Alternative mechanism for anti-obesity effect of dehydroepiandrosterone: Possible contribution of 11β-hydroxysteroid dehydrogenase type 1 inhibition in rodent adipose tissue

Steroids

Volumn 76, Issue 14, 2011, Pages 1546-1553

  Tagawa, Noriko ^a   Minamitani, Erika ^a   Yamaguchi, Yuko ^a   Kobayashi, Yoshiharu ^a  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

11 HSD1; Adipose tissue; DHEA; Obesity

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; ANTIOBESITY AGENT; CORTICOSTERONE; ESTROGEN; HYDROCORTISONE; PRASTERONE;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG MECHANISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; MICROSOME; NONHUMAN; OBESITY; RAT;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; 3T3-L1 CELLS; ADIPOSE TISSUE; ANIMALS; ANTI-OBESITY AGENTS; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; ENZYME INHIBITORS; MALE; MICE; MICROSOMES, LIVER; RATS;

RATTUS; RODENTIA;

EID: 81155148223     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2011.09.005     Document Type: Article

References (53)

1. H. Masuzaki, J. Paterson, and H. Shinyama A transgenic model of visceral obesity and the metabolic syndrome Science 294 2001 2166 2170 (Pubitemid 33150673)
2. D.J. Wake, E. Rask, and D.E. Livingstone Local and systemic impact of transcriptional up-regulation of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue in human obesity J Clin Endocrinol Metab 88 2003 3983 3988 (Pubitemid 37034555)
3. I.J. Bujalska, S. Kumar, and P.M. Stewart Does central obesity reflect "Cushing's disease of the omentum"? Lancet 349 1997 1210 1213 (Pubitemid 27190044)
4. K. Kannisto, K.H. Pietilainen, and E. Ehrenborg Overexpression of 11β-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins J Clin Endocrinol Metab 89 2004 4414 4421 (Pubitemid 39244448)
5. P.M. Stewart, and Z.S. Krozowski 11β-Hydroxysteroid dehydrogenase Vitam Horm 57 1999 249 324
6. N. Orentreich, J.L. Brind, R.L. Rizer, and J.H. Vogelman Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood J Clin Endocrinol Metab 59 1984 551 555 (Pubitemid 14031806)
7. J.E. Nestler, C.O. Barlascini, J.N. Clore, and W.G. Blackard Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men J Clin Endocrinol Metab 66 1988 57 61 (Pubitemid 18027729)
8. E. Barrett-Connor, and A. Ferrara Dehydroepiandrosterone, dehydroepiandrosterone sulfate, obesity, waist-hip ratio, and noninsulin-dependent diabetes in postmenopausal women: the Rancho Bernardo Study J Clin Endocrinol Metab 81 1996 59 64
9. D.M. Herrington Dehydroepiandrosterone and coronary atherosclerosis Ann NY Acad Sci 774 1995 271 280 (Pubitemid 26140376)
10. P. Ebeling, and V.A. Koivisto Physiological importance of dehydroepiandrosterone Lancet 343 1994 1479 1481 (Pubitemid 24176340)
11. D.P. Trivedi, and K.T. Khaw Dehydroepiandrosterone sulfate and mortality in elderly men and women J Clin Endocrinol Metab 86 2001 4171 4177 (Pubitemid 32848531)
12. M.P. Cleary, A. Shepherd, and B. Jenks Effect of dehydroepiandrosterone on growth in lean and obese Zucker rats J Nutr 114 1984 1242 1251 (Pubitemid 14081804)
13. M.P. Cleary, and J.F. Zisk Anti-obesity effect of two different levels of dehydroepiandrosterone in lean and obese middle-aged female Zucker rats Int J Obes 10 1986 193 204 (Pubitemid 16048554)
14. D.L. Coleman, E.H. Leiter, and R.W. Schwizer Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice Diabetes 31 1982 830 833 (Pubitemid 12062875)
15. D.L. Coleman, R.W. Schwizer, and E.H. Leiter Effect of genetic background on the therapeutic effects of dehydroepiandrosterone (DHEA) in diabetes-obesity mutants and in aged normal mice Diabetes 33 1984 26 32 (Pubitemid 14187198)
