The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance

Biochemical Journal

Volumn 440, Issue 2, 2011, Pages 195-202

  Cabrito, Tânia R ^a   Teixeira, Miguel C ^a   Singh, Ashutosh ^b   Prasad, Rajendra ^b   Sá Correia, Isabel ^a  

^a INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^b JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

Ergosterol homoeostasis; Herbicide resistance; Multidrug resistance; Pleiotropic drug resistance; Saccharomyces cerevisiae

Indexed keywords

2,4 DICHLOROPHENOXYACETIC ACID; ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; BINDING PROTEIN; HERBICIDE; STEROL;

ARTICLE; CELL MEMBRANE; CELLULAR STRESS RESPONSE; GENE; MULTIDRUG RESISTANCE; NONHUMAN; PDR18 GENE; PHENOTYPE; PRIORITY JOURNAL; YEAST;

2,4-DICHLOROPHENOXYACETIC ACID; ATP-BINDING CASSETTE TRANSPORTERS; CELL MEMBRANE; DNA-BINDING PROTEINS; DRUG RESISTANCE, MULTIPLE; MEMBRANE POTENTIALS; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STEROLS; TRANSCRIPTION FACTORS;

SACCHAROMYCES CEREVISIAE;

EID: 81155123735     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20110876     Document Type: Article

References (37)

