Diagnosis and antimicrobial therapy of lung infiltrates in febrile neutropenic cancer patients

Current Infectious Disease Reports

Volumn 13, Issue 6, 2011, Pages 510-516

  Maschmeyer, Georg ^a  

^a KLINIKUM ERNST VON BERGMANN   (Germany)

Author keywords

Aspergillosis; Diagnosis; Febrile neutropenia; Infection; Lung infiltrates; Treatment

Indexed keywords

AMPHOTERICIN B LIPID COMPLEX; ANTIFUNGAL AGENT; ATOVAQUONE; BIOLOGICAL MARKER; CLINDAMYCIN; COTRIMOXAZOLE; GANCICLOVIR; PENTAMIDINE; POSACONAZOLE; PRIMAQUINE; VORICONAZOLE;

ACUTE LEUKEMIA; ANTIMICROBIAL THERAPY; ARTICLE; ARTIFICIAL VENTILATION; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; BIOPSY TECHNIQUE; CANCER PATIENT; COMPUTER ASSISTED TOMOGRAPHY; CYTOMEGALOVIRUS INFECTION; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; DRUG CHOICE; DRUG MEGADOSE; EARLY DIAGNOSIS; FEBRILE NEUTROPENIA; FUNGAL DETECTION; FUNGUS ISOLATION; HEMATOLOGIC MALIGNANCY; HISTOPATHOLOGY; HUMAN; INVASIVE ASPERGILLOSIS; LUNG ASPERGILLOSIS; LUNG INFILTRATE; LUNG LAVAGE; LUNG MYCOSIS; MOLECULAR DIAGNOSIS; MUCORMYCOSIS; NONHUMAN; PNEUMOCYSTIS PNEUMONIA; RESPIRATORY FAILURE; SENSITIVITY AND SPECIFICITY; SYSTEMIC MYCOSIS; THORAX RADIOGRAPHY; VIRUS PNEUMONIA;

EID: 81155139629     PISSN: 15233847     EISSN: 15343146     Source Type: Journal    
DOI: 10.1007/s11908-011-0219-3     Document Type: Article

References (60)

