (Pubitemid 36764489)
2. A. Hall, and G. Lalli Rho and Ras GTPases in axon growth, guidance, and branching Cold Spring Harb Perspect Biol 2 2010 a001818
3. G. Meyer, and E.L. Feldman Signaling mechanisms that regulate actin-based motility processes in the nervous system J Neurochem 83 2002 490 503 (Pubitemid 35231803)
4. T. Madura, T. Yamashita, and T. Kubo Activation of Rho in the injured axons following spinal cord injury EMBO Rep 5 2004 412 417 (Pubitemid 38618285)
5. C.I. Dubreuil, M.J. Winton, and L. McKerracher Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system J Cell Biol 162 2003 233 243 (Pubitemid 36928837)
6. H. Tanaka, T. Yamashita, and K. Yachi Cytoplasmic p21(Cip1/WAF1) enhances axonal regeneration and functional recovery after spinal cord injury in rats Neuroscience 127 2004 155 164 (Pubitemid 38829161)
7. M. Lehmann, A. Fournier, and I. Selles-Navarro Inactivation of Rho signaling pathway promotes CNS axon regeneration J Neurosci 19 1999 7537 7547 (Pubitemid 29404610)
8. C. Cheng, C.A. Webber, and J. Wang Activated RHOA and peripheral axon regeneration Exp Neurol 212 2008 358 369
9. A. Hiraga, S. Kuwabara, and H. Doya Rho-kinase inhibition enhances axonal regeneration after peripheral nerve injury J Peripher Nerv Syst 11 2006 217 224 (Pubitemid 44286072)
10. T. Eichholtz, K. Jalink, I. Fahrenfort, and W.H. Moolenaar The bioactive phospholipid lysophosphatidic acid is released from activated platelets Biochem J 291 Pt 3 1993 677 680 (Pubitemid 23148436)
11. O. Kranenburg, M. Poland, and F.P. van Horck Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: induction of neurite retraction Mol Biol Cell 10 1999 1851 1857
12. H. Neumann, R. Schweigreiter, and T. Yamashita Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a rho-dependent mechanism J Neurosci 22 2002 854 862 (Pubitemid 34141766)
13. T. Yamashita, H. Higuchi, and M. Tohyama The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho J Cell Biol 157 2002 565 570 (Pubitemid 34839785)
14. T. Madura, T. Kubo, and M. Tanag The Rho-associated kinase inhibitor fasudil hydrochloride enhances neural regeneration after axotomy in the peripheral nervous system Plast Reconstr Surg 119 2007 526 535 (Pubitemid 46142936)
15. Q. Fu, J. Hue, and S. Li Nonsteroidal anti-inflammatory drugs promote axon regeneration via RhoA inhibition J Neurosci 27 2007 4154 4164 (Pubitemid 46597154)
16. J. Dill, A.R. Patel, and X.-L. Yang A molecular mechanism for ibuprofen-mediated RhoA inhibition in neurons J Neurosci 30 2010 963 972
17. X. Wang, S. Budel, and K. Baughman Ibuprofen enhances recovery from spinal cord injury by limiting tissue loss and stimulating axonal growth J Neurotrauma 26 2009 81 95
18. S. Ozmen, S. Ayhan, O. Latifoglu, and M. Siemionow Stamp and paper method: a superior technique for the walking track analysis Plast Reconstr Surg 109 2002 1760 1761 (Pubitemid 34273411)
19. J.R. Bain, S.E. Mackinnon, and D.A. Hunter Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the rat Plast Reconstr Surg 83 1989 129 138
20. K. Temporin, H. Tanaka, and Y. Kuroda Interleukin-1 beta promotes sensory nerve regeneration after sciatic nerve injury Neurosci Lett 440 2008 130 133
21. J. Ng, and L. Luo Rho GTPases regulate axon growth through convergent and divergent signaling pathways Neuron 44 2004 779 793 (Pubitemid 39575632)
22. L. Luo, L.Y. Jan, and Y.N. Jan Rho family GTP-binding proteins in growth cone signalling Curr Opin Neurobiol 7 1997 81 86 (Pubitemid 27096247)
23. P. Dergham, B. Ellezam, and C. Essagian Rho signaling pathway targeted to promote spinal cord repair J Neurosci 22 2002 6570 6577 (Pubitemid 35386413)
24. M.J. Winton, C.I. Dubreuil, D. Lasko, N. Leclerc, and L. McKerracher Characterization of new cell permeable C3-like proteins that inactivate Rho and stimulate neurite outgrowth on inhibitory substrates J Biol Chem 277 2002 32820 32829 (Pubitemid 34984792)
25. W.B. Rockwell, and H.P. Ehrlich Ibuprofen in acute-care therapy Ann Surg 211 1990 78 83 (Pubitemid 20027888)
26. C. Derry, S. Derry, R.A. Moore, and H.J. McQuay Single dose oral ibuprofen for acute postoperative pain in adults Cochrane Database Syst Rev 3 2009 CD001548
27. M. Inoue, M.H. Rashid, and R. Fujita Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling Nat Med 10 2004 712 718 (Pubitemid 38937636)
28. S. Tatsumi, T. Mabuchi, and T. Katano Involvement of Rho-kinase in inflammatory and neuropathic pain through phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS) Neuroscience 131 2005 491 498 (Pubitemid 40222456)
29. K.D. Rainsford Ibuprofen: pharmacology, efficacy and safety Inflammopharmacology 17 2009 275 342
30. C.V. Melendez-Vasquez, S. Einheber, and J.L. Salzer Rho kinase regulates schwann cell myelination and formation of associated axonal domains J Neurosci 24 2004 3953 3963 (Pubitemid 38544222)