1. Roepe, P. D., Wei, L. Y., Hoffman, M. M. and Fritz, F. (1996) Altered drug translocation mediated by the MDR protein: direct, indirect, or both? J. Bioenerg. Biomembr. 28, 541-555 (Pubitemid 26399486)
2. + antiporters in chemical stress response in yeast. Trends Microbiol. 17, 22-31
3. Jungwirth, H. and Kuchler, K. (2006) Yeast ABC transporters: a tale of sex, stress, drugs and aging. FEBS Lett. 580, 1131-1138 (Pubitemid 43185293)
4. Tomitori, H., Kashiwagi, K., Asakawa, T., Kakinuma, Y., Michael, A. J. and Igarashi, K. (2001) Multiple polyamine transport systems on the vacuolar membrane in yeast. Biochem. J. 353, 681-688 (Pubitemid 32158337)
5. + antiporter Qdr3 and the transcription factors Yap1 and Gcn4. Microbiology 157, 945-956
6. Vargas, R. C., Garcia-Salcedo, R., Tenreiro, S., Teixeira, M. C., Fernandes, A. R., Ramos, J. and Sá-Correia, I. (2007) Saccharomyces cerevisiae multidrug resistance transporter Qdr2 is implicated in potassium uptake, providing a physiological advantage to quinidine-stressed cells. Eukaryot. Cell 6, 134-142
7. Smriti, Krishnamurthy, S., Dixit, B. L., Gupta, C. M., Milewski, S. and Prasad, R. (2002) ABC transporters Cdr1p, Cdr2p and Cdr3p of a human pathogen Candida albicans are general phospholipid translocators. Yeast 19, 303-318
8. Schuller, C., Mamnun, Y. M., Wolfger, H., Rockwell, N., Thorner, J. and Kuchler, K. (2007) Membrane-active compounds activate the transcription factors Pdr1 and Pdr3 connecting pleiotropic drug resistance and membrane lipid homeostasis in Saccharomyces cerevisiae. Mol. Biol. Cell 18, 4932-4944 (Pubitemid 350246694)
9. Rockwell, N. C., Wolfger, H., Kuchler, K. and Thorner, J. (2009) ABC transporter Pdr10 regulates the membrane microenvironment of Pdr12 in Saccharomyces cerevisiae. J. Membr. Biol. 229, 27-52
10. Li, Y. and Prinz, W. A. (2004) ATP-binding cassette (ABC) transporters mediate nonvesicular, raft-modulated sterol movement from the plasma membrane to the endoplasmic reticulum. J. Biol. Chem. 279, 45226-45234 (Pubitemid 39430938)
11. van den Hazel, H. B., Pichler, H., do Valle Matta, M. A., Leitner, E., Goffeau, A. and Daum, G. (1999) PDR16 and PDR17, two homologous genes of Saccharomyces cerevisiae, affect lipid biosynthesis and resistance to multiple drugs. J. Biol. Chem. 274, 1934-1941
12. Hillenmeyer, M. E., Fung, E., Wildenhain, J., Pierce, S. E., Hoon, S., Lee, W., Proctor, M., St Onge, R. P., Tyers, M., Koller, D. et al. (2008) The chemical genomic portrait of yeast: uncovering a phenotype for all genes. Science 320, 362-365 (Pubitemid 351555656)
13. Teixeira, M. C., Fernandes, A. R., Mira, N. P., Becker, J. D. and Sá-Correia, I. (2006) Early transcriptional response of Saccharomyces cerevisiae to stress imposed by the herbicide 2,4-dichlorophenoxyacetic acid. FEMS Yeast Res. 6, 230-248
14. Teixeira, M. C., Duque, P. and Sá-Correia, I. (2007) Environmental genomics: mechanistic insights into toxicity of and resistance to the herbicide 2,4-D. Trends Biotechnol. 25, 363-370 (Pubitemid 47042918)
15. Teixeira, M. C. and Sá-Correia, I. (2002) Saccharomyces cerevisiae resistance to chlorinated phenoxyacetic acid herbicides involves Pdr1p-mediated transcriptional activation of TPO1 and PDR5 genes. Biochem. Biophys. Res. Commun. 292, 530-537 (Pubitemid 34694295)
16. Cabrito, T. R., Teixeira, M. C., Duarte, A. A., Duque, P. and Sá-Correia, I. (2009) Heterologous expression of a Tpo1 homolog from Arabidopsis thaliana confers resistance to the herbicide 2,4-D and other chemical stresses in yeast. Appl. Microbiol. Biotechnol. 84, 927-936
17. + transport systems during glucose-and H2O2-induced cell death in Saccharomyces cerevisiae. Yeast 27, 713-725
18. Madrid, R., Gomez, M. J., Ramos, J. and Rodriguez-Navarro, A. (1998) Ectopic potassium uptake in trk1 trk2 mutants of Saccharomyces cerevisiae correlates with a highly hyperpolarized membrane potential. J. Biol. Chem. 273, 14838-14844 (Pubitemid 28272771)
19. + -ATPase from Candida albicans. J. Bacteriol. 173, 6826-6836
20. Bligh, E. G. and Dyer, W. J. (1959) A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911-917
21. Sharma, M., Dhamgaye, S., Singh, A. and Prasad, R. (2011) Lipidome analysis reveals antifungal polyphenol curcumin affects membrane lipid homeostasis: targets Δ5,6 desaturase ERG3 of Candida albicans. Front. Biosci., in the press
22. Teixeira, M. C., Telo, J. P., Duarte, N. F. and Sá-Correia, I. (2004) The herbicide 2,4-dichlorophenoxyacetic acid induces the generation of free-radicals and associated oxidative stress responses in yeast. Biochem. Biophys. Res. Commun. 324, 1101-1107 (Pubitemid 39361622)
23. Abdulrehman, D., Monteiro, P. T., Teixeira, M. C., Mira, N. P., Lourenco, A. B., dos Santos, S. C., Cabrito, T. R., Francisco, A. P., Madeira, S. C., Aires, R. S. et al. (2011) YEASTRACT: providing a programmatic access to curated transcriptional regulatory associations in Saccharomyces cerevisiae through a web services interface. Nucleic Acids Res. 39, D136-D140
24. Teixeira, M. C., Monteiro, P., Jain, P., Tenreiro, S., Fernandes, A. R., Mira, N. P., Alenquer, M., Freitas, A. T., Oliveira, A. L. and Sá-Correia, I. (2006) The YEASTRACT database: a tool for the analysis of transcription regulatory associations in Saccharomyces cerevisiae. Nucleic Acids Res. 34, D446-D451
25. Harbison, C. T., Gordon, D. B., Lee, T. I., Rinaldi, N. J., Macisaac, K. D., Danford, T. W., Hannett, N. M., Tagne, J. B., Reynolds, D. B., Yoo, J. et al. (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431, 99-104 (Pubitemid 39215116)
26. Lee, T. I., Rinaldi, N. J., Robert, F., Odom, D. T., Bar-Joseph, Z., Gerber, G. K., Hannett, N. M., Harbison, C. T., Thompson, C. M., Simon, I. et al. (2002) Transcriptional regulatory networks in Saccharomyces cerevisiae. Science 298, 799-804 (Pubitemid 35231527)
27. van de Mortel, J. B., Mulders, D., Korthout, H., Theuvenet, A. P. and Borst-Pauwels, G. W. (1988) Transient hyperpolarization of yeast by glucose and ethanol. Biochim. Biophys. Acta 936, 421-428
28. Ito, H. and Gray, W. M. (2006) A gain-of-function mutation in the Arabidopsis pleiotropic drug resistance transporter PDR9 confers resistance to auxinic herbicides. Plant Physiol. 142, 63-74 (Pubitemid 44412230)
29. Sullivan, D. P., Ohvo-Rekila, H., Baumann, N. A., Beh, C. T. and Menon, A. K. (2006) Sterol trafficking between the endoplasmic reticulum and plasma membrane in yeast. Biochem. Soc. Trans. 34, 356-358 (Pubitemid 43953985)
30. Hancock, J. F. (2006) Lipid rafts: contentious only from simplistic standpoints. Nat. Rev. Mol. Cell Biol. 7, 456-462
31. Mukherjee, S. and Maxfield, F. R. (2004) Membrane domains. Annu. Rev. Cell Dev. Biol. 20, 839-866 (Pubitemid 39488660)
32. Dupont, S., Beney, L., Ferreira, T. and Gervais, P. (2011) Nature of sterols affects plasma membrane behavior and yeast survival during dehydration. Biochim. Biophys. Acta 1808, 1520-1528
33. Amborabe, B. E., Rossard, S., Perault, J. M. and Roblin, G. (2003) Specific perception of ergosterol by plant cells. C R Biol. 326, 363-370 (Pubitemid 36869567)
34. Rossard, S., Luini, E., Perault, J. M., Bonmort, J. and Roblin, G. (2006) Early changes in membrane permeability, production of oxidative burst and modification of PAL activity induced by ergosterol in cotyledons of Mimosa pudica. J. Exp. Bot. 57, 1245-1252
35. Granado, J., Felix, G. and Boller, T. (1995) Perception of fungal sterols in plants (subnanomolar concentrations of ergosterol elicit extracellular alkalinization in tomato cells). Plant Physiol. 107, 485-490
36. Kasparovsky, T., Blein, J. P. and Mikes, V. (2004) Ergosterol elicits oxidative burst in tobacco cells via phospholipase A2 and protein kinase C signal pathway. Plant Physiol. Biochem. 42, 429-435 (Pubitemid 38800993)
37. Tierney, K. J., Block, D. E. and Longo, M. L. (2005) Elasticity and phase behavior of DPPC membrane modulated by cholesterol, ergosterol, and ethanol. Biophys. J. 89, 2481-2493 (Pubitemid 41401037)