1. G Maschmeyer T Beinert D Buchheidt, et al. 2009 Diagnosis and antimicrobial therapy of pulmonary infiltrates in febrile neutropenic patients. 2008 updated guidelines of the Infectious Diseases Working Party of the German Society of Hematology and Oncology Eur J Cancer 45 2462 72 19467584 10.1016/j.ejca.2009.05.001 1:CAS:528:DC%2BD1MXhtVKls7vM
2. H Link G Maschmeyer P Meyer, et al. 1994 Interventional antimicrobial therapy in febrile neutropenic patients Ann Hematol 69 231 43 7948312 10.1007/BF01700277 1:STN:280:DyaK2M%2FjsFeqtQ%3D%3D (Pubitemid 24357930)
3. G Maschmeyer H Link W Hiddemann, et al. 1994 Pulmonary infiltrations in febrile neutropenic patients. Risk factors and outcome under empirical antimicrobial therapy in a randomized multicenter trial Cancer 73 2296 304 8168033 10.1002/1097-0142(19940501)73:9<2296::AID-CNCR2820730910>3.0.CO;2- 7 1:STN:280:DyaK2c3itFGhtw%3D%3D (Pubitemid 24129111)
4. E Azoulay G Thiery S Chevret, et al. 2004 The prognosis of acute respiratory failure in critically ill cancer patients Medicine 83 360 70 15525848 10.1097/01.md.0000145370.63676.fb (Pubitemid 39545182)
5. A Al Ameri C Koller H Kantarjian, et al. 2010 Acute pulmonary failure during remission induction chemotherapy in adults with acute myeloid leukemia or high-risk myelodysplastic syndrome Cancer 116 93 7 19862814 This updated report confirms that patients with lung infiltrates are a prognostically poor subgroup among febrile neutropenic cancer patients.
6. EM Canham TC Kennedy TA Merrick 1983 Unexplained pulmonary infiltrates in the compromised patient Cancer 52 325 9 6861075 10.1002/1097-0142(19830715)52: 2<325::AID-CNCR2820520223>3.0.CO;2-I 1:STN:280:DyaL3s3jt1Gqsg%3D%3D
7. JR Commers KJ Robichaud PA Pizzo 1984 New pulmonary infiltrates in granulocytopenic cancer patients being treated with antibiotics Pediatr Infect Dis J 3 423 8 10.1097/00006454-198409000-00007 1:STN:280:DyaL2M%2FjvVWjtQ%3D%3D (Pubitemid 14044498)
8. ME Ellis D Spence A Bouchama, et al. 1995 Open lung biopsy provides a higher and more specific diagnostic yield compared to bronchoalveolar lavage in immunocompromised patients Scand J Infect Dis 27 157 62 7660081 10.3109/00365549509018998 1:STN:280:DyaK2MzovFWhsA%3D%3D
9. SJ Rossiter DC Miller AM Churg, et al. 1979 Open lung biopsy in the immunocompromised patient. Is it really beneficial? J Thorac Cardiovasc Surg 77 338 45 762976 1:STN:280:DyaE1M7ht12nsQ%3D%3D (Pubitemid 9122830)
10. T Peikert S Rana ES Edell 2005 Safety, diagnostic yield, and therapeutic implications of flexible bronchoscopy in patients with febrile neutropenia and pulmonary infiltrates Mayo Clin Proc 80 1414 20 16295020 10.4065/80.11.1414 (Pubitemid 41567218)
11. X Schiel H Link G Maschmeyer, et al. 2006 A prospective, randomized multicenter trial of the empirical addition of antifungal therapy for febrile neutropenic cancer patients Infection 34 118 26 16804654 10.1007/s15010-006- 5113-9 1:STN:280:DC%2BD28nhsFKmug%3D%3D (Pubitemid 43979659)
12. JJ Vehreschild A Böhme D Buchheidt, et al. 2007 A double-blind trial on prophylactic voriconazole or placebo during induction chemotherapy for acute myelogenous leukaemia J Infect 55 445 9 17822770 10.1016/j.jinf.2007.07.003 (Pubitemid 47628350)
13. Mattiuzzi GN, Alvarado G, Alvarez R, et al. Incidence of pulmonary infiltrates in patients with acute myelogenous leukemia and myelodysplastic syndrome undergoing induction chemotherapy: retrospective analysis of 5 years. 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, September 14-17, 2003, abstr # K-1368.
14. TJ Walsh EJ Anaissie DW Denning, et al. 2008 Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America Clin Infect Dis 46 327 60 18177225 10.1086/525258 1:CAS:528:DC%2BD1cXitlKqt7c%3D This is the standard treatment guideline for invasive aspergillosis. (Pubitemid 351265310)