16. G.B. Gordon, J.A. Newitt, and L.M. Shantz Inhibition of the conversion of 3T3 fibroblast clones to adipocytes by dehydroepiandrosterone and related anticarcinogenic steroids Cancer Res 46 1986 3389 3395 (Pubitemid 16096878)
17. Y.R. Lea-Currie, P. Wen, and M.K. McIntosh Dehydroepiandrosterone reduces proliferation and differentiation of 3T3-L1 preadipocytes Biochem Biophys Res Commun 248 1998 497 504 (Pubitemid 28404449)
18. G. Apostolova, R.A. Schweizer, and Z. Balazs Dehydroepiandrosterone inhibits the amplification of glucocorticoid action in adipose tissue Am J Physiol Endocrinol Metab 288 2005 E957 E964
19. L.J. Williams, V. Lyons, and I. MacLeod C/EBP regulates hepatic transcription of 11β-hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways J Biol Chem 275 2000 30232 30239
20. N. Tagawa, R. Yuda, and S. Kubota 17β-Estradiol inhibits 11β-hydroxysteroid dehydrogenase type 1 activity in rodent adipocytes J Endocrinol 202 2009 131 139
21. N. Tagawa, H. Tsuruta, A. Fujinami, and Y. Kobayashi Simultaneous determination of estriol and estriol 3-sulfate in serum by column-switching semi-micro high-performance liquid chromatography with ultraviolet and electrochemical detection J. Chromatogr. B Biomed. Sci. Appl. 723 1999 39 45 (Pubitemid 29148107)
22. Y. Kobayashi, Y. Nishiguchi, and T. Kiguchi An alternative metabolic pathway of 11-deoxycorticosterone in bovine adrenal in vitro: evidence for the presence of a pathway of 11-deoxycorticosterone oxidation at 19-position J Steroid Biochem 28 1987 759 767 (Pubitemid 18024998)
23. D.T. Villareal, and J.O. Holloszy Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial JAMA 292 2004 2243 2248 (Pubitemid 39473162)
24. A. Tchernof, and F. Labrie Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies Eur J Endocrinol 151 2004 1 14 (Pubitemid 39117360)
25. R. Deckx, and P. De Moor Study of the 11β-hydroxysteroid dehydrogenase in vitro. I. Biochemical characterization in spleen homogenate Pflugers Arch Gesamte Physiol Menschen Tiere 289 1966 59 68
26. K.L. McCormick, X. Wang, and G.J. Mick Evidence that the 11β-hydroxysteroid dehydrogenase (11β-HSD1) is regulated by pentose pathway flux. Studies in rat adipocytes and microsomes J Biol Chem 281 2006 341 347 (Pubitemid 43671194)
27. J. Condon, M.L. Ricketts, C.B. Whorwood, and P.M. Stewart Ontogeny and sexual dimorphic expression of mouse type 2 11β-hydroxysteroid dehydrogenase Mol Cell Endocrinol 127 1997 121 128 (Pubitemid 27148372)
28. E. Maser, and G. Bannenberg 11β-Hydroxysteroid dehydrogenase mediates reductive metabolism of xenobiotic carbonyl compounds Biochem Pharmacol 47 1994 1805 1812
29. R.S. Ge, H.B. Gao, and V.L. Nacharaju Identification of a kinetically distinct activity of 11β-hydroxysteroid dehydrogenase in rat Leydig cells Endocrinology 138 1997 2435 2442 (Pubitemid 27215247)
30. F. Labrie, V. Luu-The, C. Labrie, and J. Simard DHEA and its transformation into androgens and estrogens in peripheral target tissues: intracrinology Front Neuroendocrinol 22 2001 185 212 (Pubitemid 32706336)
31. G. Bleau, K.D. Roberts, and A. Chapdelaine The in vitro and in vivo uptake and metabolism of steroids in human adipose tissue J Clin Endocrinol Metab 39 1974 236 246
32. L.D. Valle, V. Toffolo, and A. Nardi Tissue-specific transcriptional initiation and activity of steroid sulfatase complementing dehydroepiandrosterone sulfate uptake and intracrine steroid activations in human adipose tissue J Endocrinol 190 2006 129 139 (Pubitemid 44161068)
33. T. Feher, and L. Bodrogi A comparative study of steroid concentrations in human adipose tissue and the peripheral circulation Clin Chim Acta 126 1982 135 141 (Pubitemid 13247375)
