Anti-haemolytic effect of senicapoc and decrease in NT-proBNP in adults with sickle cell anaemia

British Journal of Haematology

Volumn 155, Issue 5, 2011, Pages 634-636

  Minniti, Caterina P ^a   Wilson, Jonathan ^a   Mendelsohn, Laurel ^a   Rigdon, Greg C ^b   Stocker, Jonathan W ^c   Remaley, Alan T ^a   Kato, Gregory J ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b Icagen Inc   (United States)

^c Clinical Pharmacology   (United States)

Author keywords

Brain natriuretic peptide; Haemolysis; Pulmonary hypertension; Senicapoc; Sickle cell anaemia

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; BILIRUBIN; ECULIZUMAB; HEMOGLOBIN; HYDROXYUREA; LACTATE DEHYDROGENASE; SENICAPOC;

ADULT; BILIRUBIN BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL LABORATORY; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; HEMOGLOBIN BLOOD LEVEL; HEMOLYSIS; HEMOLYTIC ANEMIA; HUMAN; LACTATE DEHYDROGENASE BLOOD LEVEL; LETTER; LUNG ARTERY PRESSURE; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SICKLE CELL ANEMIA;

ACETAMIDES; ADULT; ANEMIA, SICKLE CELL; FEMALE; HUMANS; MALE; NATRIURETIC PEPTIDE, BRAIN; PEPTIDE FRAGMENTS; TRITYL COMPOUNDS;

EID: 81155134190     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2011.08757.x     Document Type: Letter

References (10)

1. Ataga, K.I., Smith, W.R., De Castro, L.M., Swerdlow, P., Saunthararajah, Y., Castro, O., Vichinsky, E., Kutlar, A., Orringer, E.P., Rigdon, G.C. & Stocker, J.W. (2008) Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia. Blood, 111, 3991-3997.
2. Ataga, K.I., Reid, M., Ballas, S.K., Yasin, Z., Bigelow, C., James, L.S., Smith, W.R., Galacteros, F., Kutlar, A., Hull, J.H. & Stocker, J.W. (2011) Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: a phase III randomized, placebo-controlled, double-blind study of the gardos channel blocker senicapoc (ICA-17043). British Journal of Haematology, 153, 92-104.
3. van Beers, E.J., Nur, E., Schaefer-Prokop, C.M., Mac Gillavry, M.R., van Esser, J.W., Brandjes, D.P., Kappers-Klunne, M.C., Duits, A.J., Muskiet, F.A., Schnog, J.J. & Biemond, B.J. (2008) Cardiopulmonary imaging, functional and laboratory studies in sickle cell disease associated pulmonary hypertension. American Journal of Hematology, 83, 850-854.
4. Hill, A., Rother, R.P., Wang, X., Morris, Jr, S.M., Quinn-Senger, K., Kelly, R., Richards, S.J., Bessler, M., Bell, L., Hillmen, P. & Gladwin, M.T. (2010) Effect of eculizumab on haemolysis-associated nitric oxide depletion, dyspnoea, and measures of pulmonary hypertension in patients with paroxysmal nocturnal haemoglobinuria. British Journal of Haematology, 149, 414-425.
5. Levin, E.R., Gardner, D.G. & Samson, W.K. (1998) Natriuretic peptides. New England Journal of Medicine, 339, 321-328.
6. Machado, R.F., Anthi, A., Steinberg, M.H., Bonds, D., Sachdev, V., Kato, G.J., Taveira-DaSilva, A.M., Ballas, S.K., Blackwelder, W., Xu, X., Hunter, L., Barton, B., Waclawiw, M., Castro, O. & Gladwin, M.T. (2006) N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease. JAMA, 296, 310-318.
7. Mekontso Dessap, A., Leon, R., Habibi, A., Nzouakou, R., Roudot-Thoraval, F., Adnot, S., Godeau, B., Galacteros, F., Brun-Buisson, C., Brochard, L. & Maitre, B. (2008) Pulmonary hypertension and cor pulmonale during severe acute chest syndrome in sickle cell disease. American Journal of Respiratory and Critical Care Medicine, 177, 646-653.
8. Mokhtar, G.M., Adly, A.A., El Alfy, M.S., Tawfik, L.M. & Khairy, A.T. (2010) N-terminal natriuretic peptide and ventilation-perfusion lung scan in sickle cell disease and thalassemia patients with pulmonary hypertension. Hemoglobin, 34, 78-94.
9. Olnes, M., Chi, A., Haney, C., May, R., Minniti, C., Taylor, J.t. & Kato, G.J. (2009) Improvement in hemolysis and pulmonary arterial systolic pressure in adult patients with sickle cell disease during treatment with hydroxyurea. American Journal of Hematology, 84, 530-532.
10. Voskaridou, E., Tsetsos, G., Tsoutsias, A., Spyropoulou, E., Christoulas, D. & Terpos, E. (2007) Pulmonary hypertension in patients with sickle cell/beta thalassemia: incidence and correlation with serum N-terminal pro-brain natriuretic peptide concentrations. Haematologica, 92, 738-743.