15. D Caillot O Casasnovas A Bernard, et al. 1997 Improved management of invasive pulmonary aspergillosis in neutropenic patients using early thoracic computed tomographic scan and surgery J Clin Oncol 15 139 47 8996135 1:STN:280:DyaK2s7kvFehtQ%3D%3D (Pubitemid 27020567)
16. Cornely OA, Maertens J, Bresnik M, et al. Efficacy outcomes in a randomised trial of liposomal amphotericin B based on revised EORTC/MSG 2008 definitions of invasive mould disease. Mycoses. 2010. doi: 10.1111/j.1439-0507. 2010.01947.x [Epub ahead of print].
17. RE Greene HT Schlamm JW Oestmann, et al. 2007 Imaging findings in acute invasive pulmonary aspergillosis: clinical significance of the halo sign Clin Infect Dis 44 373 9 17205443 10.1086/509917 (Pubitemid 46147619)
18. J Maertens K Theunissen G Verhoef, et al. 2005 Galactomannan and computed tomography-based preemptive antifungal therapy in neutropenic patients at high risk for invasive fungal infection Clin Infect Dis 41 1242 50 16206097 10.1086/496927 1:CAS:528:DC%2BD2MXht1WisbfE (Pubitemid 41534660)
19. S Ahmed AK Siddiqui L Rossoff, et al. 2003 Pulmonary complications in chronic lymphocytic leukemia Cancer 98 1912 7 14584074 10.1002/cncr.11736 (Pubitemid 37310234)
20. AR Falsey PA Hennessey MA Formica, et al. 2005 Respiratory Syncytial Virus infection in elderly and high-risk adults N Engl J Med 352 1749 59 15858184 10.1056/NEJMoa043951 1:CAS:528:DC%2BD2MXjsFyhsr8%3D (Pubitemid 40570923)
21. AH Navigante LC Cerchietti P Costantini, et al. 2002 Conventional chest radiography in the initial assessment of adult cancer patients with fever and neutropenia Cancer Control 9 346 51 12228760 (Pubitemid 34921040)
22. CP Heussel HU Kauczor GE Heussel, et al. 1999 Pneumonia in febrile neutropenic patients and in bone marrow and blood stem-cell transplant recipients: use of high-resolution computed tomography J Clin Oncol 17 796 805 10071269 1:STN:280:DyaK1M7mvVyhtQ%3D%3D (Pubitemid 29109308)
23. D Caillot JF Couaillier A Bernard, et al. 2001 Increasing volume and changing characteristics of invasive pulmonary aspergillosis on sequential thoracic computed tomography scans in patients with neutropenia J Clin Oncol 19 253 9 11134220 1:STN:280:DC%2BD38%2Fls1Sqtw%3D%3D (Pubitemid 32063503)
24. B De Pauw TJ Walsh JP Donnelly, et al. 2008 Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group Consensus Group Clin Infect Dis 46 1813 21 18462102 10.1086/588660
25. CP Heussel HU Kauczor AJ Ullmann 2004 Pneumonia in neutropenic patients Eur Radiol 14 256 71 12898175 10.1007/s00330-003-1985-6 1:STN:280: DC%2BD2c%2FkvVCksA%3D%3D (Pubitemid 38181083)
26. AF Shorr GM Susla NP O'Grady 2004 Pulmonary infiltrates in the non-HIV-infected immunocompromised patient: etiologies, diagnostic strategies, and outcomes Chest 125 260 71 14718449 10.1378/chest.125.1.260 (Pubitemid 38114591)
27. R Eibel P Herzog O Dietrich, et al. 2006 Pulmonary abnormalities in immunocompromised patients: comparative detection with parallel acquisition MR imaging and thin-section helical CT Radiology 241 880 91 17032908 10.1148/radiol.2413042056 (Pubitemid 46190556)
28. H Brodoefel M Vogel H Hebart, et al. 2006 Long-term CT follow-up in 40 non-HIV immunocompromised patients with invasive pulmonary aspergillosis Am J Roentgenol 187 404 13 10.2214/AJR.05.0513 (Pubitemid 44148284)
29. E Azoulay D Mokart A Rabbat, et al. 2008 Diagnostic bronchoscopy in hematology and oncology patients with acute respiratory failure Crit Care Med 36 100 7 18090351 10.1097/01.CCM.0000295590.33145.C4
30. C Cordonnier E Escudier F Verra, et al. 1994 Bronchoalveolar lavage during neutropenic episodes Eur Respir J 7 114 20 8143809 10.1183/09031936.94. 07010114 1:STN:280:DyaK2c7pt1Omuw%3D%3D
31. M Hummel S Rudert H Hof, et al. 2008 Diagnostic yield of bronchoscopy with bronchoalveolar lavage in febrile patients with hematologic malignancies and pulmonary infiltrates Ann Hematol 87 291 7 17932672 10.1007/s00277-007-0391- 6 (Pubitemid 351445290)
