Enhanced sensitization and elicitation responses caused by mixtures of common fragrance allergens

Contact Dermatitis

Volumn 65, Issue 6, 2011, Pages 336-342

  Bonefeld, Charlotte Menné ^a   Nielsen, Morten Milek ^a   Rubin, Ingrid Maria Cecilia ^a   Vennegaard, Marie Torp ^a   Dabelsteen, Sally ^a   Gimenéz Arnau, Elena ^b   Lepoittevin, Jean Pierre ^b   Geisler, Carsten ^a   Johansen, Jeanne Duus ^c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

cocktail effect; contact allergy; perfume

Indexed keywords

ALDEHYDE DERIVATIVE; ALLERGEN; CINNAMALDEHYDE; FRAGRANCE; HYDROXYISOHEXYL 3 CYCLOHEXENE CARBOXALDEHYDE; ISOEUGENOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CONTACT ALLERGY; CONTACT SENSITIZATION; CONTROLLED STUDY; FEMALE; LYMPH NODE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; SKIN SENSITIZATION; T LYMPHOCYTE;

ACROLEIN; ALDEHYDES; ALLERGENS; ANIMALS; CD4 LYMPHOCYTE COUNT; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; CYCLOHEXENES; DERMATITIS, ALLERGIC CONTACT; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; EUGENOL; FEMALE; FLOW CYTOMETRY; MICE; MICE, INBRED CBA; PERFUME;

EID: 81155134015     PISSN: 01051873     EISSN: 16000536     Source Type: Journal    
DOI: 10.1111/j.1600-0536.2011.01945.x     Document Type: Article

References (17)

1. Johansen J D., Fragrance contact allergy: a clinical review. Am J Clin Dermatol 2003: 4: 789-798. (Pubitemid 37452638)
2. Basketter D, Kimber, I., Predictive tests for irritants and allergens and their use in quantitative risk assessment. In: Contact Dermatitis, Johansen J D, Frosch, P J, Lepoittevin J-P, (eds): Heidelberg, Springer-Verlag, 2011: pp. 229-240.
3. Yazar K, Johnsson S, Lind M L, Boman A, Lidén C., Preservatives and fragrances in selected consumer-available cosmetics and detergents. Contact Dermatitis 2011: 64: 265-272.
4. Buckley D A., Fragrance ingredient labelling in products on sale in the UK. Br J Dermatol 2007: 157: 295-300. (Pubitemid 47083858)
5. Rastogi S C, Johansen J D., Survey and risk assessment of chemical substances in deodorants, 2011. Available at: (last accessed 26 April 2011).
6. Johansen J D, Skov L, Volund A, Andersen K, Menné T., Allergens in combination have a synergistic effect on the elicitation response: a study of fragrance-sensitized individuals. Br J Dermatol 1998: 139: 264-270. (Pubitemid 28389399)
7. Agner T, Johansen J D, Overgaard L, Volund A, Basketter D, Menné T., Combined effects of irritants and allergens. Synergistic effects of nickel and sodium lauryl sulfate in nickel-sensitized individuals. Contact Dermatitis 2002: 47: 21-26.
8. Kimber I, Dearman R J, Basketter D A, Ryan C A, Gerberick G F., The local lymph node assay: past, present and future. Contact Dermatitis 2002: 47: 315-328. (Pubitemid 36246404)
9. Patlewicz G Y, Wright Z M, Basketter D A, Pease C K, Lepoittevin J P, Arnau E G., Structure-activity relationships for selected fragrance allergens. Contact Dermatitis 2002: 47: 219-226. (Pubitemid 36132488)
10. Larsen J M, Geisler C, Nielsen M W, Boding L, Von E M, Hansen A K, Skov L, Bonefeld C M., Cellular dynamics in the draining lymph nodes during sensitization and elicitation phases of contact hypersensitivity. Contact Dermatitis 2007: 57: 300-308. (Pubitemid 47568791)
11. Bonefeld C M, Larsen J M, Dabelsteen S, Geisler C, White I R, Menné T, Johansen J D., Consumer available permanent hair dye products cause major allergic immune activation in an animal model. Br J Dermatol 2010: 162: 102-107.
12. Vocanson M, Hennino A, Cluzel-Tailhardat M et al., CD8+ T cells are effector cells of contact dermatitis to common skin allergens in mice. J Invest Dermatol 2006: 126: 815-820.
13. Grabbe S, Steinert M, Mahnke K, Schwartz A, Luger T A, Schwarz T., Dissection of antigenic and irritative effects of epicutaneously applied haptens in mice. Evidence that not the antigenic component but nonspecific proinflammatory effects of haptens determine the concentration-dependent elicitation of allergic contact dermatitis. J Clin Invest 1996: 98: 1158-1164. (Pubitemid 26299929)
14. Curtsinger J M, Mescher M F., Inflammatory cytokines as a third signal for T cell activation. Curr Opin Immunol 2010: 22: 333-340.
15. Kaech S M, Wherry E J, Ahmed R., Effector and memory T-cell differentiation: implications for vaccine development. Nat Rev Immunol 2002: 2: 251-262. (Pubitemid 37323225)
16. Larsen W G., Perfume dermatitis. a study of 20 patients. Arch Dermatol 1977: 113: 623-626.
17. Frosch P J, Pirker C, Rastogi S C et al., Patch testing with a new fragrance mix detects additional patients sensitive to perfumes and missed by the current fragrance mix. Contact Dermatitis 2005: 52: 207-215. (Pubitemid 40676600)