Effect of eculizumab on haemolysis-associated nitric oxide depletion, dyspnoea, and measures of pulmonary hypertension in patients with paroxysmal nocturnal haemoglobinuria

British Journal of Haematology

Volumn 149, Issue 3, 2010, Pages 414-425

  Hill, Anita ^a,b   Rother, Russell P ^c   Wang, Xunde ^d   Morris Jr , Sidney M ^e   Quinn Senger, Kerry ^c   Kelly, Richard ^a   Richards, Stephen J ^a   Bessler, Monica ^f   Bell, Leonard ^c   Hillmen, Peter ^a   Gladwin, Mark T ^e,g  

^a ST JAMES S INSTITUTE OF ONCOLOGY   (United Kingdom)

^b BRADFORD TEACHING HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c ALEXION PHARMACEUTICALS   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Complement; Haemolysis; Nitric oxide; Paroxysmal nocturnal haemoglobinuria; Pulmonary hypertension

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; ARGININE; ECULIZUMAB; HEMOGLOBIN; LACTATE DEHYDROGENASE; NITRIC OXIDE; PLACEBO;

ANEMIA; ARTICLE; CATABOLISM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DYSPNEA; FEMALE; HEART RIGHT VENTRICLE FAILURE; HUMAN; HYPERTENSION; INTRAVASCULAR HEMOLYSIS; LUNG VASCULAR RESISTANCE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PULMONARY HYPERTENSION; RANDOMIZED CONTROLLED TRIAL; VASOMOTOR REFLEX;

ANTIBODIES, MONOCLONAL; BIOLOGICAL MARKERS; BLOOD PRESSURE; DYSPNEA; FEMALE; HEMOGLOBINS; HEMOGLOBINURIA, PAROXYSMAL; HEMOLYSIS; HUMANS; HYPERTENSION, PULMONARY; MALE; NATRIURETIC PEPTIDE, BRAIN; NITRIC OXIDE; PEPTIDE FRAGMENTS; TREATMENT OUTCOME;

EID: 77950822742     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2010.08096.x     Document Type: Article

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