32. KV Rolston GP Bodey A Safdar 2007 Polymicrobial infection in patients with cancer: an underappreciated and underreported entity Clin Infect Dis 45 228 33 17578784 10.1086/518873 (Pubitemid 47041015)
33. M Dettenkofer S Wenzler-Rottele R Babikir, et al. 2005 Surveillance of nosocomial sepsis and pneumonia in patients with a bone marrow or peripheral blood stem cell transplant Clin Infect Dis 40 926 31 15824981 10.1086/428046 1:STN:280:DC%2BD2M7ptVajsw%3D%3D (Pubitemid 40418296)
34. G Chamilos M Luna RE Lewis, et al. 2006 Invasive fungal infections in patients with hematologic malignancies in a tertiary care cancer center: an autopsy study over a 15-year period (1989-2003) Haematologica 91 986 9 16757415 (Pubitemid 44023159)
35. WG Boersma Z Erjavec TS van der Werf, et al. 2007 Bronchoscopic diagnosis of pulmonary infiltrates in granulocytopenic patients with hematologic malignancies: BAL versus PSB and PBAL Respir Med 101 317 25 16774815 10.1016/j.rmed.2006.04.021 (Pubitemid 46075961)
36. P Jain S Sandur Y Meli, et al. 2004 Role of flexible bronchoscopy in immunocompromised patients with lung infiltrates Chest 125 712 22 14769756 10.1378/chest.125.2.712 (Pubitemid 38223654)
37. L Joos M Tamm 2005 Breakdown of pulmonary host defense in the immunocompromised host: cancer chemotherapy Proc Am Thorac Soc 2 445 8 16322598 10.1513/pats.200508-097JS 1:CAS:528:DC%2BD28Xks12hug%3D%3D (Pubitemid 43128041)
38. SH Armenian WV La Via SE Siegel L Mascarenhas 2007 Evaluation of persistent pulmonary infiltrates in pediatric oncology patients Pediatr Blood Cancer 48 165 72 16411212 10.1002/pbc.20747 (Pubitemid 44958273)
39. DA White PW Wong R Downey 2000 The utility of open lung biopsy in patients with hematologic malignancies Am J Respir Crit Care Med 161 723 9 10712314 1:STN:280:DC%2BD3c7nslyqsA%3D%3D (Pubitemid 30171723)
40. SS Hwang HH Kim SH Park, et al. 2000 The value of CT-guided percutaneous needle aspiration in immunocompromised patients with suspected pulmonary infection Am J Roentgenol 175 235 8 1:STN:280:DC%2BD3czjvVWhtA%3D%3D (Pubitemid 30415569)
41. C Lass-Flörl G Resch D Nachbaur, et al. 2007 The value of computed tomography-guided percutaneous lung biopsy for diagnosis of invasive fungal infection in immunocompromised patients Clin Infect Dis 45 e101 4 17806041 10.1086/521245 (Pubitemid 47580399)
42. V Rickerts S Mousset E Lambrecht, et al. 2007 Comparison of histopathological analysis, culture, and polymerase chain reaction assays to detect invasive mold infections from biopsy specimens Clin Infect Dis 44 1078 83 17366453 10.1086/512812 (Pubitemid 46580276)
43. MJ Becker EJ Lugtenburg JJ Cornelissen, et al. 2003 Galactomannan detection in computerized tomography-based broncho-alveolar lavage fluid and serum in haematological patients at risk for invasive pulmonary aspergillosis Br J Haematol 121 448 57 12716367 10.1046/j.1365-2141.2003.04308.x 1:CAS:528:DC%2BD3sXksFKjs7o%3D (Pubitemid 36628336)
44. D Buchheidt C Baust H Skladny, et al. 2001 Detection of aspergillus species in blood and bronchoalveolar lavage samples from immunocompromised patients by means of 2-step polymerase chain reaction: clinical results Clin Infect Dis 33 428 35 11462176 10.1086/321887 1:STN:280:DC%2BD3Mvht1Sgtg%3D%3D (Pubitemid 32709572)
45. A Busca F Locatelli A Barbui, et al. 2006 Usefulness of sequential Aspergillus galactomannan antigen detection combined with early radiologic evaluation for diagnosis of invasive pulmonary aspergillosis in patients undergoing allogeneic stem cell transplantation Transplant Proc 38 1610 3 16797366 10.1016/j.transproceed.2006.02.072 1:STN:280:DC%2BD28zotlehtA%3D%3D
46. J Maertens J Verhaegen H Demuynck, et al. 1999 Autopsy-controlled prospective evaluation of serial screening for circulating galactomannan by a sandwich enzyme-linked immunosorbent assay for hematological patients at risk for invasive aspergillosis J Clin Microbiol 37 3223 8 10488181 1:CAS:528:DyaK1MXmsFektrc%3D (Pubitemid 29455209)