34. J. Szymczak, A. Milewicz, and J.H. Thijssen Concentration of sex steroids in adipose tissue after menopause Steroids 63 1998 319 321 (Pubitemid 28265669)
35. W. Arlt, H.G. Justl, and F. Callies Oral dehydroepiandrosterone for adrenal androgen replacement: pharmacokinetics and peripheral conversion to androgens and estrogens in young healthy females after dexamethasone suppression J Clin Endocrinol Metab 83 1998 1928 1934 (Pubitemid 28496318)
36. G.E. Ackerman, M.E. Smith, and C.R. Mendelson Aromatization of androstenedione by human adipose tissue stromal cells in monolayer culture J Clin Endocrinol Metab 53 1981 412 417 (Pubitemid 13250304)
37. N. Draper, E.A. Walker, and I.J. Bujalska Mutations in the genes encoding 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency Nat Genet 34 2003 434 439 (Pubitemid 36935337)
38. P.C. White, D. Rogoff, D.R. McMillan, and G.G. Lavery Hexose 6-phosphate dehydrogenase (H6PD) and corticosteroid metabolism Mol Cell Endocrinol 265-266 2007 89 92 (Pubitemid 46273968)
39. B. Mandula, S.K. Srivastava, and E. Beutler Hexose-6-phosphate dehydrogenase: distribution in rat tissues and effect of diet, age and steroids Arch Biochem Biophys 141 1970 155 161
40. K. Oka, T. Takahashi, and S.H. Hori Differential effects of the NADPH/NADP+ ratio on the activities of hexose-6-phosphate dehydrogenase and glucose-6-phosphate dehydrogenase Biochim Biophys Acta 662 1981 318 325 (Pubitemid 12164037)
41. P.A. Marks, and J. Banks Inhibition of mammalian glucose-6-phosphate dehydrogenase by steroids Proc Natl Acad Sci USA 16 1960 447 452
42. R. Raineri, and H.R. Levy On the specificity of steroid interaction with mammary glucose 6-phosphate dehydrogenase Biochemistry 9 1970 2233 2243
43. G. Gordon, M.C. Mackow, and H.R. Levy On the mechanism of interaction of steroids with human glucose 6-phosphate dehydrogenase Arch Biochem Biophys 318 1995 25 29
44. B. Hagenbuch, and P.J. Meier The superfamily of organic anion transporting polypeptides Biochim Biophys Acta 1609 2003 1 18 (Pubitemid 36044060)
45. R. Willemsen, M. Kroos, and A.T. Hoogeveen Ultrastructural localization of steroid sulphatase in cultured human fibroblasts by immunocytochemistry: a comparative study with lysosomal enzymes and the mannose 6-phosphate receptor Histochem J 20 1988 41 51
46. 4 isomerase (3 β-HSD), 17β-HSD 5α-reductase and aromatase activities in the rhesus monkey Mol Cell Endocrinol 104 1994 103 111
47. J. Karbowska, and Z. Kochan Effect of DHEA on endocrine functions of adipose tissue, the involvement of PPAR γ Biochem Pharmacol 70 2005 249 257 (Pubitemid 40814407)
48. M. Kimura, S. Tanaka, and Y. Yamada Dehydroepiandrosterone decreases serum tumor necrosis factor-α and restores insulin sensitivity: independent effect from secondary weight reduction in genetically obese Zucker fatty rats Endocrinology 139 1998 3249 3253 (Pubitemid 28512356)
49. F. Perez-de-Heredia, J. Sanchez, and T. Priego Adiponectin is involved in the protective effect of DHEA against metabolic risk in aged rats Steroids 73 2008 1128 1136
50. Z. Kochan, and J. Karbowska Dehydroepiandrosterone up-regulates resistin gene expression in white adipose tissue Mol Cell Endocrinol 218 2004 57 64 (Pubitemid 38569927)
51. Y. Kotelevtsev, M.C. Holmes, and A. Burchell 11β-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress Proc Natl Acad Sci USA 94 1997 14924 14929 (Pubitemid 28041476)
52. C.D. Boyle Recent advances in the discovery of 11β-HSD1 inhibitors Curr Opin Drug Discov Dev 11 2008 495 511 (Pubitemid 351950845)
53. M. Wamil, and J.R. Seckl Inhibition of 11β-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target Drug Discov Today 12 2007 504 520 (Pubitemid 47031664)