47. JA Maertens R Klont C Masson, et al. 2007 Optimization of the cutoff value for the Aspergillus double-sandwich enzyme immunoassay Clin Infect Dis 44 1329 36 17443470 10.1086/514349 1:CAS:528:DC%2BD2sXmtFegt7w%3D (Pubitemid 46729195)
48. B Spiess D Buchheidt C Baust, et al. 2003 Development of a LightCycler PCR assay for detection and quantification of Aspergillus fumigatus DNA in clinical samples from neutropenic patients J Clin Microbiol 41 1811 8 12734210 10.1128/JCM.41.5.1811-1818.2003 1:CAS:528:DC%2BD3sXktlGku7Y%3D (Pubitemid 36576496)
49. M Weisser C Rausch A Droll, et al. 2005 Galactomannan does not precede major signs on a pulmonary computerized tomographic scan suggestive of invasive aspergillosis in patients with hematological malignancies Clin Infect Dis 41 1143 9 16163633 10.1086/444462 1:STN:280:DC%2BD2MvptFynsA%3D%3D (Pubitemid 41429477)
50. A Aubry R Porcher J Bottero, et al. 2006 Occurrence and kinetics of false-positive Aspergillus galactomannan test results following treatment with beta-lactam antibiotics in patients with hematological disorders J Clin Microbiol 44 389 94 16455889 10.1128/JCM.44.2.389-394.2006 1:CAS:528: DC%2BD28XitFShtbg%3D (Pubitemid 43222228)
51. B Musher D Fredricks W Leisenring, et al. 2004 Aspergillus galactomannan enzyme immunoassay and quantitative PCR for diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid J Clin Microbiol 42 5517 22 15583275 10.1128/JCM.42.12.5517-5522.2004 1:CAS:528:DC%2BD2MXkt12ntQ%3D%3D (Pubitemid 39664330)
52. C Mengoli M Cruciani RA Barnes, et al. 2009 Use of PCR for diagnosis of invasive aspergillosis: systematic review and meta-analysis Lancet Infect Dis 9 89 96 19179225 10.1016/S1473-3099(09)70019-2 1:CAS:528:DC%2BD1MXjt1Snt7s%3D A comprehensive state-of-the-art review on PCR for diagnosing aspergillosis
53. UJ Schoepf RD Bruening C Hong, et al. 2001 Multislice helical CT of focal and diffuse lung disease: comprehensive diagnosis with reconstruction of contiguous and high-resolution CT sections from a single thin-collimation scan Am J Roentgenol 177 179 84 1:STN:280:DC%2BD3Mzlslemsw%3D%3D (Pubitemid 32578076)
54. L Slobbe S Polinder JK Doorduijn, et al. 2008 Outcome and medical costs of patients with invasive aspergillosis and acute myelogenous leukemia - myelodysplastic syndrome treated with intensive chemotherapy: an observational study Clin Infect Dis 47 1507 12 18990068 10.1086/591531
55. OA Cornely J Maertens M Bresnik, et al. 2007 Liposomal amphotericin B as initial therapy for invasive mold infection: a randomized trial comparing a high-loading dose regimen with standard dosing Clin Infect Dis 44 1289 97 17443465 10.1086/514341 1:CAS:528:DC%2BD2sXmtFegtro%3D (Pubitemid 46717290)
56. TJ Walsh H Teppler GR Donowitz, et al. 2004 Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia N Engl J Med 351 1391 402 15459300 10.1056/NEJMoa040446 1:CAS:528:DC%2BD2cXotVOrsro%3D (Pubitemid 39288165)
57. A Böhme M Ruhnke D Buchheidt, et al. 2009 Treatment of invasive fungal infections in cancer patients Ann Hematol 88 97 110 18853161 10.1007/s00277-008-0622-5
58. G Maschmeyer A Haas 2006 Defining clinical failure for salvage studies Med Mycol 44 S315 8 10.1080/13693780600835690 (Pubitemid 44524123)
59. H Cherif CR Martling J Hansen, et al. 2007 Predictors of short and long-term outcome in patients with hematological disorders admitted to the intensive care unit for a life-threatening complication Support Care Cancer 15 1393 8 17516092 10.1007/s00520-007-0268-1 (Pubitemid 350077228)
60. G Maschmeyer FL Bertschat KT Moesta, et al. 2003 Outcome analysis of 189 consecutive cancer patients referred to the intensive care unit as emergencies during a 2-year period Eur J Cancer 39 783 92 12651204 10.1016/S0959-8049(03) 00004-2 1:STN:280:DC%2BD3s7js1yhsg%3D%3D (Pubitemid 36315995)